J. Doehmer

发表

The level of DNA modification by (+)-syn-(11S,12R,13S,14R)- and (-)-anti-(11R,12S,13S,14R)-dihydrodiol epoxides of dibenzo[a,l]pyrene determined the effect on the proteins p53 and p21WAF1 in the human mammary carcinoma cell line MCF-7.

A. Luch, A. Seidel, W. Baird, 1999, Carcinogenesis.

Cytochrome P450

Benveniste, F. Durst, M. J. Coon, 1993, Handbook of Experimental Pharmacology.

Assessment of drug-drug interaction for silymarin.

J. Doehmer, U. Mengs, B. Tewes, 2008, Toxicology in vitro : an international journal published in association with BIBRA.

Metabolism of phenacetin in V79 Chinese hamster cell cultures expressing rat liver cytochrome P4501A2 compared to isolated rat hepatocytes.

K. G. Jensen, S. Loft, J. Doehmer, 1993, Biochemical pharmacology.

Modeling the metabolic competency of glutathione S-transferases using genetically modified cell lines.

A. Townsend, J. Doehmer, C. Morrow, 2002, Toxicology.

Protective Efficacy of hGSTM 1-1 against B [ a ] P and ( þ )-or ( )-B [ a ] P7 , 8-Dihydrodiol Cytotoxicity , Mutagenicity , and Macromolecular Adducts in V 79 Cells Coexpressing hCYP 1 A 1

A. Townsend, J. Doehmer, C. Morrow, 2007 .

Protective efficacy of hGSTM1-1 against B[a]P and (+)- or (-)-B[a]P-7,8-dihydrodiol cytotoxicity, mutagenicity, and macromolecular adducts in V79 cells coexpressing hCYP1A1.

A. Townsend, J. Doehmer, C. Morrow, 2007, Toxicological sciences : an official journal of the Society of Toxicology.

Induction of rat brain and liver cytochrome P450 1A1/1A2 and 2B1/2B2 isoenzymes by deltamethrin.

U. Dwivedi, J. Doehmer, P. Seth, 1999, Environmental toxicology and pharmacology.

The Role of Cytochrome P450 1B1 in Dibenzo[ a,l ]pyrene-induced Carcinogenesis

H. Glatt, A. Luch, A. Seidel, 2002 .

Mutations induced by (−)‐anti‐11R,12S‐dihydrodiol 13S,14R‐epoxide of dibenzo[a,l]pyrene in the coding region of the hypoxanthine phosphoribosyltransferase (Hprt) gene in Chinese hamster V79 cells

A. Luch, A. Seidel, B. Mahadevan, 2003, Environmental and molecular mutagenesis.

On the species-specific biotransformation of dibenzo[a,l]pyrene.

J. Stegeman, A. Luch, A. Seidel, 2006, Chemico-biological interactions.

Expression of human glutathione S-transferase P1 confers resistance to benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol mutagenesis, macromolecular alkylation and formation of stable N2-Gua-BPDE adducts in stably transfected V79MZ cells co-expressing hCYP1A1.

A. Townsend, J. Doehmer, C. Morrow, 2007, Carcinogenesis.

Competitive inhibition of carcinogen‐activating CYP1A1 and CYP1B1 enzymes by a standardized complex mixture of PAH extracted from coal tar

A. Luch, B. Mahadevan, W. Baird, 2007, International journal of cancer.

Kinetics and inhibition by fluvoxamine of phenacetin O-deethylation in V79 cells expressing human CYP1A2.

K. G. Jensen, S. Loft, J. Doehmer, 1995, Pharmacology & toxicology.

Expression of stably transfected murine glutathione S-transferase A3-3 protects against nucleic acid alkylation and cytotoxicity by aflatoxin B1 in hamster V79 cells expressing rat cytochrome P450-2B1.

A. Townsend, J. Doehmer, C. Morrow, 1999, Carcinogenesis.

Cytochrome P450 CYP1B1 protein expression: a novel mechanism of anticancer drug resistance.

H. McLeod, J. Doehmer, G. Murray, 2001, Biochemical pharmacology.

Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1.

J. Doehmer, J. Chipman, S. Lautraite, 2002, Mutagenesis.

Modeling the chemoprotective functions of glutathione S-transferases in cultured cell lines by heterologous expression.

A. Townsend, J. Doehmer, C. Morrow, 1999, Drug metabolism reviews.

Toxicological Implications of Enzymatic Control of Reactive Metabolites

H. Glatt, F. Oesch, P. Steinberg, 1990, Human & experimental toxicology.

Stable expression of rat cytochrome P-450IA1 cDNA in V79 Chinese hamster cells and their use in mutagenicity testing.

H. Glatt, F. Oesch, A. Seidel, 1990, Molecular pharmacology.

Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1.

A. Seidel, A. Townsend, J. Doehmer, 2009, Chemico-biological interactions.

Chemoprotective functions of glutathione S-transferases in cell lines induced to express specific isozymes by stable transfection.

R. Haynes, A. Townsend, J. Doehmer, 1998, Chemico-biological interactions.

Genetically engineered V79 Chinese hamster cells metabolically activate the cytostatic drugs cyclophosphamide and ifosfamide.

H. Glatt, F. Oesch, A. Seidel, 1990, Environmental health perspectives.

Alternative (non-animal) methods for chemicals testing: Current status and future prospects - Overview

Valérie Zuang, Silvia Casati, Andrew P. Worth, 2002 .

Stable expression and coexpression of human cytochrome P450 oxidoreductase and cytochrome P450 1A2 in V79 Chinese hamster cells: sensitivity to quinones and biotransformation of 7-alkoxyresorufins and triazines.

H. Greim, J. Doehmer, W. Schmalix, 1996, Drug metabolism and disposition: the biological fate of chemicals.

Use of V79 cells with stably transfected cytochrome P450 cDNAs in studying the metabolism and effects of cytotoxic drugs

P. Philip, J. Doehmer, Hong Lu, 1999, Cancer Chemotherapy and Pharmacology.

Molecular studies on the toxifying effects by genetically engineered cytochromes P450.

H. Glatt, W. F. Greenlee, A. Luch, 1999, Drug metabolism reviews.

CYP2D6 increases toxicity of the designer drug 4-methylthioamphetamine (4-MTA).

F. Oesch, F. Carvalho, J. Hengstler, 2007, Toxicology.

Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine (‘Ecstasy’) cytotoxicity

F. Oesch, F. Carvalho, J. Hengstler, 2006, Pharmacogenetics and genomics.

Cytochrome P450-null mice.

J. Doehmer, F. Gonzalez, J. Buters, 1999, Drug metabolism reviews.

V79 Chinese hamster cells genetically engineered for stable expression of cytochromes P450.

F. Oesch, J. Doehmer, 1991, Methods in enzymology.

Territrems B and C metabolism in human liver microsomes: major role of CYP3A4 and CYP3A5.

R. Edwards, J. Doehmer, Ching-Yao Yang, 2006, Toxicology.

Role of Human Hepatic Cytochrome P-450S in Territrem a Metabolism

J. Doehmer, F. Peng, Hsun-Yi Tseng, 2003, Journal of toxicology and environmental health. Part A.

Cytochromes P450 and drug resistance

N. Vermeulen, J. Doehmer, A. Goeptar, 2004, Cytotechnology.

Improved Determination of Drug Metabolism by Perifusion of Recombinant V79 Cells Carrying Human CYP3A4.

R. Gebhardt, J. Doehmer, A. Schneider, 1999, Toxicology in vitro : an international journal published in association with BIBRA.

The potential of acetaminophen as a prodrug in gene-directed enzyme prodrug therapy

R. Edwards, N. Lemoine, D. Davies, 2000, Cancer Gene Therapy.

Phytoalexin resveratrol attenuates the mutagenicity of the heterocyclic amines 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.

N. Gooderham, J. Doehmer, A. Boyce, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Cytochrome P450-mediated activation of phenanthrene in genetically engineered V79 Chinese hamster cells.

A. Seidel, H. Greim, J. Doehmer, 1996, Environmental toxicology and pharmacology.

Dual-colour FISH analysis to characterize a marker chromosome in cytochrome P450 2B1 recombinant V79 Chinese hamster cells.

J. Doehmer, F. Darroudi, S. Simi, 1999, Mutagenesis.

Genetically engineered mammalian cells and applications.

H. Greim, J. Doehmer, W. Schmalix, 1995, Toxicology letters.

Heterologous Co-Expression of Human Cytochrome P450 1A2 and Polymorphic Forms of N-Acetyltransferase 2 for Studies on Aromatic Amines in V79 Chinese Hamster Cells

J. Doehmer, J. Scheuenpflug, N. Krebsfänger, 2005, Alternatives to laboratory animals : ATLA.

Enhanced production of hepatitis B surface antigen in NIH 3T3 mouse fibroblasts by using extrachromosomally replicating bovine papillomavirus vector

M. Schaefer-Ridder, Y. Wang, P. Hofschneider, 1983, Molecular and cellular biology.

Assessment of a dry extract from milk thistle (Silybum marianum) for interference with human liver cytochrome-P450 activities.

J. Doehmer, G. Mcgregor, K. Appel, 2011, Toxicology in vitro : an international journal published in association with BIBRA.

Morphological, biochemical, and molecular biological characterization of a rat rhabdomyosarcoma cell line during differentiation induction in vitro.

F. Oesch, C. Gerharz, J. Doehmer, 1990, Environmental health perspectives.

Enhanced expression of the proto‐oncogenes fos and raf in the rhabdomyosarcoma cell line BA‐HAN‐1C after differentiation induction with retinoic acid and N‐methylformamide

F. Oesch, C. Gerharz, J. Doehmer, 1990, International journal of cancer.

Uniform response of c-raf expression to differentiation induction and inhibition of proliferation in a rat rhabdomyosarcoma cell line

C. Gerharz, J. Doehmer, H. Gabbert, 1990, Virchows Archiv. B, Cell pathology including molecular pathology.

Intragraft iNOS induction during human liver allograft rejection depresses cytochrome p450 activity

J. Doehmer, C. Heidecke, S. Maier, 2004, Transplant international : official journal of the European Society for Organ Transplantation.

Sequence of the rat PB-inducible CYP2B1 promoter.

J. Doehmer, M. Adesnik, P. Shaw, 1996, Biochimica et biophysica acta.

Cloning of CYP11B1 and CYP11B2 from normal human adrenal and their functional expression in COS-7 and V79 Chinese hamster cells.

J. Doehmer, R. Bernhardt, K. Denner, 1995, Endocrine research.

Inhibition of biotransformation by nitric oxide (NO) overproduction and toxic consequences.

J. Doehmer, W. Schmalix, J. Stadler, 1995, Toxicology letters.

Germ line integration of Moloney leukemia virus: identification of the chromosomal integration site.

R. Jaenisch, K. Willecke, J. Doehmer, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Metabolism of Phenanthrene, Benz[a]anthracene, Benzo[a]pyrene, Chrysene and Benzo[c]phenanthrene by Eight cDNA-expressed Human and Rat Cytochromes P450

A. Seidel, H. Greim, J. Doehmer, 1996 .

Species-dependent Metabolism of Benzo[c]phenanthrene and Dibenzo[a, l]pyrene by Various CYP450 Isoforms

J. Stegeman, A. Luch, A. Seidel, 2000 .

The use of Long-term Hepatocyte Cultures for Detecting Induction of Drug Metabolising Enzymes: The Current Status

S Coecke, V Rogiers, V. Rogiers, 1999, Alternatives to laboratory animals : ATLA.

Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas.

J. Ward, T. Pineau, J. Doehmer, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Assessment of Extracts from Mistletoe (Viscum album) for Herb–Drug Interaction by Inhibition and Induction of Cytochrome P450 Activities

J. Doehmer, J. Eisenbraun, 2012, Phytotherapy research : PTR.

Biotransformation of the naturally occurring lignan (-)-arctigenin in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.

J. Doehmer, D. Gansser, R. Kasper, 1994, Planta medica.

Genetic analysis of transformed and malignant phenotypes in somatic cell hybrids between tumorigenic Chinese hamster cells and diploid mouse fibroblasts.

K. Willecke, R. Schäfer, J. Doehmer, 1981, Cancer research.

Stable expression of rat cytochrome P-450IIB1 cDNA in Chinese hamster cells (V79) and metabolic activation of aflatoxin B1.

H. Glatt, F. Oesch, J. Doehmer, 1988, Proceedings of the National Academy of Sciences of the United States of America.

The cytotoxicity of mitomycin C and adriamycin in genetically engineered V79 cell lines and freshly isolated rat hepatocytes.

H. Glatt, N. Vermeulen, A. Seidel, 1995, Chemico-biological interactions.

Stable expression of human cytochrome P450 1A1 cDNA in V79 Chinese hamster cells and metabolic activation of benzo[a]pyrene.

H. Glatt, A. Seidel, H. Greim, 1993, European journal of pharmacology.

Species-Dependent Metabolism of Benzo[c]Chrysene Mediated by c-DNA-Expressed Human, Rodent and Fish Cytochrome P450 Enzymes

A. Luch, A. Seidel, J. Doehmer, 2000 .

Introduction of rat growth hormone gene into mouse fibroblasts via a retroviral DNA vector: expression and regulation.

R. Evans, M. Rosenfeld, M. Barinaga, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Paracetamol-induced spindle disturbances in V79 cells with and without expression of human CYP1A2.

K. G. Jensen, S. Loft, J. Doehmer, 1996, Pharmacology & toxicology.

Cytochromes P450 in Genetically Engineered Cell Cultures: The Gene Technological Approach

H. Greim, J. Doehmer, 1993 .

V79 Chinese hamster cells genetically engineered for polymorphic cytochrome P450 2D6 and their predictive value for humans.

M. Eichelbaum, J. Doehmer, U. Zanger, 2003, ALTEX.

The Construction of Cell Cultures Genetically Engineered for Metabolic Competence towards Xenobiotics

J. Doehmer, 1995 .

V79 Chinese hamster cells genetically engineered for cytochrome P450 and their use in mutagenicity and metabolism studies.

J. Doehmer, 1993, Toxicology.

Applications of stable V79-derived cell lines expressing rat cytochromes P4501A1, 1A2, and 2B1.

H. Glatt, F. Oesch, A. Seidel, 1992, Xenobiotica; the fate of foreign compounds in biological systems.

Introduction of cytochrome P-450 genes into V79 Chinese hamster cells to generate new mutagenicity test systems.

H. Glatt, A. Seidel, J. Doehmer, 1989, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.

U. Fuhr, A. Staib, J. Doehmer, 1992, Biochemical pharmacology.

Assignment of the gene for cytoplasmic glutamate-oxaloacetate transaminase to mouse chromosome 19 using Chinese hamster x mouse somatic cell hybrids

K. Willecke, R. Schäfer, J. Doehmer, 1980, Somatic cell genetics.

Genetic transmission of Moloney leukemia virus: mapping of the chromosomal integration site.

R. Jaenisch, K. Willecke, J. Doehmer, 1979, Haematology and blood transfusion.

The use of genetically engineered V79 Chinese hamster cultures expressing rat liver CYP1A1, 1A2 and 2B1 cDNAs in micronucleus assays.

S. Ellard, J. Parry, J. Doehmer, 1991, Mutagenesis.

In Vitro Systems as Analytical Tools for Understanding and Predicting Drug Metabolism In Vivo

J. Doehmer, 1995 .

Benzylic hydroxylation of 1-methylpyrene and 1-ethylpyrene by human and rat cytochromes P450 individually expressed in V79 Chinese hamster cells.

H. Glatt, J. Doehmer, W. Engst, 1999, Carcinogenesis.

Search for cell culture systems with diverse xenobiotic-metabolizing activities and their use in toxicological studies.

H. Glatt, F. Oesch, J. Doehmer, 1987, Molecular toxicology.

Cytogenetic effects of promutagens in genetically engineered V79 Chinese hamster cells expressing cytochromes P450.

H. Glatt, M. Bauchinger, J. Doehmer, 1993, European journal of pharmacology.

Inhibition of cytochromes P4501A by nitric oxide.

J. Siewert, H. Greim, J. Doehmer, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Stable expression of human cytochrome P450 1B1 in V79 Chinese hamster cells and metabolically catalyzed DNA adduct formation of dibenzo[a,l]pyrene.

A. Luch, A. Seidel, W. Baird, 1998, Chemical research in toxicology.

Regio- and stereoselectivity in the metabolism of benzo[c]phenanthrene mediated by genetically engineered V79 Chinese hamster cells expressing rat and human cytochromes P450.

A. Seidel, H. Greim, J. Doehmer, 1998, Environmental toxicology and pharmacology.

Cytotoxicity and mutagenicity of 5-methylchrysene and its 1,2-dihydrodiol in V79MZ cells modified to express human CYP1A1 or CYP1B1, in the presence or absence of human GSTP1 coexpression.

S. Amin, A. Townsend, J. Doehmer, 2008, Toxicology letters.

The K-region trans-8,9-diol does not significantly contribute as an intermediate in the metabolic activation of dibenzo[a,l]pyrene to DNA-binding metabolites by human cytochrome P450 1A1 or 1B1.

A. Luch, A. Seidel, W. Baird, 1999, Cancer research.

Cytotoxicity and mutagenicity of dibenzo[a,l]pyrene and (+/-)-dibenzo[a,l]pyrene-11,12-dihydrodiol in V79MZ cells co-expressing either hCYP1A1 or hCYP1B1 together with human glutathione-S-transferase A1.

A. Townsend, J. Doehmer, C. Morrow, 2007, Mutation research.

DNA Modification Induced After Metabolic Activation of the Potent Carcinogen Dibenzo[a, l]pyrene in V79 Chinese Hamster Cells Stably Expressing Single Cytochromes P450

A. Luch, A. Seidel, W. Baird, 2000 .

Metabolic Activation of Dibenzo[a,l]Pyrene by Cytochrome P450 Enzymes to Stable DNA Adducts Occurs Exclusively Through the Formation of the (−)-trans−(11R, 12R)-Diol

A. Luch, A. Seidel, W. Baird, 2000 .

Predicting Drug Metabolism–dependent Toxicity for Humans with a Genetically Engineered Cell Battery

J. Doehmer, 2006, Alternatives to laboratory animals : ATLA.

Stable expression of human cytochrome P450 3A4 in conjunction with human NADPH-cytochrome P450 oxidoreductase in V79 Chinese hamster cells.

P. Beaune, E. M. de Groene, H. Greim, 1996, Archives of biochemistry and biophysics.

Arylamines suppress their own activation and that of nitroarenes in V79 Chinese hamster cells by competing for acetyltransferases.

J. Doehmer, F. Kiefer, F. Wiebel, 1994, Environmental health perspectives.

Effects of benzo[a]pyrene and (+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene on mitosis in Chinese hamster V79 cells with stable expression of rat cytochrome P4501A1 or 1A2.

K. G. Jensen, S. Loft, J. Doehmer, 1993, Carcinogenesis.

Cytochrome P450 mediated reactions studied in genetically engineered V79 Chinese hamster cells.

A. Seidel, H. Greim, J. Doehmer, 1995, Pharmacogenetics.

Rat and human liver cytosolic epoxide hydrolases: evidence for multiple forms at level of protein and mRNA.

F. Oesch, J. Doehmer, H. Thomas, 1990, Environmental health perspectives.

Recombinant retroviral DNA yielding high expression of hepatitis B surface antigen.

Y. Wang, P. Hofschneider, C. Stratowa, 1982, The EMBO journal.

Metabolic activation of dibenzo[a,l]pyrene by human cytochrome P450 1A1 and P450 1B1 expressed in V79 Chinese hamster cells.

A. Luch, A. Seidel, H. Greim, 1999, Chemical Research in Toxicology.

Inhibition of cytochrome P450 enzymes by nitric oxide.

J. Doehmer, W. Schmalix, J. Stadler, 1996, Advances in experimental medicine and biology.

Inhibition of cytochromes P 4501 A by nitric oxide ( V 79 fibroblast / hepatocytes / cytoklnes / lnflammaton )

J. Siewert, J. Doehmer, T. Brill, 2022 .

The use of macroporous microcarriers for the large-scale growth of V79 cells genetically designed to express single human cytochrome P450 isoenzymes and for the characterization of the expressed cytochrome P450.

N. Vermeulen, J. Doehmer, J. Commandeur, 1996, Protein expression and purification.

Stable expression of human cytochrome P450 2E1 in V79 Chinese hamster cells.

M. Ingelman-Sundberg, H. Greim, J. Doehmer, 1995, European journal of pharmacology.

Stable expression of rat cytochrome P450IA2 cDNA and hydroxylation of 17β‐estradiol and 2‐aminofluorene in V79 Chinese hamster cells

H. Glatt, J. Doehmer, C. Wölfel, 1991, Molecular carcinogenesis.

Stable expression of human inducible nitric oxide synthase in V79 Chinese hamster cells.

T. Billiar, H. Greim, J. Doehmer, 1996, Biochemical pharmacology.

Assessment of Extracts from Mistletoe (Viscum album) for Herb–Drug Interaction by Inhibition and Induction of Cytochrome P450 Activities

J. Doehmer, J. Eisenbraun, 2011, Phytotherapy research : PTR.

Use of recombinant cells in metabolic and mechanistic studies.

J. Doehmer, W. Schmalix, 1995, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

Androgen hydroxylation catalysed by a cell line (SD1) that stably expresses rat hepatic cytochrome P-450 PB-4 (IIB1).

F. Oesch, D. Waxman, J. Doehmer, 1989, The Biochemical journal.

Genetic transmission of Moloney leukemia virus: mapping of the chromosomal integration site.

K. Willecke, J. Doehmer, Rudolf Jaenisch, 1979, Haematology and blood transfusion.

Assessment of drug-drug interaction for silymarin.

J. Doehmer, U. Mengs, B. Tewes, 2008, Toxicology in vitro : an international journal published in association with BIBRA.

Cloning and stable expression of the human mitochondrial cytochrome P45011B1 cDNA in V79 Chinese hamster cells and their application for testing of potential inhibitors.

J. Doehmer, W. Schmalix, R. Bernhardt, 1995, Pharmacogenetics.