Lei Wang

发表

A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time.

Lei Wang, G. Wahl, Yao-Cheng Li, 2014, Cell reports.

Structure-activity and structure-property relationships of novel Nrf2 activators with a 1,2,4-oxadiazole core and their therapeutic effects on acetaminophen (APAP)-induced acute liver injury.

Li Li, Lei Wang, Q. You, 2018, European journal of medicinal chemistry.

Optimization and biological evaluation of celastrol derivatives as Hsp90-Cdc37 interaction disruptors with improved druglike properties.

Lei Wang, Q. You, Xiaoli Xu, 2016, Bioorganic & medicinal chemistry.

Beyond Proteolysis-Targeting Chimeric Molecules: Designing Heterobifunctional Molecules Based on Functional Effectors.

Lei Wang, Q. You, Ruoning Wang, 2022, Journal of medicinal chemistry.

Design, synthesis and bioevaluation of inhibitors targeting HSP90-CDC37 protein-protein interaction based on a hydrophobic core.

Lei Wang, Q. You, Lixiao Zhang, 2020, European journal of medicinal chemistry.

3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation

Li Li, Lei Wang, Q. You, 2018, Oxidative medicine and cellular longevity.

Corrigendum to “3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1, 2, 4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation”

Li Li, Lei Wang, Q. You, 2018, Oxidative medicine and cellular longevity.

Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 (Cdc37) As Orally Active Inhibitors for the treatment of colorectal cancer.

Li Li, Lei Wang, Q. You, 2020, Journal of medicinal chemistry.

Heat shock protein 90 (Hsp90) Inhibitors: An Update on Achievements, Challenges, and Future Directions.

Li Li, Lei Wang, Q. You, 2020, Journal of medicinal chemistry.

NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction

Lei Wang, Hao-Peng Sun, Chao Zhang, 2016, Oncotarget.

Insight into Thermodynamic and Kinetic Profiles in Small-Molecule Optimization.

Lei Wang, Q. You, Wei Liu, 2022, Journal of medicinal chemistry.

A decade of approved first-in-class small molecule orphan drugs: Achievements, challenges and perspectives.

Lei Wang, Q. You, Qiuyu Wu, 2022, European journal of medicinal chemistry.

Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification.

Li Li, W. Dai, Lei Wang, 2021, Cell chemical biology.

Methods for the Discovery and Identification of Small Molecules Targeting Oxidative Stress-Related Protein–Protein Interactions: An Update

Lei Wang, Q. You, Heng-Yuan Zhang, 2022, Antioxidants.

Targeting the HSP90–CDC37–kinase chaperone cycle: A promising therapeutic strategy for cancer

Lei Wang, Q. You, Qiuyue Zhang, 2021, Medicinal research reviews.

Modulation of protein fate decision by small molecules: targeting molecular chaperone machinery

Lei Wang, Q. You, Zhengyu Jiang, 2020, Acta pharmaceutica Sinica. B.

Optimization and bioevaluation of Cdc37-derived peptides: An insight into Hsp90-Cdc37 protein-protein interaction modulators.

Li Li, Lei Wang, Q. You, 2017, Bioorganic & medicinal chemistry.

Protein Phosphatase 5-Recruiting Chimeras for Accelerating Apoptosis-Signal-Regulated Kinase 1 Dephosphorylation with Antiproliferative Activity.

Lei Wang, Q. You, Heng-Yuan Zhang, 2022, Journal of the American Chemical Society.

Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer

Jian Zhang, Li Li, Lei Wang, 2019, Science Advances.

Structure-based virtual screening and optimization of modulators targeting Hsp90-Cdc37 interaction.

Li Li, Xiao-Li Xu, Li Li, 2017, European journal of medicinal chemistry.

Dual function of protein phosphatase 5 (PPP5C): An emerging therapeutic target for drug discovery.

Lei Wang, Heng-Yuan Zhang, Qiuyue Zhang, 2023, European journal of medicinal chemistry.

Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90.

Lei Wang, Q. You, Dongdong Li, 2016, Journal of medicinal chemistry.

Discovery and identification of Cdc37-derived peptides targeting the Hsp90–Cdc37 protein–protein interaction

Lei Wang, Q. You, Zhengyu Jiang, 2015 .

Structure-based design and synthesis of small molecular inhibitors disturbing the interaction of MLL1-WDR5.

Lei Wang, Q. You, Yi-Yue Xie, 2016, European journal of medicinal chemistry.

Effective Screening Strategy Using Ensembled Pharmacophore Models Combined with Cascade Docking: Application to p53-MDM2 Interaction Inhibitors

Fang Liu, Xiaoli Xu, Lei Wang, 2013, J. Chem. Inf. Model..

A toxicology study to evaluate the embryotoxicity of metformin compared with the hypoglycemic drugs, the anticancer drug, the anti‐epileptic drug, the antibiotic, and the cyclo‐oxygenase (COX)‐2 inhibitor

Lei Wang, Changxiao Liu, Xiuping Shen, 2015, Journal of diabetes.

Synthesis of novel 6,7-dimethoxy-4-anilinoquinolines as potent c-Met inhibitors

Lei Wang, Lei Shi, Qing-Wen Zhang, 2018, Journal of enzyme inhibition and medicinal chemistry.

Design of Tracers in Fluorescence Polarization Assay for Extensive Application in Small Molecule Drug Discovery.

Lei Wang, Qiuyue Zhang, Liwen Hua, 2023, Journal of medicinal chemistry.

Small molecules targeting molecular chaperones for tau regulation: Achievements and challenges.

Lei Wang, Qidong You, Danni Wang, 2023, European journal of medicinal chemistry.

Targeting phosphatases: From molecule design to clinical trials.

Lei Wang, Qidong You, Mochen Guo, 2023, European journal of medicinal chemistry.

Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities

Lei Wang, Qiuyue Zhang, Zeyu Han, 2024, Acta pharmaceutica Sinica. B.

Forward or Backward: Lessons Learned from Small Molecule Drugs Approved by FDA from 2012 to 2022

Lei Wang, Qidong You, Mingxiao Gu, 2023, Molecules.

Rational design of peptide inhibitors targeting HSP90-CDC37 protein-protein interaction.

Lei Wang, Qiuyue Zhang, Qidong You, 2024, Future medicinal chemistry.