D. Piwnica-Worms

发表

Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity.

G. Wahl, A. Balmain, H. Piwnica-Worms, 2011, Genes & development.

Contribution of p53 to metastasis.

David Piwnica-Worms, H. Piwnica-Worms, D. Piwnica-Worms, 2014, Cancer discovery.

Dual-color click beetle luciferase heteroprotein fragment complementation assays.

Mustapha Samrakandi, Robin S. Dothager, David Piwnica-Worms, 2010, Chemistry & biology.

In Vitro and In Vivo Characterization of a Dual-Function Green Fluorescent Protein–HSV1-Thymidine Kinase Reporter Gene Driven by the Human Elongation Factor 1α Promoter

J. Milbrandt, T. Fahrner, D. Piwnica-Worms, 2002, Molecular imaging.

Molecular imaging of protein-protein interactions: controlled expression of p53 and large T-antigen fusion proteins in vivo.

Wei Li, D. Piwnica-Worms, G. Luker, 2003, Cancer research.

Spying on cancer: molecular imaging in vivo with genetically encoded reporters.

D. Piwnica-Worms, S. Gross, Shimon Gross, 2005, Cancer cell.

A Coclinical Radiogenomic Validation Study: Conserved Magnetic Resonance Radiomic Appearance of Periostin-Expressing Glioblastoma in Patients and Xenograft Models

Ginu A. Thomas, G. Fuller, V. Baladandayuthapani, 2018, Clinical Cancer Research.

Technoreview: Molecular imaging of host–pathogen interactions in intact small animals

D. Piwnica-Worms, D. Schuster, J. Garbow, 2004, Cellular microbiology.

Whole Genome Analysis Informs Breast Cancer Response to Aromatase Inhibition

Joshua F. McMichael, Christopher A. Miller, Joshua M. Stuart, 2012, Nature.

Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals.

H. Piwnica-Worms, D. Piwnica-Worms, G. Luker, 2004, Proceedings of the National Academy of Sciences of the United States of America.

A rapid bioluminescence assay for measuring myeloperoxidase activity in human plasma

D. Piwnica-Worms, Reece J. Goiffon, Sara C. Martinez, 2015, Nature Communications.

Spectral unmixing of multicolored bioluminescence emitted from heterogeneous biological sources.

W. M. Leevy, George W Gokel, David Piwnica-Worms, 2006, Analytical chemistry.

The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis

Kevin W. Eliceiri, Gregory D. Longmore, Patricia J. Keely, 2013, Nature Cell Biology.

Flavokawain B, the hepatotoxic constituent from kava root, induces GSH‐sensitive oxidative stress through modulation of IKK/NF‐κB and MAPK signaling pathways

S. Qiu, D. Piwnica-Worms, P. Zhou, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Characterization of novel histidine-tagged Tat-peptide complexes dual-labeled with (99m)Tc-tricarbonyl and fluorescein for scintigraphy and fluorescence microscopy.

D. Piwnica-Worms, Vijay Sharma, C. Pica, 2002, Bioconjugate chemistry.

Evidence for a plasma membrane-mediated permeability barrier to Tat basic domain in well-differentiated epithelial cells: lack of correlation with heparan sulfate.

D. Piwnica-Worms, Vijay Sharma, J. Prior, 2002, Biochemistry.

Aortic flow velocity patterns in chronic aortic regurgitation: implications for Doppler echocardiography.

R Kikinis, S E Maier, R. Kikinis, 1996, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

Dynamic nature of the aortic regurgitant orifice area during diastole in patients with chronic aortic regurgitation.

R. Kikinis, S. Maier, R. T. Lee, 1994, Circulation.

Real-time imaging of β-catenin dynamics in cells and living mice

D. Piwnica-Worms, Snehal Naik, 2007, Proceedings of the National Academy of Sciences.

Real-time imaging of beta-catenin dynamics in cells and living mice.

D. Piwnica-Worms, Snehal Naik, 2007, Proceedings of the National Academy of Sciences of the United States of America.

Bioluminescence imaging of myeloperoxidase activity in vivo

David Piwnica-Worms, L. Ratner, J. Harding, 2009, Nature Medicine.

Rational design of novel red‐shifted BRET pairs: Platforms for real‐time single‐chain protease biosensors

D. Piwnica-Worms, V. Villalobos, M. Samrakandi, 2009, Biotechnology progress.

Noninvasive Bioluminescence Imaging of Herpes Simplex Virus Type 1 Infection and Therapy in Living Mice

Gary D. Luker, J. Patrick Bardill, David Piwnica-Worms, 2002, Journal of Virology.

Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses.

Jonathan B. Mitchem, S. Hewitt, C. Wegner, 2013, Cancer research.

PDE7B Is a Novel, Prognostically Significant Mediator of Glioblastoma Growth Whose Expression Is Regulated by Endothelial Cells

Michael D. Brooks, R. Mitra, N. Warrington, 2014, PloS one.

Multiwalled Carbon Nanotubes for Combination Therapy: a Biodistribution and Efficacy Pilot Study.

H. Piwnica-Worms, P. Paoli, D. Piwnica-Worms, 2019, Journal of materials chemistry. B.

Immunodeficient Mouse Strains Display Marked Variability in Growth of Human Melanoma Lung Metastases

G. Linette, J. Engelbach, D. Piwnica-Worms, 2009, Clinical Cancer Research.

Fluorophore‐Conjugated Iron Oxide Nanoparticle Labeling and Analysis of Engrafting Human Hematopoietic Stem Cells

Dustin J. Maxwell, D. Piwnica-Worms, J. Nolta, 2008, Stem cells.

Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo.

D. Piwnica-Worms, A. Perry, J. Rubin, 2007, Cancer research.

Blocking CXCR 4-Mediated Cyclic AMP Suppression Inhibits Brain Tumor Growth In vivo

D. Piwnica-Worms, A. Perry, J. Rubin, 2007 .

The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects

R. Vij, J. Miguel, M. Tomasson, 2013, Leukemia.

Single photon emission computed tomography and positron emission tomography imaging of multi-drug resistant P-glycoprotein--monitoring a transport activity important in cancer, blood-brain barrier function and Alzheimer's disease.

D. Piwnica-Worms, A. Pichler, Vijay Sharma, 2006, Neuroimaging clinics of North America.

Novel gallium(III) complexes as potential pet imaging agents for probing multidrug resistance (MDR1) P‐glycoprotein (PGP) transport activity: Effect of MDR reversal agents

D. Piwnica-Worms, Vijay Sharma, J. Dahlheimer, 2001 .

Excess exogenous pyruvate inhibits lactate dehydrogenase activity in live cells in an MCT1-dependent manner

D. Piwnica-Worms, M. N. Sutton, P. Bhattacharya, 2021, The Journal of biological chemistry.

The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling.

J. Schneider, A. Hughes, T. Steinberg, 2012, The Journal of clinical investigation.

APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice

E. Morgan, D. Piwnica-Worms, A. Hirbe, 2008, Journal of cellular biochemistry.

CXCL12 Mediates Trophic Interactions between Endothelial and Tumor Cells in Glioblastoma

D. Piwnica-Worms, T. Sun, Rajarshi Sengupta, 2012, PloS one.

The ARF Tumor Suppressor Regulates Bone Remodeling and Osteosarcoma Development in Mice

T. Rosol, L. Ratner, J. Harding, 2010, PloS one.

Directed evolution of cyclic peptides for inhibition of autophagy†

Joshua A. Kritzer, R. Bast, M. Uddin, 2021, Chemical science.

Novel treatment option for MUC16-positive malignancies with the targeted TRAIL-based fusion protein Meso-TR3

D. Mutch, D. Piwnica-Worms, W. Hawkins, 2014, BMC Cancer.

Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner.

K. Trinkaus, E. Morgan, D. Piwnica-Worms, 2007, Blood.

A Generator-Produced Gallium-68 Radiopharmaceutical for PET Imaging of Myocardial Perfusion

D. Piwnica-Worms, Vijay Sharma, J. Prior, 2014, PloS one.

Characterization of a Novel 99mTc-Carbonyl Complex as a Functional Probe of MDR1 P-Glycoprotein Transport Activity

D. Piwnica-Worms, C. Pica, J. Dahlheimer, 2002 .

Reversal of Multidrug Resistance with LY335979: Functional Analysis of P‐glycoprotein‐Mediated Transport Activity and Its Modulation In Vivo

D. Piwnica-Worms, C. Slapak, J. Dahlheimer, 2001 .

Reversal of Multidrug Resistance with LY335979: Functional Analysis of P‐glycoprotein‐Mediated Transport Activity and Its Modulation In Vivo

D. Piwnica-Worms, C. Slapak, J. Dahlheimer, 2001, Journal of clinical pharmacology.

Combined VEGF and CXCR4 antagonism targets the GBM stem cell population and synergistically improves survival in an intracranial mouse model of glioblastoma

P. Wen, N. Warrington, D. Piwnica-Worms, 2014, Oncotarget.

Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders

G. Wahl, R. Bast, C. Der, 2020, Proceedings of the National Academy of Sciences.

Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters

Sara E. Miller, D. Piwnica-Worms, K. Cadwell, 2009, Autophagy.

MIRDOSE: Personal Computer Software for Internal Dose Assessment in Nuclear Medicine

D. Piwnica-Worms, 1996 .

RAS-Driven Macropinocytosis of Albumin or Dextran Reveals Mutation-Specific Target Engagement of RAS p.G12C Inhibitor ARS-1620 by NIR-Fluorescence Imaging

D. Piwnica-Worms, M. N. Sutton, S. Gammon, 2021, Molecular Imaging and Biology.

[18F]FHBG PET/CT Imaging of CD34-TK75 Transduced Donor T Cells in Relapsed Allogeneic Stem Cell Transplant Patients: Safety and Feasibility.

R. Fulton, K. Cornetta, J. Dipersio, 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains.

D. Piwnica-Worms, G. Luker, C. Pica, 2000, Biochemistry.

Superparamagnetic Iron Oxide Hepatic MR Imaging: Efficacy and Safety Using Conventional and Fast Spin‐Echo Pulse Sequences

C. Tempany, S. Seltzer, L. Schwartz, 1995, Journal of magnetic resonance imaging : JMRI.

A co-clinical radiogenomic validation study-Conserved magnetic resonance radiomic appearance of Periostin expressing Glioblastoma in patients and xenograft models Authors:

G. Fuller, Raymond Sawaya, J. Gumin, 2022 .

Mistiming Death: Modeling the Time-Domain Variability of Tumor Apoptosis and Implications for Molecular Imaging of Cell Death

G. Gores, D. Piwnica-Worms, S. Gammon, 2020, Molecular Imaging and Biology.

Malignant pleural mesothelioma: value of CT and MR imaging in predicting resectability.

D. Sugarbaker, E. Patz, D. Piwnica-Worms, 1992, AJR. American journal of roentgenology.

Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier.

A. Sartorelli, D. Piwnica-Worms, A. Z. Snyder, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Novel technetium (III)-Q complexes for functional imaging of multidrug resistance (MDR1) P-glycoprotein.

M. Marmion, D. Piwnica-Worms, G. Luker, 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

CD47 regulates bone mass and tumor metastasis to bone.

W. Zou, D. Piwnica-Worms, J. Prior, 2009, Cancer research.

The IL-15-Based ALT-803 Complex Enhances FcγRIIIa-Triggered NK Cell Responses and In Vivo Clearance of B Cell Lymphomas

D. Piwnica-Worms, N. Bartlett, H. Wong, 2015, Clinical Cancer Research.

Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy

C. Miller, K. Choi, D. Piwnica-Worms, 2007, Oncogene.

Clinical Molecular Imaging Today: PET and SPECT

D. Piwnica-Worms, 2003 .

PET/MR Imaging of a Lung Metastasis Model of Clear Cell Renal Cell Carcinoma with (2S,4R)-4-[18F]Fluoroglutamine

Alyssa C Pollard, Md Nasir Uddin, C. Wood, 2022, Molecular Imaging and Biology.

AACR/SNMMI State-of-the-Art Molecular Imaging in Cancer Biology and Therapy: Abstracts

C. Contag, D. Piwnica-Worms, C. Anderson, 2013, Journal of Nuclear Medicine.

AACR/SNMMI State-of-the-Art Molecular Imaging in Cancer Biology and Therapy: Abstracts

D. Piwnica-Worms, C. Anderson, 2013, The Journal of Nuclear Medicine.

Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer

R. Mach, D. Mutch, D. Piwnica-Worms, 2014, Molecular Cancer.

Synthesis and characterization of a Gd-DOTA-D-permeation peptide for magnetic resonance relaxation enhancement of intracellular targets.

D. Piwnica-Worms, A. M. Prantner, J. Garbow, 2003, Molecular imaging.

Synthesis and Characterization of a Gd-DOTA-D-Permeation Peptide for Magnetic Resonance Relaxation Enhancement of Intracellular Targets

D. Piwnica-Worms, A. M. Prantner, J. Garbow, 2003 .

Detection of protein-protein interactions in live cells and animals with split firefly luciferase protein fragment complementation.

D. Piwnica-Worms, V. Villalobos, Snehal Naik, 2008, Methods in molecular biology.

Androgen Receptor Signaling in Castration-Resistant Prostate Cancer Alters Hyperpolarized Pyruvate to Lactate Conversion and Lactate Levels In Vivo

P. Troncoso, C. Logothetis, D. Piwnica-Worms, 2019, Molecular Imaging and Biology.

Decreased hepatic accumulation and enhanced esterification of cholesterol in mice deficient in mdr1a and mdr1b P-glycoproteins.

D. Piwnica-Worms, G. Luker, J. Dahlheimer, 2001, Journal of lipid research.

Expression of recombinant human multidrug resistance P-glycoprotein in insect cells confers decreased accumulation of technetium-99m-sestamibi.

D. Piwnica-Worms, J. Kronauge, V. Rao, 1994, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

MDR 1 Gene-specific Monoclonal Antibody C 494 Cross-Reacts with Pyruvate Carboxylase 1

Douglas, C. Anthony, D. Piwnica-Worms, 2006 .

MDR1 gene-specific monoclonal antibody C494 cross-reacts with pyruvate carboxylase.

D. Anthony, D. Piwnica-Worms, V. Rao, 1994, Cancer research.

Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters

Sara E. Miller, D. Piwnica-Worms, K. Cadwell, 2009, Autophagy.

In vitro and in vivo evaluation of a green fluorescent protein-HSV1-TK dual-function pet reporter gene

J. Milbrandt, T. Fahrner, D. Piwnica-Worms, 2001 .

Automated, Resin-Based Method to Enhance the Specific Activity of Fluorine-18 Clicked PET Radiotracers.

R. Roberts, D. Piwnica-Worms, Terry T. Takahashi, 2017, Bioconjugate chemistry.

Flavokawain B, the hepatotoxic constituent from kava root, induces GSH‐sensitive oxidative stress through modulation of IKK/NF‐κB and MAPK signaling pathways

S. Qiu, D. Piwnica-Worms, P. Zhou, 2010 .

Factors Affecting Human T Cell Engraftment, Trafficking and Associated Xenogeneic Graft-Versus-Host Disease in NOD/SCID

J. Dipersio, D. Piwnica-Worms, Hanlin L. Wang, 2008 .

Factors affecting human T cell engraftment, trafficking, and associated xenogeneic graft-vs-host disease in NOD/SCID beta2mnull mice.

J. Dipersio, D. Piwnica-Worms, Hanlin L. Wang, 2007, Experimental hematology.

CXCL12 alone is insufficient for gliomagenesis in Nf1 mutant mice

D. Gutmann, D. Piwnica-Worms, T. Sun, 2010, Journal of Neuroimmunology.

A method for quantification of nucleotides and nucleotide analogues in thymidine kinase assays using lanthanum phosphate coprecipitation.

M. Bernstein, D. Piwnica-Worms, D. Schuster, 2007, Analytical biochemistry.

Caspase-activated cell-penetrating peptides reveal temporal coupling between endosomal release and apoptosis in an RGC-5 cell model.

James R. Johnson, D. Piwnica-Worms, E. Barnett, 2012, Bioconjugate chemistry.

IFNγR signaling mediates alloreactive T-cell trafficking and GVHD.

J. Dipersio, D. Piwnica-Worms, Julie K. Ritchey, 2012, Blood.

Quantitative analysis of permeation peptide complexes labeled with Technetium-99m: chiral and sequence-specific effects on net cell uptake.

D. Piwnica-Worms, V. Villalobos, J. Prior, 2003, Bioconjugate chemistry.

Chemical reaction-induced multi-molecular polarization (CRIMP).

D. Piwnica-Worms, N. Zacharias, P. Bhattacharya, 2014, Chemical communications.

Caspase-3 Substrates for Noninvasive Pharmacodynamic Imaging of Apoptosis by PET/CT.

R. Bast, Shuxing Zhang, D. Piwnica-Worms, 2018, Bioconjugate chemistry.

Measuring Brain Tumor Growth: Combined Bioluminescence Imaging–Magnetic Resonance Imaging Strategy

D. Piwnica-Worms, S. Jost, J. Garbow, 2009, Molecular imaging.

The Pancreatic Tumor Microenvironment Compensates for Loss of GOT2

Z. Nwosu, D. Piwnica-Worms, C. Lyssiotis, 2020, bioRxiv.

Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context

Z. Nwosu, D. Piwnica-Worms, H. Wen, 2022, eLife.

Multi-Modal Multi-Spectral Intravital Macroscopic Imaging of Signaling Dynamics in Real Time during Tumor–Immune Interactions

D. Piwnica-Worms, S. Gammon, D. Fuentes, 2021, Cells.

p38 MAPK inhibits nonsense-mediated RNA decay in response to persistent DNA damage in noncycling cells

S. Stewart, D. Piwnica-Worms, Zhongsheng You, 2017, The Journal of Biological Chemistry.

Reversal of Multidrug Resistance with LY335979: Functional Analysis of P‐glycoprotein‐Mediated Transport Activity and Its Modulation In Vivo

D. Piwnica-Worms, C. Slapak, J. Dahlheimer, 2001, Journal of clinical pharmacology.

Pharmacokinetic modeling of multidrug resistance P-glycoprotein transport of gamma-emitting substrates.

D. Piwnica-Worms, K. Bae, 1997, The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology.

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

Christian Pilarsky, Raghu Kalluri, Elizabeth A. Mittendorf, 2015, Nature.

FOXO1 induces p21 expression during fasting 1 Forkhead Box O1 (FOXO1), but not p53, Contributes to Robust Induction of p21 Expression in Fasted Mice*

E. Herzog, H. Piwnica-Worms, Kelsey L. Tinkum, 2013 .

Molecular imaging in vivo with PET and SPECT.

D. Piwnica-Worms, G. Luker, 2001, Academic radiology.

Synthesis and characterization in vitro of membrane permeant peptide conjugates for imaging and radiotherapy

D. Piwnica-Worms, J. Dahlheimer, V. Polyakov, 1999 .

Metal complexes for therapy and diagnosis of drug resistance.

D. Piwnica-Worms, V. Sharma, V. Sharma, 1999, Chemical reviews.

Characterization of phosphine complexes of technetium(III) as transport substrates of the multidrug resistance P-glycoprotein and functional markers of P-glycoprotein at the blood-brain barrier.

D. Piwnica-Worms, G. Luker, J. Dahlheimer, 1997, Biochemistry.

Novel hexakis(areneisonitrile)technetium(I) complexes as radioligands targeted to the multidrug resistance P-glycoprotein.

D. Piwnica-Worms, J. Kronauge, L. Herman, 1995, Journal of medicinal chemistry.

Apoptosis Detection in Retinal Ganglion Cells Using Quantitative Changes in Multichannel Fluorescence Colocalization

James R. Johnson, D. Piwnica-Worms, S. Gammon, 2022, Biosensors.

Bioluminescent Imaging Reveals Divergent Viral Pathogenesis in Two Strains of Stat1-Deficient Mice, and in αßγ Interferon Receptor-Deficient Mice

D. Piwnica-Worms, B. Berwin, D. Leib, 2011, PloS one.

Suicide genes: monitoring cells in patients with a safety switch

J. Dipersio, D. Piwnica-Worms, F. Dehdashti, 2014, Front. Pharmacol..

Human cord blood progenitors with high aldehyde dehydrogenase activity improve vascular density in a model of acute myocardial infarction

Dustin J. Maxwell, D. Piwnica-Worms, J. Nolta, 2008, Journal of Translational Medicine.

Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity.

Dustin J. Maxwell, D. Link, D. Piwnica-Worms, 2009, Blood.

Molecular Imaging of Gene Expression and Protein Function In Vivo: Cancer Drug Targets and Drug Resistance

D. Piwnica-Worms, 2004 .

Induction of antitumor immunity in mice by the combination of nanoparticle-based Photothermolysis and anti-PD-1 checkpoint inhibition.

A. Sood, D. Piwnica-Worms, H. Hatakeyama, 2020, Nanomedicine : nanotechnology, biology, and medicine.

Kinetics of In Vivo Elimination of Suicide Gene-Expressing T Cells Affects Engraftment, Graft-versus-Host Disease, and Graft-versus-Leukemia after Allogeneic Bone Marrow Transplantation1

J. Haug, J. Dipersio, D. Piwnica-Worms, 2004, The Journal of Immunology.

Characterization of coelenterazine analogs for measurements of Renilla luciferase activity in live cells and living animals.

Christopher H Contag, Hui Zhao, Ronald J Wong, 2004, Molecular imaging.

On in vivo imaging in cancer.

David Piwnica-Worms, D. Piwnica-Worms, 2012, Cold Spring Harbor perspectives in biology.

18F-AFETP, 18F-FET, and 18F-FDG Imaging of Mouse DBT Gliomas

R. Mach, J. Engelbach, D. Piwnica-Worms, 2013, The Journal of Nuclear Medicine.

PET/MR Imaging of a Lung Metastasis Model of Clear Cell Renal Cell Carcinoma with (2S,4R)-4-[18F]Fluoroglutamine

Md Nasir Uddin, C. Wood, Li Li, 2022, Molecular Imaging and Biology.

Ovarian vein thrombosis.

S. Goldhaber, D. Piwnica-Worms, G. R. Simons, 1993, American heart journal.

TLR5 agonists enhance anti-tumor immunity and overcome resistance to immune checkpoint therapy

J. Rhee, D. Piwnica-Worms, S. Gammon, 2023, Communications Biology.

Optical imaging of bacterial infection in living mice using a fluorescent near-infrared molecular probe.

W. Matthew Leevy, James R. Johnson, Hua Jiang, 2006, Journal of the American Chemical Society.

MR imaging of septic sacroiliitis.

D. Piwnica-Worms, C. Winalski, M. Wax, 1991, Journal of computer assisted tomography.

Imaging of innate immunity activation in vivo with a redox-tuned PET reporter

D. Piwnica-Worms, S. Gammon, Vincenzo Paolillo, 2022, Nature Biotechnology.

SPECT imaging in evaluating extent of malignant external otitis: case report

B. Holman, D. Piwnica-Worms, S. Tumeh, 1987 .

Novel derivatives of anaplastic lymphoma kinase inhibitors: Synthesis, radiolabeling, and preliminary biological studies of fluoroethyl analogues of crizotinib, alectinib, and ceritinib.

D. Piwnica-Worms, Ping Yang, M. Alauddin, 2019, European journal of medicinal chemistry.

Effects of multidrug resistance (MDR1) P-glycoprotein expression levels and coordination metal on the cytotoxic potency of multidentate (N4O2) (ethylenediamine)bis[propyl(R-benzylimino)]metal(III) cations.

D. Piwnica-Worms, V. Sharma, C. Crankshaw, 1996, Journal of medicinal chemistry.

Targeted Inhibition of Cyclic AMP Phosphodiesterase-4 Promotes Brain Tumor Regression

Erin Jackson, Arie Perry, David D Limbrick, 2008, Clinical Cancer Research.

Probing the Chloroquine Resistance Locus of Plasmodium falciparum with a Novel Class of Multidentate Metal(III) Coordination Complexes*

I. Gluzman, D. Goldberg, T. Wellems, 1997, The Journal of Biological Chemistry.

Molecular imaging of gene expression and protein function in vivo with PET and SPECT

Gary D Luker, David Piwnica-Worms, Vijay Sharma, 2002, Journal of magnetic resonance imaging : JMRI.

Squaraine rotaxanes: superior substitutes for Cy-5 in molecular probes for near-infrared fluorescence cell imaging.

James R. Johnson, W. M. Leevy, Bradley D. Smith, 2007, Angewandte Chemie.

Errata

E. Herzog, D. Piwnica-Worms, D. Granados-Fuentes, 2010, Diabetes Care.

Structure of a novel antimalarial gallium(III) complex with selective activity against chloroquine-resistant Plasmodium falciparum

D. Goldberg, A. Beatty, D. Piwnica-Worms, 1997 .

LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy

G. Bu, D. Piwnica-Worms, Chia-Chen Liu, 2010, Proceedings of the National Academy of Sciences.

Interleukin 12 stimulates IFN-gamma-mediated inhibition of tumor-induced regulatory T-cell proliferation and enhances tumor clearance.

T. Ley, J. Payton, R. Schreiber, 2009, Cancer research.

Current state of imaging protein-protein interactions in vivo with genetically encoded reporters.

David Piwnica-Worms, D. Piwnica-Worms, V. Villalobos, 2007, Annual review of biomedical engineering.

In vivo RNA Interference–Mediated Ablation of MDR1 P-Glycoprotein

D. Piwnica-Worms, A. Pichler, N. Zelcer, 2005, Clinical Cancer Research.

P-Glycoprotein MDR 1 Mediated Ablation of − RNA Interference In vivo

D. Piwnica-Worms, A. Pichler, N. Zelcer, 2005 .

High-Grade Gliomas

C. Q. Lee, David T. W. Jones, Michael D. Brooks, 2012, Oxford Medicine Online.

A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor.

J. Crowley, J. Ippolito, D. Piwnica-Worms, 2014, Cancer discovery.

Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4.

Todd D. Westergard, Han Liu, R. Vij, 2014, Cancer cell.

Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice.

J. Corbo, J. Engelbach, Zhenyi Liu, 2011, The Journal of clinical investigation.

Multi-Modal Multi-Spectral Intravital Microscopic Imaging of Signaling Dynamics in Real-Time during Tumor–Immune Interactions

D. Piwnica-Worms, S. Gammon, Tracy W. Liu, 2021, Cells.

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

D. Piwnica-Worms, J. Ju, C. Weihl, 2009, The Journal of cell biology.

CXCR4 Regulates Growth of Both Primary and Metastatic Breast Cancer

D. Piwnica-Worms, G. Luker, K. Luker, 2004, Cancer Research.

Tumor-associated nonmyelinating Schwann cell–expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion

Jun Yao, G. Calin, M. Hung, 2023, Science advances.

Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression.

S. Stewart, D. Piwnica-Worms, Elise Alspach, 2012, Cancer research.

Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100.

Julie L Prior, David Piwnica-Worms, T. Ley, 2009, Blood.

Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1.

N. Warrington, D. Gutmann, D. Piwnica-Worms, 2010, Cancer research.

The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development.

Zhenyi Liu, Raphael Kopan, D. Piwnica-Worms, 2013, Developmental cell.

Characterization of multidrug resistance P-glycoprotein transport function with an organotechnetium cation.

D. Piwnica-Worms, J. Kronauge, V. Rao, 1995, Biochemistry.

Real-time bioluminescence imaging of myeloperoxidase activity in small laboratory animals

D. Piwnica-Worms, B. Moss, S. Gross, 2009 .

Suppression of G-protein–Coupled Receptor Kinase 3 Expression Is a Feature of Classical GBM That Is Required for Maximal Growth

P. Mischel, D. Piwnica-Worms, S. Dahiya, 2011, Molecular Cancer Research.

GRK expression in GBM

P. Mischel, D. Piwnica-Worms, S. Dahiya, 2011 .

F11R Is a Novel Monocyte Prognostic Biomarker for Malignant Glioma

E. Mardis, O. Griffith, M. Griffith, 2013, PloS one.

A Novel Mitochondrial Inhibitor Blocks MAPK Pathway and Overcomes MAPK Inhibitor Resistance in Melanoma

R. Deberardinis, Jian Wang, J. McQuade, 2019, Clinical Cancer Research.

A bioluminescent transposon reporter-trap identifies tumor-specific microenvironment-induced promoters in Salmonella for conditional bacterial-based tumor therapy.

D. Piwnica-Worms, S. Gammon, D. Novack, 2012, Cancer discovery.

The neurofibromatosis type 1 tumor suppressor controls cell growth by regulating signal transducer and activator of transcription-3 activity in vitro and in vivo.

K. Reilly, Sutapa Banerjee, D. Gutmann, 2010, Cancer research.

Imaging 26S proteasome activity and inhibition in living mice

Jiling Song, Kathryn E Luker, Gary D Luker, 2003, Nature Medicine.

Illuminating cancer systems with genetically engineered mouse models and coupled luciferase reporters in vivo.

D. Piwnica-Worms, B. Kocher, 2013, Cancer discovery.

Forkhead Box O1 (FOXO1) Protein, but Not p53, Contributes to Robust Induction of p21 Expression in Fasted Mice*

E. Herzog, H. Piwnica-Worms, Kelsey L. Tinkum, 2013, The Journal of Biological Chemistry.

p38MAPK plays a crucial role in stromal-mediated tumorigenesis.

S. Stewart, D. Piwnica-Worms, Timothy Marsh, 2014, Cancer discovery.

Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment.

J. Schneider, D. Piwnica-Worms, R. Cagan, 2012, Cancer research.

18F-fluorodeoxyglucose positron emission tomography correlates with tumor immunometabolic phenotypes in resected lung cancer

Jing Wang, I. Wistuba, J. Lee, 2020, Cancer Immunology, Immunotherapy.

Bioluminescence Imaging Captures the Expression and Dynamics of Endogenous p21 Promoter Activity in Living Mice and Intact Cells

E. Herzog, H. Piwnica-Worms, Kelsey L. Tinkum, 2011, Molecular and Cellular Biology.

Continuous Delivery of D-Luciferin by Implanted Micro-osmotic Pumps Enables True Real-Time Bioluminescence Imaging of Luciferase Activity in Vivo

E. Herzog, D. Piwnica-Worms, S. Gross, 2007, Molecular imaging.

Knocking down nucleolin expression in gliomas inhibits tumor growth and induces cell cycle arrest

D. Piwnica-Worms, S. Dahiya, J. Weber, 2012, Journal of Neuro-Oncology.

Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers

F. Bäckhed, K. Moulder, J. Gordon, 2006, Proceedings of the National Academy of Sciences.

Quantitation of the Effect of ErbB2 on Epidermal Growth Factor Receptor Binding and Dimerization*

Linda J Pike, David Piwnica-Worms, D. Piwnica-Worms, 2012, The Journal of Biological Chemistry.

Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine.

Julie L Prior, David Piwnica-Worms, D. Piwnica-Worms, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Noninvasive imaging of protein–protein interactions in living animals

Wei Li, Gary D Luker, David Piwnica-Worms, 2002, Proceedings of the National Academy of Sciences of the United States of America.

A Fluorescence-Coupled Assay for Gamma Aminobutyric Acid (GABA) Reveals Metabolic Stress-Induced Modulation of GABA Content in Neuroendocrine Cancer

J. Ippolito, D. Piwnica-Worms, 2014, PloS one.

p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer

Nipun A. Mistry, K. Do, Han Liang, 2016, Breast Cancer Research.

A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth.

Todd D. Westergard, Adam C. Searleman, Han Liu, 2012, Cancer research.

TAT-BH4 and TAT-Bcl-xL Peptides Protect against Sepsis-Induced Lymphocyte Apoptosis In Vivo1

C. Coopersmith, R. Hotchkiss, J. Cobb, 2006, The Journal of Immunology.

Loss of Par-1a/MARK3/C-TAK1 Kinase Leads to Reduced Adiposity, Resistance to Hepatic Steatosis, and Defective Gluconeogenesis

Robert E. Schmidt, Jochen K. Lennerz, Robert W. Gereau, 2010, Molecular and Cellular Biology.

Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant β-Catenin Activation in Colon Cancer

Robin S. Dothager, D. Piwnica-Worms, Snehal Naik, 2009, Clinical Cancer Research.

Multidrug resistance transporters and modulation

L. Ratner, D. Piwnica-Worms, B. Tan, 2000, Current opinion in oncology.

Peptide‐mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis

R. Hotchkiss, L. Rachdi, W. Dunne, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

BoneGraft-versus-Leukemia after Allogeneic Engraftment , Graft-versus-Host Disease , and Gene-Expressing T Cells Affects Kinetics of In Vivo Elimination of Suicide

J. Haug, J. Dipersio, D. Piwnica-Worms, 2004 .

Senescent stromal-derived osteopontin promotes preneoplastic cell growth.

S. Stewart, D. Piwnica-Worms, Xianmin Luo, 2009, Cancer research.

EXPERIMENTAL THERAPEUTICS AND PHARMACOLOGY

Tina N. Davis, Forrest M Kievit, Atique U. Ahmed, 2013 .

Characterization of a 67Ga/68Ga radiopharmaceutical for SPECT and PET of MDR1 P-glycoprotein transport activity in vivo: validation in multidrug-resistant tumors and at the blood-brain barrier.

D. Piwnica-Worms, G. Kruh, M. Belinsky, 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Imaging Multidrug Resistance P-glycoprotein Transport Function Using MicroPET with Technetium-94m-Sestamibi

Michael J. Welch, M. Welch, D. Piwnica-Worms, 2005, Molecular imaging.

Radiopharmaceutical for SPECT and PET of MDR1 P-Glycoprotein Transport Activity In Vivo: Validation in Multidrug-Resistant Tumors and at the Blood-Brain Barrier

D. Piwnica-Worms, G. Kruh, M. Belinsky, 2005 .

Molecular Imaging in Oncology

R. Wahl, D. Piwnica-Worms, G. Luker, 2003 .

Perspectives in Imaging: Present and Future Prospects of Clinical Molecular Imaging

D. Piwnica-Worms, 2003 .

Characterization of a novel 99mTc-carbonyl complex as a functional probe of MDR1 P-glycoprotein transport activity.

D. Piwnica-Worms, C. Pica, J. Dahlheimer, 2002, Molecular imaging.

Charaterization of Tc-99m-tricarbonyl complexes as transport substrates of the multidrug resistance (MDR1) P-glycoprotein

D. Piwnica-Worms, J. Dahlheimer, M. Dyszlewski, 2001 .

Beyond the Genome: Molecular Imaging in Vivo with PET and SPECT☆

D. Piwnica-Worms, G. Luker, G. Luker, 2001 .

Effects of MDR1 and MDR3 P-glycoproteins, MRP1, and BCRP/MXR/ABCP on the transport of (99m)Tc-tetrofosmin.

D. Piwnica-Worms, G. Luker, K. Luker, 2000, Biochemical pharmacology.

Imaging Gene Expression in Cancer: Functional Identification of Multidrug Resistance P-glycoprotein In Vivo

D. Piwnica-Worms, G. Luker, K. Luker, 2000 .

Assessment of Multidrug Resistance

D. Piwnica-Worms, G. Luker, K. Luker, 1999 .

Modulation of the multidrug resistance P-glycoprotein: detection with technetium-99m-sestamibi in vivo.

J. Dobkin, P. Fracasso, D. Piwnica-Worms, 1997, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

T-cell Activation Promotes Tumorigenesis in Inflammation-associated Cancer Recommended Citation Retrovirology T-cell Activation Promotes Tumorigenesis in Inflammation-associated Cancer

Edu, L. Ratner, J. Harding, 2022 .

Combining hyperpolarized real-time metabolic imaging and NMR spectroscopy to identify metabolic biomarkers in pancreatic cancer.

S. Sen, A. Maitra, J. Fleming, 2019, Journal of proteome research.

Multidrug Resistance (MDR1) P-glycoprotein Enhances Esterification of Plasma Membrane Cholesterol*

D. Piwnica-Worms, G. Luker, D. Covey, 1999, The Journal of Biological Chemistry.

Evaluating new therapies in gastrointestinal stromal tumor using in vivo molecular optical imaging

James R. Johnson, K. Devarajan, A. Godwin, 2013, Cancer biology & therapy.

P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model.

A. Fagan, D. Holtzman, S. Paul, 2005, The Journal of clinical investigation.

Tumor receptor imaging: proceedings of the National Cancer Institute workshop, review of current work, and prospective for further investigations.

C. Osborne, R. Reba, R. Coleman, 1995, Clinical cancer research : an official journal of the American Association for Cancer Research.

DAPK3 Suppresses Acini Morphogenesis and Is Required for Mouse Development

D. Piwnica-Worms, L. White, B. Kocher, 2014, Molecular Cancer Research.

Strain-specific susceptibility for pulmonary metastasis of sarcoma 180 cells in inbred mice.

M. You, H. Vikis, A. Franklin, 2010, Cancer research.

Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo

G. Shulman, L. Cantley, J. Lennerz, 2007, Proceedings of the National Academy of Sciences.

In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia.

W. Shannon, J. Dipersio, E. Deych, 2010, Blood.

Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance.

T. Ley, D. Piwnica-Worms, T. Fehniger, 2007, Immunity.

Overexpression of IRF9 confers resistance to antimicrotubule agents in breast cancer cells.

R. Schreiber, D. Piwnica-Worms, K. Luker, 2001, Cancer research.

Myeloid cell–derived HOCl is a paracrine effector that trans-inhibits IKK/NF-κB in melanoma cells and limits early tumor progression

D. Piwnica-Worms, Ping Yang, S. Gammon, 2021, Science Signaling.

Identification of FUSE-binding protein 1 as a regulatory mRNA-binding protein that represses nucleophosmin translation

D. Piwnica-Worms, R. Townsend, B. Moss, 2011, Oncogene.

Novel gallium(III) complexes transported by MDR1 P-glycoprotein: potential PET imaging agents for probing P-glycoprotein-mediated transport activity in vivo.

M. Welch, A. Beatty, D. Piwnica-Worms, 2000, Chemistry & biology.

Characterization of Drug Specificity by Pharmacokinetic Analysis in Gene Knockout Mice

D. Piwnica-Worms, Mary Marmion, Mary Marmion, 1999, Journal of clinical pharmacology.

An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors.

D. Piwnica-Worms, M. Diamond, C. Weihl, 2012, Human molecular genetics.

Inhibition of myeloperoxidase enhances immune checkpoint therapy for melanoma

Wencai Ma, D. Piwnica-Worms, S. Gammon, 2023, Journal for ImmunoTherapy of Cancer.

In vivo optical imaging of acute cell death using a near-infrared fluorescent zinc-dipicolylamine probe.

James R. Johnson, Sarah Chapman, Wei Wang, 2011, Molecular pharmaceutics.

Advances in bioluminescence imaging of live animal models.

Robin S. Dothager, D. Piwnica-Worms, M. Pan, 2009, Current opinion in biotechnology.

Type I interferons link viral infection to enhanced epithelial turnover and repair.

H. Piwnica-Worms, D. Lenschow, H. Virgin, 2015, Cell host & microbe.

Stably Integrated luxCDABE for Assessment of Salmonella Invasion Kinetics

Aashish Manglik, David Piwnica-Worms, D. Piwnica-Worms, 2008, Molecular imaging.

Dissection of platelet and myeloid cell defects by conditional targeting of the β3‐integrin subunit

J. Schneider, T. E. Baroni, E. Morgan, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts.

D. Piwnica-Worms, A. Hirbe, M. Rogers, 2009, Bone.

Imaging spontaneous tumorigenesis: inflammation precedes development of peripheral NK tumors.

L. Ratner, J. Harding, D. Piwnica-Worms, 2009, Blood.

Real-time imaging of ligand-induced IKK activation in intact cells and in living mice

David Piwnica-Worms, D. Piwnica-Worms, S. Gross, 2005, Nature Methods.

Fasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survival

Robert Pless, H. Piwnica-Worms, Kelsey L. Tinkum, 2015, Proceedings of the National Academy of Sciences.

IL-12 Stimulates Interferon-Gamma Mediated Inhibition of Tumor-Induced Regulatory T Cell Proliferation and Enhances Tumor Clearance

T. Ley, R. Schreiber, D. Piwnica-Worms, 2008 .

Agents in Breast Cancer Cells Overexpression of IRF 9 Confers Resistance to Antimicrotubule Updated Version

R. Schreiber, D. Piwnica-Worms, K. Luker, 2001 .

Overexpression of IRF 9 Confers Resistance to Antimicrotubule Agents in Breast Cancer Cells 1

R. Schreiber, D. Piwnica-Worms, K. Luker, 2001 .

Interrogation of Inhibitor of Nuclear Factor κB α/Nuclear Factor κB (IκBα/NF-κB) Negative Feedback Loop Dynamics

C. Contag, D. Piwnica-Worms, B. Moss, 2012, The Journal of Biological Chemistry.

Intracellular Calcium Regulates Nonsense-Mediated mRNA Decay

D. Piwnica-Worms, P. Nugent, Zhongsheng You, 2014, Nature Medicine.

Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone

E. Morgan, D. Piwnica-Worms, A. Hirbe, 2007, Proceedings of the National Academy of Sciences.

Early Detection of Pancreatic Intraepithelial Neoplasias (PanINs) in Transgenic Mouse Model by Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy

S. Sen, A. Maitra, Shayan Shams, 2020, International journal of molecular sciences.

Biochemical and in vivo characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis.

Dustin J. Maxwell, D. Piwnica-Worms, S. Gammon, 2007, Biochemistry.

Multidrug resistance P-glycoprotein monoclonal antibody JSB-1 crossreacts with pyruvate carboxylase.

D. Anthony, D. Piwnica-Worms, V. Rao, 1995, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Monitoring proteasome activity in cellulo and in living animals by bioluminescent imaging: technical considerations for design and use of genetically encoded reporters.

D. Piwnica-Worms, S. Gross, Shimon Gross, 2005, Methods in enzymology.

Measuring the Metabolic Evolution of Glioblastoma throughout Tumor Development, Regression, and Recurrence with Hyperpolarized Magnetic Resonance

G. Fuller, C. Logothetis, J. Gumin, 2021, bioRxiv.

Dynamic Analysis of the Epidermal Growth Factor (EGF) Receptor-ErbB2-ErbB3 Protein Network by Luciferase Fragment Complementation Imaging*

R. Landgraf, D. Piwnica-Worms, L. Pike, 2013, The Journal of Biological Chemistry.

Generation of a highly inducible Gal4→Fluc universal reporter mouse for in vivo bioluminescence imaging

Gary D Luker, Julie L Prior, David Piwnica-Worms, 2008, Proceedings of the National Academy of Sciences.

Monitoring Molecular-Specific Pharmacodynamics of Rapamycin In vivo with Inducible Gal4→Fluc Transgenic Reporter Mice

D. Piwnica-Worms, M. Pan, Julie L. Prior, 2010, Molecular Cancer Therapeutics.

Single-Cell Resolution Imaging of Retinal Ganglion Cell Apoptosis In Vivo Using a Cell-Penetrating Caspase-Activatable Peptide Probe

James R. Johnson, D. Piwnica-Worms, S. Gammon, 2014, PloS one.

Permeation Peptide Conjugates for In Vivo Molecular Imaging Applications

D. Piwnica-Worms, V. Villalobos, S. Gammon, 2006, Molecular imaging.

Noninvasive optical imaging of staphylococcus aureus bacterial infection in living mice using a Bis-dipicolylamine-Zinc(II) affinity group conjugated to a near-infrared fluorophore.

James R. Johnson, W. M. Leevy, Bradley D. Smith, 2008, Bioconjugate chemistry.

Breast Cancer Cell Targeting by Prenylation Inhibitors Elucidated in Living Animals with a Bioluminescence Reporter

K. Kaltenbronn, K. Blumer, D. Piwnica-Worms, 2012, Clinical Cancer Research.

Reporter Elucidated in Living Animals with a Bioluminescence Breast Cancer Cell Targeting by Prenylation Inhibitors

K. Kaltenbronn, K. Blumer, D. Piwnica-Worms, 2012 .

Hyperpolarized [1-13C]pyruvate-to-[1-13C]lactate conversion is rate-limited by monocarboxylate transporter-1 in the plasma membrane

Y. Xi, D. Piwnica-Worms, P. Bhattacharya, 2020, Proceedings of the National Academy of Sciences.

Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-Time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia

C. Wood, M. Konopleva, D. Piwnica-Worms, 2019, Molecular Cancer Therapeutics.

Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation.

R. Mach, D. Piwnica-Worms, R. Faccio, 2013, Cancer discovery.

Recent advances in imaging the lungs of intact small animals.

Attila Kovacs, David Piwnica-Worms, D. Piwnica-Worms, 2004, American journal of respiratory cell and molecular biology.

In Vitro and In Vivo Characterization of a Dual-Function Green Fluorescent Protein–HSV1-Thymidine Kinase Reporter Gene Driven by the Human Elongation Factor 1α Promoter

J. Milbrandt, T. Fahrner, D. Piwnica-Worms, 2002 .

Selective cell uptake of modified Tat peptide-fluorophore conjugates in rat retina in ex vivo and in vivo models.

David Piwnica-Worms, D. Piwnica-Worms, K. Bullok, 2006, Investigative ophthalmology & visual science.

Novel Tat-peptide chelates for direct transduction of technetium-99m and rhenium into human cells for imaging and radiotherapy.

D. Piwnica-Worms, G. Luker, C. Pica, 2000, Bioconjugate chemistry.

An improved cell-penetrating, caspase-activatable, near-infrared fluorescent peptide for apoptosis imaging.

David Piwnica-Worms, Dustin J. Maxwell, D. Piwnica-Worms, 2009, Bioconjugate chemistry.

Real-Time Imaging of Notch Activation with a Luciferase Complementation-Based Reporter

Raphael Kopan, D. Piwnica-Worms, S. Lim, 2011, Science Signaling.

Prospective double-blinded comparison of MR imaging and aortography in the preoperative evaluation of abdominal aortic aneurysms.

D. Harrington, M. Donaldson, D. Piwnica-Worms, 1992, Journal of vascular and interventional radiology : JVIR.

Nucleoside Diphosphate Kinase-3 (NME3) Enhances TLR5-Induced NFκB Activation

D. Piwnica-Worms, Yue Wang, Hongtu Zhu, 2018, Molecular Cancer Research.

Nucleoside Diphosphate Kinase-3 (NME3) Enhances TLR5-Induced NFkB Activation

D. Piwnica-Worms, Yue Wang, Hongtu Zhu, 2018 .

Luciferase Fragment Complementation Imaging of Conformational Changes in the Epidermal Growth Factor Receptor*

D. Piwnica-Worms, L. Pike, M. Ilagan, 2009, Journal of Biological Chemistry.

Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [18F]FAZA PET In Vivo

M. Dewhirst, O. Mawlawi, J. D. de Groot, 2019, Cells.

Synthesis of a [(18)F]-labeled ceritinib analogue for positron emission tomography of anaplastic lymphoma kinase, a receptor tyrosine kinase, in lung cancer.

D. Piwnica-Worms, M. Alauddin, S. Perera, 2016, Journal of labelled compounds & radiopharmaceuticals.

Interrogating Cellular Communication in Cancer with Genetically Encoded Imaging Reporters.

D. Piwnica-Worms, S. Gammon, Tracy W. Liu, 2020, Radiology. Imaging cancer.

Characterization of Coelenterazine Analogs for Measurements of Renilla Luciferase Activity in Live Cells and Living Animals

D. Stevenson, C. Contag, Hui Zhao, 2004 .

Cerenkov Radiation Energy Transfer (CRET) Imaging: A Novel Method for Optical Imaging of PET Isotopes in Biological Systems

Erin Jackson, Robin S. Dothager, David Piwnica-Worms, 2010, PloS one.

TAT-Bim Induces Extensive Apoptosis in Cancer Cells

R. Hotchkiss, K. Trinkaus, D. Piwnica-Worms, 2007, Annals of Surgical Oncology.

CD8+ T cells regulate bone tumor burden independent of osteoclast resorption.

D. Piwnica-Worms, A. Hirbe, R. Faccio, 2011, Cancer research.

Single-cell imaging of retinal ganglion cell apoptosis with a cell-penetrating, activatable peptide probe in an in vivo glaucoma model

David Piwnica-Worms, Dustin J. Maxwell, D. Piwnica-Worms, 2009, Proceedings of the National Academy of Sciences.

Imaging: Strategies, Controversies, and Opportunities

R. Blasberg, D. Piwnica-Worms, 2012, Clinical Cancer Research.

Molecular imaging strategies for drug discovery and development.

D. Piwnica-Worms, S. Gross, Shimon Gross, 2006, Current opinion in chemical biology.

CXCR 4 Regulates Growth of Both Primary and Metastatic Breast Cancer

D. Piwnica-Worms, G. Luker, K. Luker, 2004 .

Structure-activity relationships, kinetics, selectivity, and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cells.

Vladimir Torchilin, Oscar Murillo, W. M. Leevy, 2005, Organic & biomolecular chemistry.

In vivo cell death mediated by synthetic ion channels.

W. M. Leevy, George W Gokel, David Piwnica-Worms, 2011, Chemical communications.

Molecular imaging of pulmonary disease in vivo.

Robin S. Dothager, D. Piwnica-Worms, 2009, Proceedings of the American Thoracic Society.

Spatial and Temporal Confined Photothermolysis of Cancer Cells Mediated by Hollow Gold Nanospheres Targeted to Epidermal Growth Factor Receptors

G. Ku, D. Piwnica-Worms, John H. Ye, 2018, ACS omega.

PET imaging of heat-inducible suicide gene expression in mice bearing head and neck squamous cell carcinoma xenografts

E. Moros, D. Piwnica-Worms, J. Parry, 2009, Cancer Gene Therapy.

Prospective comparison of T2-weighted fast spin-echo, with and without fat suppression, and conventional spin-echo pulse sequences in the upper abdomen.

S E Seltzer, C M Tempany, C. Tempany, 1993, Radiology.

Simultaneous inhibition of hedgehog signaling and tumor proliferation remodels stroma and enhances pancreatic cancer therapy.

A. Maitra, Huamin Wang, J. Bankson, 2018, Biomaterials.

Development of a Potential Gallium-68-Labelled Radiotracer Based on DOTA-Curcumin for Colon-Rectal Carcinoma: From Synthesis to In Vivo Studies

D. Piwnica-Worms, M. Asti, M. Iori, 2019, Molecules.

Molecular imaging of protein-protein interactions in living animals

D. Piwnica-Worms, V. Villalobos, K. Luker, 2005 .

Identification of a Ligand-induced Transient Refractory Period in Nuclear Factor-κB Signaling*

D. Piwnica-Worms, B. Moss, S. Gross, 2008, Journal of Biological Chemistry.

Independent Circadian Oscillations of Period1 in Specific Brain Areas In Vivo and In Vitro

E. Herzog, D. Piwnica-Worms, D. Granados-Fuentes, 2005, The Journal of Neuroscience.

Novel chemical library screen identifies naturally occurring plant products that specifically disrupt glioblastoma-endothelial cell interactions

N. Warrington, D. Piwnica-Worms, Rajarshi Sengupta, 2015, Oncotarget.

Introduction to molecular imaging.

D. Piwnica-Worms, 2004, Journal of the American College of Radiology : JACR.

Optimizing luciferase protein fragment complementation for bioluminescent imaging of protein-protein interactions in live cells and animals.

Kathryn E Luker, David Piwnica-Worms, D. Piwnica-Worms, 2004, Methods in enzymology.

Axonal Transport as an In Vivo Biomarker for Retinal Neuropathy

D. Piwnica-Worms, M. Pagel, D. Schellingerhout, 2020, Cells.

Quantitation of pulmonary transgene expression with PET imaging.

M. Mintun, P. Factor, D. Ponde, 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Streamlining the Quantitative Metrics Workflow at a Comprehensive Cancer Center.

Priya R Bhosale, Sujaya H Rao, Mayur Virarkar, 2020, Academic radiology.

[(18)F]FHBG PET/CT Imaging of CD34-TK75 Transduced Donor T Cells in Relapsed Allogeneic Stem Cell Transplant Patients: Safety and Feasibility.

R. Fulton, K. Cornetta, J. Dipersio, 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

Imaging pulmonary gene expression with positron emission tomography.

C. Dence, D. Ponde, P. Reynolds, 2003, American journal of respiratory and critical care medicine.

Visualizing protein-protein interactions in living animals.

Gary D Luker, David Piwnica-Worms, Vijay Sharma, 2003, Methods.

A Reversible Shift of Driver Dependence from EGFR to Notch1 in Non-Small Cell Lung Cancer as a Cause of Resistance to Tyrosine Kinase Inhibitors

L. Byers, D. Piwnica-Worms, M. Stoppelli, 2021, Cancers.

Evaluation of 89Zr-Labeled Anti-PD-L1 Monoclonal Antibodies Using DFO and Novel HOPO Analogues as Chelating Agents for Immuno-PET

M. Hung, D. Piwnica-Worms, M. Alauddin, 2023, ACS omega.

Bioluminescence Imaging of Period1 Gene Expression in Utero

Sara J. Aton, C. Hildebolt, E. Herzog, 2007, Molecular imaging.

Nano in cancer: linking chemistry, biology, and clinical applications in vivo.

Robin S. Dothager, D. Piwnica-Worms, 2011, Cancer research.

Proteasome inhibition blocks ligand-induced dynamic processing and internalization of epidermal growth factor receptor via altered receptor ubiquitination and phosphorylation.

D. Piwnica-Worms, M. Samrakandi, A. Kesarwala, 2009, Cancer research.

Gender Differences in a Mouse Model of Hepatocellular Carcinoma Revealed Using Multi-Modal Imaging

G. Gores, L. Beretta, D. Piwnica-Worms, 2023, Cancers.

Imaging protein-protein interactions in whole cells and living animals.

D. Piwnica-Worms, K. Luker, David Piwnica-Worms, 2005, Ernst Schering Research Foundation workshop.

Mechanics of EGF Receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging

Linda J Pike, David Piwnica-Worms, D. Piwnica-Worms, 2011, Proceedings of the National Academy of Sciences.

Veni, vidi, vici: in vivo molecular imaging of immune response.

David Piwnica-Worms, D. Piwnica-Worms, B. Moss, 2007, Immunity.

Second-Generation Triple Reporter for Bioluminescence, Micro–Positron Emission Tomography, and Fluorescence Imaging

Julie L Prior, David Piwnica-Worms, Vijay Sharma, 2006, Molecular imaging.

Imaging Cellular Networks and Protein-Protein Interactions In Vivo

D. Piwnica-Worms, Snehal Naik, B. Moss, 2008 .

Molecular and Cellular Pathobiology the Neurofibromatosis Type 1 Tumor Suppressor Controls Cell Growth by Regulating Signal Transducer and Activator of Transcription-3 Activity in Vitro and in Vivo

K. Reilly, Sutapa Banerjee, D. Gutmann, 2022 .

Breast Cancer CXCR 4 Regulates Growth of Both Primary and Metastatic

D. Piwnica-Worms, G. Luker, K. Luker, 2004 .

Intracellular water‐specific MR of microbead‐adherent cells: the HeLa cell intracellular water exchange lifetime

J. Neil, C. Kroenke, J. Ackerman, 2008, NMR in biomedicine.

Intracellular water specific MR of microbead‐adherent cells: Hela cell intracellular water diffusion

A. Sukstanskii, J. Neil, C. Kroenke, 2008, Magnetic resonance in medicine.

High grade gliomas

C. Q. Lee, David T. W. Jones, Michael D. Brooks, 2022, Progress in Brain Research.

The Neurofibromatosis Type 1 Tumor Suppressor Controls Cell Growth by Regulating Signal Transducer and Activator of Transcription-3 Activity In vitro and In vivo

K. Reilly, D. Gutmann, D. Piwnica-Worms, 2010 .

Molecular and Cellular Pathobiology the Neurofibromatosis Type 1 Tumor Suppressor Controls Cell Growth by Regulating Signal Transducer and Activator of Transcription-3 Activity in Vitro and in Vivo

Karlyne M. Reilly, K. Reilly, Sutapa Banerjee, 2022 .

Synthesis, characterization, and molecular structure of a gallium(III) complex of an amine-phenol ligand with activity against chloroquine-sensitive Plasmodium falciparum strains.

D. Goldberg, D. Piwnica-Worms, Joe A. Ocheskey, 2003, Journal of inorganic biochemistry.

An anti-apoptotic peptide improves survival in lethal total body irradiation.

P. Grigsby, R. Hotchkiss, J. McDunn, 2009, Biochemical and biophysical research communications.

Targeted Inhibition of Cyclic AMP Phosphodiesterase-4 Promotes Brain Tumor Regression

N. Warrington, D. Limbrick, D. Piwnica-Worms, 2008, Clinical Cancer Research.

Strain-specific susceptibility for pulmonary metastasis of sarcoma 180 cells in inbred mice.

M. You, H. Vikis, A. Franklin, 2010, Cancer Research.

Real-Time Imaging of Notch Activation with a Luciferase Complementation-Based Reporter

Raphael Kopan, D. Piwnica-Worms, M. Ilagan, 2011, Science Signaling.

Novel chemical library screen identifies naturally occurring plant products that specifically disrupt glioblastoma-endothelial cell interactions

N. Warrington, D. Piwnica-Worms, Rajarshi Sengupta, 2015, Oncotarget.

CD8+ T cells regulate bone tumor burden independent of osteoclast resorption.

D. Piwnica-Worms, A. Hirbe, R. Faccio, 2011, Cancer research.

LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy

G. Bu, D. Piwnica-Worms, Chia-Chen Liu, 2010, Proceedings of the National Academy of Sciences.

imaging in living transgenic mice growth factor gene expression using bioluminescence Noninvasive indirect imaging of vascular endothelial

R. Blasberg, S. Gambhir, M. Iyer, 2015 .

Multiwalled Carbon Nanotubes for Combination Therapy: a Biodistribution and Efficacy Pilot Study.

H. Piwnica-Worms, P. Paoli, D. Piwnica-Worms, 2019, Journal of materials chemistry. B.

Illuminating cancer systems with genetically engineered mouse models and coupled luciferase reporters in vivo.

D. Piwnica-Worms, B. Kocher, 2013, Cancer discovery.

Dual-color click beetle luciferase heteroprotein fragment complementation assays.

Robin S. Dothager, D. Piwnica-Worms, V. Villalobos, 2010, Chemistry & biology.

Production, processing and uses of 94mTc

M. Welch, D. Piwnica-Worms, D. McCarthy, 2001 .

Detection of protein-protein interactions in live cells and animals with split firefly luciferase protein fragment complementation.

D. Piwnica-Worms, V. Villalobos, Snehal Naik, 2008, Methods in molecular biology.

Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression.

D. Piwnica-Worms, Elise Alspach, Julie L. Prior, 2012, Cancer research.

Evaluating new therapies in gastrointestinal stromal tumor using in vivo molecular optical imaging

James R. Johnson, K. Devarajan, A. Godwin, 2014, Cancer Biology & Therapy.

Senescent stromal-derived osteopontin promotes preneoplastic cell growth.

D. Piwnica-Worms, Xianmin Luo, S. Demehri, 2009, Cancer research.

T-cell activation promotes tumorigenesis in inflammation-associated cancer

L. Ratner, J. Harding, D. Piwnica-Worms, 2009, Retrovirology.

Breast Cancer Cell Targeting by Prenylation Inhibitors Elucidated in Living Animals with a Bioluminescence Reporter

K. Kaltenbronn, K. Blumer, D. Piwnica-Worms, 2012, Clinical Cancer Research.