C. Schubert

发表

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

Maxwell D Cummings, B. Tomczuk, J. Spurlino, 2005, Journal of medicinal chemistry.

Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution

J. Clemente, R. DesJarlais, Robyn Miller, 2011, Protein science : a publication of the Protein Society.

Enhancement of kinase selectivity in a potent class of arylamide FMS inhibitors.

B. Tomczuk, R. DesJarlais, S. Meegalla, 2013, Bioorganic & medicinal chemistry letters.

A Model for Arrestin’s Regulation: The 2.8 Å Crystal Structure of Visual Arrestin

P. Sigler, C. Schubert, V. Gurevich, 1999, Cell.

The 2.8 A crystal structure of visual arrestin: a model for arrestin's regulation.

P. Sigler, C. Schubert, V. Gurevich, 1999, Cell.

Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy.

Tianbao Lu, G. Bignan, M. Cummings, 2018, Bioorganic & medicinal chemistry letters.

Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors.

P. Bonaventure, J. A. Jablonowski, Kiev S. Ly, 2007, Bioorganic & medicinal chemistry letters.

Crystal Structure of -Arrestin at 1.9

P. Sigler, C. Schubert, V. Gurevich, 2001 .

Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors.

B. Tomczuk, R. DesJarlais, S. Meegalla, 2010, Bioorganic & medicinal chemistry letters.

Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors.

R. DesJarlais, Hui-Sheng Huang, M. Player, 2008, Bioorganic & medicinal chemistry letters.

Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors.

R. DesJarlais, Hui-Sheng Huang, M. Player, 2009, Journal of medicinal chemistry.

Discovery of potent cholecystokinin-2 receptor antagonists: elucidation of key pharmacophore elements by X-ray crystallographic and NMR conformational analysis.

Jiejun Wu, C. Schubert, M. Rosen, 2008, Bioorganic & medicinal chemistry.

Abstract 801: Sensitivity of cell lines to Fatty Acid Synthase inhibitors depends on the lipid content in the cellular environment

Yolanda T. Chong, Tianbao Lu, G. Bignan, 2014 .

Structure-based design, synthesis, and biological evaluation of novel 1,4-diazepines as HDM2 antagonists.

Maxwell D Cummings, Mark R Player, D. Parks, 2005, Bioorganic & medicinal chemistry letters.

Single-step syntheses of 2-amino-7-chlorothiazolo[5,4-d]pyrimidines: intermediates for bivalent thiazolopyrimidines.

R. Patch, M. Player, C. Schubert, 2005, The Journal of organic chemistry.

Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors.

B. Tomczuk, R. DesJarlais, S. Meegalla, 2008, Bioorganic & medicinal chemistry letters.

Discovery of novel FMS kinase inhibitors as anti-inflammatory agents.

B. Tomczuk, R. DesJarlais, S. Meegalla, 2008, Bioorganic & medicinal chemistry letters.

A Practical Synthesis of Enantiopure 7-Alkoxy-4-aryl-tetrahydroisoquinoline, a Dual Serotonin Reuptake Inhibitor/Histamine H3 Antagonist

C. Schubert, J. Liang, Xiaohu Deng, 2007 .

Suzuki-Miyaura approach to JNJ-26076713, an orally active tetrahydroquinoline-containing alphaVbeta3/alphaVbeta5 integrin antagonist. enantioselective synthesis and stereochemical studies.

C. Schubert, G. Leo, R. Hansen, 2008, The Journal of organic chemistry.

On the Mechanism of the Urocanase Reaction: Confirmation of the Structure of the NAD+‐Inhibitor Adduct by Direct 13C‐13C Coupling

C. Schubert, J. Rétey, Ymin Zhao, 1994 .

Crystallographic analysis of an 8-mer p53 peptide analogue complexed with MDM2.

C. Schubert, D. Kahne, K. Sakurai, 2006, Journal of the American Chemical Society.

Protein Engineering of the Colony-stimulating Factor-1 Receptor Kinase Domain for Structural Studies*

B. Grasberger, C. Schubert, I. Deckman, 2006, Journal of Biological Chemistry.

Crystal structure of beta-arrestin at 1.9 A: possible mechanism of receptor binding and membrane Translocation.

P. Sigler, C. Schubert, V. Gurevich, 2001, Structure.

Crystal Structure of the Tyrosine Kinase Domain of Colony-stimulating Factor-1 Receptor (cFMS) in Complex with Two Inhibitors*

Mark R Player, J. Spurlino, R. Patch, 2006, Journal of Biological Chemistry.

Effect of construct design on MAPKAP kinase-2 activity, thermodynamic stability and ligand-binding affinity.

R. DesJarlais, B. Grasberger, C. Schubert, 2006, Archives of biochemistry and biophysics.

Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists.

Tianbao Lu, M. Player, J. Marugan, 2006, Bioorganic & medicinal chemistry letters.

Substituted 1,4‐Benzodiazepine‐2,5‐diones as α‐Helix Mimetic Antagonists of the HDM2‐p53 Protein–Protein Interaction

Maxwell D Cummings, D. Parks, Tianbao Lu, 2006, Chemical biology & drug design.

How Does Arrestin Respond to the Phosphorylated State of Rhodopsin?*

P B Sigler, P. Sigler, C. Schubert, 1999, The Journal of Biological Chemistry.

Optimization of a potent class of arylamide colony-stimulating factor-1 receptor inhibitors leading to anti-inflammatory clinical candidate 4-cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141).

B. Tomczuk, R. DesJarlais, S. Meegalla, 2011, Journal of medicinal chemistry.

Structure-based optimization of a potent class of arylamide FMS inhibitors.

Jinsheng Chen, Mark R Player, B. Tomczuk, 2008, Bioorganic & medicinal chemistry letters.

Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein-protein interaction through structure-based drug design.

Maxwell D Cummings, D. Parks, Tianbao Lu, 2006, Bioorganic & medicinal chemistry letters.

Formation of pi, tau-dimethylhistidine on alkylation of trypsin with active-site-directed sulfonic acid methyl esters.

F. Fiedler, C. Schubert, 1994, Journal of enzyme inhibition.

An Additional Phosphate-binding Element in Arrestin Molecule

C. Schubert, V. Gurevich, S. Vishnivetskiy, 2000, The Journal of Biological Chemistry.

Visual Arrestin Activity May Be Regulated by Self-association*

D. Engelman, P. Sigler, C. Schubert, 1999, The Journal of Biological Chemistry.

Discovery of novel FMS kinase inhibitors as anti-inflammatory agents.

B. Tomczuk, R. DesJarlais, S. Meegalla, 2008, Bioorganic & medicinal chemistry letters.

Abstract 4747: Design and synthesis of a series highly potent and bioavailable FASN KR domain inhibitors for cancer

Tianbao Lu, G. Bignan, M. Cummings, 2014 .