Ami Miller

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Multimeric antibodies with increased valency surpassing functional affinity and potency thresholds using novel formats

T. Rabbitts, Ami Miller, S. Carr, 2020, mAbs.

KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe

P. Kolasinska-Zwierz, J. Breed, J. Debreczeni, 2019, Nature Communications.

Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.

S. Phillips, T. Rabbitts, Ami Miller, 2019 .

Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds

S. Phillips, T. Rabbitts, Ami Miller, 2019, Proceedings of the National Academy of Sciences.

Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment

Narcis Fernandez-Fuentes, S. Phillips, T. Rabbitts, 2018, Nature Communications.

A cell-based screening method using an intracellular antibody for discovering small molecules targeting the translocation protein LMO2

T. Rabbitts, Ami Miller, F. Raynaud, 2021, Science Advances.

eview omplement Factor H – ligand interactions : Self-association , multivalency and issociation constants tephen

Ami Miller, Sanaullah Khan, Keying Li, 2011 .

BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions

S. Phillips, T. Rabbitts, Ami Miller, 2018, eLife.

Two distinct conformations of factor H regulate discrete complement-binding functions in the fluid phase and at cell surfaces

Ami Miller, S. Perkins, J. Gor, 2018, The Journal of Biological Chemistry.

Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled*

Jie J. Zheng, Dianqing Wu, Ami Miller, 2015, The Journal of Biological Chemistry.

Cloning, purification and structure determination of the HIV integrase-binding domain of lens epithelium-derived growth factor

S. Phillips, T. Rabbitts, O. Platonova, 2018, Acta Crystallographica Section F Structural Biology Communications.

Application of a Method for Engineering Multivalent Antibodies to Substantially Enhance Functional affinity of Clinical Trial Anti-SARS-CoV-2 Antibodies

T. Rabbitts, Ami Miller, G. Mattiuzzo, 2021 .

Implementing a method for engineering multivalency to substantially enhance binding of clinical trial anti-SARS-CoV-2 antibodies to wildtype spike and variants of concern proteins

R. V. van Montfort, T. Rabbitts, Ami Miller, 2021, Scientific Reports.

Complement factor H-ligand interactions: self-association, multivalency and dissociation constants.

Ami Miller, S. Perkins, Sanaullah Khan, 2012, Immunobiology.

The His402 allotype of complement factor H show similar self-association to the Tyr402 allotype but exhibits greater self-association in the presence of zinc

Ami Miller, S. Perkins, J. Gor, 2010 .

Surfaceome interrogation using an RNA-seq approach highlights leukemia initiating cell biomarkers in an LMO2 T cell transgenic model

P. Kearns, C. Mecucci, T. Rabbitts, 2019, Scientific Reports.

Near-planar Solution Structures of Mannose-binding Lectin Oligomers Provide Insight on Activation of Lectin Pathway of Complement

R. Wallis, Ami Miller, S. Perkins, 2011, The Journal of Biological Chemistry.

Pan RAS-binding compounds selected from a chemical library by inhibiting interaction between RAS and a reduced affinity intracellular antibody

R. V. van Montfort, T. Rabbitts, Ami Miller, 2021, Scientific Reports.

A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS

T. Rabbitts, Ami Miller, N. Bery, 2020, Nature Communications.

Complement Factor H Binds at Two Independent Sites to C-reactive Protein in Acute Phase Concentrations*♦

Ami Miller, S. Perkins, J. Gor, 2009, The Journal of Biological Chemistry.

Immunopolymer Lipid Nanoparticles for Delivery of Macromolecules to Antigen-Expressing Cells.

T. Rabbitts, Ami Miller, C. Bataille, 2020, ACS applied bio materials.

Complement factor H binds at two independent sites to C-reactive protein in acute phase concentrations

Ami Miller, S. Perkins, J. Gor, 2010 .

Zinc Binding to the Tyr402 and His402 Allotypes of Complement Factor H: Possible Implications for Age-Related Macular Degeneration

Imre Lengyel, Jayesh Gor, Stephen J. Perkins, 2011, Journal of molecular biology.

Zinc binding to the Tyr 402 and His 402 allotypes of complement factor H : possible implications for age-related macular degeneration

Imre Lengyel, Jayesh Gor, Stephen J. Perkins, 2010 .

Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein

S. Phillips, T. Rabbitts, A. Simmons, 2017, Scientific Reports.

KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe

P. Kolasinska-Zwierz, J. Breed, J. Debreczeni, 2019, Nature Communications.

A tetrameric ACE2 protein broadly neutralizes SARS-CoV-2 spike variants of concern with elevated potency

T. Rabbitts, Ami Miller, Hanif Ali, 2021, Antiviral Research.

Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein

S. Phillips, T. Rabbitts, A. Simmons, 2017, Scientific Reports.

Multiple interactions of complement Factor H with its ligands in solution: a progress report.

Ami Miller, S. Perkins, Sanaullah Khan, 2010, Advances in experimental medicine and biology.

Competitive SPR using an intracellular anti-LMO2 antibody identifies novel LMO2-interacting compounds

T. Rabbitts, Ami Miller, F. Raynaud, 2021, Journal of immunological methods.

KRAS full length G12V GPPNHP

S. Phillips, T. Rabbitts, Ami Miller, 2019 .

Surfaceome interrogation using an RNA-seq approach highlights leukemia initiating cell biomarkers in an LMO2 T cell transgenic model

Ami Miller, N. Bery, Helio Pais, 2019, Scientific Reports.

Immunopolymer Lipid Nanoparticles for Delivery of Macromolecules to Antigen-Expressing Cells.

T. Rabbitts, Ami Miller, C. Bataille, 2020, ACS applied bio materials.