P. Loetscher

发表

Posttranscriptional stabilization underlies p53-independent induction of p21WAF1/CIP1/SDI1 in differentiating human leukemic cells.

M. Fey, A. Tobler, H. Koeffler, 1995, The Journal of clinical investigation.

Signal transduction by CXC chemokine receptor 4. Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes.

I. Clark-lewis, P. Loetscher, B. Tilton, 2000 .

A Skin-selective Homing Mechanism for Human Immune Surveillance T Cells

Lisa M. Ebert, P. Loetscher, B. Moser, 2004, Journal of Experimental Medicine.

Poly(ADP-ribose) may signal changing metabolic conditions to the chromatin of mammalian cells.

F. Althaus, P. Loetscher, R. Alvarez-González, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function

P. Loetscher, B. Moser, P. Schaerli, 2000, The Journal of experimental medicine.

Cutting Edge: Induction of Follicular Homing Precedes Effector Th Cell Development1

P. Loetscher, B. Moser, P. Schaerli, 2001, The Journal of Immunology.

Lymphocyte‐specific chemokine receptor CXCR3: regulation, chemokine binding and gene localization

P. Loetscher, E. Meese, B. Moser, 1998, European journal of immunology.

of Lupus Nephritis in NZB/W Mice CCR1 Inhibition Ameliorates the Progression

P. Loetscher, M. Peuchmaur, T. Walzer, 2017 .

CCR1 Inhibition Ameliorates the Progression of Lupus Nephritis in NZB/W Mice

P. Loetscher, M. Peuchmaur, K. Balabanian, 2014, The Journal of Immunology.

N-terminal Peptides of Stromal Cell-derived Factor-1 with CXC Chemokine Receptor 4 Agonist and Antagonist Activities*

B. Dewald, M. Baggiolini, I. Clark-lewis, 1998, Journal of Biological Chemistry.

CXCR5(+) T cells: follicular homing takes center stage in T-helper-cell responses.

P. Loetscher, B. Moser, P. Schaerli, 2002, Trends in immunology.

The T cell chemokine receptor CCR7 is internalized on stimulation with ELC, but not with SLC

M. Baggiolini, P. Loetscher, G. Bardi, 2001, European journal of immunology.

Both interleukin‐8 receptors independently mediate chemotaxis

M. Baggiolini, I. Clark-lewis, P. Loetscher, 1994 .

The C terminus of mouse ornithine decarboxylase confers rapid degradation on dihydrofolate reductase. Support for the pest hypothesis.

P. Loetscher, M. Rechsteiner, G. Pratt, 1991, Journal of Biological Chemistry.

CXCR5 Chemokine Receptor

P. Loetscher, 2008 .

Monocyte chemotactic proteins MCP‐1, MCP‐2, and MCP‐3 are major attractants for human CD4+ and CD8+ T lymphocytes

M. Baggiolini, P. Loetscher, B. Moser, 1994, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The Ligands of CXC Chemokine Receptor 3, I-TAC, Mig, and IP10, Are Natural Antagonists for CCR3*

M. Baggiolini, P. Loetscher, J. Gong, 2001, The Journal of Biological Chemistry.

Precedes Effector Th Cell Development Cutting Edge: Induction of Follicular Homing

P. Loetscher, B. Moser, P. Schaerli, 2001 .

Chemokines in rheumatoid arthritis

P. Loetscher, 2005 .

Homing chemokines in rheumatoid arthritis

P. Loetscher, B. Moser, 2002, Arthritis research.

Eotaxin-2, a Novel CC Chemokine that Is Selective for the Chemokine Receptor CCR3, and Acts Like Eotaxin on Human Eosinophil and Basophil Leukocytes

M. Baggiolini, P. Loetscher, M. Thelen, 1997, The Journal of experimental medicine.

High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.

C. Mackay, M. Baggiolini, P. Loetscher, 1997, The Journal of clinical investigation.

Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin

B. Dewald, M. Baggiolini, P. Loetscher, 1996, The Journal of experimental medicine.

Interleukin‐10 differentially regulates cytokine inhibitor and chemokine release from blood mononuclear cells and fibroblasts

B. Dewald, M. Baggiolini, P. Loetscher, 1995, European journal of immunology.

Differential Regulation of Chemokine Production in Human Peritoneal Mesothelial Cells: IFN-γ Controls Neutrophil Migration Across the Mesothelium In Vitro and In Vivo1

T. S. Wilkinson, Simon A. Jones, P. Loetscher, 2001, The Journal of Immunology.

Activation of NK cells by CC chemokines. Chemotaxis, Ca2+ mobilization, and enzyme release.

M. Baggiolini, P. Loetscher, B. Moser, 1996, Journal of immunology.

Functional inhibition of CCR3‐dependent responses by peptides derived from phage libraries

L. Mazzucchelli, M. Baggiolini, P. Loetscher, 2001, European Journal of Immunology.

Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist.

T. Junt, P. Loetscher, E. Vangrevelinghe, 2022, ACS medicinal chemistry letters.

Constitutive mRNA and protein production of macrophage colony-stimulating factor but not of other cytokines by synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients.

A. Tobler, P. Loetscher, M. Seitz, 1994, British Journal of Rheumatology.

Across the Mesothelium In Vitro and In Vivo Controls Neutrophil Migration g Cells: IFN-Production in Human Peritoneal Mesothelial Differential Regulation of Chemokine

T. S. Wilkinson, Simon A. Jones, P. Loetscher, 2001 .

Monocyte chemoattractant protein-1 gene expression in prostatic hyperplasia and prostate adenocarcinoma.

L. Mazzucchelli, M. Baggiolini, J. Laissue, 1996, The American journal of pathology.

Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants

K. Mertz, T. Junt, P. Loetscher, 2022, JCI insight.

Rho kinase is required for CCR7‐mediated polarization and chemotaxis of T lymphocytes

P. Loetscher, V. Niggli, G. Bardi, 2003, FEBS Letters.

Both interleukin-8 receptors independently mediate chemotaxis. Jurkat cells transfected with IL-8R1 or IL-8R2 migrate in response to IL-8, GRO alpha and NAP-2.

M. Baggiolini, P. Loetscher, B. Moser, 1994, FEBS letters.

Opposite effects of interleukin‐13 and interleukin‐12 on the release of inflammatory cytokines, cytokine inhibitors and prostaglandin E from synovial fibroblasts and blood mononuclear cells

B. Dewald, M. Baggiolini, P. Loetscher, 1996, European journal of immunology.

Effects of methotrexate on differentiation of monocytes and production of cytokine inhibitors by monocytes.

P. Loetscher, M. Seitz, M. Zwicker, 1998, Arthritis and rheumatism.

CCR1 Inhibition Ameliorates the Progression of Lupus Nephritis in NZB/W Mice

P. Loetscher, M. Peuchmaur, K. Balabanian, 2014, Journal of Immunology.

Rapid inactivation of stromal cell‐derived factor‐1 by cathepsin G associated with lymphocytes

M. Baggiolini, P. Loetscher, M. Thelen, 2001, European journal of immunology.

Solution structure and basis for functional activity of stromal cell‐derived factor‐1; dissociation of CXCR4 activation from binding and inhibition of HIV‐1

B. Sykes, K. Rajarathnam, M. Baggiolini, 1997, The EMBO journal.

Specif ic for IP 10 and Mig : Structure , Funct ion , and Express ion in Activated T-Lymphocytes

Simon A. Jones, P. Loetscher, B. Moser, 2003 .

Leukocyte migration across human peritoneal mesothelial cells is dependent on directed chemokine secretion and ICAM-1 expression.

A. Davenport, R. Rothlein, P. Loetscher, 1998, Kidney international.

The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells

Li V. Yang, P. Loetscher, J. Velcicky, 2019, bioRxiv.

Immobilization of monoclonal antibodies for affinity chromatography using a chelating peptide.

P. Loetscher, E. Hochuli, L. Mottlau, 1992, Journal of Chromatography A.

Production of interleukin-1 receptor antagonist, inflammatory chemotactic proteins, and prostaglandin E by rheumatoid and osteoarthritic synoviocytes--regulation by IFN-gamma and IL-4.

B. Dewald, M. Baggiolini, P. Loetscher, 1994, Journal of Immunology.

Prote in 4 ( MCP-4 ) , a Nove l Structural and Funct iona l

B. Dewald, M. Baggiolini, P. Loetscher, 2003 .

Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay.

T. Junt, P. Loetscher, E. Vangrevelinghe, 2020, Journal of Medicinal Chemistry.

Expression and regulation of G1 cell-cycle inhibitors (p16INK4A , p15INK4B, p18 INK4C, p19INK4D ) in human acute myeloid leukemia and normal myeloid cells

M. Fey, A. Tobler, H. Koeffler, 1997, Leukemia.

Methotrexate action in rheumatoid arthritis: stimulation of cytokine inhibitor and inhibition of chemokine production by peripheral blood mononuclear cells.

B. Dewald, M. Baggiolini, P. Loetscher, 1995, British Journal of Rheumatology.

TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function

E. Meese, M. Baggiolini, P. Loetscher, 1997, Current Biology.

HIV Coreceptor Downregulation as Antiviral Principle: SDF-1α–dependent Internalization of the Chemokine Receptor CXCR4 Contributes to Inhibition of HIV Replication

Jean Salamero, J. Salamero, M. Baggiolini, 1997, The Journal of experimental medicine.

Chemokines and Chemokine Receptors in Allergic Inflammation

M. Baggiolini, P. Loetscher, M. Uguccioni, 1998 .

Microinjection of Cre recombinase protein into zygotes enables specific deletion of two eukaryotic selection cassettes and enhances the expression of a DsRed2 reporter gene in Ccr2/Ccr5 double‐deficient mice

P. Loetscher, H. Zerwes, H. Maier, 2009, Genesis.

Chemokines: multiple levels of leukocyte migration control.

Marlene Wolf, Bernhard Moser, P. Loetscher, 2004, Trends in immunology.

Structure-Function Relationship between the Human Chemokine Receptor CXCR3 and Its Ligands*

P. Loetscher, J. Gong, Pius Loetscher, 2003, The Journal of Biological Chemistry.

HIV blocked by chemokine antagonist

M. Baggiolini, P. Loetscher, F. Arenzana‐Seisdedos, 1996, Nature.

CKβ8, a novel CC chemokine that predominantly acts on monocytes

M. Baggiolini, P. Loetscher, M. Uguccioni, 1997 .

Lymphocyte traffic control by chemokines

Bernhard Moser, P. Loetscher, B. Moser, 2001, Nature Immunology.

Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis.

K. Seuwen, P. Loetscher, Daniela Gabriel, 2017, Bioorganic & medicinal chemistry.

Pharmacological inhibition of GPR4 remediates intestinal inflammation in a mouse colitis model

Li V. Yang, P. Loetscher, J. Velcicky, 2019, bioRxiv.

Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis.

K. Weigand, P. Loetscher, J. Velcicky, 2017, Journal of medicinal chemistry.

Interleukin 1 (IL-1) receptor antagonist, soluble tumor necrosis factor receptors, IL-1 beta, and IL-8--markers of remission in rheumatoid arthritis during treatment with methotrexate.

B. Dewald, P. Loetscher, H. Towbin, 1996, The Journal of rheumatology.

Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation

Christoph Schaniel, Antonio Lanzavecchia, Patrick Schaerli, 1998, European journal of immunology.

In vitro modulation of cytokine, cytokine inhibitor, and prostaglandin E release from blood mononuclear cells and synovial fibroblasts by antirheumatic drugs.

B. Dewald, M. Baggiolini, P. Loetscher, 1997, Journal of Rheumatology.

Monocyte chemoattractant protein 1 and interleukin 8 production by rheumatoid synoviocytes. Effects of anti-rheumatic drugs.

B. Dewald, M. Baggiolini, P. Loetscher, 1994, Cytokine.

Interleukin-8 and the chemokine family.

M. Baggiolini, P. Loetscher, B. Moser, 1995, International Journal of Immunopharmacology.

The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice.

H. Anders, P. Loetscher, S. Segerer, 2007, The American journal of pathology.

HCC-2, a human chemokine: gene structure, expression pattern, and biological activity.

M. Baggiolini, P. Loetscher, P. Schulz-Knappe, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model

M. Aoki, M. Taketo, P. Loetscher, 2010, Proceedings of the National Academy of Sciences.

Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes

Simon A. Jones, M. Baggiolini, P. Loetscher, 1996, The Journal of experimental medicine.

Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes

M. Baggiolini, P. Loetscher, B. Moser, 1996, The Journal of experimental medicine.

A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis.

F. Breedveld, B. Bresnihan, P. Tak, 2006, Arthritis & Rheumatism.

Human Polymorphonuclear Neutrophils are Recruited by Porcine Chemokines Acting on CXC Chemokine Receptor 2, and Platelet-Activating Factor

P. Loetscher, Mårten K. J. Schneider, J. Seebach, 2005, Transplantation.

Performance Evaluation of Cobas® HIV-1, a Quantitative Nucleic Acid Test for Use on the Cobas® 6800/8800 Systems

P. Loetscher, E. Marins, R. Luo, 2017 .

Activation of blood T lymphocytes down‐regulates CXCR4 expression and interferes with propagation of X4 HIV strains

M. Baggiolini, P. Loetscher, E. Oberlin, 1998, European Journal of Immunology.

Chemokines in inflammation and immunity.

M. Baggiolini, P. Loetscher, P Loetscher, 2000, Immunology today.

Lymphocyte responses to chemokines.

P. Loetscher, B. Moser, M. Loetscher, 1998, International reviews of immunology.

CCR5 is characteristic of Th1 lymphocytes

M. Baggiolini, P. Loetscher, L. Bordoli, 1998, Nature.

Poly ADP-Ribosylation in DNA Damage Processing

H. Naegeli, F. Althaus, P. Loetscher, 1991 .

The Poly-ADP-Ribosylation System of Higher Eukaryotes: How Can It Do What?

H. Naegeli, M. Collinge, F. Althaus, 1990 .

Signal Transduction by Cxc Chemokine Receptor 4

P. Loetscher, B. Tilton, L. Ho, 2000, The Journal of experimental medicine.

Chemokines and their receptors in lymphocyte traffic and HIV infection.

M. Baggiolini, P. Loetscher, B. Moser, 2000, Advances in Immunology.

Agonistic and antagonistic activities of chemokines

P. Loetscher, I. Clark‐Lewis, 2001, Journal of leukocyte biology.

CKbeta8, a novel CC chemokine that predominantly acts on monocytes.

M. Baggiolini, P. Loetscher, U. Forssmann, 1997, FEBS letters.

Changing responsiveness to chemokines allows medullary plasmablasts to leave lymph nodes

K. Toellner, I. Maclennan, M. Baggiolini, 2001, European journal of immunology.

Poly ADP-ribosylation of proteins. Processivity of a post-translational modification.

H. Naegeli, F. Althaus, P. Loetscher, 1989, The Journal of biological chemistry.

The interleukin‐8 receptor B and CXC chemokines can mediate transendothelial migration of human skin homing T cells

P. Loetscher, B. Moser, K. Blaser, 1996, European journal of immunology.

Pharmacological Blockade of the Chemokine Receptor CCR1 Protects Mice from Systemic Candidiasis of Hematogenous Origin

P. Loetscher, D. Kontoyiannis, M. Lionakis, 2016, Antimicrobial Agents and Chemotherapy.

ADP-Ribosylation and Chromatin Function

F. Althaus, P. Loetscher, G. Mathis, 1989 .

Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase.

K. Azzaoui, R. Wolf, P. Loetscher, 2021, Journal of medicinal chemistry.

Preclinical characterization of the Toll-like receptor 7/8 antagonist MHV370 for lupus therapy

T. Junt, P. Loetscher, E. Ferrero, 2023, Cell reports. Medicine.

A new highly selective physicochemical assay to measure NAD+ in intact cells.

F. Althaus, P. Loetscher, R. Eichenberger, 1986, Analytical biochemistry.

Activation of blood T lymphocytes down‐regulates CXCR4 expression and interferes with propagation of X4 HIV strains

M. Baggiolini, P. Loetscher, E. Oberlin, 1998, European journal of immunology.

Eotaxin-2, a Novel CC Chemokine that Is Selective for the Chemokine Receptor CCR3, and Acts Like Eotaxin on Human Eosinophil and Basophil Leukocytes

M. Baggiolini, P. Loetscher, M. Thelen, 1997, The Journal of experimental medicine.

Chemokines and their receptors in t cell migration

P. Loetscher, 2002 .

Eotaxin-2, a Novel Cc Chemokine That Is Selective for the Chemokine Receptor Ccr3, and Acts like Eotaxin on Human Eosinophil and Basophil Leukocytes

P. Loetscher, M. Uguccioni, Marcus Thelen, 1997 .

Hiv Coreceptor Downregulation as Antiviral Principle: Sdf-1 ␣ –dependent Internalization of the Chemokine Receptor Cxcr4 Contributes to Inhibition of Hiv Replication

P. Loetscher, F. Arenzana‐Seisdedos, J. Virelizier, 2022 .

Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function

P. Loetscher, B. Moser, P. Schaerli, 2000, The Journal of experimental medicine.

Bridged Piperazines and Piperidines as CCR1 Antagonists with Oral Activity in Models of Arthritis and Multiple Sclerosis

P. Loetscher, P. Hiestand, A. Schlapbach, 2006 .

Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis.

K. Weigand, P. Loetscher, J. Velcicky, 2017, Journal of medicinal chemistry.

Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis.

P. Loetscher, P. Hiestand, A. Schlapbach, 2005, Bioorganic & medicinal chemistry letters.