P. Duerksen-Hughes

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p53 induction as a genotoxic test for twenty-five chemicals undergoing in vivo carcinogenicity testing.

P. Duerksen-Hughes, J. Yang, O. Ozcan, 1999, Environmental health perspectives.

A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage.

P. Duerksen-Hughes, J. Yang, P Duerksen-Hughes, 1998, Carcinogenesis.

A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

C. Mason, Tieliu Shi, Y. Nikolsky, 2014, Nature Communications.

Viral Carcinogenesis: Factors Inducing DNA Damage and Virus Integration

P. Duerksen-Hughes, V. Williams, Yan Chen, 2014, Cancers.

Complexes of Human Papillomavirus Type 16 E6 Proteins Form Pseudo-Death-Inducing Signaling Complex Structures during Tumor Necrosis Factor-Mediated Apoptosis

P. Duerksen-Hughes, M. Filippova, V. Filippov, 2008, Journal of Virology.

ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses.

Yingnian Yu, Hope E. Hamrick, P. Duerksen-Hughes, 2003, Carcinogenesis.

The Interaction between Human Papillomavirus Type 16 and FADD Is Mediated by a Novel E6 Binding Domain

Sandy S. Tungteakkhun, P. Duerksen-Hughes, J. W. Neidigh, 2008, Journal of Virology.

Bid is cleaved upstream of caspase-8 activation during TRAIL-mediated apoptosis in human osteosarcoma cells

P. Duerksen-Hughes, M. Filippova, T. Garnett, 2007, Apoptosis.

C18 ceramide analysis in mammalian cells employing reversed-phase high-performance liquid chromatography tandem mass spectrometry.

P. Duerksen-Hughes, M. Filippova, V. Filippov, 2008, Analytical biochemistry.

Benzo[a]pyrene induces complex H2AX phosphorylation patterns by multiple kinases including ATM, ATR, and DNA-PK.

P. Duerksen-Hughes, Zhengping Shao, Guanglin Zhang, 2011, Toxicology in vitro : an international journal published in association with BIBRA.

F. Chen, P. Duerksen-Hughes, Jun Yang, 2013, Mutation research.

Methylomes in Vegans versus Pescatarians and Nonvegetarians

Charles Wang, P. Duerksen-Hughes, K. Jaceldo-Siegl, 2020, Epigenomes.

The Full-Length Isoform of Human Papillomavirus 16 E6 and Its Splice Variant E6* Bind to Different Sites on the Procaspase 8 Death Effector Domain

Sandy S. Tungteakkhun, P. Duerksen-Hughes, M. Filippova, 2009, Journal of Virology.

Flavonol and imidazole derivatives block HPV16 E6 activities and reactivate apoptotic pathways in HPV+ cells

P. Duerksen-Hughes, M. Filippova, J. Krstenansky, 2016, Cell Death and Disease.

The small splice variant of HPV16 E6, E6, reduces tumor formation in cervical carcinoma xenografts.

P. Duerksen-Hughes, M. Reeves, V. Williams, 2014, Virology.

DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells.

Jun Yang, P. Duerksen-Hughes, M. Filippova, 2012, Biochimica et biophysica acta.

Artles p 53 Induction as a Genotoxic Test for Twenty-Five Chemicals Undergoing in Vivo Carcinogenicity Testing

P. Duerksen-Hughes, Jun Yang, O. Ozcan, 2006 .

PPI Modulators of E6 as Potential Targeted Therapeutics for Cervical Cancer: Progress and Challenges in Targeting E6

P. Duerksen-Hughes, L. Chitsike, 2021, Molecules.

Affinity chromatography using protein immobilized via arginine residues: purification of ubiquitin carboxyl-terminal hydrolases.

K. Wilkinson, P. Duerksen-Hughes, M. M. Williamson, 1989, Biochemistry.

Long-term, progressive, aerobic training increases adiponectin in middle-aged, overweight, untrained males and females

P. Duerksen-Hughes, A. Firek, Pooja P Mujumdar, 2011, Scandinavian journal of clinical and laboratory investigation.

Macrophage-Mediated Cytotoxicity

P. Duerksen-Hughes, L. Gooding, 1993 .

Selenium Attenuates HPV-18 Associated Apoptosis in Embryo-Derived Trophoblastic Cells but Not Inner Cell Mass In Vitro

P. Duerksen-Hughes, P. Chan, K. Lau, 2015, International journal of reproductive medicine.

The amino-terminal portion of CD1 of the adenovirus E1A proteins is required to induce susceptibility to tumor necrosis factor cytolysis in adenovirus-infected mouse cells

P. Duerksen-Hughes, W. Wold, L. Gooding, 1991, Journal of virology.

Ceramide and other sphingolipids in cellular responses

P. Duerksen-Hughes, Jun Yang, Yingnian Yu, 2007, Cell Biochemistry and Biophysics.

The adenovirus E3-14.7K protein is a general inhibitor of tumor necrosis factor-mediated cytolysis.

P. Duerksen-Hughes, W. Wold, L. Gooding, 1990, Journal of immunology.

Vegetarian diets, circulating miRNA expression and healthspan in subjects living in the Blue Zone

Charles Wang, P. Duerksen-Hughes, H. Qiu, 2020, Precision clinical medicine.

Convalescent Plasma for COVID-19: A Single Center Prospective Experience with Serial Antibody Measurements and Review of the Literature

P. Duerksen-Hughes, M. Reeves, V. Filippov, 2022, Pathogens.

Adenovirus E1A renders infected cells sensitive to cytolysis by tumor necrosis factor.

P. Duerksen-Hughes, W. Wold, L. Gooding, 1989, Journal of immunology.

Cellular Levels of Oxidative Stress Affect the Response of Cervical Cancer Cells to Chemotherapeutic Agents

P. Duerksen-Hughes, V. Williams, M. Filippova, 2014, BioMed research international.

Specificity of the mouse cytotoxic T lymphocyte response to adenovirus 5. E1A is immunodominant in H-2b, but not in H-2d or H-2k mice.

R. Ricciardi, P. Duerksen-Hughes, W. Wold, 1991, Journal of immunology.

Combined ultrasound-curcumin treatment of human cervical cancer cells.

K. R. Carr, P. Duerksen-Hughes, M. Filippova, 2015, European journal of obstetrics, gynecology, and reproductive biology.

Quantification of ceramide levels in mammalian cells by high performance liquid chromatography coupled to tandem mass spectrometry with multiple-reaction-monitoring mode (HPLC-MS/MS-MRM)

P. Duerksen-Hughes, M. Filippova, V. Filippov, 2011 .

The human papillomavirus 16 E6 protein can either protect or further sensitize cells to TNF: effect of dose

P. Duerksen-Hughes, M. Filippova, C. Casiano, 2005, Cell Death and Differentiation.

Effects of Lifestyle Factors on Cognitive Resilience: Commentary on “What This Sunny, Religious Town in California Teaches Us About Living Longer”

John H. Zhang, P. Duerksen-Hughes, M. Orlich, 2020, Translational Stroke Research.

Proton-induced DNA damage promotes integration of foreign plasmid DNA into human genome

P. Duerksen-Hughes, A. Bertucci, V. Filippov, 2022, Frontiers in Oncology.

Methyl methanesulfonate induces apoptosis in p53-deficient H1299 and Hep3B cells through a caspase 2- and mitochondria-associated pathway.

P. Duerksen-Hughes, Jun Yang, Xinqiang Zhu, 2012, Environmental toxicology and pharmacology.

Inorganic and dimethylated arsenic species induce cellular p53.

P. Duerksen-Hughes, M. Filippova, 2003, Chemical research in toxicology.

The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase.

K D Wilkinson, K. Wilkinson, P. Duerksen-Hughes, 1989, Science.

Chronic oxidative stress increases the integration frequency of foreign DNA and human papillomavirus 16 in human keratinocytes.

P. Duerksen-Hughes, V. Williams, M. Filippova, 2016, American journal of cancer research.

The Interaction between Human Papillomavirus Type 16 and FADD Is Mediated by a Novel E6 Binding Domain (cid:1)

Sandy S. Tungteakkhun, P. Duerksen-Hughes, M. Filippova, 2008 .

The Large and Small Isoforms of Human Papillomavirus Type 16 E6 Bind to and Differentially Affect Procaspase 8 Stability and Activity

Sandy S. Tungteakkhun, P. Duerksen-Hughes, M. Filippova, 2007, Journal of Virology.

Approaches and Methods to Measure Oxidative Stress in Clinical Samples: Research Applications in the Cancer Field

P. Duerksen-Hughes, M. Filippova, Meghri Katerji, 2019, Oxidative medicine and cellular longevity.

The early response to DNA damage can lead to activation of alternative splicing activity resulting in CD44 splice pattern changes.

P. Duerksen-Hughes, M. Filippova, V. Filippov, 2007, Cancer research.

Human Papillomavirus Type 16 E6* Induces Oxidative Stress and DNA Damage

P. Duerksen-Hughes, V. Williams, M. Filippova, 2014, Journal of Virology.

HPV-DNA integration and carcinogenesis: putative roles for inflammation and oxidative stress.

P. Duerksen-Hughes, V. Williams, M. Filippova, 2011, Future virology.

Increased ceramide in brains with Alzheimer's and other neurodegenerative diseases.

H. Vinters, Jun Yang, P. Duerksen-Hughes, 2012, Journal of Alzheimer's disease : JAD.

Cellular binding partners of the human papillomavirus E6 protein

Sandy S. Tungteakkhun, P. Duerksen-Hughes, 2008, Archives of Virology.

Effects of benzo(a)pyrene on the contractile function of the thoracic aorta of Sprague-Dawley rats.

P. Duerksen-Hughes, S. Xiao, Jun Yang, 2012, Biomedical and environmental sciences : BES.

Protein kinases and their involvement in the cellular responses to genotoxic stress.

P. Duerksen-Hughes, Jun Yang, Yingnian Yu, 2003, Mutation research.

The E1B 19,000-molecular-weight protein of group C adenoviruses prevents tumor necrosis factor cytolysis of human cells but not of mouse cells

P. Duerksen-Hughes, T. Horton, L. Aquino, 1991, Journal of virology.

The 10,400- and 14,500-dalton proteins encoded by region E3 of adenovirus function together to protect many but not all mouse cell lines against lysis by tumor necrosis factor

P. Duerksen-Hughes, T. Horton, T. Ranheim, 1991, Journal of virology.

Induction of susceptibility to tumor necrosis factor by E1A is dependent on binding to either p300 or p105-Rb and induction of DNA synthesis

T. Hermiston, P. Duerksen-Hughes, W. Wold, 1996, Journal of virology.

Cisplatin treatment leads to changes in nuclear protein and microRNA expression.

P. Duerksen-Hughes, Guanglin Zhang, Jun Yang, 2012, Mutation research.

Association between markers of glucose metabolism and risk of colorectal cancer

Han Wu, P. Duerksen-Hughes, D. Xia, 2016, BMJ Open.

DNA damage in cancer development: special implications in viral oncogenesis.

P. Duerksen-Hughes, Meghri Katerji, 2021, American journal of cancer research.

Cancer stem cell self-renewal as a therapeutic target in human oral cancer

Xiangpeng Yuan, P. Duerksen-Hughes, Jinwei Hu, 2019, Oncogene.

ATM and ATR: sensing DNA damage.

Ying-Nian Yu, Hope E. Hamrick, P. Duerksen-Hughes, 2004, World journal of gastroenterology.

Subpopulations of cancer stem cells found in papillary thyroid carcinoma

Xiangpeng Yuan, P. Duerksen-Hughes, S. Mirshahidi, 2018, Experimental cell research.

The Human Papillomavirus 16 E6 Protein Binds to Fas-associated Death Domain and Protects Cells from Fas-triggered Apoptosis*

P. Duerksen-Hughes, M. Filippova, Lindsey Parkhurst, 2004, Journal of Biological Chemistry.

Linifanib (ABT-869), enhances cytotoxicity with poly (ADP-ribose) polymerase inhibitor, veliparib (ABT-888), in head and neck carcinoma cells.

R. Ferris, P. Duerksen-Hughes, C. Chen, 2014, Oral oncology.

Overexpression of HPV16 E6* Alters β-Integrin and Mitochondrial Dysfunction Pathways in Cervical Cancer Cells.

P. Duerksen-Hughes, M. Reeves, M. Filippova, 2016, Cancer genomics & proteomics.

Keep out! SARS-CoV-2 entry inhibitors: their role and utility as COVID-19 therapeutics

P. Duerksen-Hughes, L. Chitsike, 2021, Virology journal.

Paraspeckle Protein 1 (PSPC1) Is Involved in the Cisplatin Induced DNA Damage Response—Role in G1/S Checkpoint

P. Duerksen-Hughes, Yihua Wu, Guanglin Zhang, 2014, PloS one.

DNA Methylation Profiles of Vegans and Non-Vegetarians in the Adventist Health Study-2 Cohort

K. Siegmund, Charles Wang, P. Duerksen-Hughes, 2020, Nutrients.

Modulation of Apoptotic Pathways by Human Papillomaviruses (HPV): Mechanisms and Implications for Therapy

P. Duerksen-Hughes, M. Filippova, Chung-Hsiang Yuan, 2012, Viruses.

Modulation of apoptosis by human papillomavirus (HPV) oncoproteins

P. Duerksen-Hughes, T. O. Garnett, P. J. Duerksen-Hughes, 2006, Archives of Virology.

Accelerated degradation of FADD and procaspase 8 in cells expressing human papilloma virus 16 E6 impairs TRAIL-mediated apoptosis

P. Duerksen-Hughes, M. Filippova, T. Garnett, 2006, Cell Death and Differentiation.

Recent Progress in Therapeutic Treatments and Screening Strategies for the Prevention and Treatment of HPV-Associated Head and Neck Cancer

P. Duerksen-Hughes, M. Filippova, Sonia N. Whang, 2015, Viruses.

Oxidative stress markers in patient-derived non-cancerous cervical tissues and cells

P. Duerksen-Hughes, M. Filippova, S. Siddighi, 2020, Scientific Reports.

Targeting Tumor Microenvironment Akt Signaling Represents a Potential Therapeutic Strategy for Aggressive Thyroid Cancer

Xiangpeng Yuan, P. Duerksen-Hughes, S. Mirshahidi, 2023, International journal of molecular sciences.

Interleukin 24: mechanisms and therapeutic potential of an anti-cancer gene.

P. Duerksen-Hughes, V. Filippov, Erin L. Whitaker, 2012, Cytokine & growth factor reviews.

Splice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells.

P. Duerksen-Hughes, C. Guerrero-Juarez, M. Filippova, 2011, Cytokine.

Benzo[a]pyrene treatment leads to changes in nuclear protein expression and alternative splicing.

P. Duerksen-Hughes, Haiyan Li, Guanglin Zhang, 2010, Mutation research.

Mass Spectrometric Studies on Epigenetic Interaction Networks in Cell Differentiation*

P. Duerksen-Hughes, Lei Xiong, C. Chen, 2011, The Journal of Biological Chemistry.

The Human Papillomavirus 16 E6 Protein Binds to Tumor Necrosis Factor (TNF) R1 and Protects Cells from TNF-induced Apoptosis*

Helen Song, P. Duerksen-Hughes, T. Dermody, 2002, The Journal of Biological Chemistry.

The Potential of Immune Checkpoint Blockade in Cervical Cancer: Can Combinatorial Regimens Maximize Response? A Review of the Literature

P. Duerksen-Hughes, L. Chitsike, 2020, Current Treatment Options in Oncology.

HPV 16 E6 blocks TNF-mediated apoptosis in mouse fibroblast LM cells.

P. Duerksen-Hughes, J. Yang, S. Schwartz, 1999, Virology.

Activation of a p53-independent, Sphingolipid-mediated Cytolytic Pathway in p53-negative Mouse Fibroblast Cells Treated with N-Methyl-N-nitro-N-nitrosoguanidine*

P. Duerksen-Hughes, Jun Yang, 2001, The Journal of Biological Chemistry.

Inhibitory Effects of Indomethacin in Human MNNG/HOS Osteosarcoma Cell Line In Vitro

P. Duerksen-Hughes, M. Reeves, S. Mirshahidi, 2019, Cancer investigation.

The Biology of Veganism: Plasma Metabolomics Analysis Reveals Distinct Profiles of Vegans and Non-Vegetarians in the Adventist Health Study-2 Cohort

P. Duerksen-Hughes, J. Lampe, M. Orlich, 2022, Nutrients.

Toxicological profile for white phosphorus

P. Duerksen-Hughes, P. Richter, 1997 .

Nuclear proteome analysis of benzo(a)pyrene-treated HeLa cells.

P. Duerksen-Hughes, Guanglin Zhang, Jun Yang, 2012, Mutation research.

Nuclear proteome analysis of cisplatin-treated HeLa cells.

P. Duerksen-Hughes, Jun Yang, Xinqiang Zhu, 2010, Mutation research.

Both tumor necrosis factor and nitric oxide participate in lysis of simian virus 40-transformed cells by activated macrophages.

P. Duerksen-Hughes, L. Aquino, L. Gooding, 1992, Journal of immunology.

Targeted Therapy as a Potential De-Escalation Strategy in Locally Advanced HPV-Associated Oropharyngeal Cancer: A Literature Review

P. Duerksen-Hughes, L. Chitsike, 2021, Frontiers in Oncology.

Cold parenting is associated with cellular aging in offspring: A retrospective study

P. Duerksen-Hughes, G. Fraser, S. Knutsen, 2019, Biological Psychology.

Toxicological profile for 4,4'-methylenebis(2-chloroaniline) MBOCA

P. Duerksen-Hughes, V. Brankovan, 1994 .

Proteomic Analysis of Cellular Response Induced by Multi-Walled Carbon Nanotubes Exposure in A549 Cells

F. Chen, P. Duerksen-Hughes, Guanglin Zhang, 2014, PloS one.

Small molecule inhibitors of the HPV16-E6 interaction with caspase 8.

Sandy S. Tungteakkhun, P. Duerksen-Hughes, M. Filippova, 2012, Bioorganic & medicinal chemistry letters.

ACE2 : S1 RBD Interaction-Targeted Peptides and Small Molecules as Potential COVID-19 Therapeutics

P. Duerksen-Hughes, L. Chitsike, J. Krstenansky, 2021, Advances in pharmacological and pharmaceutical sciences.

Structure and function of ubiquitin: evidence for differential interactions of arginine-74 with the activating enzyme and the proteases of ATP-dependent proteolysis.

K. Wilkinson, P. Duerksen-Hughes, X. X. Xu, 1987, Biochemistry.

A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV+ head and neck squamous cell carcinomas

P. Duerksen-Hughes, L. Chitsike, Anuradha Roy, 2021, Oncotarget.

GA-OH enhances the cytotoxicity of photon and proton radiation in HPV+ HNSCC cells

P. Duerksen-Hughes, A. Bertucci, L. Chitsike, 2023, Frontiers in Oncology.

Bupivacaine and Lidocaine Induce Apoptosis in Osteosarcoma Tumor Cells.

Xiangpeng Yuan, P. Duerksen-Hughes, M. Reeves, 2020, Clinical orthopaedics and related research.

Effects of Lifestyle Factors on Cognitive Resilience: Commentary on “What This Sunny, Religious Town in California Teaches Us About Living Longer”

John H. Zhang, P. Duerksen-Hughes, M. Orlich, 2020, Translational Stroke Research.

Splicing and splice factor SRp55 participate in the response to DNA damage by changing isoform ratios of target genes.

P. Duerksen-Hughes, M. Filippova, V. Filippov, 2008, Gene.

Long-term, Aerobic Training Increases Adiponectin Levels in Trained, Middle-aged Females more than in Comparable Males

P. Duerksen-Hughes, A. Firek, Pooja P Mujumdar, 2014 .

Oxidative Stress and DNA Damage Human Papillomavirus Type 16 E6* Induces

P. Duerksen-Hughes, V. Williams, M. Filippova, 2014 .

Comprehensive Review: Unveiling the Pro-Oncogenic Roles of IL-1ß and PD-1/PD-L1 in NSCLC Development and Targeting Their Pathways for Clinical Management

P. Duerksen-Hughes, M. Reeves, D. Castillo, 2023, International journal of molecular sciences.

Comprehensive Review: Unveiling the Pro-Oncogenic Roles of IL-1ß and PD-1/PD-L1 in NSCLC Development and Targeting Their Pathways for Clinical Management.

P. Duerksen-Hughes, M. Reeves, D. Castillo, 2023, International journal of molecular sciences.

Splice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells.

P. Duerksen-Hughes, C. Guerrero-Juarez, M. Filippova, 2011, Cytokine.

Splicing and splice factor SRp55 participate in the response to DNA damage by changing isoform ratios of target genes.

P. Duerksen-Hughes, M. Filippova, V. Filippov, 2008, Gene.

Modern Molecular and Clinical Approaches to Eradicate HPVMediated Cervical Cancer

P. Duerksen-Hughes, M. Filippova, R. Swensen, 2013 .

Duocarmycin SA Reduces Proliferation and Increases Apoptosis in Acute Myeloid Leukemia Cells In Vitro

P. Duerksen-Hughes, C. Casiano, S. Dovat, 2024, International journal of molecular sciences.

Increased ceramide in brains with Alzheimer's and other neurodegenerative diseases.

H. Vinters, Jun Yang, P. Duerksen-Hughes, 2012, Journal of Alzheimer's disease : JAD.

Basic Science

D. Gridley, P. Duerksen-Hughes, M. Filippova, 2007, Evidence-based Complementary and Alternative Medicine : eCAM.

Linifanib (ABT-869), enhances cytotoxicity with poly (ADP-ribose) polymerase inhibitor, veliparib (ABT-888), in head and neck carcinoma cells.

R. Ferris, P. Duerksen-Hughes, C. Chen, 2014, Oral oncology.