D. Wynford‐Thomas

发表

p53-Dependent growth arrest and altered p53-immunoreactivity following metabolic labelling with 32P ortho-phosphate in human fibroblasts

T. Hupp, K. Webley, A. Craig, 1999, Oncogene.

Dissociation of telomere dynamics from telomerase activity in human thyroid cancer cells.

M. Schlumberger, F. Wyllie, D. Wynford‐Thomas, 1998, Experimental cell research.

REVIEW ARTICLE. p53: GUARDIAN OF CELLULAR SENESCENCE

David Wynford-Thomas, D. Wynford‐Thomas, 1996 .

Does telomere shortening drive selection for p53 mutation in human cancer?

N. Colburn, H. Moses, E. Bresnick, 1995 .

Is TFIIH an activator of the p53-mediated G1/S checkpoint?

D. Wynford‐Thomas, C. Jones, C. J. Jones, 1995, Trends in genetics : TIG.

Direct growth stimulation of normal human epithelial cells by mutant p53

J. Bond, F. Wyllie, D. Wynford‐Thomas, 1993, Molecular carcinogenesis.

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?

R. Marais, D. Bennett, Z. Abdel‐Malek, 2006, British Journal of Cancer.

An immunohistochemical study of p16(INK4a) expression in multistep thyroid tumourigenesis.

J. Bond, D. Wynford‐Thomas, B. Franc, 2007, European journal of cancer.

P53 in tumour pathology: Can we trust immunocytochemistry?

D. Wynford‐Thomas, 1992, The Journal of pathology.

Opposing effects of mutant ras oncoprotein on human fibroblast and epithelial cell proliferation: implications for models of human tumorigenesis

A. Bounacer, J. Bond, D. Wynford‐Thomas, 2004, Oncogene.

Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1.

J. R. Smith, J. Blaydes, J. Bond, 1995, Cancer research.

Control of Replicative Life Span in Human Cells: Barriers to Clonal Expansion Intermediate Between M1 Senescence and M2 Crisis

P. Smith, J. Bond, F. Wyllie, 1999, Molecular and Cellular Biology.

Origin and progression of thyroid epithelial tumours: cellular and molecular mechanisms.

D. Wynford‐Thomas, D. Wynford-Thomas, 1997, Hormone research.

DNA damage checkpoint kinase Chk2 triggers replicative senescence

V. Dulic, D. Wynford‐Thomas, P. Roux, 2004, The EMBO journal.

Telomere erosion triggers growth arrest but not cell death in human cancer cells retaining wild-type p53: implications for antitelomerase therapy

Christopher J. Jones, D. Wynford‐Thomas, M. Haughton, 2004, Oncogene.

An amphotropic retroviral vector expressing a mutant gsp oncogene: effects on human thyroid cells in vitro.

M. Ivan, J. Bond, D. Wynford‐Thomas, 1997 .

Does autocrine growth factor secretion form part of a mechanism which paradoxically protects against tumour development?

D. Wynford‐Thomas, T. Dawson, Tim Dawson, 1995, British Journal of Cancer.

Conditional immortalization of human thyroid epithelial cells: a tool for analysis of oncogene action

N. Lemoine, D. Sheer, J. Bond, 1990, Molecular and cellular biology.

Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death.

C. Eng, D. Wynford‐Thomas, G. Leone, 2001, Human molecular genetics.

Desensitisation of rat thyroid to the growth-stimulating action of TSH during prolonged goitrogen administration. Persistence of refractoriness following withdrawal of stimulation.

D. Wynford‐Thomas, B. Stringer, E. Williams, 1982, Acta Endocrinologica.

Goitrogen-induced thyroid growth in the rat: a quantitative morphometric study.

D. Wynford‐Thomas, B. Stringer, E. Williams, 1982, The Journal of endocrinology.

Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.

J. Blaydes, J. Bond, F. Wyllie, 1996, Oncogene.

Contrasting effects of activating mutations of GαS and the thyrotropin receptor on proliferation and differentiation of thyroid follicular cells

M. Ivan, D. Wynford‐Thomas, R. Ajjan, 1999, Oncogene.

Sporadic ret‐rearranged papillary carcinoma of the thyroid: a subset of slow growing, less aggressive thyroid neoplasms?

D. Wynford‐Thomas, E. Fonseca, P. Soares, 1998, The Journal of pathology.

Activated ras oncogenes in human thyroid cancers.

F. Wyllie, D. Wynford‐Thomas, N. Lemoine, 1988, Cancer research.

Radiation-associated and 'spontaneous' human thyroid carcinomas show a different pattern of ras oncogene mutation.

D. Wynford‐Thomas, P. Wright, N. Lemoine, 1991, Oncogene.

Mutant p53 can delay growth arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21(WAF1) expression.

J. Bartek, F. Wyllie, D. Wynford‐Thomas, 2003, Experimental cell research.

Simian virus 40 detection in human mesothelioma: reliability and significance of the available molecular evidence.

M. Mason, D. Wynford‐Thomas, C. Jones, 2001, Frontiers in bioscience : a journal and virtual library.

Characterisation of human thyroid epithelial cells immortalised in vitro by simian virus 40 DNA transfection.

D. Sheer, D. Wynford‐Thomas, N. Lemoine, 1989, British Journal of Cancer.

Loss of responsiveness to transforming growth factor β (TGFβ) is tightly linked to tumorigenicity in a model of thyroid tumour progression

J. Blaydes, D. Wynford‐Thomas, 1996 .

Telomerase activity and telomere length in thyroid neoplasia: biological and clinical implications

Christopher J. Jones, D. Wynford‐Thomas, J. Skinner, 2001, The Journal of pathology.

Telomere-dependent senescence

R. DePinho, C. Harley, M. Blasco, 1999, Nature biotechnology.

p53 promotes adenoviral replication and increases late viral gene expression

J. Royds, L. Hananeia, A. Braithwaite, 2006, Oncogene.

Analysis of Ras transformation of human thyroid epithelial cells.

D. Wynford‐Thomas, Z. Poghosyan, Zaruhi Poghosyan, 2006, Methods in enzymology.

Direct evidence from siRNA-directed "knock down" that p16(INK4a) is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation.

J. Bond, Christopher J. Jones, D. Wynford‐Thomas, 2004, Experimental cell research.

Mutant ras-induced proliferation of human thyroid epithelial cells requires three effector pathways

A. Bounacer, J. Bond, D. Wynford‐Thomas, 2004, Oncogene.

Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function

D. Wynford‐Thomas, M. Morris, P. Hepburn, 2002, Oncogene.

Posttranslational Modifications of p 53 in Replicative Senescence Overlapping but Distinct from Those Induced by DNA Damage

T. Hupp, J. Blaydes, K. Webley, 2000 .

Segregational fidelity of chromosomes in human thyroid tumour cells

E. Parry, J. Parry, F. Wyllie, 1998, Chromosoma.

Activated ras Oncogenes in Human Thyroid Cancers 1

F. Wyllie, D. Wynford‐Thomas, N. Lemoine, 1988 .

Detection of theH-RAS oncogene in human thyroid anaplastic carcinomas

D. Wynford‐Thomas, B. Stringer, M. Parkar, 1989, Experientia.

Optimisation of conditions for detection of activated oncogenes by transfection of NIH 3T3 cells.

D. Wynford‐Thomas, N. Lemoine, V. Wynford-Thomas, 1987, British Journal of Cancer.

Stepwise transformation of primary thyroid epithelial cells by a mutant Ha‐ras oncogene: An in vitro model of tumor progression

J. Blaydes, J. Bond, D. Wynford‐Thomas, 1992, Molecular carcinogenesis.

In vitro demonstration of a TSH-specific growth desensitising mechanism in rat thyroid epithelium

D. Wynford‐Thomas, P. Smith, E. Williams, 1987, Molecular and Cellular Endocrinology.

The influence of cell context on the selection pressure for p53 mutation in human cancer.

J. Blaydes, D. Wynford‐Thomas, 1998, Carcinogenesis.

Cellular senescence and cancer

D. Wynford‐Thomas, 1999, The Journal of pathology.

The role of p53 in growth of mouse fibroblast lines.

D. Prescott, D. Wynford‐Thomas, G. Marin, 1985, Experimental cell research.

Escape from senescence in human diploid fibroblasts induced directly by mutant p53.

J. Bond, F. Wyllie, D. Wynford‐Thomas, 1994, Oncogene.

Growth factor control of rat thyroid follicular cell proliferation.

D. Wynford‐Thomas, B. Stringer, P. Smith, 1986, Endocrinology.

Dissociation of growth and function in the rat thyroid during prolonged goitrogen administration.

D. Wynford‐Thomas, B. Stringer, E. Williams, 1982, Acta endocrinologica.

IN‐SITU ANALYSIS OF CALCITONIN AND CGRP EXPRESSION IN MEDULLARY THYROID CARCINOMA

D. Wynford‐Thomas, J. Boultwood, R. Craig, 1990, Clinical endocrinology.

Reinitiation of DNA Synthesis and Cell Division in Senescent Human Fibroblasts by Microinjection of Anti-p53 Antibodies

D. Wynford‐Thomas, V. Gire, 1998, Molecular and Cellular Biology.

Papillary and follicular thyroid carcinomas show a different pattern of ras oncogene mutation.

N. Lemoine, F. Wyllie, D. Wynford‐Thomas, 1989, British Journal of Cancer.

Commentary: The evolutionary biology of the paternal age effect on telomere length

D. Wynford‐Thomas, W. Byrd, J. Rowson, 2013 .

Location of the isoleucine arrest point in CHO and 3T3 cells.

D. Prescott, D. Wynford‐Thomas, G. Marin, 1985, Experimental cell research.

Presence or absence of a G1 period in the cell cycle and growth control in a Chinese hamster cell line.

D. Prescott, D. Wynford‐Thomas, G. Marin, 1985, Experimental cell research.

Mutation of the p53 gene in a differentiated human thyroid carcinoma cell line, but not in primary thyroid tumours.

N. Lemoine, J. Bond, F. Wyllie, 1991, Oncogene.

Detection and partial purification of a potent mitogenic factor for human thyroid follicular cells

J. Bond, D. Wynford‐Thomas, T. Dawson, 1992, Molecular and Cellular Endocrinology.

J. Bond, F. Wyllie, D. Wynford‐Thomas, 1991, Molecular and Cellular Endocrinology.

Oncoprotein p53 expression in normal, immortalized, and transformed mouse fibroblasts.

D. Wynford‐Thomas, N. Williams, 1989, Experimental cell research.

A variant epithelial sub-population in normal thyroid with high proliferative capacity in vitro

M. Ivan, J. Bond, F. Wyllie, 1993, Molecular and Cellular Endocrinology.

Biological activity of activating thyroid-stimulating hormone receptor mutants depends on the cellular context.

R. Paschke, D. Wynford‐Thomas, D. Fuhrer, 2003, Endocrinology.

Heterogeneity in distribution and content of p53 in SV40-transformed mouse fibroblasts.

D. Wynford‐Thomas, D. Davis, 1986, Experimental cell research.

The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2

J. Blaydes, D. Wynford‐Thomas, 1998, Oncogene.

Density-dependent regulation of growth in somatic hybrids between normal Chinese hamster fibroblasts and V79-8 (G1-) cells.

D. Prescott, D. Wynford‐Thomas, G. Marin, 1984, Experimental cell research.

A phenotypically and karyotypically stable human thyroid epithelial line conditionally immortalized by SV40 large T antigen.

R. Davies, J. Bond, F. Wyllie, 1992, Cancer research.

Vascular changes in early TSH-induced thyroid tumours in the rat.

D. Wynford‐Thomas, B. Stringer, E. Williams, 1983, British Journal of Cancer.

Loss of dependence on IGF-1 for proliferation of human thyroid adenoma cells.

D. Wynford‐Thomas, E. Williams, D. W. Williams, 1988, British Journal of Cancer.

High frequency deletion of the tumour suppressor gene P16INK4a (MTS1) in human thyroid cancer cell lines

M. Schlumberger, F. Wyllie, D. Wynford‐Thomas, 1996, Molecular and Cellular Endocrinology.

S phase cell-cycle arrest following DNA damage is independent of the p53/p21(WAF1) signalling pathway.

J. Bond, F. Wyllie, D. Wynford‐Thomas, 1996, Oncogene.

Abnormalities of the EGF receptor system in human thyroid neoplasia

D. Wynford‐Thomas, N. Lemoine, W. Gullick, 1991, International journal of cancer.

Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T.

D. Wynford‐Thomas, N. Lemoine, J. Burns, 1989, British Journal of Cancer.

Proliferative response to cyclic AMP elevation of thyroid epithelium in suspension culture

D. Wynford‐Thomas, P. Smith, E. Williams, 1987, Molecular and Cellular Endocrinology.

In vitro evidence for an intracellular mechanism limiting the thyroid follicular cell growth response to thyrotropin.

D. Wynford‐Thomas, B. Stringer, E. Williams, 1985, Endocrinology.

Reinitiation of DNA Synthesis and Cell Division in Senescent Human Fibroblasts by Microinjection of Anti-p53 Antibodies

D. Wynford‐Thomas, V. Gire, 1998, Molecular and Cellular Biology.

Loss of responsiveness to transforming growth factor beta (TGFbeta) is tightly linked to tumorigenicity in a model of thyroid tumour progression.

J. Blaydes, D. Wynford‐Thomas, 1996, International journal of cancer.

Control of human thyroid follicular cell proliferation in suspension and monolayer culture

D. Wynford‐Thomas, E. Williams, D. W. Williams, 1987, Molecular and Cellular Endocrinology.

Rise in serum calcium and magnesium concentrations after vitamin D administration in hypocalcaemic hypomagnesaemic magnesium deficiency.

D. Wynford‐Thomas, R. Ghose, 1980, Postgraduate medical journal.

Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2

J. Blaydes, D. Wynford‐Thomas, V. Gire, 1997, Oncogene.

Simian virus 40 large T antigen (SV40LTAg) primer specific DNA amplification in human pleural mesothelioma tissue.

D. Wynford‐Thomas, B. Jasani, H. Navabi, 1996, Thorax.

Increased apoptosis and reduced replication efficiency of the E3 region-modified dl309 adenovirus in cancer cells.

J. Royds, A. Braithwaite, D. Wynford‐Thomas, 2009, Virus research.

Telomeres, p53 and cellular senescence.

D. Wynford‐Thomas, 1996, Oncology research.

Evidence for autocrine production of IGF-1 in human thyroid adenomas

D. Wynford‐Thomas, E. Williams, D. W. Williams, 1989, Molecular and Cellular Endocrinology.

The polymerase chain reaction: Miracle or mirage? A critical review of its uses and limitations in diagnosis and research

D. Wynford‐Thomas, P. Wright, 1990, The Journal of pathology.

Thyroid Tumours: Molecular Basis of Pathogenesis

D. Wynford‐Thomas, E. D. Williams, 1989 .

Investigation of putative control mechanisms for thyroid growth

D. Wynford‐Thomas, E. D. Williams, B. Stringer, 1982, Virchows Archiv. B, Cell pathology including molecular pathology.

Use of Bromodeoxyuridine For Cell Kinetic Studies In Intact Animals

D Wynford-Thomas, D. Wynford‐Thomas, E D Williams, 1986, Cell and tissue kinetics.

Oncogenes and anti‐oncogenes; the molecular basis of tumour behaviour

D. Wynford‐Thomas, 1991, The Journal of pathology.

p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.

G. Peters, V. Bataille, D. Bennett, 2003, Journal of the National Cancer Institute.

Effect of serum growth factors and phorbol ester on growth and survival of human thyroid epithelial cells expressing mutant ras

J. Bond, D. Wynford‐Thomas, N. Lemoine, 1992, Molecular carcinogenesis.

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

R. Faragher, F. Wyllie, Christopher J. Jones, 2000, Nature Genetics.

Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms

R. Faragher, F. Wyllie, Christopher J. Jones, 2003, Journal of Cell Science.

Activated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells

M. Ivan, P. Comoglio, J. Bond, 1997, Oncogene.

High Frequency of ras Oncogene Activation in Benign and Malignant Human Thyroid Tumours

F. Wyllie, D. Wynford‐Thomas, N. Lemoine, 1989 .

Evidence for a Telomere-Independent “Clock” Limiting RAS Oncogene-Driven Proliferation of Human Thyroid Epithelial Cells

A. Bounacer, M. Ivan, J. Bartek, 2000, Molecular and Cellular Biology.

Activation of mitogen-activated protein kinase is necessary but not sufficient for proliferation of human thyroid epithelial cells induced by mutant Ras

C. Marshall, D. Wynford‐Thomas, V. Gire, 1999, Oncogene.

Human thyroid cancer cells as a source of iso-genic, iso-phenotypic cell lines with or without functional p53

F. Wyllie, D. Wynford‐Thomas, M. Haughton, 1999, British Journal of Cancer.

Abnormalities of theP16INK4A gene in thyroid cancer cell lines

M. Ivan, D. Wynford‐Thomas, C. Jones, 1996 .

Characterisation of novel mutations in Cockayne syndrome type A and xeroderma pigmentosum group C subjects

Christopher J. Jones, D. Wynford‐Thomas, A. Ridley, 2005, Journal of Human Genetics.

Ha-ras restriction fragment length polymorphisms in colorectal cancer.

F. Wyllie, D. Wynford‐Thomas, G. Williams, 1988, British Journal of Cancer.

Structure and expression of nuclear oncogenes in multi-stage thyroid tumorigenesis.

F. Wyllie, D. Wynford‐Thomas, N. Lemoine, 1989, British Journal of Cancer.

Papillary thyroid carcinoma oncogene (RET/PTC) alters the nuclear envelope and chromatin structure.

J A Bond, D Wynford-Thomas, A. Fischer, 1998, The American journal of pathology.

An amphotropic retroviral vector expressing a mutant gsp oncogene: effects on human thyroid cells in vitro.

M Ivan, M Ludgate, V Gire, 1997, The Journal of clinical endocrinology and metabolism.

Spontaneous de‐differentiation correlates with extended lifespan in transformed thyroid epithelial cells: An epigenetic mechanism of tumour progression?

M. Ivan, J. Bond, D. Wynford‐Thomas, 1996, International journal of cancer.

Proliferative lifespan checkpoints: cell-type specificity and influence on tumour biology.

D. Wynford‐Thomas, D. Wynford-Thomas, 1997, European journal of cancer.

Posttranslational Modifications of p53 in Replicative Senescence Overlapping but Distinct from Those Induced by DNA Damage

T. Hupp, J. Blaydes, K. Webley, 2000, Molecular and Cellular Biology.

Expression of mutant p21ras induces insulin-like growth factor 1 secretion in thyroid epithelial cells.

D. Wynford‐Thomas, T. Dawson, A. Rădulescu, 1995, Cancer research.

The tumour suppressor gene p53 as a regulator of proliferative life-span and tumour progression.

F. Wyllie, D. Wynford‐Thomas, C. J. Jones, 1996, Biological signals.

A P53-dependent, telomere-independent proliferative life span barrier in human astrocytes consistent with the molecular genetics of glioma development.

F. Wyllie, Christopher J. Jones, D. Wynford‐Thomas, 2003, Cancer research.

How may clonality be assessed in human tumours?

D. Wynford‐Thomas, G. Williams, 1994, Histopathology.

PI-3-kinase is an essential anti-apoptotic effector in the proliferative response of primary human epithelial cells to mutant RAS

C. Marshall, D. Wynford‐Thomas, V. Gire, 2000, Oncogene.

Suppression of transformation and immortality in human/chinese hamster fibroblast hybrids—a model for suppressor gene isolation

J. Bond, D. Wynford‐Thomas, H. Paterson, 1989, International journal of cancer.

Extensive allelic variation and ultrashort telomeres in senescent human cells

D. Wynford‐Thomas, D. Kipling, D. Baird, 2003, Nature Genetics.

N-myc expression in neoplasia of human thyroid C-cells.

F. Wyllie, D. Wynford‐Thomas, J. Boultwood, 1988, Cancer Research.

In vitro reconstruction of tumour initiation in a human epithelium.

J. Bond, F. Wyllie, D. Wynford‐Thomas, 1994, Oncogene.

In vitro models of thyroid cancer.

D. Wynford‐Thomas, 1993, Cancer surveys.

Human thyroid epithelial cells.

D. Wynford‐Thomas, D. W. Williams, 1997, Methods in molecular biology.

Transfection and transformation of human thyroid epithelial cells.

D. Wynford‐Thomas, N. Lemoine, 1990, Methods in molecular biology.

Importance of maintaining species homology in thyroid hormone radioimmunoassays: modification of 'human' radioimmunoassay kits for use with rat samples.

D. Wynford‐Thomas, B. Stringer, 1982, Hormone research.

A study of long acting propranolol in the early management of hyperthyroidism.

D. Wynford‐Thomas, J. Lazarus, G. Jones, 1981, British journal of clinical pharmacology.

The effects of hyperthyroidism on experimental autoimmune thyroiditis in the rat.

D. Wynford‐Thomas, A. Weetman, B. Stringer, 1985, Endocrinology.

Molecular basis of epithelial tumorigenesis: the thyroid model.

D. Wynford‐Thomas, 1993, Critical reviews in oncogenesis.

Evasion of p53-mediated growth control occurs by three alternative mechanisms in transformed thyroid epithelial cells.

M. Schlumberger, J. Blaydes, F. Wyllie, 1995, Oncogene.

Mitogenic stimulation of normal and oncogene-transformed human thyroid epithelial cells by hepatocyte growth factor

M. Ivan, D. Wynford‐Thomas, N. Eccles, 1996, Molecular and Cellular Endocrinology.

Interaction between p53 and TGF beta 1 in control of epithelial cell proliferation.

M. Schlumberger, J. Blaydes, F. Wyllie, 1995, Oncogene.

Molecular genetic study comparing follicular variant versus classic papillary thyroid carcinomas: association of N-ras mutation in codon 61 with follicular variant.

David Wynford-Thomas, Nicolas Fakhry, D. Wynford‐Thomas, 2006, Human pathology.

High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis.

N. Lemoine, F. Wyllie, D. Wynford‐Thomas, 1989, Oncogene.

Thyrotropin receptor transcripts in human adipose tissue.

M Halliwell, D Wynford-Thomas, M. Halliwell, 1997, The Journal of clinical endocrinology and metabolism.

Molecular genetics of thyroid cancer

David Wynford-Thomas, D. Wynford‐Thomas, 1993, Trends in Endocrinology & Metabolism.

In vitro responsiveness to serum growth factors is inversely related to in vivo malignancy in human thyroid epithelial cells.

F. Wyllie, D. Wynford‐Thomas, T. Dawson, 1991, British Journal of Cancer.

Immunocytochemically detectable TGF-beta associated with malignancy in thyroid epithelial neoplasia.

F. Wyllie, D. Wynford‐Thomas, B. Jasani, 1990, Growth factors.

Physical randomization of tissue architecture: an alternative to systematic sampling

D. Wynford‐Thomas, B. Stringer, E. Williams, 1982, Journal of microscopy.

Replicative senescence: mechanisms and implications for human cancer.

D. Wynford‐Thomas, 2000, Pathologie-biologie.

Control of growth in the rat thyroid-an example of specific desensitization to trophic hormone stimulation

D. Wynford‐Thomas, B. Stringer, E. Williams, 1983, Experientia.

Mitotic Response to Wounding In Goitrous and Normal Rat Thyroid: Implications For Thyroid Growth Control

D. Wynford‐Thomas, E. D. Williams, H. R. Harach, 1985, Cell and tissue kinetics.

Reparative Growth In the Rat Thyroid: Effect of Tsh Suppression

D. Wynford‐Thomas, M. Gómez-Morales, B. Stringer, 1986, Cell and tissue kinetics.

Reparative growth in the rat thyroid.

D. Wynford‐Thomas, B. Stringer, E. Williams, 1983, Cell and tissue kinetics.

Circadian rhythm of mitotic activity in normal and hyperplastic rat thyroid.

D. Wynford‐Thomas, B. Stringer, E. Williams, 1982, Acta endocrinologica.

Effect of goitrogen administration on the circadian rhythm of serum thyroid stimulating hormone in the rat.

D. Wynford‐Thomas, B. Jasani, E. Williams, 1981, Acta endocrinologica.

Evidence against involvement of APC mutation in papillary thyroid carcinoma.

D. Haugen, J. Lillehaug, J. Varhaug, 1994, European journal of cancer.

IN VIVO PHOTOINDUCTION OF METALLOTHIONEIN IN HUMAN SKIN BY ULTRAVIOLET IRRADIATION

D. Wynford‐Thomas, B. Jasani, A. Anstey, 1996, The Journal of pathology.

Induction of cell death by stimulation of protein kinase C in human epithelial cells expressing a mutant ras oncogene: a potential therapeutic target.

J. Bond, D. Wynford‐Thomas, T. Dawson, 1998, British Journal of Cancer.

Radiation-induced transformation of SV40-immortalized human thyroid epithelial cells by single and fractionated exposure to gamma-irradiation in vitro.

Z. Herceg, A. Riches, P. Bryant, 1994, International journal of radiation biology.

GH3 cells expressing constitutively active Gsα (Q227L) show enhanced hormone secretion and proliferation

M. Ivan, D. Wynford‐Thomas, J. Ham, 1997, Molecular and Cellular Endocrinology.

Agent-specific ras oncogene activation in rat thyroid tumours.

D. Wynford‐Thomas, N. Lemoine, E. Williams, 1988, Oncogene.

ALTERED c-H-ras GENE IN NON-NEOPLASTIC TISSUE

M. Stratton, C. Cooper, D. Wynford‐Thomas, 1989, The Lancet.

In vitro transformation of epithelial cells by ras oncogenes.

D. Wynford‐Thomas, N. Lemoine, C. Barton, 1993, Epithelial cell biology.

Mutations in familial cancer

D. Wynford‐Thomas, P. Wright, 1994, The Journal of pathology.

Immunohistochemical localization of cell surface receptors using a novel method permitting simple, rapid and reliable LM/EM correlation

D. Wynford‐Thomas, B. Jasani, G. Newman, 1986, The Histochemical Journal.

Hydroxyethylmethacrylate embedding: an improved technique.

D. Wynford‐Thomas, G. Newman, B. Stringer, 1981, Medical laboratory sciences.

Prolongation of fibroblast life span associated with epithelial rat tumor development.

D. Wynford‐Thomas, P. Smith, E. Williams, 1986, Cancer research.

Receptor secretion hypothesis for regulation of hormone action.

D. Wynford‐Thomas, B. Jasani, E. Williams, 1983, Medical hypotheses.

Cytotoxic action of phorbol esters on human pancreatic cancer cells

R. Errington, J. Bond, D. Wynford‐Thomas, 2007, International journal of cancer.

Experimental induction of parathyroid adenomas in the rat.

D. Wynford‐Thomas, E. Williams, V. Wynford-Thomas, 1983, Journal of the National Cancer Institute.

Immunohistochemical localization of cell using a novel method permitting simple, LM/EM correlation surface receptors rapid and reliable

D. Wynford‐Thomas, B. Jasani, G. Newman, 1986 .

Comparison of differential gene expression of hot and cold thyroid nodules with primary epithelial cell culture models by investigation of co-regulated gene sets.

R. Paschke, J. Läuter, M. Eszlinger, 2006, Biochimica et biophysica acta.

Toxicity of phorbol esters for human epithelial cells expressing a mutant ras Oncogene

J. Bond, D. Wynford‐Thomas, T. Dawson, 1993, Molecular carcinogenesis.

RAS oncogene activation induces proliferation in normal human thyroid epithelial cells without loss of differentiation

D. Wynford‐Thomas, V. Gire, 2000, Oncogene.

Absence of abnormalities of the c-erbB-1 and c-erbB-2 proto-oncogenes in human thyroid neoplasia.

J. Lillehaug, C. Brown, J. Varhaug, 1990, European journal of cancer.

RFLP for the human erb-A beta locus.

F. Wyllie, D. Wynford‐Thomas, L. Lazarou, 1988, Nucleic Acids Research.

Koch's postulates revisited

D. Wynford‐Thomas, P. Wright, D. Winford‐Thomas, 1991, The Journal of pathology.

Telomerase: Cancer and the knockout mouse

D. Wynford‐Thomas, D. Kipling, 1997, Nature.