J. Stuckey

发表

Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.

Su Qiu, Guoping Wang, Wei Gao, 2006, Journal of medicinal chemistry.

Conformational Sampling and Binding Site Assessment of Suppression of Tumorigenicity 2 Ectodomain

Chao-yie Yang, James Delproposto, W. C. Brown, 2016, PloS one.

Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER).

Shaomeng Wang, Chao-yie Yang, James Delproposto, 2019, Journal of medicinal chemistry.

Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.

H. Abaan, Shaomeng Wang, Renxiao Wang, 2006, Journal of medicinal chemistry.

Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins.

Shaomeng Wang, Renxiao Wang, Chao-yie Yang, 2007, Journal of medicinal chemistry.

Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 Å and the complex with tungstate

E. Fauman, J. Dixon, J. Stuckey, 1994, Nature.

Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression.

Liu Liu, Shaomeng Wang, Chao-yie Yang, 2012, Journal of medicinal chemistry.

Structure-based design of potent non-peptide MDM2 inhibitors.

J. Deschamps, Shaomeng Wang, Yipin Lu, 2005, Journal of the American Chemical Society.

A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation

Liu Liu, Shaomeng Wang, Chao-yie Yang, 2017, Nature Communications.

Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.

Xueliang Fang, Renxiao Wang, Shaomeng Wang, 2004, Analytical biochemistry.

SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression.

Shanghai Yu, Liu Liu, Wei Sun, 2014, Cancer research.

Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity

Yi Xue, Jeanne A. Stuckey, Charles M. Rice, 2015, Cell.

The Tail of KdsC

J. Rubin, J. Stuckey, O. Tsodikov, 2009, The Journal of Biological Chemistry.

Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands.

Shaomeng Wang, Chao-yie Yang, J. Stuckey, 2019, Journal of medicinal chemistry.

Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer.

Shaomeng Wang, Chao-yie Yang, James Delproposto, 2019, Journal of medicinal chemistry.

SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.

Shaomeng Wang, Yi Sun, Z. Nikolovska-Coleska, 2008, Cancer research.

High-Resolution Cryo-Electron Microscopy Structures of Murine Norovirus 1 and Rabbit Hemorrhagic Disease Virus Reveal Marked Flexibility in the Receptor Binding Domains

Neil R. Voss, N. Voss, J. Rubin, 2010, Journal of Virology.

d-Cysteine Ligands Control Metal Geometries within De Novo Designed Three-Stranded Coiled Coils.

Anna F. A. Peacock, L. Hemmingsen, L. Ruckthong, 2017, Chemistry.

Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression.

Shaomeng Wang, S. Gross, J. Stuckey, 2021, Journal of medicinal chemistry.

Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction.

Liu Liu, Shaomeng Wang, James Delproposto, 2019, Journal of medicinal chemistry.

Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction.

Liu Liu, Shaomeng Wang, J. Stuckey, 2018, Angewandte Chemie.

Ordering a dynamic protein via a small-molecule stabilizer.

Jessica K. Gagnon, Chinmay Y. Majmudar, C. Brooks, 2013, Journal of the American Chemical Society.

Expression, purification, and physicochemical characterization of a recombinant Yersinia protein tyrosine phosphatase.

J. C. Clemens, J. Dixon, J. Stuckey, 1992, The Journal of biological chemistry.

Two substrate‐targeting sites in the Yersinia protein tyrosine phosphatase co‐operate to promote bacterial virulence

J. Stuckey, J. Bliska, H. Schubert, 2005, Molecular microbiology.

A Crystallographic Examination of Predisposition versus Preorganization in de Novo Designed Metalloproteins.

M. Zastrow, L. Ruckthong, V. Pecoraro, 2016, Journal of the American Chemical Society.

Insights into Substrate and Metal Binding from the Crystal Structure of Cyanobacterial Aldehyde Deformylating Oxygenase with Substrate Bound

B. Buer, J. Stuckey, E. Marsh, 2014, ACS chemical biology.

The First Crystal Structure of the UP1 Domain of hnRNP A1 Bound to RNA Reveals a New Look for an Old RNA Binding Protein.

Jeffrey D Levengood, James Delproposto, J. Stuckey, 2015, Journal of molecular biology.

Form and Function in Protein Dephosphorylation

J. Dixon, J. Denu, J. Stuckey, 1996, Cell.

Changing the Ap Evolutionary Pro

Design, Yang Zhang, Huang, 2019 .

Changing the Ap through Evolutio

Yang Zhang, Huang, Liu Liu, 2019 .

3-Substituted-N-(4-Hydroxynaphthalen-1-yl)arylsulfonamides as a Novel Class of Selective Mcl-1 Inhibitors: Structure-Based Design, Synthesis, SAR, and Biological Evaluation

T. Cierpicki, Z. Nikolovska-Coleska, J. Stuckey, 2014, Journal of medicinal chemistry.

Constructs of human neuropathy target esterase catalytic domain containing mutations related to motor neuron disease have altered enzymatic properties.

J. Stuckey, J. Fink, R. Richardson, 2010, Toxicology letters.

Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor.

Liu Liu, Shaomeng Wang, Chao-yie Yang, 2018, Journal of medicinal chemistry.

The role of HTS in drug discovery at the University of Michigan.

D. Sherman, A. Mapp, J. Grembecka, 2014, Combinatorial chemistry & high throughput screening.

Structure-Activity relationship of 1-(Furan-2ylmethyl)Pyrrolidine-Based Stimulation-2 (ST2) inhibitors for treating graft versus host disease.

Chao-yie Yang, J. Stuckey, Krishnapriya Chinnaswamy, 2022, Bioorganic & medicinal chemistry.

Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences

P. Bieniasz, Janet L. Smith, J. Stuckey, 2019, Proceedings of the National Academy of Sciences.

Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains.

Shaomeng Wang, Z. Nikolovska-Coleska, Wei-Lin Gao, 2008, Analytical biochemistry.

High-Resolution X-Ray Structure and Functional Analysis of the Murine Norovirus 1 Capsid Protein Protruding Domain (cid:1)

J. Rubin, J. Stuckey, C. Wobus, 2010 .

Cloning, Expression, and Characterization of the Galα1,3Gal High Affinity Lectin from the Mushroom Marasmius oreades *

J. Dixon, I. Goldstein, J. Stuckey, 2002, The Journal of Biological Chemistry.

Expression, Characterization, and Mutagenesis of theYersinia pestis Murine Toxin, a Phospholipase D Superfamily Member*

J. Dixon, J. Moss, J. Stuckey, 1999, The Journal of Biological Chemistry.

Discovery of Mcl-1 inhibitors from integrated high throughput and virtual screening

H. Fu, Z. Nikolovska-Coleska, J. Stuckey, 2018, Scientific Reports.

A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.

Liu Liu, Shaomeng Wang, J. Stuckey, 2013, Journal of medicinal chemistry.

Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors.

Liu Liu, Shaomeng Wang, J. Stuckey, 2015, Journal of medicinal chemistry.

Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity.

Liu Liu, Chao-Yie Yang, Liu Liu, 2012, Journal of medicinal chemistry.

Structural comparisons of apo- and metalated three-stranded coiled coils clarify metal binding determinants in thiolate containing designed peptides.

Anna F. A. Peacock, V. Pecoraro, J. Stuckey, 2010, Journal of the American Chemical Society.

Clarifying the Copper Coordination Environment in a de Novo Designed Red Copper Protein.

L. Ruckthong, V. Pecoraro, J. Stuckey, 2018, Inorganic chemistry.

Heteromeric three-stranded coiled coils designed using a Pb(ii)(Cys)3 template mediated strategy

Vindi M. Jayasinghe-Arachchige, Thomas J. Paul, L. Ruckthong, 2020, Nature Chemistry.

Hydrolytic catalysis and structural stabilization in a designed metalloprotein

Jeanne A. Stuckey, Anna F. A. Peacock, M. Zastrow, 2011, Nature chemistry.

Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor.

Liu Liu, Shaomeng Wang, J. Stuckey, 2017, Journal of medicinal chemistry.

Computational Cosolvent Mapping Analysis Leads to Identify Salicylic Acid Analogs as Weak Inhibitors of ST2 and IL33 Binding.

J. Stuckey, Krishnapriya Chinnaswamy, Xinrui Yuan, 2022, The journal of physical chemistry. B.

Identifying important structural characteristics of arsenic resistance proteins by using designed three-stranded coiled coils

V. Pecoraro, J. Stuckey, C. Nordman, 2007, Proceedings of the National Academy of Sciences.

Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor

N. Neamati, J. Sebolt-Leopold, M. Ljungman, 2016, Nature Communications.

Crystal structure of a phospholipase D family member

Jeanne A. Stuckey, Jack E. Dixon, J. Dixon, 1999, Nature Structural Biology.

High-Resolution X-Ray Structure and Functional Analysis of the Murine Norovirus 1 Capsid Protein Protruding Domain

J. Rubin, T. Smith, J. Stuckey, 2010, Journal of Virology.

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.

Liu Liu, Shaomeng Wang, J. Stuckey, 2019, Cancer cell.

Structural and Functional Characterization of a Cytochrome P450 2B4 F429H Mutant with an Axial Thiolate–Histidine Hydrogen Bond

S. Shaik, L. Waskell, C. Sun, 2014, Biochemistry.

Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP.

Sheng Jiang, Yumi Ueda, Su Qiu, 2007, Journal of the American Chemical Society.

Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase.

Shirley Y. Lee, Liu Liu, Shaomeng Wang, 2020, ACS medicinal chemistry letters.

Lipid-based vaccine nanoparticles for induction of humoral immune responses against HIV-1 and SARS-CoV-2

Seung Won Shin, Kyung Soo Park, D. Montefiori, 2020, Journal of Controlled Release.

Crystal structure of banana lectin reveals a novel second sugar binding site.

I. Goldstein, J. Stuckey, J. Meagher, 2005, Glycobiology.

Targeted disruption of pi–pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity

M. Swanson, D. Markovitz, J. Stuckey, 2021, Scientific Reports.

Targeted disruption of pi–pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity

M. Swanson, D. Markovitz, J. Stuckey, 2021, Scientific reports.

From proteomics to discovery of first-in-class ST2 inhibitors active in vivo.

Greg L. Hura, J. Stuckey, Krishnapriya Chinnaswamy, 2018, JCI insight.

Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression.

Liu Liu, Shaomeng Wang, J. Stuckey, 2018, Journal of Medicinal Chemistry.

Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes

Inkyung Jung, J. Stuckey, J. Meagher, 2017, The Journal of Biological Chemistry.

Expression, characterization, and crystallization of a member of the novel phospholipase D family of phosphodiesterases

J. Stuckey, J. Dixon, D. Lohse, 1997, Protein science : a publication of the Protein Society.

KRAS Engages AGO2 to Enhance Cellular Transformation.

S. Dhanasekaran, A. Chinnaiyan, Xuhong Cao, 2016, Cell reports.

A Unique Carbohydrate Binding Domain Targets the Lafora Disease Phosphatase to Glycogen*

J. Dixon, J. Stuckey, M. Wishart, 2002, The Journal of Biological Chemistry.

Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity.

M. Seeliger, J. Stuckey, M. Soellner, 2016, ACS chemical biology.

Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression.

Shaomeng Wang, J. Stuckey, D. McEachern, 2021, Journal of medicinal chemistry.

Differential Conformational Dynamics Encoded by the Inter-qRRM linker of hnRNP H.

J. Stuckey, J. Meagher, Liang-Yuan Chiu, 2018 .

Differential Conformational Dynamics Encoded by the Linker between Quasi RNA Recognition Motifs of Heterogeneous Nuclear Ribonucleoprotein H

J. Stuckey, J. Meagher, Liang-Yuan Chiu, 2018, Journal of the American Chemical Society.

The X-ray Crystal Structures of Yersinia Tyrosine Phosphatase with Bound Tungstate and Nitrate

E. Fauman, J. Stuckey, H. Schubert, 1996, The Journal of Biological Chemistry.

Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer.

M. Ellis, Shunqiang Li, Liu Liu, 2017, Cancer research.

Interaction between Pyrin and the Apoptotic Speck Protein (ASC) Modulates ASC-induced Apoptosis*

J. Stuckey, D. Gumucio, E. Shelden, 2001, The Journal of Biological Chemistry.

Structure-based design, synthesis, evaluation, and crystallographic studies of conformationally constrained Smac mimetics as inhibitors of the X-linked inhibitor of apoptosis protein (XIAP).

Su Qiu, Jianfeng Lu, Chao-Yie Yang, 2008, Journal of medicinal chemistry.

Interaction of a cyclic, bivalent smac mimetic with the x-linked inhibitor of apoptosis protein.

Shaomeng Wang, Z. Nikolovska-Coleska, S. Qiu, 2008, Biochemistry.

Crystal Structure of Patatin-17 in Complex with Aged and Non-Aged Organophosphorus Compounds

J. Stuckey, R. Richardson, S. Wijeyesakere, 2014, PloS one.

Neuropathy Target Esterase ( NTE ) : Probing the Enigma

J. Stuckey, 2009 .

Modeling the Tertiary Structure of the Patatin Domain of Neuropathy Target Esterase

J. Stuckey, R. Richardson, S. Wijeyesakere, 2007, The protein journal.

Co‐operative Versus Independent Transport of Different Cargoes by Kinesin‐1

J. Stuckey, K. Verhey, Jennetta W. Hammond, 2008, Traffic.

Small Molecule Therapeutics A Novel Small-Molecule Inhibitor of Mcl-1 Blocks Pancreatic Cancer Growth In Vitro and In Vivo

J. Stuckey, L. Y. Almeida, 2014 .

A Novel Small-Molecule Inhibitor of Mcl-1 Blocks Pancreatic Cancer Growth In Vitro and In Vivo

Tao Zhang, Jeanne A. Stuckey, Chenzhong Liao, 2013, Molecular Cancer Therapeutics.

Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome.

J. Dixon, J. Stuckey, G. Taylor, 2003, Molecular cell.

A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions.

R. Dingledine, H. Fu, Shaomeng Wang, 2011, Assay and drug development technologies.

CSAR Data Set Release 2012: Ligands, Affinities, Complexes, and Docking Decoys

Richard D. Smith, Heather A. Carlson, Emilio Xavier Esposito, 2013, J. Chem. Inf. Model..

Open Reading Frame 1 Protein of the Human Long Interspersed Nuclear Element 1 Retrotransposon Binds Multiple Equivalents of Lead.

L. Ruckthong, V. Pecoraro, J. Stuckey, 2021, Journal of the American Chemical Society.

Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity.

J. Marto, J. Stuckey, C. Carter-Su, 2010, Molecular endocrinology.

Discovery of CJ-2360 as a Potent and Orally Active Inhibitor of Anaplastic Lymphoma Kinase Capable of Achieving Complete Tumor Regression.

Liu Liu, Shaomeng Wang, Dajun Yang, 2020, Journal of medicinal chemistry.

Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors.

James Delproposto, J. Stuckey, Krishnapriya Chinnaswamy, 2016, ACS medicinal chemistry letters.

Specific residues of the cytoplasmic domains of cardiac inward rectifier potassium channels are effective antifibrillatory targets

O. Berenfeld, J. Jalife, J. Stuckey, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

THE TAIL OF KDSC: CONFORMATIONAL CHANGES CONTROL THE ACTIVITY OF A HALOACID DEHALOGENASE SUPERFAMILY PHOSPHATASE*

J. Rubin, J. Stuckey, O. Tsodikov, 2009 .

CSAR Benchmark Exercise of 2010: Selection of the Protein–Ligand Complexes

Richard D. Smith, Heather A. Carlson, Shaomeng Wang, 2011, J. Chem. Inf. Model..

A ligand‐induced conformational change in the yersinia protein tyrosine phosphatase

E. Fauman, J. Stuckey, J. Dixon, 1995, Protein science : a publication of the Protein Society.

Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity

Liu Liu, Shaomeng Wang, Yi Sun, 2021, Nature Communications.

A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation

Liu Liu, Shaomeng Wang, Yi Sun, 2017, Nature Communications.

LplA1‐dependent utilization of host lipoyl peptides enables Listeria cytosolic growth and virulence

J. Stuckey, K. Keeney, M. O’Riordan, 2007, Molecular microbiology.

Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-Apoptotic Mcl-1 and Bfl-1 Proteins.

Z. Nikolovska-Coleska, J. Stuckey, Krishnapriya Chinnaswamy, 2020, Journal of medicinal chemistry.

Comparison of the structures and stabilities of coiled‐coil proteins containing hexafluoroleucine and t‐butylalanine provides insight into the stabilizing effects of highly fluorinated amino acid side‐chains

B. Buer, J. Stuckey, J. Meagher, 2012, Protein science : a publication of the Protein Society.

Structure-Based Design of N-(5-Phenylthiazol-2-yl)acrylamides as Novel and Potent Glutathione S-Transferase Omega 1 Inhibitors.

N. Neamati, J. Stuckey, Yong Wu, 2019, Journal of medicinal chemistry.

Structure of cytochrome P450 2B4 with an acetate ligand and an active site hydrogen bond network similar to oxyferrous P450cam.

L. Waskell, J. Stuckey, J. Meagher, 2018, Journal of inorganic biochemistry.

Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance

I. Barroso, I. Farooqi, J. Stuckey, 2019, Diabetes.

Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2).

Brent R. Martin, C. Brooks, J. Stuckey, 2016, ACS chemical biology.

CSAR Benchmark Exercise 2013: Evaluation of Results from a Combined Computational Protein Design, Docking, and Scoring/Ranking Challenge

Richard D. Smith, Heather A. Carlson, David Baker, 2016, J. Chem. Inf. Model..

Structural analysis and binding properties of isoforms of tarin, the GNA-related lectin from Colocasia esculenta.

I. Goldstein, J. Stuckey, J. Meagher, 2015, Biochimica et biophysica acta.

CSAR 2014: A Benchmark Exercise Using Unpublished Data from Pharma

Richard D. Smith, Heather A. Carlson, Aqeel Ahmed, 2016, J. Chem. Inf. Model..

CSAR Benchmark Exercise 2011–2012: Evaluation of Results from Docking and Relative Ranking of Blinded Congeneric Series

Richard D. Smith, Heather A. Carlson, James B. Dunbar, 2013, J. Chem. Inf. Model..

Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with Strong In Vivo Antitumor Activity.

Shaomeng Wang, J. Stuckey, D. McEachern, 2020, Journal of medicinal chemistry.

Structure-Based Discovery of SD-36 as a Potent, Selective and Efficacious PROTAC Degrader of STAT3 Protein.

Liu Liu, Shaomeng Wang, J. Stuckey, 2019, Journal of medicinal chemistry.

Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.

F. Cao, Elizabeth C. Townsend, Hacer Karatas, 2017, Journal of medicinal chemistry.

How Outer Coordination Sphere Modifications Can Impact Metal Structures in Proteins: A Crystallographic Evaluation.

L. Ruckthong, V. Pecoraro, J. Stuckey, 2019, Chemistry.

Switching the chirality of the metal environment alters the coordination mode in designed peptides.

V. Pecoraro, J. Stuckey, A. Peacock, 2009, Angewandte Chemie.

D3R grand challenge 2015: Evaluation of protein–ligand pose and affinity predictions

Shuai Liu, Huanwang Yang, Stephen K. Burley, 2016, Journal of Computer-Aided Molecular Design.

The Cys(X)5Arg catalytic motif in phosphoester hydrolysis.

E. Fauman, J. Dixon, L. Wu, 1994, Biochemistry.

Structural Basis for the Recognition of Peptide RJPXD33 by Acyltransferases in Lipid A Biosynthesis*

J. Stuckey, J. Meagher, G. Dotson, 2014, The Journal of Biological Chemistry.

Structural bases for the different anti-fibrillatory effects of chloroquine and quinidine.

José Jalife, Sandeep V Pandit, J. Jalife, 2011, Cardiovascular research.

EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development.

Shaomeng Wang, J. Stuckey, D. McEachern, 2020, Journal of medicinal chemistry.

Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic.

Shaomeng Wang, W. Gao, Z. Nikolovska-Coleska, 2006, Journal of medicinal chemistry.

Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1

J. Whisstock, J. Stuckey, D. Lawrence, 2013, Proceedings of the National Academy of Sciences.

A model of the platelet factor 4 complex with heparin

B. Edwards, J. Stuckey, R. S. Charles, 1992, Proteins.

High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction.

Liu Liu, Shaomeng Wang, Yi Sun, 2018, Journal of Medicinal Chemistry.

Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis

J. Stuckey, E. Weh, S. Chaudhury, 2023, Pharmaceuticals.

Changing the Apoptosis Pathway through Evolutionary Protein Design.

Pralay Mitra, Yang Zhang, Christoph H. Borchers, 2019, Journal of molecular biology.

Laboratory evolution of one disulfide isomerase to resemble another

Jennifer L. Martin, J. Stuckey, J. Bardwell, 2007, Proceedings of the National Academy of Sciences.

Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins.

Sheng Jiang, Renxiao Wang, Su Qiu, 2007, Journal of medicinal chemistry.

Precise Conformational Control Yielding Highly Potent and Exceptionally Selective BRD4 Degraders with Strong Antitumor Activity.

Shaomeng Wang, J. Stuckey, D. McEachern, 2023, Journal of medicinal chemistry.

Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia.

Shaomeng Wang, J. Stuckey, D. McEachern, 2023, Journal of medicinal chemistry.

A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo

Wei Jiang, J. Stuckey, D. McEachern, 2023, Nature Chemical Biology.

SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.

Shaomeng Wang, J. Stuckey, D. McEachern, 2021, ACS medicinal chemistry letters.

Conserved Residues in the HAMP Domain Define a New Family of Proposed Bipartite Energy Taxis Receptors

I. Zhulin, V. DiRita, J. Stuckey, 2008, Journal of bacteriology.

Profiling the Binding Activities of Peptides and Inhibitors to the U2 Auxiliary Factor Homology Motif (UHM) Domains.

J. Stuckey, Krishnapriya Chinnaswamy, Xinrui Yuan, 2023, ACS medicinal chemistry letters.

Abstract 2917: Design, synthesis and biological evaluation of two chemical classes as novel small molecule Mcl-1 inhibitors

A. Azmi, R. Mohammad, T. Cierpicki, 2012 .

High-resolution crystal structures of Colocasia esculenta tarin lectin

I. Goldstein, J. Stuckey, J. Meagher, 2017, Glycobiology.

Methods for Solving Highly Symmetric De Novo Designed Metalloproteins: Crystallographic Examination of a Novel Three-Stranded Coiled-Coil Structure Containing d-Amino Acids.

V. Pecoraro, J. Stuckey, Leela Ruckthong, 2016, Methods in enzymology.

Prophylactic Mitigation of Acute Graft versus Host Disease by Novel 2-(Pyrrolidin-1-ylmethyl)pyrrole-Based Stimulation-2 (ST2) Inhibitors.

J. Stuckey, Krishnapriya Chinnaswamy, Hebao Yuan, 2023, ACS pharmacology & translational science.

Structural basis for the enhanced stability of highly fluorinated proteins

J. Stuckey, J. Meagher, E. Marsh, 2012, Proceedings of the National Academy of Sciences.

Function of His185 in Aquifex aeolicus 3-deoxy-D-manno-octulosonate 8-phosphate synthase.

H. Duewel, J. Stuckey, R. Woodard, 2002, Journal of molecular biology.

Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression.

Liu Liu, Shaomeng Wang, J. Stuckey, 2012, Journal of medicinal chemistry.

Design of Bcl-2 and Bcl-xL inhibitors with subnanomolar binding affinities based upon a new scaffold.

Liu Liu, Shaomeng Wang, Xueliang Fang, 2012, Journal of medicinal chemistry.

A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions.

R. Dingledine, H. Fu, Shaomeng Wang, 2011, Assay and drug development technologies.

Structural basis for the enhanced stability of highly fluorinated proteins

J. Stuckey, J. Meagher, E. Marsh, 2012, Proceedings of the National Academy of Sciences.

Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity.

M. Seeliger, J. Stuckey, M. Soellner, 2016, ACS chemical biology.

Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor.

Liu Liu, Shaomeng Wang, J. Stuckey, 2017, Journal of medicinal chemistry.

Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer

J. Stuckey, J. Meagher, E. L. Cárdenas, 2023, bioRxiv.

Clarifying the Copper Coordination Environment in a de Novo Designed Red Copper Protein.

V. Pecoraro, J. Stuckey, N. Lehnert, 2018, Inorganic chemistry.

A Crystallographic Examination of Predisposition versus Preorganization in de Novo Designed Metalloproteins.

M. Zastrow, V. Pecoraro, J. Stuckey, 2016, Journal of the American Chemical Society.

Structure-Activity relationship of 1-(Furan-2ylmethyl)Pyrrolidine-Based Stimulation-2 (ST2) inhibitors for treating graft versus host disease.

J. Stuckey, Krishnapriya Chinnaswamy, Hebao Yuan, 2022, Bioorganic & medicinal chemistry.