R. Bone

发表

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

Maxwell D Cummings, B. Tomczuk, J. Spurlino, 2005, Journal of medicinal chemistry.

Structural analysis of inositol monophosphatase complexes with substrates.

J. Springer, R. Bone, L. Frank, 1994, Biochemistry.

Serendipity meets precision: the integration of structure-based drug design and combinatorial chemistry for efficient drug discovery.

J. Spurlino, F. Salemme, R. Bone, 1997, Structure.

X-Ray Crystal Structure of the HIV Protease Complex with L-700,417, an Inhibitor with Pseudo C2 Symmetry

M. Katharine Holloway, Roger F. Bone, P. Anderson, 1991 .

Inhibition of thymidine kinase by P1-(adenosine-5')-P5-(thymidine-5')-pentaphosphate.

R. Wolfenden, R. Bone, Y. Cheng, 1986, The Journal of biological chemistry.

Pharmacokinetic properties of TDP4815 after single intravenous and oral administrations to rat, rabbit, monkey, dog and in vitro drug metabolism

B. Tomczuk, R. Bone, Yanmin Chen, 2008, Biopharmaceutics & drug disposition.

Design and synthesis of 4,5-disubstituted-thiophene-2-amidines as potent urokinase inhibitors.

R. DesJarlais, J. Spurlino, C. Illig, 2002, Bioorganic & medicinal chemistry letters.

X-Ray Crystal Structure of the HIV Protease Complex with L-700,417 (I), an Inhibitor with Pseudo C2 Symmetry.

P. Anderson, M. Holloway, J. Vacca, 1992 .

Amino Acid Transport in Suspension-Cultured Plant Cells : III. COMMON CARRIER SYSTEM FOR THE UPTAKE OF l-ARGININE, l-ASPARTIC ACID, l-HISTIDINE, l-LEUCINE, AND l-PHENYLALANINE.

R. Bone, C. McDaniel, R. Holterman, 1982, Plant physiology.

Non-peptidic phenyl-based thrombin inhibitors: exploring structural requirements of the S1 specificity pocket with amidines.

B. Tomczuk, F. Salemme, R. Bone, 2000, Bioorganic & medicinal chemistry letters.

Amidinohydrazones as guanidine bioisosteres: application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitors.

B. Tomczuk, J. Spurlino, C. Illig, 2000, Bioorganic & medicinal chemistry letters.

In vitro evaluation and crystallographic analysis of a new class of selective, non-amide-based thrombin inhibitors.

B. Tomczuk, J. Spurlino, C. Illig, 1998, Bioorganic & medicinal chemistry letters.

Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis.

B. Tomczuk, J. Spurlino, Tianbao Lu, 2004, Bioorganic & medicinal chemistry letters.

Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors.

B. Tomczuk, J. Spurlino, Tianbao Lu, 2003, Bioorganic & medicinal chemistry letters.

Structure-activity and crystallographic analysis of a new class of non-amide-based thrombin inhibitor.

B. Tomczuk, J. Spurlino, C. Illig, 2000, Bioorganic & medicinal chemistry letters.

In vitro Evaluation and Crystallographic Analysis of a New Class of Selective, Non‐Amide‐Based Thrombin Inhibitors.

B. Tomczuk, J. Spurlino, C. Illig, 1998 .

Mutational remodeling of enzyme specificity.

D. Agard, R. Bone, 1991, Methods in enzymology.

Structural analysis of thrombin complexed with potent inhibitors incorporating a phenyl group as a peptide mimetic and aminopyridines as guanidine substitutes.

J. Spurlino, C. Illig, R. Bone, 1998, Journal of medicinal chemistry.

Amidinohydrazones as Guanidine Bioisosteres: Application to a New Class of Potent, Selective and Orally Bioavailable, Non‐amide‐based Small‐Molecule Thrombin Inhibitors.

B. Tomczuk, J. Spurlino, C. Illig, 2000 .

Solvent isotope effects on formation of protease complexes with inhibitory aldehydes

R. Wolfenden, R. Bone, 1985 .

Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif.

B. Tomczuk, J. Spurlino, Tianbao Lu, 2010, Journal of medicinal chemistry.

Crystal structures of alpha-lytic protease complexes with irreversibly bound phosphonate esters.

D. Agard, R. Bone, N. Sampson, 1993, Biochemistry.

Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors.

R. DesJarlais, J. Spurlino, C. Illig, 2001, Bioorganic & medicinal chemistry letters.

Structure-based design, synthesis and SAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors.

R. DesJarlais, J. Spurlino, C. Illig, 2001, Bioorganic & medicinal chemistry letters.

Inhibition of adenosine and thymidylate kinases by bisubstrate analogs.

R. Wolfenden, R. Bone, Y. Cheng, 1986, The Journal of biological chemistry.

Kinetic properties of the binding of alpha-lytic protease to peptide boronic acids.

D. Agard, R. Bone, W. Bachovchin, 1988, Biochemistry.

Structural basis for broad specificity in alpha-lytic protease mutants.

D A Agard, D. Agard, R. Bone, 1993, Biochemistry.

Serine protease mechanism: structure of an inhibitory complex of alpha-lytic protease and a tightly bound peptide boronic acid.

D. Agard, R. Bone, C. Kettner, 1987, Biochemistry.

A novel series of potent and selective small molecule inhibitors of the complement component C1s.

R. DesJarlais, J. Spurlino, C. Illig, 2004, Bioorganic & medicinal chemistry letters.

Structural plasticity broadens the specificity of an engineered protease

David A. Agard, D. Agard, R. Bone, 1989, Nature.

Failure of enflurane and halothane anesthesia to inhibit lymphocyte transformation in volunteers.

N. T. Smith, E. Eger, R. Bone, 1976, Anesthesiology.

REGULATION OF EXTRACELLULAR MATRIX PROTEINS BY TRANSFORMING GROWTH FACTOR β1IN CULTURED PULMONARY ENDOTHELIAL CELLS

R. Bone, D. Olson, G. Shanker, 1999 .

Analysis of prepro-alpha-lytic protease expression in Escherichia coli reveals that the pro region is required for activity

D. Agard, R. Bone, J. L. Silen, 1989, Journal of bacteriology.

Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion catalysis.

J. Springer, R. Bone, L. Frank, 1995, Biochemistry.

Structural analysis of specificity: .alpha.-lytic protease complexes with analogs of reaction intermediates

D. Agard, R. Bone, D. Frank, 1989 .

Structural analysis of inositol monophosphatase complexes with substrates.

J. Springer, R. Bone, L. Frank, 1995, Biochemistry.

Structural analysis of specificity: alpha-lytic protease complexes with analogues of reaction intermediates.

D. Agard, R. Bone, D. Frank, 1990, Biochemistry.

Structure of inositol monophosphatase, the putative target of lithium therapy.

J. Springer, R. Bone, J. Atack, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s.

B. Tomczuk, C. Molloy, R. Bone, 2012, Bioorganic & medicinal chemistry letters.

Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s.

B. Tomczuk, R. DesJarlais, Hui-Sheng Huang, 2008, Bioorganic & medicinal chemistry letters.

A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s.

B. Tomczuk, R. DesJarlais, Hui-Sheng Huang, 2006, Bioorganic & medicinal chemistry letters.

Decrypting the Biochemical Function of an Essential Gene from Streptococcus pneumoniae Using ThermoFluor® Technology*

Michael L Doyle, Edward P Jaeger, Maxwell D Cummings, 2005, Journal of Biological Chemistry.

SOLVENT EFFECTS ON EQUILIBRIA OF ADDITION OF NUCLEOPHILES TO ACETALDEHYDE AND THE HYDROPHILIC CHARACTER OF DIOLS

R. Wolfenden, P. Cullis, R. Bone, 1983 .