A. Williams

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Inhibition of radiation-induced G2 delay potentiates cell death by apoptosis and/or the induction of giant cells in colorectal tumor cells with disrupted p53 function.

C. Paraskeva, T. Bracey, A. Williams, 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

Modulation of p53 expression in cultured colonic adenoma cell lines by the naturally occurring lumenal factors butyrate and deoxycholate

C. Paraskeva, A. Williams, D. Palmer, 1997, International journal of cancer.

Nuclear BAG-1 expression inhibits apoptosis in colorectal adenoma-derived epithelial cells

G. Packham, C. Paraskeva, A. Williams, 2005, Apoptosis.

β-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?

J. Mariadason, C. Paraskeva, A. Williams, 2012, British Journal of Cancer.

The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2

D. Hicks, C. Paraskeva, A. Williams, 2005, Gut.

Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor beta (TGF-beta): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-beta.

A. Manning, C. Paraskeva, A. Williams, 1991, Oncogene.

Parkinson's disease: the first common neurological disease due to auto-intoxication?

A. Williams, D. Ramsden, L. Cartwright, 2005, QJM : monthly journal of the Association of Physicians.

Insulin-like growth factor binding protein 3 (IGFBP-3) potentiates TRAIL-induced apoptosis of human colorectal carcinoma cells through inhibition of NF-kappaB.

C. Paraskeva, A. Williams, H. Smartt, 2007, Cell death and differentiation.

Hyperproinsulinaemia in patients with myotonic dystrophy

A. Williams, A. Krentz, P. Clark, 1992, Diabetologia.

Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: implications for targeting cancer stem cells

E. Molnár, C. Paraskeva, A. Williams, 2015, British Journal of Cancer.

Bax Inhibitor 1 in apoptosis and disease

A. Williams, G. Frankel, K. S. Robinson, 2011, Oncogene.

The retinoblastoma protein (Rb) as an anti-apoptotic factor: expression of Rb is required for the anti-apoptotic function of BAG-1 protein in colorectal tumour cells

P. Townsend, C. Paraskeva, A. Williams, 2012, Cell Death and Disease.

Are different events involved in the development of sporadic versus hereditary tumours? The possible importance of the microenvironment in hereditary cancer.

C. Paraskeva, A. Williams, 1990, British Journal of Cancer.

Insulin and Proinsulin-Like Molecules in Motor Neurone Disease

A. Williams, A. Krentz, P. Clark, 1993, Annals of clinical biochemistry.

An investigation into the role of reactive oxygen species in the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity using neuronal cell lines.

A. Williams, H. Griffiths, J. Lunec, 1993, Biochemical pharmacology.

D-penicillamine metabolism in neurodegenerative diseases: an in vivo/in vitro sulphydryl methylation study.

A. Williams, R. Waring, G. Steventon, 1994, Xenobiotica; the fate of foreign compounds in biological systems.

A direct correlation between nicotinamide N-methyltransferase activity and protein levels in human liver cytosol.

M. L. Smith, A. Williams, R. Waring, 1998, Biochimica et Biophysica Acta.

Development of an in vitro model for cysteine dioxygenase expression in the brain

A. Williams, R. Waring, S. Qusti, 2004, Cell Biology and Toxicology.

BAG-1L promotes keratinocyte differentiation in organotypic culture models and changes in relative BAG-1 isoform abundance may lead to defective stratification.

A. Williams, T. Benn, A. Hague, 2011, Experimental cell research.

Complete structural characterisation of the human aryl hydrocarbon receptor gene

A. Williams, D. Ramsden, P. Bennett, 1996, Clinical molecular pathology.

Synthesis and Nuclear Magnetic Resonance Spectroscopic, Mass Spectroscopic, and Plasma Amine Oxidase Inhibitory Properties of Analogues of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine

A. Williams, H. Pall, J. Burdon, 1988, Journal of neurochemistry.

Cytochrome P450 1B1 mRNA in the human central nervous system.

A. Williams, D. Ramsden, C. Rieder, 1998, Molecular pathology : MP.

Intra-operative blood glucose and serum insulin concentrations in the surgical management of insulinoma.

A. Williams, P. J. Hale, R. Baddeley, 1990, Postgraduate medical journal.

Insulin resistance in multiple aspects of intermediary metabolism in myotonic dystrophy.

A. Williams, A. Krentz, M. Nattrass, 1991, Metabolism: clinical and experimental.

Mutant p53 is not fully dominant over endogenous wild type p53 in a colorectal adenoma cell line as demonstrated by induction of MDM2 protein and retention of a p53 dependent G1 arrest after gamma irradiation.

C. Paraskeva, T. Bracey, A. Williams, 1995, Oncogene.

Prospects in NSAID-derived chemoprevention of colorectal cancer.

D. Hicks, D. Qualtrough, C. Paraskeva, 2005, Biochemical Society transactions.

Cannabinoids and cancer: potential for colorectal cancer therapy.

D. Hicks, C. Paraskeva, A. Williams, 2005, Biochemical Society transactions.

Plasma membrane phospholipid integrity and orientation during hypoxic and toxic proximal tubular attack.

A. Williams, R. Zager, B. Sacks, 1999, Kidney international.

Hormonal regulation of circulating insulin-like growth factor-binding protein-1 phosphorylation status.

A. Williams, P. Clayton, M. Westwood, 1995, The Journal of clinical endocrinology and metabolism.

Expression of cysteine dioxygenase (EC 1.13.11.20) and sulfite oxidase in the human lung: a potential role for sulfate production in the protection from airborne xenobiotica

A. Williams, R. Waring, R. Parsons, 2003, Molecular pathology : MP.

Functional Significance of the Pentose Phosphate Pathway and Glutathione Reductase in the Antioxidant Defenses of Human Sperm1

A. Williams, W. Ford, 2004, Biology of reproduction.

The role of glucose in supporting motility and capacitation in human spermatozoa.

A. Williams, W. Ford, 2001, Journal of andrology.

Molecular events including p53 and k-ras alterations in the in vitro progression of a human colorectal adenoma cell line to an adenocarcinoma.

D. Lane, C. Marshall, C. Paraskeva, 1993, Oncogene.

Experiences with local chemotherapy and immunotherapy in premalignant and malignant skin lesions

A. Williams, E. Klein, Ashbel C. Williams, 1970, Cancer.

Sucrose reduces the efficiency of protein denaturation by a chaotropic agent.

H. G. Edwards, A. Clarke, G. Jackson, 1995, Biochimica et biophysica acta.

Activation of bovine plasma benzylamine oxidase (BzAO) by 1-methyl-4-(2-methylphenyl)-1,2,3,6-tetrahydropyridine.

A. Williams, A. Bhatti, D. Ramsden, 1992, Toxicology letters.

Hydrogen symbioses in evolution and disease.

A. Williams, D. Ramsden, D. B. Ramsden, 2007, QJM : monthly journal of the Association of Physicians.

Neoplastic transformation of a human colonic epithelial cell line: in vitro evidence for the adenoma to carcinoma sequence.

C. Paraskeva, A. Williams, S. Harper, 1990, Cancer research.

Alterations in concentrations of cyclic guanosine 3',5'-monophosphate in guinea pig urine during the development of a transplantable leukaemia.

A. Williams, P. Light, 1985, Cancer letters.

LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity

A. Williams, A. Greenhough, T. Collard, 2017, British Journal of Cancer.

Insulin-like growth factor binding protein 3 (IGFBP-3) potentiates TRAIL-induced apoptosis of human colorectal carcinoma cells through inhibition of NF-κB

C. Paraskeva, A. Williams, H. Smartt, 2007, Cell Death and Differentiation.

An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis

C. Paraskeva, A. Williams, T. Collard, 1999, Oncogene.

IGFBP-3 and apoptosis—a licence to kill?

A. Williams, A. Butt, A. Williams, 2001, Apoptosis.

Potentiating the effects of radiotherapy in rectal cancer: the role of aspirin, statins and metformin as adjuncts to therapy

A. Williams, M. Thomas, A. Chambers, 2017, British Journal of Cancer.

Transcriptional down-regulation of the retinoblastoma protein is associated with differentiation and apoptosis in human colorectal epithelial cells

C. Paraskeva, J. Bond, A. Williams, 2001, British Journal of Cancer.

The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival.

G. Packham, C. Paraskeva, A. Williams, 2005, Biochemical Society transactions.

Influence of food intake during late gestation on serum lipids of sows and their progeny.

A. Williams, R. Martin, L. Hentges, 1987, Biology of the neonate.

Chromosomal localisation of genes coding for human and mouse liver cytosolic cysteine dioxygenase

M. Fox, S. Povey, A. Williams, 1996, Annals of human genetics.

Transcriptional upregulation of the insulin-like growth factor binding protein IGFBP-3 by sodium butyrate increases IGF-independent apoptosis in human colonic adenoma-derived epithelial cells.

C. Paraskeva, A. Williams, A. Butt, 2003, Carcinogenesis.

Palatability and Appearance Traits of Beef/Pork Meat Patties

G. W. Davis, A. Williams, M. Miller, 1987 .

Increased p53-dependent apoptosis by the insulin-like growth factor binding protein IGFBP-3 in human colonic adenoma-derived cells.

C. Paraskeva, A. Williams, P. Newcomb, 2000, Cancer research.

In vitro models for studying colorectal carcinogenesis: cellular and molecular events including APC and Rb cleavage in the control of proliferation, differentiation and apoptosis.

C. Paraskeva, A. Williams, D. Elder, 1996, Biochimica et biophysica acta.

Pathways of cysteine metabolism in MND/ALS

A. Williams, R. Waring, G. Steventon, 1994, Journal of the Neurological Sciences.

Demographic trends in the incidence of young‐onset colorectal cancer: a population‐based study

A. Williams, M. Thomas, D. Messenger, 2020, The British journal of surgery.

Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA.

A. Williams, M. Akbari, D. Ramsden, 1994, Biochimica et biophysica acta.

Hepatic localisation of rat cysteine dioxygenase.

A. Williams, R. Waring, R. Parsons, 1998, Journal of hepatology.

Human cysteine dioxygenase type I (CDO-I; EC 1.13.11.20): 5' flanking region and intron-exon structure of the gene.

A. Williams, N. Fitch, D. Ramsden, 1997, Molecular pathology : MP.

In vitro models of human colorectal cancer.

A. Manning, C. Paraskeva, A. Williams, 1993, Cancer Surveys.

Inhibition of dopamine uptake into PC-12 cells by analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

A. Williams, D. Ramsden, N. S. Athwal, 1996, Parkinsonism & related disorders.

Toxicity of sulphur-containing compounds to neuronal cell lines

A. Williams, R. Waring, R. Parsons, 1995, Journal of the Neurological Sciences.

In vitro effect of the cysteine metabolites homocysteic acid, homocysteine and cysteic acid upon human neuronal cell lines.

A. Williams, R. Waring, R. Parsons, 1998, Neurotoxicology.

Assessment of a point‐of‐care test for measurement of blood triglyceride levels for rapid detection of equid hypertriglyceridaemia

R. Christley, A. Williams, L. Peachey, 2012 .

Targeting LGR5 in Colorectal Cancer: therapeutic gold or too plastic?

A. Williams, R. Morgan, E. Mortensson, 2018, British Journal of Cancer.

BAG-1 enhances cell-cell adhesion, reduces proliferation and induces chaperone-independent suppression of hepatocyte growth factor-induced epidermal keratinocyte migration.

A. Williams, J. Uney, A. Hague, 2010, Experimental cell research.

Nicotinamide homeostasis: a xenobiotic pathway that is key to development and degenerative diseases.

A. Williams, D. Ramsden, 2005, Medical hypotheses.

Abnormal regulation of carbohydrate metabolism in motor neurone disease.

A. Williams, A. Krentz, M. Nattrass, 1991, Diabetes research.

Colorectal carcinogenesis: sequential steps in the in vitro immortalization and transformation of human colonic epithelial cells (review).

C. Paraskeva, A. Williams, A. Corfield, 1990, Anticancer research.

Abnormal regulation of intermediary metabolism after oral glucose ingestion in myotonic dystrophy.

A. Williams, A. Krentz, M. Nattrass, 1990, Metabolism: clinical and experimental.

Optimized delivery of siRNA into 3D tumor spheroid cultures in situ

A. Williams, A. Greenhough, A. Chambers, 2018, Scientific Reports.

Selegiline increases heme oxygenase-1 expression and the cytotoxicity produced by dopamine treatment of neuroblastoma SK-N-SH cells.

A. Williams, D. Ramsden, C. Rieder, 2004, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Biological consequences of the genetic changes which occur during human colorectal carcinogenesis.

A. Manning, C. Paraskeva, A. Williams, 1993, Seminars in cancer biology.