A. Maroney

发表

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

Maxwell D Cummings, B. Tomczuk, J. Spurlino, 2005, Journal of medicinal chemistry.

Mixed lineage kinase 3 mediates gp120IIIB‐induced neurotoxicity

A. Maroney, A. Bodner, J. P. Finn, 2002, Journal of neurochemistry.

K‐252a Induces Tyrosine Phosphorylation of the Focal Adhesion Kinase and Neurite Outgrowth in Human Neuroblastoma SH‐SY5Y Cells

N. Neff, M. Glicksman, C. Dionne, 1995, Journal of neurochemistry.

CEP‐1347 (KT7515), an Inhibitor of JNK Activation, Rescues Sympathetic Neurons and Neuronally Differentiated PC12 Cells from Death Evoked by three Distinct Insults

N. Neff, L. Greene, D. Bozyczko‐Coyne, 1999, Journal of neurochemistry.

Targeted Therapy: Genomic Approaches

S. Ilyin, A. Maroney, 2006 .

Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells

D. Bozyczko‐Coyne, A. Maroney, G. Ghadge, 2004, Brain Research.

c-Jun N-terminal Kinase Specifically Phosphorylates p66ShcA at Serine 36 in Response to Ultraviolet Irradiation*

A. Maroney, Siyuan Le, T. Connors, 2001, The Journal of Biological Chemistry.

Randomised clinical trial: vercirnon, an oral CCR9 antagonist, vs. placebo as induction therapy in active Crohn's disease

S. Vermeire, I. Lawrance, G. D'Haens, 2015, Alimentary pharmacology & therapeutics.

Cloning and characterization of a thermolabile v-src gene for use in reversible transformation of mammalian cells.

J. Brugge, A. Maroney, D. A. Foster, 1992, Oncogene.

Translocation of diacylglycerol kinase from the cytosol to the membrane in phorbol ester–treated Swiss 3T3 fibroblasts

A. Maroney, I. Macara, 1989, Journal of cellular biochemistry.

The synthesis and SAR of 2-amino-pyrrolo[2,3-d]pyrimidines: a new class of Aurora-A kinase inhibitors.

H. Koblish, A. Maroney, Dana L. Johnson, 2006, Bioorganic & medicinal chemistry letters.

The value of participation in the CDC-national nosocomial infection surveillance (NNIS) in a large teaching hospital

A. Maroney, S. Forlenza, J. Selva, 1989 .

Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity.

Tianbao Lu, M. Player, J. Marugan, 2006, Bioorganic & medicinal chemistry letters.

Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo

D. Parks, Tianbao Lu, J. Marugan, 2006, Molecular Cancer Therapeutics.

Structure-based design, synthesis, and biological evaluation of novel 1,4-diazepines as HDM2 antagonists.

Maxwell D Cummings, Mark R Player, D. Parks, 2005, Bioorganic & medicinal chemistry letters.

Phorbol ester-induced translocation of diacylglycerol kinase from the cytosol to the membrane in Swiss 3T3 fibroblasts.

A. Maroney, I. Macara, 1989, The Journal of biological chemistry.

The MLK Family Mediates c-Jun N-Terminal Kinase Activation in Neuronal Apoptosis

Zhiheng Xu, Pawel Dobrzanski, L. Greene, 2001, Molecular and Cellular Biology.

Discovery of CEP-1347/KT-7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases.

A. Maroney, Anna C Maroney, Michael S Saporito, 2002, Progress in medicinal chemistry.

Motoneuron Apoptosis Is Blocked by CEP-1347 (KT 7515), a Novel Inhibitor of the JNK Signaling Pathway

N. Neff, M. Glicksman, A. Maroney, 1998, The Journal of Neuroscience.

CEP-1347 (KT7515), a Semisynthetic Inhibitor of the Mixed Lineage Kinase Family*

L. Greene, A. Maroney, Zhiheng Xu, 2001, The Journal of Biological Chemistry.

β‐Amyloid‐induced neuronal apoptosis requires c‐Jun N‐terminal kinase activation

L. Greene, S. Rabacchi, A. Maroney, 2001, Journal of neurochemistry.

A radioactive binding assay for inhibitors of trkA kinase.

C. Dionne, A. Maroney, T. Angeles, 1997, Analytical biochemistry.

JNK-Mediated BIM Phosphorylation Potentiates BAX-Dependent Apoptosis

Eugene M. Johnson, S. Frank, A. Maroney, 2003, Neuron.

Inhibition of the c-Jun N-Terminal Kinase Signaling Pathway by the Mixed Lineage Kinase Inhibitor CEP-1347 (KT7515) Preserves Metabolism and Growth of Trophic Factor-Deprived Neurons

Charles A. Harris, Eugene M. Johnson, A. Maroney, 2002, The Journal of Neuroscience.

Nickolay Kinase Activation in Neuronal Apoptosis The MLK Family Mediates c-Jun N-Terminal

L. Greene, P. Dobrzanski, A. Maroney, 2001 .

Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists.

Tianbao Lu, M. Player, J. Marugan, 2006, Bioorganic & medicinal chemistry letters.

v-Src activates both protein kinase C-dependent and independent signaling pathways in murine fibroblasts.

A. Maroney, D. A. Foster, C. Joseph, 1991, Oncogene.

Identification of JNK‐dependent and ‐independent components of cerebellar granule neuron apoptosis

Charles A. Harris, Eugene M. Johnson, A. Maroney, 2002, Journal of neurochemistry.

CEP‐751 inhibits trk receptor tyrosine kinase activity in vitro and exhibits anti‐tumor activity

N. Neff, J. Isaacs, A. Maroney, 1997, International journal of cancer.

How Partnership Should Work to Bring Innovative Medicines to Patients.

A. Maroney, Gunilla Osswald, Marco Giorgetti, 2020, Drug discovery today.

Triazolopyridazines as tyrosine kinase

Tianbao Lu, M. Cummings, A. Maroney, 2006 .

Dihydroquinone ansamycins: toward resolving the conflict between low in vitro affinity and high cellular potency of geldanamycin derivatives.

J. Marugan, H. Koblish, I. Deckman, 2006, Biochemistry.

Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein-protein interaction through structure-based drug design.

Maxwell D Cummings, D. Parks, Tianbao Lu, 2006, Bioorganic & medicinal chemistry letters.

Development of a quantitative, high-throughput cell-based enzyme-linked immunosorbent assay for detection of colony-stimulating factor-1 receptor tyrosine kinase inhibitors.

A. Maroney, L. Zeng, Robert R Donatelli, 2004, Journal of biochemical and biophysical methods.

K‐252b Potentiation of Neurotrophin‐3 Is trkA Specific in Cells Lacking p75NTR

N. Neff, A. Maroney, C. Dionne, 1997, Journal of neurochemistry.