B. Grasberger

发表

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

Maxwell D Cummings, B. Tomczuk, J. Spurlino, 2005, Journal of medicinal chemistry.

Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution

J. Clemente, R. DesJarlais, Robyn Miller, 2011, Protein science : a publication of the Protein Society.

Production, purification, and crystallization of human interleukin‐1β converting enzyme derived from an Escherichia coli expression system

B. Grasberger, J. Koehn, R. Alexander, 1995, Protein science : a publication of the Protein Society.

Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy.

Tianbao Lu, G. Bignan, M. Cummings, 2018, Bioorganic & medicinal chemistry letters.

Design and synthesis of 4,5-disubstituted-thiophene-2-amidines as potent urokinase inhibitors.

R. DesJarlais, J. Spurlino, C. Illig, 2002, Bioorganic & medicinal chemistry letters.

Abstract 801: Sensitivity of cell lines to Fatty Acid Synthase inhibitors depends on the lipid content in the cellular environment

Yolanda T. Chong, Tianbao Lu, G. Bignan, 2014 .

Analysis of the backbone dynamics of interleukin-8 by 15N relaxation measurements.

A. Gronenborn, G. Clore, B. Grasberger, 1993, Journal of molecular biology.

Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo

D. Parks, Tianbao Lu, J. Marugan, 2006, Molecular Cancer Therapeutics.

1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2-p53 interaction: discovery and SAR.

Maxwell D Cummings, D. Parks, Tianbao Lu, 2005, Bioorganic & medicinal chemistry letters.

Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors.

R. DesJarlais, J. Spurlino, C. Illig, 2001, Bioorganic & medicinal chemistry letters.

Structure-based design, synthesis and SAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors.

R. DesJarlais, J. Spurlino, C. Illig, 2001, Bioorganic & medicinal chemistry letters.

High-resolution structure of Ascaris trypsin inhibitor in solution: direct evidence for a pH-induced conformational transition in the reactive site.

A. Gronenborn, G. Clore, B. Grasberger, 1994, Structure.

Protein Engineering of the Colony-stimulating Factor-1 Receptor Kinase Domain for Structural Studies*

B. Grasberger, C. Schubert, I. Deckman, 2006, Journal of Biological Chemistry.

Effect of construct design on MAPKAP kinase-2 activity, thermodynamic stability and ligand-binding affinity.

R. DesJarlais, B. Grasberger, C. Schubert, 2006, Archives of biochemistry and biophysics.

Investigation of the backbone dynamics of the igg‐binding domain of streptococcal protein g by heteronuclear two‐dimensional 1H‐15N nuclear magnetic resonance spectroscopy

A. Gronenborn, G. Clore, B. Grasberger, 1994, Protein science : a publication of the Protein Society.

Interaction between proteins localized in membranes.

C DeLisi, C. DeLisi, A. Minton, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1

R. DesJarlais, D. Lin, Robyn Miller, 2021, Communications Biology.

Reconstitution of the high-affinity receptor for immunoglobulin E.

J. Kinet, B. Grasberger, 1989, Sub-cellular biochemistry.

Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein-protein interaction through structure-based drug design.

Maxwell D Cummings, D. Parks, Tianbao Lu, 2006, Bioorganic & medicinal chemistry letters.

Abstract 4747: Design and synthesis of a series highly potent and bioavailable FASN KR domain inhibitors for cancer

Tianbao Lu, G. Bignan, M. Cummings, 2014 .