C. Molloy

发表

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

Maxwell D Cummings, B. Tomczuk, J. Spurlino, 2005, Journal of medicinal chemistry.

Enhancement of kinase selectivity in a potent class of arylamide FMS inhibitors.

B. Tomczuk, R. DesJarlais, S. Meegalla, 2013, Bioorganic & medicinal chemistry letters.

Purification and characterization of two forms of N-acetylglucosaminidase from Candida albicans showing widely different outer chain glycosylation.

C. Molloy, R. Cannon, M. Shepherd, 1994, Microbiology.

Pharmacokinetic and Pharmacodynamic Modeling of Pegylated Thrombopoietin Mimetic Peptide (PEG‐TPOm) After Single Intravenous Dose Administration in Healthy Subjects

J. Pérez-Ruixo, C. Molloy, M. Samtani, 2009, Journal of clinical pharmacology.

Purification and characterization of two forms of N-acetylglucosaminidase from Cancfida albicans showing widely different outer chain g

Maxwell, C. Molloy, G., 2008 .

Novel signal transduction targets in cardiovascular disease: Role of platelet‐derived growth factor in vascular smooth muscle cell proliferation

C. Molloy, 1993 .

Platelet-derived growth factor stimulation of GTPase-activating protein tyrosine phosphorylation in control and c-H-ras-expressing NIH 3T3 cells correlates with p21ras activation.

A. Cuadrado, T. Fleming, S. Aaronson, 1992, Molecular and cellular biology.

Development of a highly efficient expression cDNA cloning system: application to oncogene isolation.

T. Fleming, M. Crescenzi, S. Aaronson, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Keratin polypeptide expression in mouse epidermis and cultured epidermal cells.

C. Molloy, J. Laskin, 1988, Differentiation; research in biological diversity.

Overexpression of phospholipase C-gamma in NIH 3T3 fibroblasts results in increased phosphatidylinositol hydrolysis in response to platelet-derived growth factor and basic fibroblast growth factor

A. Cuadrado, C. Molloy, 1990, Molecular and cellular biology.

Angiotensin II induces delayed mitogenesis and cellular proliferation in rat aortic smooth muscle cells. Correlation with the expression of specific endogenous growth factors and reversal by suramin.

C. Molloy, H. Weber, D. Taylor, 1994, The Journal of clinical investigation.

Endothelin-1 and angiotensin-II stimulate delayed mitogenesis in cultured rat aortic smooth muscle cells: evidence for common signaling mechanisms.

M. Webb, S. Moreland, C. Molloy, 1994, Molecular endocrinology.

Molecular characterization of angiotensin II type II receptors in rat pheochromocytoma cells

E. Liu, M. Webb, S. Moreland, 1992, Peptides.

Interrelationships between uptake of urea and uptake of ammonium by microalgae

C. Molloy, P. J. Syrett, 1988 .

Orally Active Endothelin Receptor Antagonist BMS‐182874 Suppresses Neointimal Development in Balloon‐Injured Rat Carotid Arteries

M. Valentine, S. Moreland, C. Molloy, 1995, Journal of cardiovascular pharmacology.

Design and synthesis of 4,5-disubstituted-thiophene-2-amidines as potent urokinase inhibitors.

R. DesJarlais, J. Spurlino, C. Illig, 2002, Bioorganic & medicinal chemistry letters.

Angiotensin II stimulation of rapid protein tyrosine phosphorylation and protein kinase activation in rat aortic smooth muscle cells.

C. Molloy, H. Weber, D. Taylor, 1993, The Journal of biological chemistry.

Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors.

B. Tomczuk, R. DesJarlais, S. Meegalla, 2010, Bioorganic & medicinal chemistry letters.

Identification of envelope proteins of Candida albicans by vectorial iodination.

C. Molloy, M. Shepherd, P. Sullivan, 1989, Microbios.

Carboxylic acid bioisosteres acylsulfonamides, acylsulfamides, and sulfonylureas as novel antagonists of the CXCR2 receptor.

B. Tomczuk, D. Ryan, Shuyuan Zhao, 2008, Bioorganic & medicinal chemistry letters.

The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency

C. Molloy, S. Rhee, P. P. Di Fiore, 1991, Molecular and cellular biology.

EGF Triggers a Similar Signalling Cascade in Different Cell Types Overexpressing the EGF Receptor

T. Fleming, T. Matsui, M. Ruggiero, 1990 .

Thrombin receptor activation elicits rapid protein tyrosine phosphorylation and stimulation of the raf-1/MAP kinase pathway preceding delayed mitogenesis in cultured rat aortic smooth muscle cells: evidence for an obligate autocrine mechanism promoting cell proliferation induced by G-protein-coupled

C. Turner, C. Molloy, J. Pawlowski, 1996, The Journal of clinical investigation.

Stimulation of activin A expression in rat aortic smooth muscle cells by thrombin and angiotensin II correlates with neointimal formation in vivo.

M. Kowala, M. Valentine, C. Molloy, 1997, The Journal of clinical investigation.

Characterization of platelet-derived growth factor and platelet-derived growth factor receptor expression in asbestos-induced rat mesothelioma.

C. Molloy, C. Walker, J. Everitt, 1992, Cancer research.

Autocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors.

T. Fleming, T. Matsui, S. Aaronson, 1989, Proceedings of the National Academy of Sciences of the United States of America.

A functional radioreceptor assay of alpha-V-beta-3 (αvβ3) inhibitors in plasma: Application as an ex vivo pharmacodynamic model

B. Tomczuk, J. Marugan, C. Manthey, 2005 .

Epidermal growth factor activates phosphoinositide turnover and protein kinase C in BALB/MK keratinocytes.

T. Fleming, S. Aaronson, C. Molloy, 1988, Molecular endocrinology.

JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia

B. Tomczuk, S. Meegalla, C. Illig, 2009, Molecular Cancer Therapeutics.

Effect of retinoid deficiency on keratin expression in mouse bladder.

C. Molloy, J. Laskin, 1988, Experimental and molecular pathology.

Specific alterations in keratin biosynthesis in mouse epidermis in vivo and in explant culture following a single exposure to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.

C. Molloy, J. Laskin, 1987, Cancer research.

The discovery of novel cyclohexylamide CCR2 antagonists.

C. Molloy, E. Opas, Z. Sui, 2011, Bioorganic & medicinal chemistry letters.

Activin A and TGF-beta stimulate phosphorylation of focal adhesion proteins and cytoskeletal reorganization in rat aortic smooth muscle cells.

M. Brown, C. Turner, C. Molloy, 1999, Experimental cell research.

EFFECTS OF NITROGEN DEPRIVATION ON RATES OF UPTAKE OF NITROGENOUS COMPOUNDS BY THE DIATOM, PHAEODACTYLUM TRICORNUTUM BOHLIN.

C. Molloy, K. Flynn, G. Dixon, 1986, The New phytologist.

Epiregulin is a potent vascular smooth muscle cell-derived mitogen induced by angiotensin II, endothelin-1, and thrombin.

David S. Taylor, C. Molloy, J. Pawlowski, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo

D. Parks, Tianbao Lu, J. Marugan, 2006, Molecular Cancer Therapeutics.

Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors.

R. DesJarlais, J. Spurlino, C. Illig, 2001, Bioorganic & medicinal chemistry letters.

Structure-based design, synthesis and SAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors.

R. DesJarlais, J. Spurlino, C. Illig, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors.

B. Tomczuk, R. DesJarlais, S. Meegalla, 2008, Bioorganic & medicinal chemistry letters.

Discovery of novel FMS kinase inhibitors as anti-inflammatory agents.

B. Tomczuk, R. DesJarlais, S. Meegalla, 2008, Bioorganic & medicinal chemistry letters.

An analysis of the metabolism and cell wall composition of Candida albicans during germ-tube formation.

C. Molloy, M. Templeton, M. Shepherd, 1983, Canadian journal of microbiology.

CHAPTER 6 – ROLE OF MATRIX METALLOPROTEINASES AND PLASMINOGEN ACTIVATORS IN CANCER INVASION AND METASTASIS: THERAPEUTIC STRATEGIES

C. Molloy, S. Zucker, Jian Cao, 2002 .

PDGF induction of tyrosine phosphorylation of GTPase activating protein

T. Fleming, S. Aaronson, C. Molloy, 1989, Nature.

Autocrine interaction between TGF alpha and the EGF-receptor: quantitative requirements for induction of the malignant phenotype.

T. Fleming, M. Kraus, S. Aaronson, 1989, Oncogene.

Expression of protein kinase C I in NIH 3T3 cells increases its growth response to specific activators

C. Molloy, M. Pech, A. Cuadrado, 1990, FEBS letters.

Novel cardiovascular actions of the activins.

C. Molloy, J. Pawlowski, D. Taylor, 1999, The Journal of endocrinology.

Activation of the colony-stimulating factor 1 receptor leads to the rapid tyrosine phosphorylation of GTPase-activating protein and activation of cellular p21ras.

T. Fleming, C. Molloy, G. G. Choudhury, 1992, Oncogene.

Effect of light and N deprivation on inhibition of nitrate uptake by urea in microalgae

C. Molloy, P. J. Syrett, 1988 .

Uneven distribution of protein kinase C‐α and ‐β isozymes in human sarcomas and carcinomas

A. Cuadrado, T. Fleming, C. Molloy, 1994 .

Effects of the chemical irritants anthralin and benzoyl peroxide on mouse skin epithelial cell protein production

M. Gallo, C. Molloy, J. Laskin, 1984 .

Angiotensin II stimulation of rapid paxillin tyrosine phosphorylation correlates with the formation of focal adhesions in rat aortic smooth muscle cells.

C. Turner, C. Molloy, D. Taylor, 1995, Journal of cell science.

Fighting pulmonary fibrosis: new science brings new therapeutic opportunities

G. Laurent, C. Molloy, A. Protter, 2004 .

The calcium signal for Balb/MK keratinocyte terminal differentiation induces sustained alterations in phosphoinositide metabolism without detectable protein kinase C activation.

T. Fleming, S. Aaronson, C. Molloy, 1989, The Journal of biological chemistry.

JOURNAL SYMPOSIUM Novel cardiovascular actions of the activins

C. Molloy, J. Pawlowski, David S. Taylor, 1999 .

Stimulation of Platelet Production in Healthy Volunteers by a Novel Pegylated Peptide-Based Thrombopoietin (TPO) Receptor Agonist.

H. Koblish, C. Molloy, C. Franks, 2005 .

Induced resistance against Sclerotinia sclerotiorum in carrots treated with enzymatically hydrolysed chitosan

C. Molloy, J. Koolaard, L. Cheah, 2004 .

Morphological response of human rotavirus to ultra-violet radiation, heat and disinfectants.

C. Molloy, S. Morgan, F. Rodgers, 1985, Journal of medical microbiology.

Uneven distribution of protein kinase C-alpha and -beta isozymes in human sarcomas and carcinomas.

A. Cuadrado, T. Fleming, C. Molloy, 1994, Journal of Cellular Physiology.

Proliferation in Rat Aortic Smooth Muscle Cells

C. Molloy, H. Weber, David S. Taylor, 2013 .

Towards a cryopreserved germplasm collection of apple – results of dormant bud cryopreservation in the mild maritime winter climate of Hawkes Bay, New Zealand

C. Molloy, S. Kumar, J. Seelye, 2018, Acta Horticulturae.

Expression and secretion of Janthinobacterium lividumchitinase in Saccharomyces cerevisiae

C. Molloy, B. Burke, 1997, Biotechnology Letters.

Optimization of a potent class of arylamide colony-stimulating factor-1 receptor inhibitors leading to anti-inflammatory clinical candidate 4-cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141).

B. Tomczuk, R. DesJarlais, S. Meegalla, 2011, Journal of medicinal chemistry.

Structure-based optimization of a potent class of arylamide FMS inhibitors.

Jinsheng Chen, Mark R Player, B. Tomczuk, 2008, Bioorganic & medicinal chemistry letters.

Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s.

B. Tomczuk, C. Molloy, R. Bone, 2012, Bioorganic & medicinal chemistry letters.

Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s.

B. Tomczuk, R. DesJarlais, Hui-Sheng Huang, 2008, Bioorganic & medicinal chemistry letters.

Combinatorial RNAi on intestinal cathepsin B-like proteinases in Caenorhabditis elegans questions the perception of their role in nematode biology.

C. Molloy, P. Geldhof, D. Knox, 2006, Molecular and biochemical parasitology.

Demonstration of an activated platelet-derived growth factor autocrine pathway and its role in human tumor cell proliferation in vitro.

T. Fleming, T. Matsui, S. Aaronson, 1992, Oncogene.

A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s.

B. Tomczuk, R. DesJarlais, Hui-Sheng Huang, 2006, Bioorganic & medicinal chemistry letters.