C. Toulas

发表

Preferential cytoplasmic localization of p34cdc2 in recurrent human squamous cell carcinoma after radiotherapy.

E. Cohen-Jonathan, C. Toulas, P. Rochaix, 1997, Radiation research.

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Jane E. Carpenter, Jaana M. Hartikainen, W. Chung, 2019, Nature Genetics.

Germline mutation p.N363K in POLE is associated with an increased risk of colorectal cancer and giant cell glioblastoma

C. Toulas, E. Uro-Coste, R. Guimbaud, 2018, Familial Cancer.

BRCA1 wild-type allele modifies risk of ovarian cancer in carriers of BRCA1 germ-line mutations.

J. Simard, D. Yannoukakos, J. Peyrat, 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

BRCA 1 Wild-Type Allele Modifies Risk of Ovarian Cancer in Carriers of BRCA 1 GermLine Mutations 1

J. Simard, D. Yannoukakos, J. Peyrat, 2003 .

Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance

C. Toulas, V. Lubrano, P. Dahan, 2014, Cell Death and Disease.

Int 6 / eIF 3 e Is Essential for Proliferation and Survival of Human Glioblastoma Cells

C. Toulas, C. Seva, A. Cammas, 2016 .

Int6/eIF3e Is Essential for Proliferation and Survival of Human Glioblastoma Cells

C. Toulas, C. Seva, A. Cammas, 2014, International journal of molecular sciences.

The radioprotective effect of the 24 kDa FGF-2 isoform in HeLa cells is related to an increased expression and activity of the DNA dependent protein kinase (DNA-PK) catalytic subunit

E. Cohen-Jonathan, C. Toulas, G. Favre, 2002, Oncogene.

Activation of RhoB by hypoxia controls hypoxia-inducible factor-1alpha stabilization through glycogen synthase kinase-3 in U87 glioblastoma cells.

E. Cohen-Jonathan-Moyal, C. Toulas, G. Favre, 2006, Cancer research.

Radioresistance induced by the high molecular forms of the basic fibroblast growth factor is associated with an increased G2 delay and a hyperphosphorylation of p34CDC2 in HeLa cells.

H. Prats, E. Cohen-Jonathan, C. Toulas, 1997, Cancer research.

The contribution of germline rearrangements to the spectrum of BRCA2 mutations

P. Chappuis, R. Lidereau, D. Stoppa-Lyonnet, 2006, Journal of Medical Genetics.

Potential prognostic value in human breast cancer of cytosolic Nme1 protein detection using an original hen specific antibody.

C. Toulas, G. Favre, J. Mihura, 1996, British Journal of Cancer.

FGFR1 Induces Glioblastoma Radioresistance through the PLCγ/Hif1α Pathway.

E. Cohen-Jonathan-Moyal, C. Toulas, S. Evrard, 2016, Cancer research.

Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of human farnesyltransferase, BIM‐46228

C. Toulas, G. Favre, T. Gordon, 2001, International journal of cancer.

Targeting progastrin enhances radiosensitization of colorectal cancer cells

E. Cohen-Jonathan-Moyal, C. Toulas, A. Kowalski-Chauvel, 2017, Oncotarget.

Clinical relevance of 8q23, 15q13 and 18q21 SNP genotyping to evaluate colorectal cancer risk

P. Laurent-Puig, J. Duffour, J. Saurin, 2015, European Journal of Human Genetics.

5′ Region Large Genomic Rearrangements in the BRCA1 Gene in French Families: Identification of a Tandem Triplication and Nine Distinct Deletions with Five Recurrent Breakpoints

I. Bièche, M. Stern, R. Lidereau, 2021, Cancers.

αvβ3 and αvβ5 integrins control glioma cell response to ionising radiation through ILK and RhoB

E. Cohen-Jonathan-Moyal, C. Toulas, G. Favre, 2008, International journal of cancer.

The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS.

S. Sebti, E. Cohen-Jonathan, C. Toulas, 1999, Radiation research.

Colon‐specific phenotype in Lynch syndrome associated with EPCAM deletion

C. Toulas, J. Tinat, S. Baert-Desurmont, 2012, Clinical genetics.

Characterization of atypical dMMR (deficient MisMatch Repair) tumors: A study from a large cohort of 4948 cases

C. Toulas, R. Guimbaud, J. Selves, 2019, Annals of Oncology.

A new hybrid record linkage process to make epidemiological databases interoperable: application to the GEMO and GENEPSO studies involving BRCA1 and BRCA2 mutation carriers

F. Révillion, Chloé-Agathe Azencott, N. Sevenet, 2020, BMC Medical Research Methodology.

Alphavbeta3/alphavbeta5 integrins-FAK-RhoB: a novel pathway for hypoxia regulation in glioblastoma.

C. Toulas, G. Favre, J. Bonnet, 2009, Cancer research.

A v B 3 / A v B 5 Integrins-FAK-RhoB: A Novel Pathway for Hypoxia Regulation in Glioblastoma

C. Toulas, G. Favre, J. Bonnet, 2009 .

Alpha6-Integrin Regulates FGFR1 Expression through the ZEB1/YAP1 Transcription Complex in Glioblastoma Stem Cells Resulting in Enhanced Proliferation and Stemness

E. Cohen-Jonathan-Moyal, C. Toulas, A. Kowalski-Chauvel, 2019, Cancers.

By modulating &agr;2&bgr;1 integrin signalling, gastrin increases adhesion oF AGS‐GR gastric cancer cells

E. Cohen-Jonathan-Moyal, C. Toulas, A. Kowalski-Chauvel, 2018, Experimental cell research.

The farnesyltransferase inhibitor R115777 reduces hypoxia and matrix metalloproteinase 2 expression in human glioma xenograft.

E. Cohen-Jonathan, C. Toulas, P. Rochaix, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Association and performance of polygenic risk scores for breast cancer among French women presenting or not a familial predisposition to the disease.

Edith Le Floch, P. Guénel, T. Truong, 2022, European journal of cancer.

Common BRCA2 variants and modification of breast and ovarian cancer risk in BRCA1 mutation carriers.

J. Simard, D. Yannoukakos, J. Peyrat, 2005, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Common BRCA 2 Variants and Modification of Breast and Ovarian Cancer Risk in BRCA 1 Mutation Carriers

J. Simard, D. Yannoukakos, J. Peyrat, 2005 .

An unusual phenotype occurs in 15% of mismatch repair-deficient tumors and is associated with non-colorectal cancers and genetic syndromes

C. Toulas, R. Guimbaud, J. Selves, 2021, Modern Pathology.

Alpha-6 integrin promotes radioresistance of glioblastoma by modulating DNA damage response and the transcription factor Zeb1

E. Cohen-Jonathan-Moyal, C. Toulas, A. Kowalski-Chauvel, 2018, Cell Death & Disease.

Differential estrogenic responsiveness of MCF-7 cells. Relationship to the presence of two different estrogen receptors.

C. Toulas, J. Faye, F. Bayard, 1989, Journal of receptor research.

Modulation of the estrogen receptor structure, evidence of a heterogeneity.

C. Toulas, F. Bayard, F. Delassus, 1990, Journal of receptor research.

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

A. Whittemore, L. Kiemeney, S. Cross, 2016, Nature Communications.

Phase I trial of tipifarnib (R115777) concurrent with radiotherapy in patients with glioblastoma multiforme.

C. Toulas, F. Dalenc, A. Laprie, 2007, International journal of radiation oncology, biology, physics.

Translation reprogramming by eIF3 linked to glioblastoma resistance

E. Dassi, C. Toulas, E. Uro-Coste, 2020, NAR cancer.

RND1 regulates migration of human glioblastoma stem-like cells according to their anatomical localization and defines a prognostic signature in glioblastoma

C. Toulas, M. Tosolini, V. Lubrano, 2018, Oncotarget.

Metformin Inhibits Growth of Human Glioblastoma Cells and Enhances Therapeutic Response

C. Toulas, H. Brem, B. Tyler, 2015, PloS one.

Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids

C. Toulas, C. Zurzolo, C. Brou, 2020, bioRxiv.

Interest of integrins targeting in glioblastoma according to tumor heterogeneity and cancer stem cell paradigm: an update

C. Toulas, A. Kowalski-Chauvel, T. Filleron, 2017, Oncotarget.

The m6A RNA Demethylase ALKBH5 Promotes Radioresistance and Invasion Capability of Glioma Stem Cells

E. Cohen-Jonathan-Moyal, C. Toulas, A. Kowalski-Chauvel, 2020, Cancers.

Ionizing radiation induces endothelial transdifferentiation of glioblastoma stem-like cells through the Tie2 signaling pathway

C. Toulas, M. Tosolini, A. Siegfried, 2019, Cell Death & Disease.

Classification of 101 BRCA1 and BRCA2 variants of uncertain significance by cosegregation study: A powerful approach.

F. Révillion, R. Lidereau, N. Sevenet, 2021, American journal of human genetics.

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Jane E. Carpenter, Jack A. Taylor, W. Chung, 2019, Nature Genetics.

Further delineation of the NTHL1 associated syndrome: A report from the French Oncogenetic Consortium

C. Houdayer, T. Frebourg, C. Toulas, 2021, Clinical genetics.

A novel germline CHEK2 deletion truncating the kinase domain identified in a French family with high-risk of breast/ovarian cancer

C. Toulas, G. Favre, R. Guimbaud, 2010, Breast Cancer Research and Treatment.

Alpha-6 integrin promotes radioresistance of glioblastoma by modulating DNA damage response and the transcription factor Zeb1

E. Cohen-Jonathan-Moyal, C. Toulas, A. Kowalski-Chauvel, 2018, Cell Death & Disease.

Targeting progastrin enhances radiosensitization of colorectal cancer cells

E. Cohen-Jonathan-Moyal, C. Toulas, A. Kowalski-Chauvel, 2017, Oncotarget.

Basic fibroblast growth factor-2/beta3 integrin expression profile: signature of local progression after chemoradiotherapy for patients with locally advanced non-small-cell lung cancer.

E. Cohen-Jonathan-Moyal, J. Mazières, J. Armand, 2009, International journal of radiation oncology, biology, physics.

Farnesyltransferase inhibitor, R115777, reverses the resistance of human glioma cell lines to ionizing radiation

E. Cohen-Jonathan, C. Toulas, G. Favre, 2002, International journal of cancer.

Inhibiting Integrin β8 to Differentiate and Radiosensitize Glioblastoma-Initiating Cells

C. Toulas, A. Kowalski-Chauvel, T. Filleron, 2018, Molecular Cancer Research.

A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Jane E. Carpenter, Jack A. Taylor, W. Chung, 2021, Nature Communications.

FGFR1/FOXM1 pathway: a key regulator of glioblastoma stem cells radioresistance and a prognosis biomarker

C. Toulas, V. Lubrano, E. Cohen-Jonathan Moyal, 2018, Oncotarget.

TUMOSPEC: A Nation-Wide Study of Hereditary Breast and Ovarian Cancer Families with a Predicted Pathogenic Variant Identified through Multigene Panel Testing

J. Lemonnier, N. Sevenet, D. Stoppa-Lyonnet, 2021, Cancers.

Prognostic value of uPA and p53 accumulation measured by quantitative biochemical assays in 1245 primary breast cancer patients: a multicentre study

B. Asselain, F. Spyratos, C. Toulas, 1999, British Journal of Cancer.

The prognostic significance of lymphovascular invasion on biopsy specimens in lung cancer treated with definitive chemoradiotherapy.

J. Mazières, C. Toulas, J. Bachaud, 2012, Clinical lung cancer.

Association of the Variants CASP8 D302H and CASP10 V410I with Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

F. Couch, T. Rebbeck, J. Benítez, 2010, Cancer Epidemiology, Biomarkers & Prevention.

BRCA Share: A Collection of Clinical BRCA Gene Variants

Christophe Béroud, Dominique Vaur, Izabela Karbassi, 2016, Human mutation.

ociation of the Variants CASP 8 D 302 H and CASP 10 0 I with Breast and Ovarian Cancer Risk in B & P A 1 and BRCA 2 Mutation Carriers

Rob, T. Rebbeck, J. Benítez, 2010 .

The c.5242C>A BRCA1 missense variant induces exon skipping by increasing splicing repressors binding

C. Toulas, G. Favre, F. Fouque, 2010, Breast Cancer Research and Treatment.

Two prognostic groups of inflammatory breast cancer have distinct genotypes.

M. Espié, I. Bièche, M. Marty, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

The STEMRI trial: magnetic resonance spectroscopy imaging can define tumor areas enriched in glioblastoma-initiating cells

C. Toulas, T. Filleron, V. Lubrano, 2023, medRxiv.

Breast cancer risk in BRCA1 and BRCA2 mutation carriers and polyglutamine repeat length in the AIB1 gene

V. Gaborieau, D. Yannoukakos, J. Peyrat, 2005, International journal of cancer.

Continuous Infusion of Cilengitide Plus Chemoradiotherapy for Patients With Stage III Non-Small-cell Lung Cancer: A Phase I Study.

J. Mazières, C. Toulas, I. Rouquette, 2017, Clinical lung cancer.

Increased expression of a COOH‐truncated nucleophosmin resulting from alternative splicing is associated with cellular resistance to ionizing radiation in HeLa cells

Florence Dalenc, Gilles Favre, E. Cohen-Jonathan, 2002, International journal of cancer.

αvβ3 Integrin and Fibroblast growth factor receptor 1 (FGFR1): Prognostic factors in a phase I-II clinical trial associating continuous administration of Tipifarnib with radiotherapy for patients with newly diagnosed glioblastoma.

C. Toulas, G. Favre, E. Uro-Coste, 2013, European journal of cancer.

Farnesylated RhoB inhibits radiation-induced mitotic cell death and controls radiation-induced centrosome overduplication

E. Cohen-Jonathan, C. Toulas, G. Favre, 2005, Cell Death and Differentiation.

RhoB controls the 24 kDa FGF-2-induced radioresistance in HeLa cells by preventing post-mitotic cell death

E. Cohen-Jonathan, C. Toulas, G. Favre, 2002, Oncogene.

Radiation-induced mitotic cell death and glioblastoma radioresistance: a new regulating pathway controlled by integrin-linked kinase, hypoxia-inducible factor 1 alpha and survivin in U87 cells.

E. Cohen-Jonathan-Moyal, C. Toulas, B. Couderc, 2013, European journal of cancer.

DIFFERENTIAL ESTROGENIC RESPONSIVENESS OF RELATIONSHIP TO THE PRESENCE OF TWO DIFFERENT ESTROGEN RECEPTORS MCF-7 CELLS

C. Toulas, J. Faye, F. Bayard, 1989 .

Applications of a laser-induced fluorescence detector for capillary electrophoresis to measure attomolar and zeptomolar amounts of compounds

C. Toulas, L. Hernández, 1992 .

Decreased efficiency of MSH6 mRNA polyadenylation linked to a 20-base-pair duplication in Lynch syndrome families

P. Pujol, C. Toulas, G. Favre, 2012, Cell cycle.

Simplified identification of Lynch syndrome: a prospective, multicenter study.

C. Toulas, R. Guimbaud, L. Buscail, 2012, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

Germline mutation p.N363K in POLE is associated with an increased risk of colorectal cancer and giant cell glioblastoma

C. Toulas, E. Uro-Coste, R. Guimbaud, 2018, Familial Cancer.

Rare germline large rearrangements in the BRCA1/2 genes and eight candidate genes in 472 patients with breast cancer predisposition

I. Bièche, V. Chabaud, J. Peyrat, 2012, Breast Cancer Research and Treatment.

Inhibition of Rho pathways induces radiosensitization and oxygenation in human glioblastoma xenografts

E. Cohen-Jonathan-Moyal, C. Toulas, P. Rochaix, 2003, Oncogene.

Genotyping of a family with a novel deleterious DPYD mutation supports the pretherapeutic screening of DPD deficiency with dihydrouracil/uracil ratio

C. Toulas, N. Penel, A. Gonçalves, 2016, Clinical pharmacology and therapeutics.

Target size analysis of estrogen receptor in cultured intact cells: Change in receptor structure between subconfluency and superconfluency in culture

C. Toulas, L. Thauvette, F. Bayard, 1990, Molecular and Cellular Endocrinology.

The RND1 Small GTPase: Main Functions and Emerging Role in Oncogenesis

C. Toulas, G. Favre, O. Sordet, 2019, International journal of molecular sciences.

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Jane E. Carpenter, W. Chung, M. Beckmann, 2019, npj Breast Cancer.

Multigene Panel Sequencing Identifies a Novel Germline Mutation Profile in Male Breast Cancer Patients

C. Toulas, T. Filleron, L. Gladieff, 2023, International journal of molecular sciences.

Preclinical evidence that SSR128129E--a novel small-molecule multi-fibroblast growth factor receptor blocker--radiosensitises human glioblastoma.

C. Toulas, J. Bonnet, F. Bono, 2014, European journal of cancer.

The STEMRI trial: Magnetic resonance spectroscopy imaging can define tumor areas enriched in glioblastoma stem-like cells

C. Toulas, T. Filleron, A. Siegfried, 2023, Science advances.

Radiation inactivation of estrogen receptor in intact human breast cancer cells (MCF‐7) Lack of energy transfer to the estradiol binding domain

C. Toulas, J. Faye, F. Bayard, 1991, FEBS letters.

Int6/eIF3e Is Essential for Proliferation and Survival of Human Glioblastoma Cells

C. Toulas, C. Seva, A. Cammas, 2014, International journal of molecular sciences.