P. Danenberg

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Transfection of wild-type but not mutant p53 induces early monocytic differentiation in HL60 cells and increases their sensitivity to stress.

H. Lenz, D. Banerjee, J. Bertino, 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Intratumoral expression profiling of genes involved in angiogenesis in colorectal cancer patients treated with chemotherapy plus the VEGFR inhibitor PTK787/ZK 222584 (vatalanib)

W. Zhang, G. Folprecht, K. Danenberg, 2012, The Pharmacogenomics Journal.

ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy.

S. Groshen, L. Laine, H. Silberman, 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy.

S. Groshen, H. Lenz, K. Danenberg, 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Prediction of chemosensitivity of colorectal cancer to 5-fluorouracil by gene expression profiling with cDNA microarrays.

Y. Okazaki, T. Ishikawa, H. Shimada, 2005, International journal of oncology.

MethyLight: a high-throughput assay to measure DNA methylation.

P. Laird, D. Shibata, L. Saltz, 2000, Nucleic acids research.

DPD is a molecular determinant of capecitabine efficacy in colorectal cancer.

J. Lindebjerg, K. Danenberg, P. Danenberg, 2007, International journal of oncology.

Comprehensive expression analysis of retinoic acid receptors and retinoid X receptors in non-small cell lung cancer: implications for tumor development and prognosis.

A. Hölscher, K. Danenberg, P. Danenberg, 2004, Carcinogenesis.

High Gene Expression of TS1, GSTP1, and ERCC1 Are Risk Factors for Survival in Patients Treated with Trimodality Therapy for Esophageal Cancer

D. Harpole, J. Herndon, K. Danenberg, 2005, Clinical Cancer Research.

Intratumoral COX-2 Gene Expression Is a Predictive Factor for Colorectal Cancer Response to Fluoropyrimidine-Based Chemotherapy

K. Hayashi, K. Danenberg, P. Danenberg, 2005, Clinical Cancer Research.

DNA of Patients with Lung Cancer Methylation Analysis in Tumor Tissue , Serum , and Plasma Quantitative Adenomatous Polyposis Coli Promoter Updated

D. Sidransky, K. Danenberg, Stephen C. Yang, 2002 .

The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer.

S. Groshen, A. Hölscher, K. Danenberg, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

Low ERCC 1 Expression Correlates with Prolonged Survival after Cisplatin plus Gemcitabine Chemotherapy in Non-Small Cell Lung Cancer 1

D. Gandara, R. Rosell, K. Danenberg, 2002 .

Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival

David Sidransky, Kumari Wickramasinghe, D. Sidransky, 2001, Oncogene.

Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer Is correlated with survival.

A. Hölscher, K. Danenberg, P. Danenberg, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma.

S. Groshen, P. Laird, D. Beer, 2000, Journal of the National Cancer Institute.

High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with nonresponse to 5-fluorouracil.

S. Groshen, H. Lenz, K. Danenberg, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen.

A. Monks, J. Grem, C. Allegra, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Quantitative determination of the ratio of mutated to normal ras genes in the blood of leukemia patients by allele-specific PCR.

H. Lenz, J. Bertino, K. Danenberg, 1994, Leukemia research.

Detection of point mutations in human DNA by analysis of RNA conformation polymorphism(s).

H. Lenz, J. Bertino, A. Dicker, 1992, Nucleic acids research.

Genistein‐induced neuroendocrine differentiation of prostate cancer cells

J. Pinski, K. Danenberg, P. Danenberg, 2006, The Prostate.

Epidermal growth factor receptor and epidermal growth factor receptor variant III gene expression in metastatic colorectal cancer.

H. Lenz, A. El-Khoueiry, K. Danenberg, 2006, Clinical colorectal cancer.

Inhibition of cyclin D1 expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes.

M. Korc, N. Arber, K. Danenberg, 1999, Cancer research.

Predictors of response and survival for neoadjuvant treated patients with esophageal adenocarcinoma.

K. Becker, J. Siewert, K. Danenberg, 2008, Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus.

High Specificity of Quantitative Excision Repair Cross-Complementing 1 Messenger RNA Expression for Prediction of Minor Histopathological Response to Neoadjuvant Radiochemotherapy in Esophageal Cancer

W. Doerfler, S. Baldus, H. Dienes, 2004, Clinical Cancer Research.

Increased c-myb mRNA expression in Barrett's esophagus and Barrett's-associated adenocarcinoma.

S. Groshen, A. Hölscher, K. Danenberg, 2001, The Journal of surgical research.

Loss of heterozygosity at thymidylate synthase locus in Barrett's metaplasia, dysplasia, and carcinoma sequences

K. Danenberg, P. Danenberg, D. Shimizu, 2009, BMC Cancer.

Glutathione S-transferase-Pi expression is downregulated in patients with Barrett’s esophagus and esophageal adenocarcinoma

A. Hölscher, K. Danenberg, P. Danenberg, 2002, Journal of Gastrointestinal Surgery.

Telomerase reverse transcriptase expression is increased early in the Barrett’s metaplasia, dysplasia, adenocarcinoma sequence

J. Peters, Ji Min Park, K. Danenberg, 2000, Journal of Gastrointestinal Surgery.

HER‐2 receptor expression, localization, and activation in colorectal cancer cell lines and human tumors

G. Ayers, R. Broaddus, F. Sinicrope, 2004, International journal of cancer.

p53 and thymidylate synthase expression in untreated stage II colon cancer: associations with recurrence, survival, and site.

S. Groshen, P. Johnston, H. Lenz, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

High intratumoral dihydropyrimidine dehydrogenase mRNA levels in pancreatic cancer associated with a high rate of response to S-1

Masakazu Yamamoto, K. Hayashi, K. Danenberg, 2008, Cancer Chemotherapy and Pharmacology.

Dynamic changes in RAS gene status in circulating tumour DNA: a phase II trial of first-line FOLFOXIRI plus bevacizumab for RAS-mutant metastatic colorectal cancer (JACCRO CC-11)

M. Takeuchi, K. Danenberg, P. Danenberg, 2022, ESMO open.

Serum lactate dehydrogenase levels and glycolysis significantly correlate with tumor VEGFA and VEGFR expression in metastatic CRC patients.

H. Lenz, A. El-Khoueiry, K. Danenberg, 2007, Pharmacogenomics.

Therapeutic response of leukemic mice treated with fluorinated pyrimidines and inhibitors of deoxyuridylate synthesis.

C. Heidelberger, P. Danenberg, R. Moran, 1982, Biochemical pharmacology.

Response prediction in metastasised colorectal cancer using intratumoural thymidylate synthase: results of a randomised multicentre trial.

K. Danenberg, P. Danenberg, M. Kornmann, 2012, European journal of cancer.

Concurrent paclitaxel and radiation therapy for breast cancer.

W. Symmans, P. Danenberg, D. Spicer, 1999, Seminars in radiation oncology.

The relationship between proangiogenic gene expression levels in prostate cancer and their prognostic value for clinical outcomes

S. Groshen, J. Pinski, W. Ye, 2010, The Prostate.

Advances in Brief Epidermal Growth Factor Receptor and HER 2-neu mRNA Expression in Non-Small Cell Lung Cancer Is Correlated with Survival

A. Hölscher, K. Danenberg, P. Danenberg, 2001 .

Molecular determinants in targeted therapy for esophageal adenocarcinoma.

Dong Yang, J. Peters, K. Danenberg, 2006, Archives of surgery.

Low HER2/neu gene expression is associated with pathological response to concurrent paclitaxel and radiation therapy in locally advanced breast cancer.

S. Groshen, K. Danenberg, M. Press, 2002, International journal of radiation oncology, biology, physics.

Increased p21/WAF-1 and p53 protein levels following sequential three drug combination regimen of fludarabine, cytarabine and docetaxel induces apoptosis in human leukemia cells.

P. Danenberg, L. Cohen, V. Avramis, 1998, Anticancer research.

Validation of a rodent model of Barrett’s esophagus using quantitative gene expression profiling

K. Danenberg, P. Danenberg, J. Hagen, 2009, Surgical Endoscopy.

Reduction of interleukin 8 gene expression in reflux esophagitis and Barrett's esophagus with antireflux surgery.

K. Danenberg, P. Danenberg, J. Hagen, 2007, Archives of surgery.

Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis.

M. Fukushima, K. Danenberg, P. Danenberg, 2008, International journal of molecular medicine.

Pharmacogenomics of thymidylate synthase in cancer treatment.

P. Danenberg, 2004, Frontiers in bioscience : a journal and virtual library.

Molecular Markers of Chemotherapy Resistance in Colorectal Cancer

P. Danenberg, 2002 .

Desensitization and sensitization of cells to fluoropyrimidines with different antisenses directed against thymidylate synthase messenger RNA.

S. Kane, H. Lenz, K. Danenberg, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

Quantitative, tissue-specific analysis of cyclooxygenase gene expression in the pathogenesis of Barrett’s adenocarcinoma

J. Peters, K. Danenberg, P. Danenberg, 2004, Journal of Gastrointestinal Surgery.

Cyclooxygenase-2 in Barrett's Esophagus, Barrett's Adenocarcinomas, and Esophageal SCC: Ready for Clinical Trials

K. Danenberg, P. Danenberg, R. Lord, 1999, American Journal of Gastroenterology.

Plasma DNA: A Molecular Marker of Surgical Insult and Postoperative Recovery in Esophageal Cancer

K. Danenberg, P. Danenberg, J. Hagen, 2008, European Surgical Research.

A novel RT-PCR approach to detecting EML4-ALK fusion genes in archival NSCLC tissue.

D. Gandara, K. Danenberg, P. Danenberg, 2010 .

Molecular predictors of lymph node metastasis in colon cancer: Increased risk with decreased thymidylate synthase expression

R. Beart, A. Kaiser, K. Danenberg, 2005, Journal of Gastrointestinal Surgery.

Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma.

S. Jhanwar, N. Kemeny, D. Banerjee, 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Effect of 5-fluoro- and 5-bromouracil substitution on the translation of human thymidylate synthase mRNA.

Thomas D. Schmittgen, H. Lenz, K. Danenberg, 1995, The Journal of Biological Chemistry.

Expression of metastases-associated genes in cervical cancers resected in the proliferative and secretory phases of the menstrual cycle.

M. Pike, K. Danenberg, P. Danenberg, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Separate identities of ligandin and the h-protein, a major protein to which carcinogenic hydrocarbons are covalently bound.

C. Heidelberger, P. Danenberg, A. Sarrif, 1976, Biochemical and biophysical research communications.

Thymidylate synthetase — substrate complex formation

P. Danenberg, A. Lockshin, 1982, Molecular and Cellular Biochemistry.

Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of action.

G. Peters, N. Petrelli, P. Johnston, 2016, Critical reviews in oncology/hematology.

Inhibition of Cyclin D 1 Expression in Human Pancreatic Cancer Cells Is Associated with Increased Chemosensitivity and Decreased Expression of Multiple Chemoresistance Genes 1

M. Korc, N. Arber, K. Danenberg, 1999 .

Role of Retinoid X receptor mRNA expression in Barrett’s esophagus

A. Hölscher, K. Danenberg, P. Danenberg, 2004, Journal of Gastrointestinal Surgery.

Biochemical factors affecting the tightness of 5-fluorodeoxyuridylate binding to human thymidylate synthetase.

P. Danenberg, A. Lockshin, 1981, Biochemical pharmacology.

Studies on the Mechanism of Fluoropyrimidine Cytotoxicity in L1210 Cells: Correlation with Inhibition of Thymidylate Synthetase but Not with Incorporation into RNA

K. Danenberg, P. Danenberg, M. Mulkins, 1984, Pharmaceutical Research.

A longterm follow-up study of thymidylate synthase as a predictor for survival of patients with liver tumours receiving hepatic arterial infusion chemotherapy.

K. Danenberg, P. Danenberg, M. Kornmann, 2004, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase.

C. Cordon-Cardo, S. Jhanwar, D. Banerjee, 2000, Cancer research.

Frequencies and expression levels of programmed death ligand 1 (PD-L1) in circulating tumor RNA (ctRNA) in various cancer types.

J. Pinski, Y. Elshimali, A. Barzi, 2016, Biochemical and biophysical research communications.

P2.03b-039 Cell-Free (cf) DNA and cfRNA levels in Plasma of Lung Cancer Patients Indicate Disease Status and Predict Progression: Topic: Biomarkers

K. Danenberg, P. Danenberg, L. Raez, 2017 .

Correlation of cell-free circulating DNA, RNA, and PD-L1 from plasma with clinical response in patients with metastatic lung and breast cancers.

K. Danenberg, P. Danenberg, L. Raez, 2017 .

Plasma DNA is more reliable than carcinoembryonic antigen for diagnosis of recurrent esophageal cancer.

K. Danenberg, P. Danenberg, J. Hagen, 2008, Journal of the American College of Surgeons.

Differential SPARC mRNA expression in Barrett's oesophagus

Ji Min Park, A. Hölscher, K. Danenberg, 2003, British Journal of Cancer.

Rapid and sensitive molecular subtyping of microorganisms in clinical specimens

J. Bertino, M. Volkenandt, P. Danenberg, 1993, The Lancet.

Markedly Decreased Binding of Vincristine to Tubulin in Vinca Alkaloid-Resistant Chinese Hamster Cells Is Associated with Selective Overexpression of α and β Tubulin Isoforms

K. Danenberg, F. Sirotnak, P. Danenberg, 2000 .

Rapid activation of MDR1 gene expression in human metastatic sarcoma after in vivo exposure to doxorubicin.

M. Burt, A. Abolhoda, K. Scotto, 1999, Clinical Cancer Research.

Loss of Heterozygosity at the Thymidylate Synthase (TS) Locus on Chromosome 18 Affects Tumor Response and Survival in Individuals Heterozygous for a 28-bp Polymorphism in the TS Gene

K. Hayashi, K. Kawakami, K. Danenberg, 2004, Clinical Cancer Research.

Functional Polymorphism of the Thymidylate Synthase Gene in Colorectal Cancer Accompanied by Frequent Loss of Heterozygosity

G. Watanabe, K. Kawakami, Y. Ishida, 2002, Japanese journal of cancer research : Gann.

Thymidylate synthetase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil.

L. Bernstein, P. Danenberg, D. Spicer, 1984, Cancer research.

Differential S100 beta expression in choroidal and skin melanomas: quantitation by the polymerase chain reaction.

K. Danenberg, P. Danenberg, L. V. Van Eldik, 1993, Investigative ophthalmology & visual science.

Thymidylate synthase expression in advanced colorectal cancer predicts for response to raltitrexed.

David Cunningham, D. Cunningham, K. Danenberg, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Conformational polymorphisms of cRNA of T-cell-receptor genes as a clone-specific molecular marker for cutaneous lymphoma.

J. Buer, J. Bertino, K. Danenberg, 1993, The Journal of investigative dermatology.

Incorporation of 5-fluorouracil into U2 and U6 snRNA inhibits mRNA precursor splicing.

H. Lenz, K. Danenberg, D. J. Manno, 1994, The Journal of biological chemistry.

Effect of 5-fluorouracil substitution on the self-splicing activity of Tetrahymena ribosomal RNA.

K. Danenberg, P. Danenberg, L. C. Shea, 1990, Cancer research.

Deoxyribonucleoside-induced selective modulation of cytotoxicity and mutagenesis.

P. Danenberg, A. R. Peterson, H. Peterson, 1985, Basic life sciences.

Alterations of p16 and p14ARF genes and their 9p21 locus in oral squamous cell carcinoma.

I. Tohnai, K. Danenberg, P. Danenberg, 2009, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in breast cancer predicts 5-FU sensitivity by a histocultural drug sensitivity test.

K. Danenberg, P. Danenberg, K. Sugihara, 2005, Cancer letters.

Retinoic acid receptor-alpha messenger RNA expression is increased and retinoic acid receptor-gamma expression is decreased in Barrett's intestinal metaplasia, dysplasia, adenocarcinoma sequence.

S. Groshen, J. Peters, K. Danenberg, 2001, Surgery.

Standing the test of time: targeting thymidylate biosynthesis in cancer therapy

P. Johnston, H. Lenz, P. Wilson, 2014, Nature Reviews Clinical Oncology.

Fluorinated pyrimidines as tight-binding inhibitors of thymidylate synthetase.

P. Danenberg, A. Lockshin, 1981, Pharmacology & therapeutics.

Restoration of wild-type p53 activity in p53-null HL-60 cells confers multidrug sensitivity.

Thomas D. Schmittgen, A. Schönthal, H. Lenz, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

Predictive value of MSH2 gene expression in colorectal cancer treated with capecitabine.

K. Danenberg, P. Danenberg, L. Jensen, 2007, Clinical colorectal cancer.

Biochemical and molecular effects of UCN-01 in combination with 5-fluorodeoxyuridine in A431 human epidermoid cancer cells

J. Grem, K. Danenberg, P. Danenberg, 2002, Anti-cancer drugs.

High Expression of Heparanase is Significantly Associated with Dedifferentiation and Lymph Node Metastasis in Patients with Pancreatic Ductal Adenocarcinomas and Correlated to PDGFA and Via HIF1a to HB-EGF and bFGF

S. Baldus, K. Danenberg, P. Danenberg, 2008, Journal of Gastrointestinal Surgery.

Quantitative analysis of folylpolyglutamate synthetase gene expression in tumor tissues by the polymerase chain reaction: marked variation of expression among leukemia patients.

H. Lenz, J. Bertino, K. Danenberg, 1994, Oncology research.

Quantitative measurement of relative gene expression in human tumors.

K. Danenberg, M. Volkenandt, P. Danenberg, 1993, Methods in molecular biology.

Biochemical Loci for Modulation of 5-Fluorouracil Activity

P. Danenberg, 1986 .

Recent Studies on the Interaction of 5-Fluoro-2′-deoxyuridylate with Thymidylate Synthetase

K. Danenberg, P. Danenberg, A. Lockshin, 1979 .

Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Analysis of the phenylalanine binding site.

D. Santi, P. Danenberg, 1971, Biochemistry.

Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Analysis of the adenosine triphosphate binding site.

D. Santi, P. Danenberg, K. Montgomery, 1971, Biochemistry.

Assay and time course of 5-fluorouracil incorporation into RNA of L1210/0 ascites cells in vivo.

C. Heidelberger, P. Danenberg, W. Wolf, 1985, Molecular pharmacology.

Immune checkpoint molecule expression measured using circulating cell-free RNA isolated from the blood of metastatic prostate cancer patients.

J. Pinski, K. Danenberg, P. Danenberg, 2018 .

Normal Liver of Patients Given Intravenous 5-Fluorouracil Thymidylate Synthetase Inhibition in Malignant Tumors and Updated

L. Bernstein, C. Spears, P. Danenberg, 2006 .

Preoperative twice-weekly paclitaxel with concurrent radiation therapy followed by surgery and postoperative doxorubicin-based chemotherapy in locally advanced breast cancer: a phase I/II trial.

E. Perez, S. Groshen, M. Press, 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Low HER 2/NEU gene expression is associated with pathological response to primary paclitaxel and radiation in locally advanced breast cancer (LABC)

S. Groshen, M. J. Park, P. Danenberg, 2000 .

A molecular/epidemiologic analysis of expression of cyclooxygenases 1 and 2, use of nonsteroidal antiinflammatory drugs, and risk of colorectal adenoma.

V. Cortessis, K. Danenberg, P. Danenberg, 2005, Clinical colorectal cancer.

Evidence that intracellular synthesis of 5-fluorouridine-5'-phosphate from 5-fluorouracil and 5-fluorouridine is compartmentalized.

P. Danenberg, J. Shani, 1984, Biochemical and biophysical research communications.

Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides.

P. Danenberg, C. Zarow, A. Bapat, 1983, The Journal of biological chemistry.

The incorporation of 5-fluoro-2'-deoxyuridine into DNA of mammalian tumor cells.

C. Heidelberger, P. Danenberg, A. R. Peterson, 1981, Biochemical and biophysical research communications.

Tumor suppressor gene P53 mutations in human prostate cancer

K. Danenberg, T. Shuin, P. Danenberg, 1995, The Prostate.

Spectroscopic studies of ternary complexes of thymidylate synthetase, deoxyribonucleotides, and folate analogs.

P. Danenberg, A. Lockshin, K. Mondal, 1984, The Journal of biological chemistry.

Downregulation of TS, DPD, ERCC1, GST-Pi, EGFR, and HER2 gene expression after neoadjuvant three-modality treatment in patients with esophageal cancer.

S. Groshen, S. Baldus, K. Danenberg, 2005, Journal of the American College of Surgeons.

Rapid quantitative PCR for determination of relative gene expressions in tissue specimens.

H. Lenz, K. Danenberg, P. Danenberg, 1995, PCR methods and applications.

Identification and Characterization of Monoclonal Lymphoid Populations by Analysis of Complementary RNA of Clonespecific DNA Sequences

J. Buer, H. Lenz, D. Banerjee, 1994 .

Thymidylate synthetase - a target enzyme in cancer chemotherapy.

P. Danenberg, 1977, Biochimica et biophysica acta.

Thymidylate synthase inhibitors.

P. Danenberg, H. Malli, S. Swenson, 1999, Seminars in oncology.

Fluorinated pyrimidines and their nucleosides.

C. Heidelberger, P. Danenberg, R. Moran, 1983, Advances in enzymology and related areas of molecular biology.

Growth inhibition of cells in cultures and of vaccinia virus infected HeLa cells by derivatives of trifluorothymidine.

C. Heidelberger, P. Danenberg, J. Parkhurst, 1976, Chemotherapy.

Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides.

C. Heidelberger, P. Danenberg, R. Langenbach, 1974, Biochemistry.

Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate.

C. Heidelberger, P. Danenberg, R. Langenbach, 1972, Biochemical and biophysical research communications.

Large-scale and small-scale methods for the preparation of 5,10-methylenetetrahydrofolate.

P. Danenberg, C. Zarow, A. Pellino, 1982, Preparative biochemistry.

Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival.

S. Groshen, L. Laine, H. Silberman, 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression.

P. Laird, L. Saltz, K. Kawakami, 1999, Cancer research.

Tight-binding complexes of thymidylate synthetase, folate analogs and deoxyribonucleotides.

P. Danenberg, A. Lockshin, 1982, Advances in enzyme regulation.

Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Reaction parameters and order of substrate addition.

D. Santi, P. Danenberg, P. Satterly, 1971, Biochemistry.

Synthesis and interaction with uridine phosphorylase of 5'-deoxy-4',5-difluorouridine, a new prodrug of 5-fluorouracil.

P. Danenberg, A. Bapat, E. Stephanian, 1988, Journal of Medicinal Chemistry.

Interaction of 5-ethynyl-2'-deoxyuridylate with thymidylate synthetase.

C. Heidelberger, K. Danenberg, P. Danenberg, 1981, Journal of medicinal chemistry.

The effect of Raney nickel on the covalent thymidylate synthetase-5-fluoro-2'-deoxyuridylate-5,10-methylenetetrahydrofolate complex.

C. Heidelberger, P. Danenberg, 1976, Biochemistry.

Retinoic acid receptor-α messenger RNA expression is increased and retinoic acid receptor-γ expression is decreased in Barrett's intestinal metaplasia, dysplasia, adenocarcinoma sequence

S. Groshen, J. Peters, Ji Min Park, 2001 .

Ornithine decarboxylase mRNA expression in curatively resected non-small-cell lung cancer.

A. Hölscher, K. Danenberg, P. Danenberg, 2010, Clinical lung cancer.

Characterization of the mode of binding of substrates to the active site of Tetrahymena self-splicing RNA using 5-fluorouracil-substituted mini-exons.

K. Danenberg, P. Danenberg, L. C. Shea, 1989, Biochemistry.

Synthesis and biological activity of 5'-substituted 5-fluoropyrimidine nucleosides.

P. Danenberg, S. Ajmera, 1982, Journal of medicinal chemistry.

Synthesis and biological activity of 5-fluoro-2'-deoxyuridine 5'-phosphorodiamidates.

P. Danenberg, M. Phelps, P. W. Woodman, 1980, Journal of Medicinal Chemistry.

Concentration and time dependence of the toxicity of fluorinated pyrimidines to HT 29 colorectal carcinoma cells

P. Danenberg, K. Schwemmle, K. Aigner, 2004, Cancer Chemotherapy and Pharmacology.

INTERACTION OF 5-ETHYNYL-2′-DEOXYURIDYLATE WITH THYMIDYLATE SYNTHETASE

C. Heidelberger, K. Danenberg, P. Danenberg, 1982 .

Effect of 5, 10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2'-deoxyuridylate from thymidylate synthetase: evidence for an ordered mechanism.

K. Danenberg, P. Danenberg, 1978, Biochemistry.

Deoxyuridylate effects on thymidylate synthase-5-fluorodeoxyuridylate-folate ternary complex formation.

P. Danenberg, B. Gustavsson, A. Shahinian, 1989, Biochemical pharmacology.

Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase.

D. Santi, P. Danenberg, A. Pogolotti, 1986, Journal of medicinal chemistry.

Hydrodynamic behavior of human and bacterial thymidylate synthetases and thymidylate synthetase--5-fluoro-2'-deoxyuridylate--5,10-methylenetetrahydrofolate complexes. Evidence for large conformational changes during catalysis.

P. Danenberg, A. Lockshin, 1980, Biochemistry.

Purification of thymidylate synthetase from L. casei by affinity chromatography.

C. Heidelberger, P. Danenberg, R. Langenbach, 1972, Biochemical and biophysical research communications.

Modulates DT-Diaphorase Activity and Mitomycin Sensitivity Colon Carcinoma Cells : Characterization of a Mutation Which NAD ( P ) H : Quinone Oxidoreductase Gene Expression in Human Updated

K. Danenberg, D. Ross, P. Danenberg, 2006 .

NAD ( P ) H : Quinone Oxidoreductase Gene Expression in Human Colon Carcinoma Cells : Characterization of a Mutation Which Modulates DT-Diaphorase Activity and Mitomycin Sensitivity 1

K. Danenberg, D. Ross, P. Danenberg, 2006 .

NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity.

K. Danenberg, D. Ross, P. Danenberg, 1992, Cancer research.

Synthesis and Biological Activity of 5′-Substituted S-Fluoropyrimidine Nucleosides.

P. Danenberg, S. Ajmera, 1983 .

SYNTHESIS AND BIOLOGICAL ACTIVITY OF 5-FLUORO-2′-DEOXYURIDINE 5′-PHOSPHORODIAMIDATES

P. Danenberg, M. Phelps, P. W. Woodman, 1981 .

Induction of mutations by 5-fluorodeoxyuridine: a mechanism of self-potentiated drug resistance?

P. Danenberg, A. R. Peterson, H. Peterson, 1983, Biochemical and biophysical research communications.

Cdx-2 expression in squamous and metaplastic columnar epithelia of the esophagus.

J. Peters, K. Danenberg, P. Danenberg, 2006, Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus.

A Three-Gene Signature for Outcome in Soft Tissue Sarcoma

H. Taubert, K. Danenberg, Peter Wuerl, 2009, Clinical Cancer Research.

Vascular endothelial growth factor and basic fibroblast growth factor expression in esophageal adenocarcinoma and Barrett esophagus.

J. Peters, Ji Min Park, K. Danenberg, 2003, The Journal of thoracic and cardiovascular surgery.

Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma.

P. Laird, J. Peters, T. Long, 2000, Cancer research.

An In vivo Platform for Translational Drug Development in Pancreatic Cancer

R. Hruban, J. Eshleman, C. Iacobuzio-Donahue, 2006, Clinical Cancer Research.

Quantitative determination of p16 gene expression by RT-PCR.

K. Danenberg, P. Danenberg, D. Salonga, 2004, Methods in molecular biology.

Quantitative adenomatous polyposis coli promoter methylation analysis in tumor tissue, serum, and plasma DNA of patients with lung cancer.

D. Sidransky, K. Danenberg, Stephen C. Yang, 2002, Cancer research.

DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value.

A. Hölscher, K. Danenberg, P. Danenberg, 2006, Clinical lung cancer.

High frequency of simultaneous loss of p16 and p16β gene expression in squamous cell carcinoma of the esophagus but not in adenocarcinoma of the esophagus or stomach

S. Groshen, K. Hayashi, H. Lenz, 1997, Oncogene.

The Molecular Signature of Normal Squamous Esophageal Epithelium Identifies the Presence of a Field Effect and Can Discriminate between Patients with Barrett's Esophagus and Patients with Barrett's-Associated Adenocarcinoma

P. Marjoram, A. Hölscher, K. Danenberg, 2005, Cancer Epidemiology Biomarkers & Prevention.

Gene expression levels of epidermal growth factor receptor, survivin, and vascular endothelial growth factor as molecular markers of lymph node involvement in patients with locally advanced rectal cancer.

S. Groshen, H. Lenz, A. El-Khoueiry, 2006, Clinical colorectal cancer.

p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: an analysis of response and survival.

S. Groshen, H. Lenz, D. Banerjee, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

Regulation of MLH1 mRNA and protein expression by promoter methylation in primary colorectal cancer: a descriptive and prognostic cancer marker study

J. Lindebjerg, K. Danenberg, P. Danenberg, 2013, Cellular Oncology.

A multigene expression panel for the molecular diagnosis of Barrett's esophagus and Barrett's adenocarcinoma of the esophagus

Paul Marjoram, Jing Yin, P. Marjoram, 2004, Oncogene.

Multiparametric liquid biopsy analysis in metastatic prostate cancer.

J. Carpten, T. Dorff, A. Goldkorn, 2019, JCI insight.

Regulation of MLH1 mRNA and protein expression by promoter methylation in primary colorectal cancer: a descriptive and prognostic cancer marker study

Lars Henrik Jensen, J. Lindebjerg, K. Danenberg, 2013, Cellular Oncology.

Messenger RNA expression of COX-2 and angiogenic factors in primary colorectal cancer and corresponding liver metastasis.

H. Lenz, K. Danenberg, P. Danenberg, 2009, International journal of oncology.

Gene profiling and pathway analysis of neuroendocrine transdifferentiated prostate cancer cells

J. Pinski, H. Shimada, K. Danenberg, 2009, The Prostate.

ERCC1 and RRM1 gene expressions but not EGFR are predictive of shorter survival in advanced non-small-cell lung cancer treated with cisplatin and gemcitabine.

M Volante, G. Scagliotti, M. Papotti, 2006, Annals of oncology : official journal of the European Society for Medical Oncology.

Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression.

G. Watanabe, Ji Min Park, K. Kawakami, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

S. Groshen, R. Diasio, H. Lenz, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Detection of clonal T‐cell populations in gastrointestinal lymphomas by analysis of cRNA conformational polymorphisms of rearranged T‐cell‐receptor‐gamma genes

M. Tiemann, J. Buer, H. Lenz, 1994, British journal of haematology.

Molecular detection and characterization of clonal cell populations in acute lymphocytic leukemia by analysis of conformational polymorphisms of cRNA molecules of rearranged T-cell-receptor-gamma and immunoglobulin heavy-chain genes.

J. Buer, D. Banerjee, J. Bertino, 1994, Leukemia.

High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF.

S. Baldus, K. Danenberg, P. Danenberg, 2008, Neoplasia.

Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors.

P. Johnston, H. Lenz, C. Allegra, 1995, Cancer research.

Activity of thymidylate synthetase and its inhibition by 5-fluorouracil in highly enzyme-overproducing cells resistant to 10-propargyl-5,8-dideazafolate.

K. Danenberg, P. Danenberg, 1989, Molecular pharmacology.

Epidermal Growth Factor Receptor Messenger RNA Expression, Gene Dosage, and Gefitinib Sensitivity in Non–Small Cell Lung Cancer

F. Cappuzzo, F. Hirsch, P. Bunn, 2006, Clinical Cancer Research.

Rapid Activation of MDR 1 Gene Expression in Human Metastatic Sarcoma after in Vivo Exposure to Doxorubicin 1

M. Burt, A. Abolhoda, K. Scotto, 1999 .

Gender differences in the predictive power of prognostic factors in NSCLC

K. Danenberg, P. Danenberg, P. Schneider, 2004 .

Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer.

D. Gandara, R. Rosell, K. Danenberg, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

TS and ERCC-1 mRNA expressions and clinical outcome in patients with metastatic colon cancer in CONFIRM-1 and -2 clinical trials

H. Lenz, C. Vigen, K. Danenberg, 2011, The Pharmacogenomics Journal.

Epidermal growth factor receptor (EGFR) mRNA levels and protein expression levels in primary colorectal cancer and corresponding liver metastases

Masakazu Yamamoto, K. Hayashi, K. Danenberg, 2010, Cancer Chemotherapy and Pharmacology.

Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinoma.

P. Danenberg, P. Schneider, J. Brabender, 2005, Surgery.

Both β‐actin and GAPDH are useful reference genes for normalization of quantitative RT‐PCR in human FFPE tissue samples of prostate cancer

J. Pinski, K. Danenberg, P. Danenberg, 2008, The Prostate.

Gene amplification and multidrug resistance induced by the phosphatase-inhibitory tumor promoter, okadaic acid.

A. Schönthal, H. Lenz, K. Danenberg, 1995, Carcinogenesis.

Human equilibrative nucleoside transporter 1 is associated with the chemosensitivity of gemcitabine in human pancreatic adenocarcinoma and biliary tract carcinoma cells.

Takashi Ishikawa, Yasushi Ichikawa, Hiroshi Shimada, 2007, Oncology reports.

Plasma DNA as a molecular marker for completeness of resection and recurrent disease in patients with esophageal cancer.

K. Danenberg, P. Danenberg, Koji Tanaka, 2007, Archives of surgery.

Update of prognostic and predictive biomarkers in oropharyngeal squamous cell carcinoma: a review

P. Danenberg, Carolin M. Grimminger, 2010, European Archives of Oto-Rhino-Laryngology.

Prognostic value of the androgen receptor and its coactivators in patients with D1 prostate cancer.

S. Groshen, J. Pinski, H. Shimada, 2008, Anticancer research.

Analyses of p53 gene mutations in primary human bladder cancer.

K. Danenberg, T. Shuin, P. Danenberg, 1993, Oncology research.

EGFR, FLT1 and Heparanase as Markers Identifying Patients at Risk of Short Survival in Cholangiocarcinoma

D. Aust, P. Danenberg, G. Ehninger, 2013, PloS one.

Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer

A. Hölscher, P. Danenberg, P. Schneider, 2009, Journal of oncology.

p53 gene mutation in primary human renal cell carcinoma.

K. Danenberg, T. Shuin, P. Danenberg, 1992, Oncology research.

Theoretical considerations and in vitro concentration response studies with two human colorectal carcinoma cell lines. The rational experimental base for clinical studies in regional chemotherapy.

P. Danenberg, M. Kornmann, K. Link, 2000, Gan to kagaku ryoho. Cancer & chemotherapy.

Quantitative O(6)-methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcome.

S. Groshen, A. Hölscher, K. Danenberg, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

MDR1 and ERCC1 expression predict outcome of patients with locally advanced bladder cancer receiving adjuvant chemotherapy.

M. Stöckle, A. Hartmann, P. Wild, 2010, Neoplasia.

Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin.

S. Groshen, H. Lenz, K. Danenberg, 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Vascular Endothelial Growth Factor Messenger RNA Expression Level Is Preserved in Liver Metastases Compared with Corresponding Primary Colorectal Cancer

K. Hayashi, K. Danenberg, P. Danenberg, 2006, Clinical Cancer Research.

Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy.

H. Lenz, K. Danenberg, P. Danenberg, 1997, Cancer letters.

Synthesis and biological studies of 3-(beta-D-ribofuranosyl)-2,3,-dihydro-6H-1,3-oxazine-2,6-dione, a new pyrimidine nucleoside analog related to uridine.

S. Nesnow, C. Heidelberger, P. Danenberg, 1976, Journal of medicinal chemistry.

Synthesis and Biological Studies of 3-(β-D-Ribofuranosyl)-2,3-dihydro-6H-1,3-oxazine-2,6-dione, a New Pyrimidine Nucleoside Analog Related to Uridine.

S. Nesnow, C. Heidelberger, P. Danenberg, 1976 .

Expression of thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyl transferase in prostate cancer

P. Danenberg, Y. Kubota, H. Ishiguro, 2005, Prostate Cancer and Prostatic Diseases.

Increasing cyclooxygenase‐2 (cox‐2) gene expression in the progression of Barrett's esophagus to adenocarcinoma correlates with that of Bcl‐2

H. Shimada, J. Peters, K. Danenberg, 2006, International journal of cancer.

Modulation of RTX cytotoxicity by thymidine and dipyridamole in vitro: implications for chemotherapy

N. Lehman, P. Danenberg, 2000, Cancer Chemotherapy and Pharmacology.

Epidermal Growth Factor Receptor Messenger RNAExpression , Gene Dosage , and Gefitinib Sensitivity in Non ^ Small Cell Lung Cancer

F. Cappuzzo, F. Hirsch, P. Bunn, 2006 .

Efficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer

K. Danenberg, P. Danenberg, H. Makino, 2008, BMC Cancer.

Inhibition of hexokinase by multisubstrate analogs.

K. Danenberg, P. Danenberg, 1977, Biochimica et biophysica acta.

Association between Cyclooxygenase expression and colorectal adenoma characteristics.

D. Alberts, A. Bhattacharyya, K. Danenberg, 2003, Cancer research.

Evidence for a sequential interaction of the subunits of thymidylate synthetase.

K. Danenberg, P. Danenberg, 1979, The Journal of biological chemistry.

Purification of thymidylate synthetase with 2'-deoxyuridylate-agarose.

C. Heidelberger, P. Danenberg, 1974, Methods in enzymology.

Thymidylate synthetase purified to homogeneity from human leukemic cells.

P. Danenberg, R. Moran, A. Lockshin, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Osteopontin But Not Osteonectin Messenger RNA Expression Is a Prognostic Marker in Curatively Resected Non-Small Cell Lung Cancer

A. Hölscher, K. Danenberg, P. Danenberg, 2004, Clinical Cancer Research.

Sex differences in the predictive power of the molecular prognostic factor HER2/neu in patients with non-small-cell lung cancer.

K. Danenberg, P. Danenberg, Dongyun Yang, 2006, Clinical lung cancer.

Low thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase mRNA expression correlate with prolonged survival in resected non-small-cell lung cancer.

A. Hölscher, P. Danenberg, P. Schneider, 2010, Clinical lung cancer.

Thymidylate synthase, dihydropyrimidine dehydrogenase, ERCC1, and thymidine phosphorylase gene expression in primary and metastatic gastrointestinal adenocarcinoma tissue in patients treated on a phase I trial of oxaliplatin and capecitabine

J. Grem, K. Danenberg, P. Danenberg, 2008, BMC Cancer.

Expression and clinical significance of methylenetetrahydrofolate reductase in patients with colorectal cancer.

P. Danenberg, R. Willén, B. Gustavsson, 2006, Clinical colorectal cancer.

Gene expression of the mismatch repair gene MSH2 in primary colorectal cancer

J. Lindebjerg, K. Danenberg, P. Danenberg, 2011, Tumor Biology.

Glutathione S-transferase PI (GST-PI) mRNA expression and DNA methylation is involved in the pathogenesis and prognosis of NSCLC.

H. Sugita, A. Hölscher, P. Danenberg, 2012, Lung cancer.

Gene mutation status in circulating tumor DNA (ctDNA) and first-line FOLFOXIRI plus bevacizumab (bev) in metastatic colorectal cancer (mCRC) harboring RAS mutation.

H. Lenz, M. Takeuchi, K. Danenberg, 2018, Annals of oncology : official journal of the European Society for Medical Oncology.

Biomarkers for Cetuximab-Based Neoadjuvant Radiochemotherapy in Locally Advanced Rectal Cancer

R. Semrau, A. Debucquoy, C. Sempoux, 2011, Clinical Cancer Research.

Predictive Biomarkers and Personalized Medicine Biomarkers for Cetuximab-Based Neoadjuvant Radiochemotherapy in Locally Advanced Rectal Cancer

R. Semrau, A. Debucquoy, C. Sempoux, 2011 .

Efficiency of fluorodeoxyglucose positron emission tomography/computed tomography to predict prognosis in breast cancer patients received neoadjuvant chemotherapy

Tomoyuki Fujioka, Kazunori Kubota, M. Kasahara, 2015, SpringerPlus.

The prognostic role of Bcl-2 mRNA expression in curatively resected non-small cell lung cancer (NSCLC).

A. Hölscher, K. Danenberg, P. Danenberg, 2010, Lung cancer.

Antireflux Surgery Normalizes Cyclooxygenase-2 Expression in Squamous Epithelium of the Distal Esophagus

J. Peters, K. Danenberg, P. Danenberg, 2006, The American Journal of Gastroenterology.

Increased acid exposure in patients with gastroesophageal reflux disease influences cyclooxygenase-2 gene expression in the squamous epithelium of the lower esophagus.

J. Peters, K. Danenberg, P. Danenberg, 2004, Archives of surgery.

Prognostic Significance of Cyclooxygenase 2 mRNA Expression in Non-Small Cell Lung Cancer

A. Hölscher, K. Danenberg, P. Danenberg, 2002, Annals of surgery.

Survivin, a potential biomarker in the development of Barrett's adenocarcinoma.

J. Peters, K. Danenberg, P. Danenberg, 2005, Surgery.

Large-scale screening of ALK fusion oncogene transcripts in archival NSCLC tumor specimens using multiplexed RT-PCR assays.

K. Kelly, D. Gandara, K. Danenberg, 2011, Journal of Clinical Oncology.

Expression of DT-diaphorase and cytochrome P450 reductase correlates with mitomycin C activity in human bladder tumors.

K. Danenberg, P. Danenberg, M. Wientjes, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Original p53 status predicts for pathological response in locally advanced breast cancer patients treated preoperatively with continuous infusion 5-fluorouracil and radiation therapy.

G. Dunnington, S. Groshen, H. Silberman, 1997, International journal of radiation oncology, biology, physics.

Thymidylate synthase polymorphisms and mRNA expression are independent chemotherapy predictive markers in esophageal adenocarcinoma patients.

K. Danenberg, P. Danenberg, Dongyun Yang, 2008, International journal of oncology.

5‐fluorouracil‐related gene expression levels in primary colorectal cancer and corresponding liver metastasis

K. Hayashi, K. Danenberg, P. Danenberg, 2006, International journal of cancer.

Upregulation of ornithine decarboxylase mrna expression in barrett’s esophagus and barrett’s-associated adenocarcinoma

J. Peters, Ji Min Park, K. Kawakami, 2001, Journal of Gastrointestinal Surgery.

I point mutations in human ition polymorphism !

Peter A. Jones, H. Lenz, J. Bertino, 2005 .

Abstract 2693: MDR1 and ERCC1 expression predict outcome in patients with locally advanced bladder cancer and adjuvant chemotherapy

A. Hartmann, P. Wild, M. Schuler, 2010 .

P-752 Biomarkers for small cell lung cancer (SCLC): DNA methylationand GD2 synthase transcript levels

M. Kris, C. Azzoli, L. Krug, 2005 .

Inhibition of pre-mRNA splicing by cisplatin and platinum analogs.

Thomas D. Schmittgen, K. Danenberg, J. Ju, 2003, International journal of oncology.

Adenocarcinoma developing in de novo Barrett's mucosa in the remnant esophagus after esophagectomy: clinical and molecular assessment.

M. Stolte, C. Gutschow, A. Hölscher, 2008, Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus.

Thymidylate synthetase and 2'-deoxyuridylate form a tight complex in the presence of pteroyltriglutamate.

P. Danenberg, A. Lockshin, 1979, The Journal of biological chemistry.

Evidence from chemical degradation studies for a covalent bond from 5-fluoro-2'-deoxyuridylate to N-5 of tetrahydrofolate in the ternary complex of thymidylate synthetase-5-fluoro-2'-deoxyuridylate-5,10-methylenetetrahydrofolate.

P. Danenberg, A. Pellino, 1985, The Journal of biological chemistry.

The incorporation of trifluorothymidine into calf thymus DNA in a cell-free system does not lead to chain termination.

C. Heidelberger, P. Danenberg, A. Sarrif, 1980, Molecular pharmacology.

Relative gene expression in normal and tumor tissue by quantitative RT-PCR.

Ji Min Park, J. Grem, K. Danenberg, 2002, Methods in molecular biology.

Molecular profiling including epidermal growth factor receptor and p21 expression in high-risk breast cancer patients as indicators of outcome.

S. Groshen, W. Ye, P. Chu, 2008, Annals of oncology : official journal of the European Society for Medical Oncology.

Messenger RNA Expression of Vascular Endothelial Growth Factor and Its Receptors in Primary Colorectal Cancer and Corresponding Liver Metastasis

H. Lenz, K. Danenberg, P. Danenberg, 2008, Annals of Surgical Oncology.

Association of Epidermal Growth Factor Receptor Activating Mutations with Low ERCC1 Gene Expression in Non-small Cell Lung Cancer

D. Gandara, K. Danenberg, P. Danenberg, 2010, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Molecular factors of 5-fluorouracil metabolism in colorectal cancer: analysis of primary tumor and lymph node metastasis.

J. Lindebjerg, K. Danenberg, P. Danenberg, 2006, International journal of oncology.

Thymidylate synthase quantitation and in vitro chemosensitivity testing predicts responses and survival of patients with isolated nonresectable liver tumors receiving hepatic arterial infusion chemotherapy

K. Danenberg, P. Danenberg, M. Kornmann, 2000, Cancer.

Correlate with Levels of Thymidylate Synthase Colon Cancer As Compared with Hepatic Metastasis and Levels of E 2 F-1 Expression Are Higher in Lung Metastasis of Updated

C. Cordon-Cardo, S. Jhanwar, D. Banerjee, 2000 .

Messenger RNA expression of TS and ERCC1 in colorectal cancer and matched liver metastasis.

H. Lenz, K. Danenberg, P. Danenberg, 2008, International Journal of Oncology.

Reversal of cytosine arabinoside (ara-C) resistance by the synergistic combination of 6-thioguanine plus ara-C plus PEG-asparaginase (TGAP) in human leukemia lines lacking or expressing p53 protein

K. Weinberg, P. Danenberg, C. Fu, 2001, Cancer Chemotherapy and Pharmacology.

Towards the Molecular Characterization of Disease: Comparison of Molecular and Histological Analysis of Esophageal Epithelia

J. Peters, P. Marjoram, K. Danenberg, 2007, Journal of Gastrointestinal Surgery.

ERCC1 and RRM1 gene expressions but not EGFR are predictive of shorter survival in advanced non-small-cell lung cancer treated with cisplatin and gemcitabine.

G. Scagliotti, M. Papotti, S. Novello, 2006, Annals of oncology : official journal of the European Society for Medical Oncology.

Clinical Study Prognostic Significance and Clinicopathological Associations of Cox-2 Snp in Patients with Nonsmall Cell Lung Cancer

A. Hölscher, P. Danenberg, P. Schneider, 2009 .

Histology- and gender-related associations of ERCC1, RRM1, and TS biomarkers in 1,802 patients with NSCLC: Implications for therapy.

D. Gandara, K. Danenberg, P. Danenberg, 2010 .

Reduction of interleukin 8 gene expression in reflux esophagitis and Barrett's esophagus with antireflux surgery.

K. Danenberg, P. Danenberg, J. Hagen, 2007, Archives of surgery.

MethyLight: a high-throughput assay to measure DNA methylation.

P. Laird, D. Shibata, L. Saltz, 2000, Nucleic acids research.

Vascular endothelial growth factor and basic fibroblast growth factor expression in esophageal adenocarcinoma and Barrett esophagus.

J. Peters, Ji Min Park, K. Danenberg, 2003, The Journal of thoracic and cardiovascular surgery.

Alterations of p16 and p14ARF genes and their 9p21 locus in oral squamous cell carcinoma.

I. Tohnai, K. Danenberg, P. Danenberg, 2009, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of action.

G. Peters, N. Petrelli, P. Johnston, 2016, Critical reviews in oncology/hematology.

KRAS mutations (MTs) in non-small cell lung cancer (NSCLC) versus colorectal cancer (CRC): Implications for cetuximab therapy.

D. Gandara, K. Danenberg, P. Danenberg, 2010 .