B. Rigas

B. Rigas, H. Kalofonos, E. Lebovics, 2003, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress.

Jianjun Gao, Xiaoping Liu, B. Rigas, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Nitric Oxide-Donating Aspirin Inhibits Colon Cancer Cell Growth via Mitogen-Activated Protein Kinase Activation

B. Rigas, T. Hundley, 2006, Journal of Pharmacology and Experimental Therapeutics.

Regioselective oxidation of phospho‐NSAIDs by human cytochrome P450 and flavin monooxygenase isoforms: implications for their pharmacokinetic properties and safety

B. Rigas, P. Constantinides, Liqun Huang, 2012, British journal of pharmacology.

NO-donating aspirin inhibits angiogenesis by suppressing VEGF expression in HT-29 human colon cancer mouse xenografts.

B. Rigas, N. Ouyang, Nengtai Ouyang, 2008, Carcinogenesis.

Nitric oxide-donating aspirin inhibits beta-catenin/T cell factor (TCF) signaling in SW480 colon cancer cells by disrupting the nuclear beta-catenin-TCF association.

K. Kashfi, N. Nath, B. Rigas, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Growth inhibition of human colon cancer cells by nitric oxide (NO)-donating aspirin is associated with cyclooxygenase-2 induction and beta-catenin/T-cell factor signaling, nuclear factor-kappaB, and NO synthase 2 inhibition: implications for chemoprevention.

Jianjun Gao, L. Kopelovich, K. Kashfi, 2003, Cancer research.

NO-donating aspirin inhibits intestinal carcinogenesis in Min (APC(Min/+)) mice.

L. Kopelovich, K. Kashfi, B. Rigas, 2004, Biochemical and biophysical research communications.

NO-donating aspirin inhibits both the expression and catalytic activity of inducible nitric oxide synthase in HT-29 human colon cancer cells.

Jianjun Gao, Xiaoping Liu, K. Kashfi, 2005, Biochemical pharmacology.

The use of nitric oxide-donating nonsteroidal anti-inflammatory drugs in the chemoprevention of colorectal neoplasia

B. Rigas, 2007, Current opinion in gastroenterology.

NO-donating NSAIDs and cancer: an overview with a note on whether NO is required for their action.

B. Rigas, Jennie Williams, 2008, Nitric oxide : biology and chemistry.

Novel agents for cancer prevention based on nitric oxide.

B. Rigas, 2007, Biochemical Society transactions.

Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells

Y. Hannun, E. Jones, B. Rigas, 2017, Stem cell reports.

The Evolving Role of Nonsteroidal Anti-Inflammatory Drugs in Colon Cancer Prevention: A Cause for Optimism

B. Rigas, G. Tsioulias, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Nanodelivery strategies in cancer chemotherapy: biological rationale and pharmaceutical perspectives.

B. Rigas, P. Constantinides, G. Mattheolabakis, 2012, Nanomedicine.

Simplified ex-vivo drug evaluation in ocular surface cells: Culture on cellulose filters of cells obtained by impression cytology.

R. Honkanen, B. Rigas, A. Master, 2021, Experimental eye research.

Dietary induction of colonic tumors in a mouse model of sporadic colon cancer.

G. Corner, L. Augenlicht, W. Edelmann, 2008, Cancer research.

Decreased expression of DNA-dependent protein kinase, a DNA repair protein, during human colon carcinogenesis.

M. Lipkin, B. Rigas, N. Kurihara, 2001, Cancer research.

Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations.

R. Kucherlapati, L. Augenlicht, L. Kopelovich, 2003, Carcinogenesis.

Phosphosulindac is efficacious in an improved concanavalin A‐based rabbit model of chronic dry eye disease

R. Honkanen, B. Rigas, Liqun Huang, 2018, Translational research : the journal of laboratory and clinical medicine.

Oncogenes and suppressor genes: their involvement in colon cancer.

B. Rigas, 1990, Journal of clinical gastroenterology.

Phospho-valproic acid (MDC-1112) reduces pancreatic cancer growth in patient-derived tumor xenografts and KPC mice: enhanced efficacy when combined with gemcitabine.

B. Rigas, Joseph F LaComb, G. Mackenzie, 2019, Carcinogenesis.

Oxidative Stress Mediates through Apoptosis the Anticancer Effect of Phospho-Nonsteroidal Anti-Inflammatory Drugs: Implications for the Role of Oxidative Stress in the Action of Anticancer Agents

B. Rigas, Liqun Huang, G. Mackenzie, 2011, Journal of Pharmacology and Experimental Therapeutics.

The ocular pharmacokinetics and biodistribution of phospho‐sulindac (OXT‐328) formulated in nanoparticles: Enhanced and targeted tissue drug delivery

Jennifer Yang, R. Honkanen, B. Rigas, 2019, International journal of pharmaceutics.

JPET #220806 1 The evolving role of NSAIDs in colon cancer prevention: A cause for optimism

B. Rigas, G. Tsioulias, 2015 .

Is COX-2 a 'collateral' target in cancer prevention?

K. Kashfi, B. Rigas, 2005, Biochemical Society transactions.

cacy of topical P-S hydrogel in the treatment of non-melanoma skin cancer in preclinical models. P-S is a potent inhibitor of A431 epidermoid carcinoma in vitro and achieves this effect by inhibiting cell proliferation and inducing apoptosis

B. Rigas, P. Constantinides, N. Ouyang, 2012 .

Nitric oxide-donating aspirin derivatives suppress microsatellite instability in mismatch repair-deficient and hereditary nonpolyposis colorectal cancer cells.

L. Kopelovich, B. Rigas, R. Fishel, 2007, Cancer research.

Nitric Oxide-Donating Nonsteroidal Anti-Inflammatory Drugs Inhibit the Growth of Various Cultured Human Cancer Cells: Evidence of a Tissue Type-Independent Effect

F. Traganos, K. Kashfi, B. Rigas, 2002, Journal of Pharmacology and Experimental Therapeutics.

Food Components, Alternative Medicine, and Cancer: Progress and Promise

R. Cooney, Shivendra V. Singh, B. Rigas, 2008, Nutrition and Cancer.

Phospho-NSAIDs Have Enhanced Efficacy in Mice Lacking Plasma Carboxylesterase: Implications for their Clinical Pharmacology

B. Rigas, N. Ouyang, G. Mattheolabakis, 2014, Pharmaceutical Research.

Carboxylesterases 1 and 2 Hydrolyze Phospho-Nonsteroidal Anti-Inflammatory Drugs: Relevance to Their Pharmacological Activity

B. Rigas, P. Constantinides, C. Wong, 2012, Journal of Pharmacology and Experimental Therapeutics.

The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon cancer cells: alterations in tumor suppressor and cell cycle-regulatory proteins.

B. Dynlacht, B. Rigas, S. Shiff, 1996, Oncogene.

Altered gastric epithelial cell kinetics in Helicobacter pylori‐associated intestinal metaplasia: Implications for gastric carcinogenesis

E. Furth, B. Rigas, S. Shiff, 2000, International journal of cancer.

The effect of eicosanoids on the expression of MHC genes in cultured human colon cancer cells and mouse colonocytes in vivo.

E. Papavassiliou, B. Rigas, G. Tsioulias, 1996, Prostaglandins, leukotrienes, and essential fatty acids.

Nonsteroidal anti-inflammatory drugs and the induction of apoptosis in colon cells: Evidence for PHS-dependent and PHS-independent mechanisms

B. Rigas, S. Shiff, 1999, Apoptosis.

Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect.

B. Rigas, Liqun Huang, G. Mackenzie, 2010, Carcinogenesis.

Human salivary eicosanoids: circadian variation.

B. Rigas, L. Levine, 1983, Biochemical and biophysical research communications.

The effect of leukotrienes B and selected HETEs on the proliferation of colon cancer cells.

K. Kashfi, B. Rigas, S. Shiff, 1996, Biochimica et biophysica acta.

The retinoid fenretinide inhibits proliferation and downregulates cyclooxygenase-2 gene expression in human colon adenocarcinoma cell lines.

K. Kashfi, B. Rigas, G. Merritt, 2001, Cancer letters.

In Vitro and In Vivo Metabolic Studies of Phospho-aspirin (MDC-22)

B. Rigas, P. Constantinides, Liqun Huang, 2012, Pharmaceutical Research.

Lithocholic acid inhibits the expression of HLA class I genes in colon adenocarcinoma cells. Differential effect on HLA-A, -B and -C loci.

E. Papavassiliou, B. Rigas, L. Staiano‐Coico, 1994, Molecular immunology.

The anticancer effect of phospho-tyrosol-indomethacin (MPI-621), a novel phosphoderivative of indomethacin: in vitro and in vivo studies.

B. Rigas, N. Ouyang, Liqun Huang, 2013, Carcinogenesis.

Aspirin for cancer

B. Rigas, S. Shiff, 1999, Nature Medicine.

Phospho-Sulindac (OXT-328) Combined with Difluoromethylornithine Prevents Colon Cancer in Mice

L. Kopelovich, B. Rigas, N. Ouyang, 2011, Cancer Prevention Research.

Curcumin enhances the lung cancer chemopreventive efficacy of phospho-sulindac by improving its pharmacokinetics

B. Rigas, G. Mattheolabakis, Liqun Huang, 2013, International journal of oncology.

The effect of bile acids and piroxicam on MHC antigen expression in rat colonocytes during colon cancer development.

B. Rigas, R. Wali, T. Brasitus, 1994, Immunology.

NO-donating aspirin induces phase II enzymes in vitro and in vivo.

Jianjun Gao, Xiaoping Liu, K. Kashfi, 2006, Carcinogenesis.

FT-IR microspectroscopy of mouse colon tissues: insight into the chemistry of carcinogenesis and diagnostic potential.

Chris W. Brown, B. Rigas, M. Cohenford, 2012, The American journal of pathology.

Reduced expression of HLA class I and II antigens in colon cancer.

B. Rigas, T. Godwin, J. Felix, 1990, Cancer research.

Phospho-sulindac inhibits pancreatic cancer growth: NFATc1 as a drug resistance candidate

B. Rigas, C. Wong, Kvetoslava Vranková, 2013, International journal of oncology.

Pegylation Improves the Pharmacokinetics and Bioavailability of Small-Molecule Drugs Hydrolyzable by Esterases: A Study of Phospho-Ibuprofen

B. Rigas, P. Constantinides, G. Mattheolabakis, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Sulindac sulfide alters the expression of cyclin proteins in HT‐29 colon adenocarcinoma cells

B. Rigas, S. Shiff, L. Qiao, 1998, International journal of cancer.

Concentrations of arachidonic-acid metabolites in human mixed saliva are independent of flow rate.

B. Rigas, L. Levine, 1983, Archives of oral biology.

Identification and quantitation of arachidonic-acid metabolic products in rabbit, rat and human saliva.

E. Corey, K. Austen, B. Rigas, 1983, Archives of oral biology.

Molecular targets of calcium and vitamin D in mouse genetic models of intestinal cancer.

L. Augenlicht, B. Rigas, C. Daroqui, 2007, Nutrition reviews.

An Improved Ocular Impression Cytology Method: Quantitative Cell Transfer to Microscope Slides Using a Novel Polymer

R. Honkanen, B. Rigas, A. Master, 2021, Current eye research.

Induction of oxidative stress as a mechanism of action of chemopreventive agents against cancer

B. Rigas, Y. Sun, 2008, British Journal of Cancer.

Circadian periodicity and other clinical features of biliary pain.

G. Spinzi, B. Rigas, G. Minoli, 1991, Journal of clinical gastroenterology.

Circadian periodicity of the time of onset of acute lower gastrointestinal bleeding.

B. Rigas, G. Ergun, 1990, Progress in clinical and biological research.

Development of novel agents based on nitric oxide for the control of colon cancer

B. Rigas, T. Rosenberg, Vassiliki Kozoni, 2007, Acta Pharmacologica Sinica.

NSAID-induced corneal melt: Clinical importance, pathogenesis and risk mitigation.

R. Honkanen, B. Rigas, Wei Huang, 2020, Survey of ophthalmology.

The Considerable Conundrum of NSAID-induced Melt

Wei Huang, R. Honkanen, B. Rigas, 2020 .

Commentary: NSAID-Induced Corneal Melt: Clinical Importance, Pathogenesis and Risk Mitigation

R. Honkanen, B. Rigas, Wei Huang, 2019 .

Targeting Mitochondrial STAT3 with the Novel Phospho-Valproic Acid (MDC-1112) Inhibits Pancreatic Cancer Growth in Mice

B. Rigas, P. Constantinides, N. Ouyang, 2013, PloS one.

Preclinical Predictors of Anticancer Drug Efficacy: Critical Assessment with Emphasis on Whether Nanomolar Potency Should Be Required of Candidate Agents

B. Rigas, Basil Rigas, C. C. Wong, 2012, Journal of Pharmacology and Experimental Therapeutics.

Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway.

B. Rigas, L. Staiano‐Coico, L. Qiao, 1996, Biochemical pharmacology.

Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis.

B. Rigas, S. Shiff, B Rigas, 1996, Experimental cell research.

The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents.

B. Rigas, Yu Sun, 2008, Cancer research.

Cancer Prevention: A New Era beyond Cyclooxygenase-2

K. Kashfi, B. Rigas, 2005, Journal of Pharmacology and Experimental Therapeutics.

Positional Isomerism Markedly Affects the Growth Inhibition of Colon Cancer Cells by Nitric Oxide-Donating Aspirin in Vitro and in Vivo

Francesca Benedini, Jianjun Gao, K. Kashfi, 2005, Journal of Pharmacology and Experimental Therapeutics.

Topically Applied Phospho-Sulindac Hydrogel is Efficacious and Safe in the Treatment of Experimental Arthritis in Rats

B. Rigas, N. Ouyang, G. Mattheolabakis, 2013, Pharmaceutical Research.

Detection of biotinylated nucleic acids directly on agarose gels.

B. Rigas, Y. Sun, 1994, BioTechniques.

Animal models of dry eye disease: Useful, varied and evolving (Review)

R. Honkanen, B. Rigas, H. Perry, 2021, Experimental and therapeutic medicine.

Infrared spectroscopy of normal and abnormal cervical smears: evaluation by principal component analysis.

B. Rigas, T. Godwin, T. Caputo, 1997, Gynecologic oncology.

Infrared spectroscopy of exfoliated human cervical cells: evidence of extensive structural changes during carcinogenesis.

B. Rigas, T. Godwin, T. Caputo, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Human colorectal cancers display abnormal Fourier-transform infrared spectra.

B. Rigas, S. Morgello, P. Wong, 1990, Proceedings of the National Academy of Sciences of the United States of America.

NF-κB, inflammation and pancreatic carcinogenesis: NF-κB as a chemoprevention target (Review)

B. Rigas, Zhiquan Zhang, 2006 .

The effect of physiologically relevant additives on the rheological properties of concentrated Pluronic copolymer gels

B. Rigas, M. Rafailovich, J. Sokolov, 2008 .

Altered eicosanoid levels in human colon cancer.

B. Rigas, I. S. Goldman, L. Levine, 1993, The Journal of laboratory and clinical medicine.

Selected eicosanoids increase the proliferation rate of human colon carcinoma cell lines and mouse colonocytes in vivo.

B. Rigas, S. Shiff, V. Kozoni, 1995, Biochimica et biophysica acta.

TGF-α and TGF-β expression during sodium-N-butyrate-induced differentiation of human keratinocytes: Evidence for subpopulation-specific up-regulation of TGF-β mRNA in suprabasal cells☆

A. Gottlieb, P. Higgins, B. Rigas, 1990 .

The metabolism and pharmacokinetics of phospho‐sulindac (OXT‐328) and the effect of difluoromethylornithine

L. Kopelovich, B. Rigas, P. Constantinides, 2012, British journal of pharmacology.

Molecular targets of nitric-oxide-donating aspirin in cancer.

K. Kashfi, B. Rigas, 2005, Biochemical Society transactions.

Prostaglandins E2 and E2 alpha are elevated in saliva of cystic fibrosis patients.

J. Korenberg, B. Rigas, W. Merrill, 1989, The American journal of gastroenterology.

A New Rabbit Model of Chronic Dry Eye Disease Induced by Complete Surgical Dacryoadenectomy

R. Honkanen, B. Rigas, Liqun Huang, 2019, Current eye research.

Annexin 1 induced by anti-inflammatory drugs binds to NF-kappaB and inhibits its activation: anticancer effects in vitro and in vivo.

B. Rigas, Zhiquan Zhang, Liqun Huang, 2010, Cancer research.

The Chemoprevention of Ovarian Cancer: the Need and the Options

A. Kudelka, B. Rigas, Rishil J. Kathawala, 2018, Current Pharmacology Reports.

Phosphodiester Stretching Bands in the Infrared Spectra of Human Tissues and Cultured Cells

E. Papavassiliou, B. Rigas, P. Wong, 1991 .

Phospho-valproic acid inhibits pancreatic cancer growth in mice: Enhanced efficacy by its formulation in poly-(L)-lactic acid-poly(ethylene glycol) nanoparticles

B. Rigas, G. Mattheolabakis, G. Mackenzie, 2017, International journal of oncology.

Phospho-valproic acid inhibits pancreatic cancer growth in mice: Enhanced efficacy by its formulation in poly-(L)-lactic acid-poly(ethylene glycol) nanoparticles

B. Rigas, G. Mattheolabakis, G. Mackenzie, 2017, International journal of oncology.

Phospho-Aspirin (MDC-22) Prevents Pancreatic Carcinogenesis in Mice

Jennifer Yang, B. Rigas, N. Ouyang, 2016, Cancer Prevention Research.

Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells.

B. Rigas, S. Shiff, L. Qiao, 1995, The Journal of clinical investigation.

The circadian rhythm of biliary colic.

H. Spiro, B. Rigas, K J Vener, 1990, Journal of clinical gastroenterology.

NO-Donating NSAIDs, PPARδ, and Cancer: Does PPARδ Contribute to Colon Carcinogenesis?

B. Rigas, Shaheen Rasheed, G. Mackenzie, 2008, PPAR research.

Nonsteroidal anti-inflammatory drugs and colorectal cancer: evolving concepts of their chemopreventive actions.

B. Rigas, S. Shiff, 1997, Gastroenterology.

Non-COX-2 targets and cancer: expanding the molecular target repertoire of chemoprevention.

K. Kashfi, B. Rigas, 2005, Biochemical pharmacology.

The effect of ethanol on the expression of HLA class I genes in human colon adenocarcinoma cell lines.

E. Papavassiliou, B. Rigas, L. Staiano‐Coico, 1994, Cancer letters.

Phosphosulindac (OXT‐328) Selectively Targets Breast Cancer Stem Cells In Vitro and in Human Breast Cancer Xenografts

B. Rigas, P. Constantinides, N. Ouyang, 2012, Stem cells.

Insulin Resistance and Its Contribution to Colon Carcinogenesis

B. Rigas, Basil Rigas, J. Richie, 2003, Experimental biology and medicine.

NO-donating aspirin inhibits the growth of leukemic Jurkat cells and modulates beta-catenin expression.

K. Kashfi, N. Nath, B. Rigas, 2004, Biochemical and biophysical research communications.

Sulindac sulfide inhibits the proliferation of colon cancer cells: diminished expression of the proliferation markers PCNA and Ki-67.

B. Rigas, S. Shiff, L. Qiao, 1997, Cancer letters.

Altered Interactions between the Gut Microbiome and Colonic Mucosa Precede Polyposis in APCMin/+ Mice

B. Rigas, D. Frank, C. Robertson, 2015, PloS one.

Application of gene expression profiling to colon cell maturation, transformation and chemoprevention.

Andrew J. Wilson, D. Arango, Wancai Yang, 2003, The Journal of nutrition.

The Role of NSAIDs in the Prevention of Colon Cancer

B. Rigas, Jennie Williams, Y. Rayyan, 2002, Cancer investigation.

The Role of Cyclooxygenase Inhibition in the Antineoplastic Effects of Nonsteroidal Antiinflammatory Drugs (Nsaids)

B. Rigas, S. Shiff, 1999, The Journal of experimental medicine.

Title : Repurposing the anti-psychotic trifluoperazine as an anti-metastasis agent

B. Rigas, S. Zucker, N. Ouyang, 2014 .

Breast-feeding and maternal smoking in the etiology of Crohn's disease and ulcerative colitis in childhood.

D. Trichopoulos, E. Petridou, B. Rigas, 1993, Annals of epidemiology.

Nitric oxide-donating aspirin prevents pancreatic cancer in a hamster tumor model.

Jianjun Gao, L. Kopelovich, K. Kashfi, 2006, Cancer research.

The novel phenylester anticancer compounds: Study of a derivative of aspirin (phoshoaspirin).

B. Rigas, V. Kozoni, 2008, International journal of oncology.

Human colon adenocarcinoma cell lines display infrared spectroscopic features of malignant colon tissues.

B. Rigas, P. Wong, B Rigas, 1992, Cancer research.

Effect of aspirin on induction of apoptosis in HT-29 human colon adenocarcinoma cells.

B. Rigas, S. Shiff, L. Qiao, 1998, Biochemical pharmacology.

Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: an effect controlled by the thioredoxin system

B. Rigas, Leahana M. Rowehl, Liqun Huang, 2012, Breast Cancer Research.

Effect on treatment outcome of coinfection with SEN viruses in patients with hepatitis C

K. Wittkowski, B. Rigas, E. Lebovics, 2001, The Lancet.

Nitric oxide-donating aspirin inhibits the growth of pancreatic cancer cells through redox-dependent signaling.

B. Rigas, Liqun Huang, Yu Sun, 2009, Cancer letters.

NF-kappaB, inflammation and pancreatic carcinogenesis: NF-kappaB as a chemoprevention target (review).

B. Rigas, Zhiquan Zhang, 2006, International journal of oncology.

Curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin-independent pathway.

B. Rigas, S. Shiff, L. Qiao, 1997, The Journal of laboratory and clinical medicine.

The bile acids: Chemistry, physiology, and metabolism. Volume 4. Methods and applications

B. Rigas, 1989 .

Chemopreventive agents induce oxidative stress in cancer cells leading to COX-2 overexpression and COX-2-independent cell death.

B. Rigas, Jie Chen, Yu Sun, 2009, Carcinogenesis.

Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice.

L. Kopelovich, B. Rigas, F. Johnson, 2010, Gastroenterology.

IN PRESS hospho-Sulindac ( OXT-328 ) , a Novel Sulindac Derivative , Is Safe and ffective in Colon Cancer Prevention in Mice

L. Kopelovich, B. Rigas, N. Ouyang, 2022 .

Repurposing the Antipsychotic Trifluoperazine as an Antimetastasis Agent

B. Rigas, S. Zucker, N. Ouyang, 2015, Molecular Pharmacology.

Aerosol Administration of Phospho-Sulindac Inhibits Lung Tumorigenesis

B. Rigas, N. Ouyang, T. Wiedmann, 2013, Molecular Cancer Therapeutics.

Colon cancer prevention with NO-releasing NSAIDs.

K. Kashfi, B. Rigas, C. Kaza, 2002, Prostaglandins & other lipid mediators.

Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds.

B. Rigas, N. Ouyang, Liqun Huang, 2011, Cancer research.

Phosphoaspirin (MDC-43), a novel benzyl ester of aspirin, inhibits the growth of human cancer cell lines more potently than aspirin: a redox-dependent effect.

B. Rigas, Zhiquan Zhang, G. Mackenzie, 2009, Carcinogenesis.

NO-donating aspirin isomers downregulate peroxisome proliferator-activated receptor (PPAR)delta expression in APC(min/+) mice proportionally to their tumor inhibitory effect: Implications for the role of PPARdelta in carcinogenesis.

B. Rigas, N. Ouyang, Jennie Williams, 2006, Carcinogenesis.

Phospho-Ibuprofen (MDC-917) Is a Novel Agent against Colon Cancer: Efficacy, Metabolism, and Pharmacokinetics in Mouse Models

L. Kopelovich, B. Rigas, Liqun Huang, 2011, Journal of Pharmacology and Experimental Therapeutics.

Fecal occult blood testing in hospitalized patients.

B. Rigas, M. Pochapin, S. Fine, 1994, Journal of clinical gastroenterology.

Relative sensitivity and specificity of salivary and serum cotinine in identifying tobacco-smoking status of self-reported nonsmokers and smokers of tobacco and/or marijuana.

V. Clark, B. Rigas, D. Tashkin, 1989, Archives of environmental health.

Loss of colonic HLA antigens in familial adenomatous polyposis.

B. Rigas, T. Godwin, G. Tsioulias, 1992, Cancer research.

Phospho-valproic acid (MDC-1112) suppresses glioblastoma growth in preclinical models through the inhibition of STAT3 phosphorylation.

C. Ho, B. Rigas, M. Nemesure, 2019, Carcinogenesis.

NSAIDs and Colorectal Cancer Control: Promise and Challenges

B. Rigas, G. Tsioulias, M. Go, 2015, Current Pharmacology Reports.

A novel ibuprofen derivative with anti-lung cancer properties: synthesis, formulation, pharmacokinetic and efficacy studies.

B. Rigas, N. Ouyang, G. Mattheolabakis, 2014, International journal of pharmaceutics.

The in vitro metabolism of phospho-sulindac amide, a novel potential anticancer agent.

B. Rigas, Liqun Huang, Ka-Wing Cheng, 2014, Biochemical pharmacology.

Phospho-aspirin (MDC-22) inhibits breast cancer in preclinical animal models: an effect mediated by EGFR inhibition, p53 acetylation and oxidative stress

B. Rigas, N. Ouyang, Liqun Huang, 2014, BMC Cancer.

A novel Ras inhibitor (MDC-1016) reduces human pancreatic tumor growth in mice.

B. Rigas, N. Ouyang, G. Mackenzie, 2013, Neoplasia.

Topical phospho-sulindac (OXT-328) is effective in the treatment of non-melanoma skin cancer

B. Rigas, P. Constantinides, N. Ouyang, 2012, International journal of oncology.

Phospho-Sulindac (OXT-328) Inhibits the Growth of Human Lung Cancer Xenografts in Mice: Enhanced Efficacy and Mitochondria Targeting by its Formulation in Solid Lipid Nanoparticles

B. Rigas, P. Constantinides, Liqun Huang, 2012, Pharmaceutical Research.

Phospho‐ibuprofen (MDC‐917) incorporated in nanocarriers: anti‐cancer activity in vitro and in vivo

B. Rigas, P. Aro, Cc Wong, 2012, British journal of pharmacology.

Sterically Stabilized Liposomes Incorporating the Novel Anticancer Agent Phospho-Ibuprofen (MDC-917): Preparation, Characterization, and In Vitro/In Vivo Evaluation

B. Rigas, P. Constantinides, G. Mattheolabakis, 2011, Pharmaceutical Research.

Therapeutics , Targets , and Chemical Biology ChemotherapeuticPropertiesofPhospho-Nonsteroidal Anti-In fl ammatory Drugs , a New Class of Anticancer Compounds

B. Rigas, N. Ouyang, Liqun Huang, 2011 .

NSAIDs and Colorectal Cancer Control: Promise and Challenges

B. Rigas, G. Tsioulias, M. Go, 2015, Current Pharmacology Reports.

Protein nitration and nitrosylation by NO-donating aspirin in colon cancer cells: Relevance to its mechanism of action.

L. Kopelovich, P. Ji, B. Rigas, 2011, Experimental cell research.

Structure-activity relationship study of novel anticancer aspirin-based compounds.

B. Rigas, F. Johnson, Liqun Huang, 2011, Molecular medicine reports.

Selective Induction of Colon Cancer Cell Apoptosis by 5-Fluorouracil in Humans

B. Rigas, S. Shiff, C. Dervenis, 2002, Cancer investigation.

Infrared spectroscopic study of cervical smears in patients with HIV: implications for cervical carcinogenesis.

B. Rigas, T. Caputo, M. Cohenford, 2000, The Journal of laboratory and clinical medicine.

John Lykoudis: an unappreciated discoverer of the cause and treatment of peptic ulcer disease

E. Papavassiliou, B. Rigas, C. Feretis, 1999, The Lancet.

NO-donating nonsteroidal antiinflammatory drugs (NSAIDs) inhibit colon cancer cell growth more potently than traditional NSAIDs: a general pharmacological property?

F. Traganos, K. Kashfi, B. Rigas, 2004, Biochemical pharmacology.

Diagnosis of Dry Eye Disease Using Principal Component Analysis: A Study in Animal Models of the Disease

B. Nemesure, R. Honkanen, B. Rigas, 2021, Current eye research.

Platinum folate nanoparticles toxicity: cancer vs. normal cells.

Marcia Simon, B. Rigas, M. Rafailovich, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

Nitric-oxide-donating NSAIDs as agents for cancer prevention.

K. Kashfi, B. Rigas, 2004, Trends in molecular medicine.

Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NSAIDs) alter the kinetics of human colon cancer cell lines more effectively than traditional NSAIDs: implications for colon cancer chemoprevention.

F. Traganos, B. Rigas, J. L. Williams, 2001, Cancer research.

MC-12, an Annexin A1-Based Peptide, Is Effective in the Treatment of Experimental Colitis

B. Rigas, N. Ouyang, M. Go, 2012, PloS one.

Screening for colorectal cancer: does it all start with aberrant crypt foci?

B. Rigas, Shaheen Rasheed, 2008, Gastrointestinal endoscopy.

Comparative in vitro metabolism of phospho-tyrosol-indomethacin by mice, rats and humans.

B. Rigas, C. Wong, Ka-Wing Cheng, 2013, Biochemical pharmacology.

NO-donating aspirin inhibits the activation of NF-kappaB in human cancer cell lines and Min mice.

Xiaoping Liu, P. Ji, B. Rigas, 2008, Carcinogenesis.

HLA and disease association: the case of gastric cancer.

B. Rigas, 1996, Gastroenterology.

Rapid plasmid library screening using RecA-coated biotinylated probes.

S. Weissman, D. Ward, B. Rigas, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Nitric oxide–releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets

V. Steele, L. Kopelovich, Xiaoping Liu, 2006, Molecular Cancer Therapeutics.

SEN viruses and treatment response in chronic hepatitis C virus

K. Wittkowski, B. Rigas, E. Lebovics, 2002, The Lancet.

Expression of HLA class I antigens in sporadic adenomas and histologically normal mucosa of the colon.

E. Papavassiliou, B. Rigas, G. Triadafilopoulos, 1993, Cancer research.

Sterically Stabilized Liposomes Incorporating the Novel Anticancer Agent Phospho-Ibuprofen (MDC-917): Preparation, Characterization, and In Vitro/In Vivo Evaluation

B. Rigas, P. Constantinides, G. Mattheolabakis, 2012, Pharmaceutical Research.

Phospho-Sulindac (OXT-328) Inhibits the Growth of Human Lung Cancer Xenografts in Mice: Enhanced Efficacy and Mitochondria Targeting by its Formulation in Solid Lipid Nanoparticles

B. Rigas, P. Constantinides, Liqun Huang, 2012, Pharmaceutical Research.

Eicosanoids and the gastrointestinal tract: promising but no verdict yet.

B. Rigas, 1986, The American journal of gastroenterology.

Rapid placement of the Sengstaken-Blakemore tube using a guidewire.

B. Rigas, C. Kaza, 2002, Journal of clinical gastroenterology.

Fenretinide inhibits phorbol ester-induced cyclooxygenase-2 expression in human colon adenocarcinoma cells.

K. Kashfi, B. Rigas, G. Merritt, 1997, Biochemical Society Transactions.

Curcumin, a natural plant phenolic inhibits cell proliferation and induces cell changes in colon adenocarcinoma cell prostaglandin-independent pathway food additive, cycle lines by a

B. Rigas, S. Shiff, L. Qiao, 1997 .

The mechanism of action of nitric oxide-donating aspirin.

K. Kashfi, B. Rigas, 2007, Biochemical and biophysical research communications.

NO-releasing NSAIDs and colon cancer chemoprevention: a promising novel approach (Review).

B. Rigas, Jennie Williams, 2002, International journal of oncology.

Distinct infrared spectroscopic patterns of human basal cell carcinoma of the skin.

S. M. Goldstein, B. Rigas, T. Godwin, 1993, Cancer research.

In Vitro and In Vivo Metabolic Studies of Phospho-aspirin (MDC-22)

B. Rigas, P. Constantinides, Liqun Huang, 2012, Pharmaceutical Research.

The differential cell signaling effects of two positional isomers of the anticancer NO-donating aspirin.

B. Rigas, G. Mackenzie, Amy Hua, 2009, International journal of oncology.

Regulation of peroxisome proliferator‐activated receptor‐β/δ by the APC/β‐CATENIN pathway and nonsteroidal antiinflammatory drugs

B. Rigas, J. Peters, M. Clapper, 2009, Molecular carcinogenesis.

Nitric oxide-releasing medications and colorectal cancer risk: the framingham study.

B. Rigas, J. Muscat, A. Dyer, 2005, Anticancer research.

In Vitro Metabolism of Nitric Oxide-Donating Aspirin: The Effect of Positional Isomerism

Jianjun Gao, K. Kashfi, B. Rigas, 2005, Journal of Pharmacology and Experimental Therapeutics.

Phospho-Aspirin-2 (MDC-22) Inhibits Estrogen Receptor Positive Breast Cancer Growth Both In Vitro and In Vivo by a Redox-Dependent Effect

B. Rigas, Liqun Huang, C. Wong, 2014, PloS one.

Sulindac sulfide induces several subpopulations of colon cancer cells, defined by PCNA/Ki-67 and DNA strand breaks.

B. Rigas, S. Shiff, L. Qiao, 1997, Biochimica et biophysica acta.

The transcriptome of rabbit conjunctiva in dry eye disease: Large-scale changes and similarity to the human dry eye

R. Honkanen, B. Rigas, A. Master, 2021, PloS one.

A simplified urea breath test for the diagnosis of Helicobacter pylori infection using the LARA System. Laser Assisted Ratio Analyzer.

B. Rigas, G. Minoli, A. Prada, 1998, Journal of Clinical Gastroenterology.

Colon adenomatous polyps—do they grow inward?

B. Rigas, S. Shiff, 1997, The Lancet.

Hydrogel formulation of phosphosulindac allows once-a-day ocular dosing and limits its biodistribution to the anterior chamber: Application to dry eye disease treatment

R. Honkanen, B. Rigas, Liqun Huang, 2021, Journal of Drug Delivery Science and Technology.

A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies.

R. Honkanen, B. Rigas, Liqun Huang, 2020, Journal of Visualized Experiments.

Phospho-NSAIDs Have Enhanced Efficacy in Mice Lacking Plasma Carboxylesterase: Implications for their Clinical Pharmacology

B. Rigas, N. Ouyang, G. Mattheolabakis, 2015, Pharmaceutical Research.

Topically Applied Phospho-Sulindac Hydrogel is Efficacious and Safe in the Treatment of Experimental Arthritis in Rats

B. Rigas, N. Ouyang, G. Mattheolabakis, 2013, Pharmaceutical Research.

Once-Daily Topical Phosphosulindac Is Efficacious in the Treatment of Dry Eye Disease: Studies in Rabbit Models of Its Main Clinical Subtypes

R. Honkanen, B. Rigas, A. Master, 2021, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits.

R. Honkanen, B. Rigas, Liqun Huang, 2020, Journal of visualized experiments : JoVE.

The Antiangiogenic Effect and Ocular Pharmacology of Novel Modified Nonsteroidal Anti-Inflammatory Drugs in the Treatment of Oxygen-Induced Retinopathy

R. Honkanen, B. Rigas, Liqun Huang, 2023, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

Phospho-aspirin (MDC-22) inhibits breast cancer in preclinical animal models: an effect mediated by EGFR inhibition, p53 acetylation and oxidative stress

B. Rigas, N. Ouyang, Liqun Huang, 2014, BMC Cancer.

Is inhibition of cyclooxygenase required for the chemopreventive effect of NSAIDs in colon cancer? A model reconciling the current contradiction.

B. Rigas, S. Shiff, 2000, Medical hypotheses.

Induction of oxidative stress as a mechanism of action of chemopreventive agents against cancer

B. Rigas, Yu Sun, 2008, British Journal of Cancer.

RecA-assisted rapid enrichment of specific clones from model DNA libraries.

B. Rigas, M. Teintze, I. Arzimanoglou, 1995, Biochemical and biophysical research communications.

PAI-1 gene expression is growth state-regulated in cultured human epidermal keratinocytes during progression to confluence and postwounding.

P. Higgins, B. Rigas, B. Bailey, 1996, Experimental cell research.

Aspirin and aspirin-like drugs induce HLA-DR expression in HT29 colon cancer cells.

E. Papavassiliou, B. Rigas, E. Goldin, 1996, International journal of oncology.