Yijun Huang

发表

Transient protein states in designing inhibitors of the MDM2-p53 interaction.

Alexander Dömling, Michal Bista, Kareem Khoury, 2013, Structure.

Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists

Grzegorz M. Popowicz, Alexander Dömling, Carlos J. Camacho, 2012, PloS one.

Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists.

Alexander Dömling, Michal Bista, Stuti Srivastava, 2010, Angewandte Chemie.

New macrocycles with potent antituberculosis activity accessed by one-pot multicomponent reactions

Yijun Huang, Kan Wang, A. Dömling, 2013, Chemistry of Heterocyclic Compounds.

Discovery of small molecule inhibitors of protein-protein interactions

Yijun Huang, 2011 .

In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of pyrazole-based small molecule inhibitors of Mdm2/4–p53 interaction

A. Dömling, Yijun Huang, J. Beumer, 2015, Cancer Chemotherapy and Pharmacology.

The Piperazine Space in Isocyanide-based MCR Chemistry

A. Dömling, K. Khoury, Yijun Huang, 2010 .

Discovery of Highly Potent p53-MDM2 Antagonists and Structural Basis for Anti-Acute Myeloid Leukemia Activities

T. Holak, A. Dömling, G. Popowicz, 2014, ACS chemical biology.

Evolution of compstatin family as therapeutic complement inhibitors

Yijun Huang, 2018, Expert opinion on drug discovery.

Exhaustive Fluorine Scanning toward Potent p53–Mdm2 Antagonists

T. Holak, C. Camacho, A. Dömling, 2012, ChemMedChem.

18. Multicomponent Reactions

Yijun Huang, A. Dömling, Ahmed Yazbak and, 2012 .

Multicomponent synthesis of diverse 1,4-benzodiazepine scaffolds.

K. Khoury, Yijun Huang, A. Dömling, 2012, Organic letters.

Highly enantioselective Biginelli reaction using a new chiral ytterbium catalyst: asymmetric synthesis of dihydropyrimidines.

Yijun Huang, Chengjian Zhu, Feng-Yu Yang, 2006, Journal of the American Chemical Society.

1,4‐Thienodiazepine‐2,5‐diones via MCR (II): Scaffold Hopping by Gewald and Ugi‐Deprotection‐Cyclization Strategy

Yijun Huang, A. Dömling, 2010, Chemical biology & drug design.

Enantioselective ring-opening reaction of meso-epoxides with ArSeH catalyzed by heterometallic Ti-Ga-Salen system.

Yijun Huang, Yi Pan, Chengjian Zhu, 2005, Organic letters.

The Gewald multicomponent reaction

Yijun Huang, A. Dömling, 2011, Molecular Diversity.

Piperazine scaffolds via isocyanide-based multicomponent reactions

Yijun Huang, A. Dömling, 2010 .

Cyanoacetamide multicomponent reaction (I): Parallel synthesis of cyanoacetamides.

Yijun Huang, Kan Wang, A. Dömling, 2009, Journal of combinatorial chemistry.

1,4‐Thienodiazepine‐2,5‐diones via MCR (I): Synthesis, Virtual Space and p53‐Mdm2 Activity

T. Holak, C. Camacho, A. Dömling, 2010, Chemical biology & drug design.

Isocyanide‐Based Multicomponent Reactions towards Benzodiazepines

Yijun Huang, A. Dömling, 2012 .

Hantzsch 1,4-Dihydropyridine - An Effective and Convenient Reducing Agent

Yijun Huang, 2007 .

Enantioselective ring-opening reaction of meso-epoxides with ArSeH catalyzed by heterometallic Ti-Ga-Salen system.

Yijun Huang, Yi Pan, Chengjian Zhu, 2005, Organic letters.

Asymmetric Synthesis of Chiral Organoselenium Compounds

Yijun Huang, Chengjian Zhu, Cheng Huang, 2006 .

Fragment-Based Library Generation for the Discovery of a Peptidomimetic p53-Mdm4 Inhibitor

T. Holak, Katarzyna Guzik, A. Dömling, 2014, ACS combinatorial science.