M. Ikehara

发表

Kinetic analyses of DNA‐linked ribonucleases H with different sizes of DNA

Y. Uchiyama, E. Kanaya, S. Kanaya, 1994, FEBS letters.

NMR studies of a DNA containing 8-hydroxydeoxyguanosine.

E. Ohtsuka, M. Ikehara, S. Nishimura, 1991, Nucleic acids research.

Joining of ribooligonucleotides with T4 RNA ligase and identification of the oligonucleotide-adenylate intermediate.

E. Ohtsuka, M. Ikehara, M. Sugiura, 1976, Nucleic acids research.

Preliminary crystallographic study of pyrimidine dimer-specific excision-repair enzyme from bacteriophage T4.

K. Morikawa, E. Ohtsuka, M. Ikehara, 1988, Journal of molecular biology.

Crystallization and preliminary X-ray investigation of non-specific complexes of a mutant ribonuclease T1 (Y45W) with 2'AMP and 2'UMP.

T. Hakoshima, E. Ohtsuka, M. Ikehara, 1990, Journal of molecular biology.

Two histidine residues are essential for ribonuclease T1 activity as is the case for ribonuclease A.

H. J. Kim, T. Tanaka, T. Hakoshima, 1987, Biochemistry.

Semiautomated synthesis of oligonucleotides on a silica gel support

E. Ohtsuka, M. Ikehara, H. Takashima, 1982 .

Studies of nucleosides and nucleotides. XXXV. Purine cyclonucleosides. 5. Synthesis of purine cyclonucleoside having 8,2'-O-anhydro linkage and its cleavage reactions.

M. Ikehara, H. Tada, M. Kaneko, 1968, Tetrahedron.

Synthesis and expression of a human growth hormone (somatotropin) gene mutated to change cysteine-165 to alanine.

T. Tanaka, E. Ohtsuka, M. Ikehara, 1985, European journal of biochemistry.

Overproduction and preliminary crystallographic study of ribonuclease H from Escherichia coli.

K. Morikawa, S. Kanaya, M. Ikehara, 1989, The Journal of biological chemistry.

Photo CIDNP study on the complex formation of λ‐ cro protein with OR3

M. Shirakawa, Y. Kyōgoku, E. Ohtsuka, 1985 .

Studies on transfer ribonucleic acids and related compounds. XVI. Synthesis of ribooligonucleotides using a photosensitive o-nitrobenzyl protection for the 2'-hydroxyl group.

E. Ohtsuka, M. Ikehara, Shoji Tanaka, 1977 .

Studies of the interactions between Escherichia coli ribonuclease HI and its substrate.

Y. Uchiyama, E. Ohtsuka, Y. Ueno, 1994, Journal of molecular biology.

[Synthesis of polynucleotides].

M. Ikehara, 1966, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

A → Z transition in the synthetic hexanucleotide (dCdGfl)3

M. Ikehara, S. Uesugi, G. Fazakerley, 1985, FEBS letters.

Hybrid oligomer of cyclonucleotides and deoxynucleotides. A high anti left-handed double helical DNA structure.

Y. Kyōgoku, M. Ikehara, S. Uesugi, 1985, Journal of biomolecular structure & dynamics.

Induction of differentiation of human monoblastic and myeloblastic leukemia cell lines by TNF muteins.

M. Ikehara, K. Inaka, K. Takeda, 1989, Biochemical and biophysical research communications.

De novo design and the synthesis of TIM barrel proteins

T. Hubbard, M. Ikehara, M. Hayashi, 1992 .

Inhibitory effect of methylated derivatives of guanylic acid for protein synthesis with reference to the functional structure of the 5'-'cap' in viral messenger RNA.

M. Ikehara, K. Miura, T. Fukui, 1979, Biochimica et biophysica acta.

Comparison of the antigenicities of native human growth hormone (hGH) and three forms of recombinant hGHs using monoclonal antibodies.

J. Sawada, E. Ohtsuka, M. Ikehara, 1986, Molecular immunology.

Recent developments in the chemical synthesis of polynucleotides.

D. Söll, E. Ohtsuka, M. Ikehara, 1982, Nucleic acids research.

Studies of nucleosides and nucleotides.: LVIII. Deamination of adenosine analogs with calf intestine adenosine deaminase☆

M. Ikehara, T. Fukui, 1974 .

Interaction of methionine‐specific tRNAs from Escherichia coli with immobilized elongation factor Tu

E. Ohtsuka, M. Ikehara, W. Fischer, 1985, FEBS letters.

Carbon-13 Nuclear-Magnetic-Resonance Spectra of Adenine Cyclonucleosides and Their Phosphates

M. Ikehara, S. Uesugi, Sumie Tanaka, 1978 .

Secretion of recombinant ribonuclease T1 into the periplasmic space of Escherichia coli with the aid of the signal peptide of alkaline phosphatase

T. Tanaka, M. Ikehara, H. Morioka, 1990, FEBS letters.

Modification of Glu 58, an amino acid of the active center of ribonuclease T1, to Gln and Asp.

T. Tanaka, E. Ohtsuka, M. Ikehara, 1986, Biochemical and Biophysical Research Communications - BBRC.

Inquiries into the structure-function relationship of ribonuclease T1 using chemically synthesized coding sequences.

E. Ohtsuka, M. Ikehara, S. Nishikawa, 1986, Proceedings of the National Academy of Sciences of the United States of America.

1H‐ and 31P‐nuclear magnetic resonance studies on the conformation of d‐(CpGpCpG)2 and d‐(CpGpCpGpCpG)2 short helices in B‐conformation

L. Kan, M. Ikehara, S. Uesugi, 1984 .

Left-handed helical polynucleotides with D-sugar phosphodiester backbones.

M. Ikehara, J. Yano, S. Uesugi, 1972, Nature: New biology.

Synthesis and template-directed polymerization of adenylyl(3'-5')adenosine cyclic 2', 3'-phosphate.

M. Ikehara, S. Uesugi, 1977, Biochemistry.

Structure and Function of Ribonuclease HI from Escherichia coli

S. Kanaya, M. Ikehara, 1993 .

Left handed double helices: effect of sequence on the spatial configuration of high anti nucleic acids.

R. Sarma, M. Ikehara, S. Uesugi, 1981, Biochemistry.

Stabilization of Escherichia coli ribonuclease H by introduction of an artificial disulfide bond.

H. Nakamura, K. Morikawa, S. Kanaya, 1991, The Journal of biological chemistry.

Chemical synthesis of the 5 - ́half molecule of E.coli tRNA2GLY

E. Ohtsuka, M. Ikehara, T. Doi, 1984 .

Recognition by restriction endonuclease EcoRI of deoxyoctanucleotides containing modified sugar moieties.

Y. Ishino, E. Ohtsuka, M. Ikehara, 1984, European journal of biochemistry.

A method for the synthesis of oligonucleotide by single addition of 2'-O-(o-nitrobenzyl)nucleoside 5'-diphosphates using polynucleotide phosphorylase.

E. Ohtsuka, M. Ikehara, S. Tanaka, 1979, Biochimica et biophysica acta.

Joining of 3'-modified oligonucleotides by T4 RNA ligase. Synthesis of a heptadecanucleotide corresponding to the bases 61--77 from Escherichia coli tRNAfMet.

A. Markham, E. Ohtsuka, M. Ikehara, 1978, Biochemistry.

Polynucleotides. VII. Synthesis of ribopolynucleotides containing 8-substituted purine nucleotides by polynucleotide phosphorylase.

M. Ikehara, T. Fukui, I. Tazawa, 1969, Biochemistry.

Hydrolysis by myosin A of several synthetic adenosine triphosphate analogues.

Y. Tonomura, E. Ohtsuka, M. Ikehara, 1962, Biochimica et biophysica acta.

Carbon-13 magnetic resonance spectra of 8-substituted purine nucleosides. Characteristic shifts for the syn conformation.

M. Ikehara, S. Uesugi, 1977, Journal of the American Chemical Society.

Studies of nucleosides and nucleotides. XXXIX. Synthesis of 8-substituted purine nucleotides by the direct replacement reactions.

M. Ikehara, T. Fukui, I. Tazawa, 1969, Chemical & pharmaceutical bulletin.

[Chemical synthesis of polynucleotides].

M. Ikehara, 1968, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

Interferon induction by a 2'-modified double-helical RNA, poly(2'-azido-2'-deoxyinosinic acid) . polycytidylic acid.

E. De Clercq, M. Ikehara, B. Stollar, 1978, European journal of biochemistry.

Polynucleotides. LV. Synthesis and Properties of Dinucleoside Monophosphates derived from Adenine 8, 2'-S- and Uracil 6, 2'-O-Cyclonucleosides. Further Support for the Left-Handed Stacking of Oligonucleotides having High-Anti Base Torsion Angles

M. Ikehara, S. Uesugi, T. Shida, 1980 .

Solid-phase synthesis of protected oligonucleotide blocks : Applications to block condensation on a polymer support and synthesis of a 3'-modified oligonucleotides

E. Ohtsuka, M. Ikehara, S. Iwai, 1987 .

Polynucleotides XLVII. Synthesis and properties of poly(2-methylthio- and 2-ethylthioadenylic acid). Formation of non-Watson-Crick type complexes.

M. Ikehara, T. Fukui, 1979, Biochimica et biophysica acta.

Polynucleotides. XLIV. Synthesis and properties of poly (2-azaadenylic acid) and poly(2-azainosinic acid).

M. Ikehara, N. Kakiuchi, T. Fukui, 1978, Biochimica et biophysica acta.

Poly(2-methyl-N6-methyladenylic acid): synthesis, properties, and interaction with poly(uridylic acid).

M. Ikehara, M. Hattori, H. Miles, 1974, Biochemistry.

Polynucleotides,. XIV. Synthesis and properties of polynucleotides containing 2,6-bis(methylthio)purine ribonucleotides.

M. Hattori, M. Ikehara, 1972, Biochimica et biophysica acta.

Polynucleotides. XI. Synthesis and properties of poly(2-methylinosinic acid).

M. Hattori, M. Ikehara, 1972, Biochimica et biophysica acta.

Synthesis and properties of poly(2-methylthioinosinic acid).

M. Hattori, M. Ikehara, 1972, Biochimica et biophysica acta.

Synthesis and properties of polyribonucleotides containing N 2 -methyl and N 2 -dimethylguanylic acid in polyguanylic acid.

M. Hattori, M. Ikehara, 1971, Biochemistry.

The effect of guanosine 5'-triphosphate analogues on protein synthesis.

M. Ikehara, E. Otsuka, H. Uno, 1971, Biochimica et biophysica acta.

The selective utilization of tubercidin triphosphate as an ATP analog in the DNA-dependent RNA polymerase system

M. Ikehara, S. Nishimura, F. Harada, 1966 .

The complete nucleotide sequence of the influenza virus neuraminidase gene of A/NJ/8/76 strain and its evolution by segmental duplication and deletion.

T. Miyata, Y. Nishida, E. Ohtsuka, 1983, Molecular biology & medicine.

Three-dimensional structure of ribonuclease H from E. coli

K. Morikawa, S. Kanaya, M. Ikehara, 1990, Nature.

DNA-linked RNase H for site-selective cleavage of RNA.

Y. Uchiyama, S. Kanaya, E. Ohtsuka, 1994, Bioconjugate chemistry.

Binding of metal ions toE. coli RNase HI observed by1H−15N heteronuclear 2D NMR

H. Nakamura, S. Kanaya, M. Ikehara, 1991, Journal of biomolecular NMR.

Identification of I:A mismatch base-pairing structure in DNA.

E. Ohtsuka, M. Ikehara, Y. Oda, 1987, The Journal of biological chemistry.

Protein synthesis directed by ribopolynucleotide containing formycin.

M. Ikehara, S. Nishimura, F. Harada, 1969, Biochimica et biophysica acta.

Role of the Mg2+ ion in the Escherichia coli ribonuclease HI reaction.

Y. Uchiyama, E. Ohtsuka, Y. Ueno, 1994, Journal of biochemistry.

Studies on transfer ribonucleic acids and related compounds. 23. Synthesis of a heptanucleotide corresponding to a eukaryotic initiator tRNA loop sequence

E. Ohtsuka, M. Ikehara, S. Tanaka, 1978 .

Synthesis of formycin triphosphate and its incorpoartion into ribopolynucleotide by DNA-dependent RNA polymers.

M. Ikehara, S. Nishimura, F. Harada, 1968, Biochimica et biophysica acta.

SYNTHESIS OF tRNAfMet FROM E. COLI

A. Markham, E. Ohtsuka, M. Ikehara, 1980 .

Reconstitution of chemically synthesized ribooligonucleotides with naturally occurring tRNA fragments.

E. Ohtsuka, M. Ikehara, S. Nishikawa, 1976, European journal of biochemistry.

Synthesis of ribooligonucleotides having sequences of transfer ribonucleic acids

M. Ikehara, 1974 .

Polynucleotides. XV. Synthesis and properties of polynucleotides containing N 2 -dimethylguanylic acid residues in polyinosinate and polyadenylate chains.

M. Hattori, M. Ikehara, 1972, Biochimica et biophysica acta.

Solid phase synthesis of oligoribonucleotides using o-nitrobenzyl protection of 2'-hydroxyl via a phosphotriester approach

M. Ikehara, M. Orita, Toshiki Tanaka, 1988 .

Studies of nucleosides and nucleotides—XLVI : Purine cyclonucleosides—13. Synthesis and properties of 8,5′-anhydro-8-mercaptoadenosine

M. Ikehara, M. Sagai, M. Kaneko, 1970 .

Poly(8-methyladenylic acid): a single-stranded regular structure with alternating syn-anti conformations.

M. Ikehara, S. Uesugi, H. Miles, 1983, Biochemistry.

Monoclonal Antibodies with Affinity to Self-Complementary Left-Handed DNA Containing Cyclonucleosides with High Anti Conformation

E. Ohtsuka, M. Ikehara, J. Kawakami, 1994 .

1H‐nmr studies on the dinucleoside monophosphates containing 2′‐halogeno‐2′‐deoxypurinenucleosides: Effects of 2′‐substitutes on conformation

L. Kan, M. Ikehara, S. Uesugi, 1983 .

Influence of terminal 3' phosphates or 2',3'-cyclic phosphates on the conformations of oligoriboadenylates, oligoribocytidylates, and the corresponding monomers.

A. Markham, E. Ohtsuka, M. Ikehara, 1979, Biochemistry.

Conformational difference between 8-bromo-2'-O-triisopropyl-benzenesulfonyl-adenosine and its 3'-isomer determined by x-ray method.

M. Ikehara, T. Fujihara, T. Fujiwara, 1972, Biochemical and biophysical research communications.

Crystal structure of ribonuclease Ms (as a ribonuclease T1 homologue) complexed with a guanylyl-3',5'-cytidine analogue.

M Ikehara, S Uesugi, T. Nonaka, 1993, Biochemistry.

Studies on Nucleosides and Nucleotides. LXXXVIII. Synthesis of a Non-hydrolyzable Substrate Analog of Ribonuclease Tl, 2'-Deoxy-2'-fluoroguanylyl-(3'-5')-uridine

M. Ikehara, J. Imura, 1981 .

Studies on transfer ribonucleic acids and related compounds. XLIV. A large-scale synthesis of the anticodon heptanucleotide of formyl-methionine transfer ribonucleic acid by using 2'-O-tetrahydrofuranylnucleosides.

E. Ohtsuka, M. Ikehara, M. Ohkubo, 1983, Chemical & pharmaceutical bulletin.

Studies on Transfer Ribonucleic Acids and Related Compounds. XLIII. Synthesis of Oligoribonucleotides by using 5'-Selective Phosphorylation of 2'-O-Tetrahydrofuranyl Nucleosides

E. Ohtsuka, M. Ikehara, A. Yamane, 1983 .

Studies on transfer ribonucleic acids and related compounds. I. Synthesis of ribooligonucleotides using aromatic phosphoramidates as a protecting group.

E. Ohtsuka, M. Ikehara, M. Ubasawa, 1970, Journal of the American Chemical Society.

Stereoselective synthesis of dinucleoside phosphate aryl esters by using new condensing reagents, arenesulfonyl 5-(pyridin-2-yl)-tetrazole

E. Ohtsuka, M. Ikehara, M. Shiraishi, 1985 .

Synthesis of 1-(2-Deoxy-β-D-ribofuranosyl)benzimidazole via Cyclonucleosides

M. Ikehara, T. Inaoka, 1985 .

Synthesis of Thioinosine and Thio-AICA-riboside Analogs

M. Ikehara, T. Furukawa, A. Yamazaki, 1973 .

Synthesis of Thio-AICA, 6-Thioxanthine, Isoguanine Analogs, and Their Ribosides

M. Ikehara, A. Yamazaki, I. Kumashiro, 1968 .

A New and Convenient Synthesis of 1-O-Acetyl-2, 3, 5-tri-O-benzoyl-β-D-ribofuranose from Guanosine ; Some Observations on Solvolysis of 2', 3', 5'-Tri-O-benzoylguanosine

M. Ikehara, T. Ueda, A. Nomura, 1960 .

New approach to the synthesis of deoxynucleoside-phosphoramidite derivatives

M. Ikehara, Toshiki Tanaka, S. Tamatsukuri, 1986 .

Potential Antimetabolites. I. Selective Thiation of Uracil and 1,2,4-Triazine-3,5 (2H, 4H)-dione (6-Azauracil).

M. Ikehara, Kyoichi A. Watanabe, Y. Mizuno, 1962 .

Synthetic Studies of Potential Antimetabolites. IX. The Anomeric Configuration of Tubercidin

M. Ikehara, Kyoichi A. Watanabe, Y. Mizuno, 1963 .

Synthetic Studies of Potential Antimetabolites. VII. Evidences that the supposed 1-β-D-Ribofuranosyl-1H-imidazo [4, 5-b] pyridine is actually 3-β-D-Ribofuranosyl-3H-imidazo [4, 5-b] pyridine (1-Deazapurine Ribofuranoside)

M. Ikehara, Kazuko Saito, Y. Mizuno, 1963 .

SYNTHESIS OF A PROTEIN BIOSYNTHESIS INHIBITOR, 5′-TRIPHOSPHORYLADENYLYL-(2′-5′)-ADENYLYL-(2′-5′)-ADENOSINE

E. Ohtsuka, M. Ikehara, K. Oshie, 1980 .

Studies on transfer ribonucleic acids and related compounds. 29. Synthesis of a decaribonucleotide of Escherichia coli tRNAfMet (bases 11-20) using a new phosphorylating reagent

E. Ohtsuka, M. Ikehara, Toshiki Tanaka, 1979 .

A new method for 3'-labelling of polyribonucleotides by phosphorylation with RNA ligase and its application to the 3'-modification for joining reactions.

E. Ohtsuka, M. Ikehara, T. Miyake, 1979, Nucleic acids research.

Synthesis of a protein biosynthesis inhibitor, 5′-tri-phosphoryladenylyl-(2′-5′)-adenosine

E. Ohtsuka, M. Ikehara, K. Oshie, 1979 .

Polynucleotides. XLVIII. Synthesis and Template-Directed Polymerization of Tri-(adenylic Acid) having a 2'-O-(o-nitrobenzyl) Group at the 3'-End

E. Ohtsuka, M. Ikehara, Shoji Tanaka, 1978 .

Studies on transfer ribonucleic acids and related compounds. 20. A new versatile ribooligonucleotide block with 2'-(o-nitrobenzyl) and 3'-phosphorodianilidate groups suitable for elongation of chains in the 3' and 5' directions

E. Ohtsuka, M. Ikehara, Toŝhiyuki Tanaka, 1978 .

Studies on transfer ribonucleic acids and related compounds. XVII. Studies on protecting groups of trisubstituted phosphates in the synthesis of ribooligonucleotides.

E. Ohtsuka, M. Ikehara, T. Miyake, 1977 .

Studies on Transfer Ribonucleic Acids and Related Compounds; XVIII1. A Photolabile 2′-Ether of Guanosine as an Intermediate for Oligonucleotide Synthesis

E. Ohtsuka, M. Ikehara, S. Tanaka, 1977 .

Polynucleotides. XLII1. Limited addition of 2'O-onitrobenzyl nucleotides to the 3'-end of ribooligonucleotide with polynucleotide phosphorylase.

E. Ohtsuka, M. Ikehara, S. Tanaka, 1976, Nucleic acids research.

Studies on transfer ribonucleic acids and related compounds. IX. Ribooligonucleotide synthesis using a photosensitive o-nitrobenzyl protection at the 2'-hydroxyl group.

E. Ohtsuka, M. Ikehara, S. Tanaka, 1974, Nucleic acids research.

Studies on transfer ribonucleic acids and related compounds. XLI. Synthesis of tRNA fragments containing modified nucleosides.

E. Ohtsuka, M. Ikehara, T. Miyake, 1983, Chemical & pharmaceutical bulletin.

Studies of nucleosides and nucleotides—LIV : Purine cyclonucleosides—19. Further investigations on the cleavage of the 8,2′-O-anhydro linkage. A new synthesis of 9-β-D-arabinofuranosyladenine

M. Ikehara, Y. Ogiso, 1972 .

Studies of Nucleosides and Nucleotides. LXXXII. Cyclonucleosides. (39). Synthesis and Properties of 2'-Halogeno-2'-deoxyadenosines

M. Ikehara, H. Miki, 1978 .

Studies of Nucleosides and Nucleotides. LXXXV. Purine Cyclonucleosides. (35). Synthesis of Purine Nucleosides having 2'-Azido and 2'-Amino Functions by Cleavage of Purine Cyclonucleosides

M. Ikehara, T. Maruyama, H. Miki, 1977 .

Solid phase synthesis of ribo-oligonucleotides on a polyacrylmorpholide support

E. Ohtsuka, M. Ikehara, H. Takashima, 1981 .

Interaction between synthetic ATP analogues and actomyosin systems. IV.

Y. Tonomura, M. Ikehara, F. Harada, 1964, Journal of biochemistry.

Cleavage of 8,2′-anhydro-8-oxy-9-β-D-arabinofuranosyladenine with hydrogen sulfide and its interconversion with 8,5′-cyclonucleoside

M. Ikehara, M. Kaneko, Y. Ogiso, 1970 .

Synthesis and properties of CpG analogues containing an 8-bromoguanosine residue. Evidence for Z-RNA duplex formation.

M. Ikehara, S. Uesugi, T. Shida, 1982, Biochemistry.

Raman diagnosis of nucleic acid structure: sugar-puckering and glycosidic conformation in the guanosine moiety.

E. Ohtsuka, M. Ikehara, Y. Nishimura, 1983, Nucleic acids research.

Studies of nucleosides and nucleotides— LIII : Purine cyclonucleosides-18. Selective tosylation of adenine nucleotides. Synthesis of 8,2′-anhydro-8-mercapto-9-β-D-arabinofuranosyladenine 5′- and 3′,5-cyclic phosphate

M. Ikehara, S. Uesugi, 1972 .

Studies of Nucleosides and Nucleotides. XXXVIII. Synthesis of 8-Bromoadenosine Nucleotides

M. Ikehara, S. Uesugi, 1969 .

Synthesis and properties of the dinucleoside monophosphate of adenine 8-thiocyclonucleoside.

M. Ikehara, S. Uesugi, M. Yasumoto, 1972, Journal of the American Chemical Society.

Purine 8-cyclonucleosides

M. Ikehara, 1969 .

Studies of nucleosides and nucleotides. XLI. Purine cyclonucleosides. 8. Selective sulfonylation of 8-bromoadenosine derivatives and an alternate synthesis of 8,2'-and 8,3'-S-cyclonucleosides.

M. Ikehara, M. Kaneko, 1970, Tetrahedron.

A linear relationship between electronegativity of 2′-substituents and conformation of adenine nucleosides

Y. Kyōgoku, M. Ikehara, S. Uesugi, 1979 .

Structure and activity of artificial mutant variants of human growth hormone.

T. Tanaka, T. Hayakawa, M. Ikehara, 1989, Protein Engineering.

Synthesis of a gene for human growth hormone and its expression in Escherichia coli.

E. Ohtsuka, M. Ikehara, S. Miyamoto, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Studies of nucleosides and nucleotides—XLV: Purine cyclonucleosides.-12. Synthesis of adenine cyclonucleosides having 8,5′-0-anhydro linkage☆☆☆

M. Ikehara, M. Kaneko, R. Okano, 1970 .

Interaction between synthetic ATP analogues and actomyosin systems. IV.

Y. Tonomura, M. Ikehara, F. Harada, 1964, Journal of biochemistry.

3. INTERACTION BETWEEN SYNTHETIC ADENOSINE TRIPHOSPHATE ANALOGUES AND ACTOMYOSIN SYSTEMS.

Y. Tonomura, E. Ohtsuka, M. Ikehara, 1965, Biochimica et biophysica acta.

Interferon induction by two 2'-modified double-helical RNAs, poly(2'-fluoro-2'-deoxyinosinic acid) x poly(cytidylic acid) and poly(2'-chloro-2'-deoxyinosinic acid) x poly(cytidylic acid).

E. De Clercq, M. Ikehara, B. Stollar, 1980, European journal of biochemistry.

Studies on the conformation of purine nucleosides and their 5'-phosphates.

M. Ikehara, S. Uesugi, K. Yoshida, 1972, Biochemistry.

Studies of Nucleosides and Nucleotides. LXXIII. Chlorination of Adenosine and Its N6-Methyl Derivatives with t-Butyl Hypochlorite

M. Ikehara, T. Maruyama, Y. Ogiso, 1977 .

Studies of Nucleosides and Nucleotides. XLIX. Synthesis of 8-Fluoroadenosine

M. Ikehara, S. Yamada, 1971 .

NMR lanthanoid-probe analyses of conformational properties of 8,2'-S-cycloadenosine 3'-monophosphate in aqueous solution.

S. Yokoyama, M. Ikehara, S. Uesugi, 1983 .

Solid phase synthesis of oligoribonucleotides using o-nitrobenzyl protection of 2'-hydroxyl via a phosphite triester approach.

T. Tanaka, M. Ikehara, S. Tamatsukuri, 1986, Nucleic acids research.

Studies on transfer ribonucleic acids and related compounds. XL. Synthesis of an eicosaribonucleotide corresponding to residues 35-54 of tRNAfMet from E. coli.

E. Ohtsuka, M. Ikehara, K. Fujiyama, 1981, Nucleic acids research.

Synthesis and Properties of Oligonucleotides

E. Ohtsuka, M. Ikehara, Toshiki Tanaka, 1988 .

Improved Synthesis of 2′-Fluoro-2′-Deoxyadenosine and Synthesis and Carbon-13 NMR Spectrum of Its 3′,5′-Cyclic Phosphate Derivative1

M. Ikehara, S. Uesugi, J. Matsugi, 1983 .

Studies of nucleosides and nucleotides—LXI : Purine cyclonucleosides 23 synthesis of sulfoxides of adenine s-cyclonucleosides

M. Ikehara, Y. Ogiso, T. Morii, 1976 .

Studies of nucleosides and nucleotides—LXV : Purine cyclonucleosides-26 a versatile method for the synthesis of purine O-cyclo-nucleosides. The first synthesis of 8,2′-anhydro-8-oxy 9-β-d-arabinofuranosylguanine

M. Ikehara, T. Maruyama, 1975 .

Synthesis and properties of 8,2′-N-cycloadenosines

M. Ikehara, M. Kaneko, B. Shimizu, 1971 .

A novel rearrangement of S- to O-cyclonucleosides

M. Ikehara, Y. Ogiso, Y. Matsuda, 1971 .

Studies of Nucleosides and Nucleotides. XL. Synthesis of 8, 5'-O-Cyclonucleoside derived from 8-Oxyguanosine and Its Cleavage by Nucleophilic Reagents

M. Ikehara, K. Muneyama, 1970 .

Studies of nucleosides and nucleotides. XXXVI. Purine cyclonucleosides. 6. Further investigation on the formation of 8,5'-S-cyclonucleoside from guanosine.

M. Ikehara, K. Muneyama, 1967, The Journal of organic chemistry.

Studies of nucleosides and nucleotides. XXXII. Purine cyclonucleosides. 3. Synthesis of2 2'-deoxy- and 3'-deoxyadenosine from adenosine.

M. Ikehara, H. Tada, 1967, Chemical & pharmaceutical bulletin.

Direct evidence of the interaction between base and the protective group in the sugar moiety of nucleosides.

M. Ikehara, H. Tada, 1966, Chemical & pharmaceutical bulletin.

Studies of Nucleosides and Nucleotides. XXV. Purine Cyclonucleosides. 2. Synthesis of 5'-Deoxyguanosine via an 5', 8-Cyclonucleoside

M. Ikehara, K. Muneyama, H. Tada, 1965 .

Studies on transfer ribonucleic acids and related compounds. XXI. Synthesis and properties of guanine rich fragments from E. coli tRNAfMet 5'-end.

A. Markham, E. Ohtsuka, M. Ikehara, 1978 .

Polynucleotides. I. Formation of internucleotidic linkage by means of dimethylformamidethionyl chloride complex.

M. Ikehara, H. Uno, 1965, Chemical & pharmaceutical bulletin.

Studies on transfer ribonucleic acids and related compounds. V. Synthesis of ribonucleotides with phosphomonoester end groups on a polymer support.

E. Ohtsuka, M. Ikehara, S. Morioka, 1972, Journal of the American Chemical Society.

Studies on Transfer Ribonucleic Acids and Related Compounds. VII. Synthesis and Properties of Cyclic Oligoadenylic Acids

E. Ohtsuka, M. Ikehara, Hisayo Tsuji, 1974 .

Solid phase synthesis of oligoribonucleotides using the o-nitrobenzyl group for 2'-hydroxyl protection and H-phosphonate chemistry.

T. Tanaka, M. Ikehara, Toshiki Tanaka, 1987, Nucleic acids research.

An active site of growth hormone for eliciting the differentiation of preadipose 3T3-F442A cells to adipose cells.

T. Hayakawa, M. Ikehara, S. Nishikawa, 1990, Biochemical and biophysical research communications.

Synthesis of a new helical protein: the effect of secondary structure rearrangement on structure formation.

T. Tanaka, M. Ikehara, Y. Yamamoto, 1990, Biochemical and biophysical research communications.

Studies of nucleosides and nucleotides—LXXIV1: Purine cyclonucleosides—34 a new method for the synthesis of 2'-substituted 2'-deoxyadenosines

M. Ikehara, T. Maruyama, H. Miki, 1978 .

Polynucleotides. XII. Synthesis and Properties of Dinucleoside Monophosphates containing 8-Bromoadenosine

M. Ikehara, S. Uesugi, Mayumi Kobayashi, 1972 .

A Possible Mechanism of the Transformation of Purine Ribonucleoside to Deoxyribonucleoside

M. Ikehara, H. Tada, A. Nomura, 1964, Nature.

Synthetic Studies of Potential Antimetabolites. X.1Synthesis of 4-Hydroxy-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine, a Tubercidin Analog

M. Ikehara, Kyoichi A. Watanabe, Y. Mizuno, 1963 .

Studies on coenzyme analogs. XIII. Oxidation of methylmercaptopurine and its nucleoside by means of N-chloro-and N-bromosuccinimide.

M. Ikehara, A. Yamazaki, T. Fujieda, 1962, Chemical and pharmaceutical bulletin.

Synthesis of 2'- and 3'-Deoxyinosines

M. Ikehara, A. Yamazaki, I. Kumashiro, 1973 .

Chemical synthesis of 5′-phosphorylated oligodeoxyribonucleotide on a polymer support

M. Ikehara, Toshiki Tanaka, Yasuki Yamada, 1986 .

Hybrid hexanucleotide duplex containing cyclonucleotides and deoxynucleotides: the d(TA) segment can adopt a high anti left-handed double-helical structure.

M. Ikehara, S. Fujii, K. Tomita, 1988, Biochemistry.

Hybridization of polymers of antibiotic C-nucleoside phosphates, poly(formycin phosphate) and poly(laurusin phosphate)

M. Ikehara, S. Uesugi, T. Tezuka, 1975, Biochemistry.

Multinuclear magnetic resonance studies of monomers and diemrs containing 2′‐fluoro‐2′‐deoxyadenosine

L. Kan, M. Ikehara, S. Uesugi, 1983, Biopolymers.

C(2')-substituted purine nucleoside analogs. Interactions with adenosine deaminase and purine nucleoside phosphorylase and formation of analog nucleotides.

M. Ikehara, C. K. Chu, R. Parks, 1982, Biochemical pharmacology.

Studies of Nucleosides and Nucleotides. LXIX. Purine Cyclonucleosides. (30). Elimination of the 8-Oxy Function of Purine Nucleosides

M. Ikehara, T. Maruyama, 1976 .

Studies of Nucleosides and Nucleotides. XLII. Purine Cyclonucleosides. (9). Synthesis of Adenine Cyclonucleosides having 8,2'-and 8,3'-O-Anhydro Linkages

M. Ikehara, M. Kaneko, 1970 .

Studies of Nucleosides and Nucleotides. LII. Purine Cyclonucleosides.(17). Synthesis and Properties of Cyclonucleosides derived from Inosine and Thioinosine

M. Ikehara, M. Muraoka, 1972 .

Studies of Nucleosides and Nucleotides. LI. Purine Cyclonucleosides. (16). Synthesis of Cyclonucleosides derived from N 6 -Dimethyladenosine

M. Ikehara, H. Morisawa, 1971 .

Studies in organic mass spectrometry. III. Adenosine 8-Cyclonucleosides

M. Ikehara, Y. Tamura, M. Ikeda, 1970 .

A highly stacked dinucleoside monophosphate derived from adenine 8-cyclonucleosides.

M. Ikehara, S. Uesugi, M. Yasumoto, 1970, Journal of the American Chemical Society.

CARBON-13 MAGNETIC RESONANCE SPECTRA OF 8-SUBSTITUTED PURINE NUCLEOSIDES. CHARACTERISTIC SHIFTS FOR THE SYN CONFORMATION

M. Ikehara, S. Uesugi, 1977 .

Studies of Nucleosides and Nucleotides. LXVIII. Purine Cyclonucleosides. (29). Synthesis and Properties of O-Cyclonucleosides derived from Hypoxanthine, Mercaptopurine, Methylmer-captopurine and Purine

M. Ikehara, M. Muraoka, 1976 .

Studies on transfer ribonucleic acids and related compounds. XXVI. Circular dichroic properties of cyclic oligoribonucleotides and their linear counterparts

E. Ohtsuka, M. Ikehara, A. Markham, 1980, Biopolymers.

Interaction between Synthetic ATP Analogs and Actomyosin Systems1

Y. Tonomura, E. Ohtsuka, M. Ikehara, 1961 .

Formation of phosphodiester linkages by oxidation of a phosphoramidate

E. Ohtsuka, M. Ikehara, S. Morioka, 1972 .

Studies on coenzyme analogs. XI. Synthesis of N-methyl-and N, N-dimethyl-cytidine 5'-phosphate.

M. Ikehara, T. Ueda, K. Ikeda, 1962, Chemical & pharmaceutical bulletin.

One step rearrangement of 8,5′-o-cycloadenosine to n3,5′-cyclonucleoside

M. Ikehara, Shōji Tanaka, 1974 .

Synthesis of 8,5'-anhydro-8-mercaptoadenosine.

M. Ikehara, M. Sagai, M. Kaneko, 1968, Chemical & pharmaceutical bulletin.

A novel method for the synthesis of cyclonucleosides. Synthesis of 8,5'-o-anhydro-8-oxyadenosine.

M. Ikehara, M. Kaneko, 1968, Journal of the American Chemical Society.

Synthesis of purine cyclonucleoside having 8,3'-O-anhydro linkage.

M. Ikehara, M. Kaneko, 1967, Chemical and pharmaceutical bulletin.

Synthesis of Purine Cyclonucleoside Having a 8,2'-O-Anhydro Linkage

M. Ikehara, K. Muneyama, H. Tada, 1966 .

Nucleosides and nucleotides. XLVIII. Conformation of purine nucleoside pyrophosphates as studies by circular dichroism

M. Ikehara, Katsumi Yoshida, S. Uesugi, 1972 .

Studies of nucleosides and nucleotides. XXXIV. Purine cyclonucleosides. 4. Synthesis of a cyclonucleoside having an O cyclo linkage derived from guanosine.

M. Ikehara, K. Muneyama, 1967, The Journal of organic chemistry.

INTERFERON INDUCING ACTIVITY OF A 2'-MODIFIED DOUBLESTRANDED COMPLEX, POLY (2'-AZIDO-2'-DEOXYINOSINIC ACID) POLY (CYTIDYLIC ACID)

M. Ikehara, N. Kakiuchi, T. Fukui, 1978 .

NMR studies for identification of dI:dG mismatch base-pairing structure in DNA.

E. Ohtsuka, M. Ikehara, Y. Oda, 1991, Nucleic acids research.

An alternative approach to deoxyoligonucleotides as hybridization probes by insertion of deoxyinosine at ambiguous codon positions.

E. Ohtsuka, M. Ikehara, Y. Takahashi, 1985, The Journal of biological chemistry.

Functions and structures of ribonuclease H enzymes.

S. Kanaya, M. Ikehara, Shigenori Kanaya, 1995, Sub-cellular biochemistry.

Synthesis and properties of d(ATACGCGTAT) and its derivatives containing one and two 5-methylcytosine residues. Effect of the methylation on deoxyribonucleic acid conformation

M. Ikehara, K. Tomita, S. Uesugi, 1986 .

Molecular cloning of the human cholecystokinin gene by use of a synthetic probe containing deoxyinosine.

Y. Hayashizaki, K. Kato, E. Ohtsuka, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Studies of nuclesides and nucleotides. 31. Reaction of nitrous acid with mono- and di-esters of phosphoramidate.

M. Ikehara, S. Uesugi, T. Fukui, 1967, Chemical and pharmaceutical bulletin.

Carbon-13 NMR spectra of nucleoside 3′,5′-cyclic phosphates. Proposition for revised signal assignments

M. Ikehara, S. Uesugi, Sumie Tanaka, 1979 .

The crystal and molecular structure of 8-methyladenosine 3'-monophosphate dihydrate.

Y. Yamagata, M. Ikehara, S. Fujii, 1979, Biochimica et Biophysica Acta.

Studies of nucleosides and nucleotides. XXVI. Further studies on the chlorination of inosine derivatives with dimethylformamide-thionyl chloride complex.

M. Ikehara, H. Uno, 1965, Chemical & pharmaceutical bulletin.

Studies of Nucleosides and Nucleotides. XXIII. A Versatile Method for Replacement of 6-Hydroxyl Group of Purine Nucleoside.

M. Ikehara, F. Ishikawa, H. Uno, 1964 .

Deoxyribonucleic Acids and Related Compounds. VIII. Solid-Phase Synthesis of Deoxyribooligonucleotides with 3'-Modification by Elongation in the 3'-Direction

E. Ohtsuka, M. Ikehara, S. Iwai, 1984 .

Inhibition of a novel subspecies of DNA polymerase α by 2′-deoxy-2′-azidoadenosine 5′-triphosphate

T. Seno, E. Ohtsuka, M. Ikehara, 1982 .

The crystal and molecular structure of 2'-deoxy-2'-fluoroinosine monohydrate.

T. Hakoshima, M. Ikehara, K. Tomita, 1981, Nucleic Acids Research.

Influence of various 2- and 2'-substituted polyadenylic acids on murine leukemia virus reverse transcriptase.

E. De Clercq, M. Hattori, M. Ikehara, 1979, Cancer letters.

STUDIES OF NUCLEOSIDES AND NUCLEOTIDES. LXVIII. PURINE CYCLONUCLEOSIDES. (29). SYNTHESIS AND PROPERTIES OF O-CYCLONUCLEOSIDES DERIVED FROM HYPOXANTHINE, MERCAPTOPURINE, METHYLMERCAPTOPURINE AND PURINE

M. Ikehara, M. Muraoka, 1976 .

Studies on Condensed Systems of Aromatic Nitrogenous Series. XXII. Structural Studies of β-D-Ribofuranosylimidazopyridines1

M. Ikehara, Kazuko Saito, Y. Mizuno, 1963 .

Crystal and molecular structure of a cyclonucleoside, 8,5'-anhydro-2',3'-isopropylidene-8-mercaptoadenosine.

M. Ikehara, T. Fujiwara, K. Tomita, 1970, Biochemical and biophysical research communications.

UNUSUAL RAPID CLEAVAGE OF TERMINAL PHOSPHATE GROUP OF N-6-DISUBSTITUTED ADENOSINE 5'-TRIPHOSPHATE BY DIVALENT CATION.

M. Ikehara, H. Uno, 1964, Biochimica et biophysica acta.

Total synthesis of a RNA molecule with sequence identical to that of Escherichia coli formylmethionine tRNA.

T. Tanaka, A. Markham, E. Ohtsuka, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis of 5' fragments of formylmethionine transfer ribonucleic acid and their reconstitution with a natural three-quarter molecule.

T. Tanaka, E. Ohtsuka, M. Ikehara, 1980, European journal of biochemistry.

Synthesis of E.coli tRNAfMet fragments and their joining with RNA ligase

E. Ohtsuka, M. Ikehara, S. Nishikawa, 1978 .

STUDIES ON TRANSFER RIBONUCLEIC ACIDS AND RELATED COMPOUNDS PART 6, SYNTHESIS OF YEAST ALANINE TRANSFER RIBONUCLEIC ACID 3′-TERMINAL NONANUCLEOTIDES AND 5′-TERMINAL HEXANUCLEOTIDES

E. Ohtsuka, M. Ikehara, M. Ubasawa, 1973 .

SYNTHESIS OF RIBO‐OLIGONUCLEOTIDES HAVING THE SEQUENCE OF TRANSFER RIBONUCLEIC ACID *

M. Ikehara, 1975, Annals of the New York Academy of Sciences.

A new method for the synthesis of protected ribooligonucleotides with 3'-phosphate end groups.

E. Ohtsuka, M. Ikehara, M. Ubasawa, 1969, Journal of the American Chemical Society.

Chemistry of Cyclonucleosides

M. Ikehara, T. Ueda, 1974 .

STUDIES OF NUCLEOSIDES AND NUCLEOTIDES. XXIV. PURINE CYCLONUCLEOSIDES. I. 8,2'-CYCLONUCLEOSIDE DERIVED FROM 2-CHLORO-8-MERCAPTO-9-BETA-D-XYLOFURANOSYLADENINE.

M. Ikehara, H. Tada, 1965, Journal of the American Chemical Society.

Studies on Coenzyme Analogs. VIII.

E. Ohtsuka, M. Ikehara, 1961 .

Studies on transfer ribonucleic acids and related compounds. XXVII. Linear and cyclic oligonucleotides obtained by polymerization of protected ribonucleoside 3'-phosphates.

A. Markham, E. Ohtsuka, M. Ikehara, 1979 .

Studies on transfer ribonucleic acids and related compounds. XLV. Block condensation of ribooligonucleotides containing 2'-O-tetrahydrofuranyl-5'-O-dimethoxytritylnucleosides.

E. Ohtsuka, M. Ikehara, A. Yamane, 1983, Nucleic acids research.

Studies of Nucleosides and Nucleotides. XLIII, Purine Cyclonucleosides.(10). Optical Rotatory Dispersion and Circular Dichroism of Adenine 8-Cyclonucleosides

M. Ikehara, S. Uesugi, M. Kaneko, 1971 .

Synthesis of adenine 8,2′-cyclonucleosides using diphenyl carbonate

M. Ikehara, S. Tezuka, 1972 .

Studies on deoxynucleic acids and related compounds. IV. Syntheses of an octanucleotide containing a recognition site for restriction enzyme Eco RI and of an arabinosyladenine analog.

E. Ohtsuka, M. Ikehara, H. Morisawa, 1982, Chemical & pharmaceutical bulletin.

Stimulation of the binding of aminoacyl-sRNA to ribosomes by tubercidin (7-deazaadenosine) and N 6-dimethyladenosine containing trinucleoside diphosphate analogs.

E. Ohtsuka, M. Ikehara, 1965, Biochemical and biophysical research communications.

Polynucleotides. LIII. Conformation of Dinucleoside Monophosphates containing 8-Methyladenosine Residue as studied by Proton Magnetic Resonance

M. Ikehara, S. Uesugi, W. Limn, 1978 .

Studies of Nucleosides and Nucleotides. LXXXI. Synthesis and Characterization of 8-Methyladenosine

M. Ikehara, T. Fukui, W. Limn, 1977 .

STUDIES ON COENZYME ANALOGS. XVI. SYNTHESIS OF 9-D-ERYTHRITYLADENINE AND ITS PHOSPHATES.

E. Ohtsuka, M. Ikehara, 1963, Chemical & pharmaceutical bulletin.

Structural elucidation of tubercidin.

M. Ikehara, K. Watanabe, S. Suzaki, 1963, Chemical & pharmaceutical bulletin.

Synthesis of 8-hydroxypurine nucleosides.

M. Ikehara, K. Muneyama, H. Tada, 1965, Chemical & pharmaceutical bulletin.

Studies of Nucleosides and Nucleotides. XXXVII. Synthesis of 8-Oxyguanosine Nucleotides and Uric Acid 9-Riboside 5'-Phosphate

M. Ikehara, K. Murao, 1968 .

Studies on coenzyme analogs. XV. A novel phosphorylating agent, P-diphenyl-, P'-Morpholino pyrophosphorochloridate.

M. Ikehara, E. Otsuka, 1963, Chemical & pharmaceutical bulletin.

Polynucleotides. LVII. Synthesis and properties of poly (2'-chloro-2'-deoxyinosinic acid).

M. Ikehara, N. Kakiuchi, T. Fukui, 1979, Nucleic acids research.

Polynucleotides. XL. Synthesis and properties of poly 2'-azido-2'-deoxyadenylic acid.

M. Ikehara, N. Kakiuchi, T. Fukui, 1976, Nucleic acids research.

New condensing reagents for stereospecific synthesis of dinucleoside monophosphate aryl esters

E. Ohtsuka, M. Ikehara, Z. Tozuka, 1981 .

Structural details of ribonuclease H from Escherichia coli as refined to an atomic resolution.

K Morikawa, M Ikehara, T Matsuzaki, 1992, Journal of molecular biology.

Some physical properties of poly 7-deazaadenylic acid (poly Tubercidin phosphoric acid).

M. Ikehara, T. Fukui, 1968, Journal of molecular biology.

Synthesis and Properties of Phosphoramidite Derivatives of MOdified Nucleosides

M. Ikehara, Toshiki Tanaka, S. Tamatsukuri, 1986 .

Synthesis of oligodeoxyribonucleotide with aliphatic amino or phosphate group at the 5' end by the phosphotriester method on a polystyrene support.

T. Tanaka, M. Ikehara, K. Fujimoto, 1987, Nucleic acids research.

Trityloxyethylamino group for the protection of phosphoryl group in oligonucleotide synthesis

M. Ikehara, Yusuke Yamada, Toshiki Tanaka, 1986 .

Polynucleotides. XXI. Synthesis and properties of poly 1-deazaadenylic acid and poly 3-deazaadenylic acid.

M. Ikehara, S. Uesugi, T. Fukui, 1974, Journal of biochemistry.

Molecular structure of a double helix that has non-Watson-Crick type base pairing formed by 2-substituted poly(A) and poly(U).

T. Hakoshima, M. Ikehara, K. Tomita, 1981, Proceedings of the National Academy of Sciences of the United States of America.

A NEW SYNTHETIC METHOD FOR 5'-TRIPHOSPHORYL-ADENYLYL-(2'-5')-ADENYLYL-(2'-5')-ADENOSINE (2-5A) AND 2-5A CORE USING 3'-O-TETRAHYDROFURANYL-ADENOSINE DERIVATIVES

E. Ohtsuka, M. Ikehara, A. Yamane, 1982 .

Synthesis and properties of 5'-triphosphoryl 2'-5' oligoadenylates (2-5A), and a general method for synthesis of 3', 5'-bisphosphorylated oligonucleotides.

E. Ohtsuka, M. Ikehara, A. Hasegawa, 1981, Nucleic acids research.

Studies on deoxyribonucleic acids and related compounds. V. Synthesis of pentadecanucleotide duplex containing the ideal Pribnow sequence of promoter by the phosphotriester method using a new phosphorylating reagent.

E. Ohtsuka, M. Ikehara, Y. Taniyama, 1982, Nucleic acids research.

Preparation of a new phosphorylating agent: S-(N-monomethoxytrxtylaminoethyl)-O-(o-chlorophenyl)phosphorothioate and its application in oligonucleotide synthesis

M. Ikehara, Toshiki Tanaka, S. Uesugi, 1989 .

Studies on Coenzyme Analogs. IX. Synthesis of 6-Alkylamino-9-β-D-ribofuranosylpurine 5'-Monophosphate.

E. Ohtsuka, M. Ikehara, F. Ishikawa, 1961 .

Polymer support synthesis of oligodeoxyribonucleotide with an aminoethyl or aminohexyl group at the 5' end by the phosphite-triester approach.

T. Tanaka, M. Ikehara, Y. Yamada, 1988, Chemical & pharmaceutical bulletin.

Interaction between actomyosin and 8-substituted ATP analogs.

Y. Tonomura, M. Ikehara, H. Takenaka, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and properties of the dinucleoside monophosphates containing adenine S-cyclonucleosides and adenosine. Factors determining the stability and handedness of the stacking conformation in a dinucleoside monophosphate.

M. Ikehara, J. Yano, S. Uesugi, 1977, Journal of the American Chemical Society.

Polynucleotides. XXIV1. Synthesis and properties of a dinucleoside monophosphate derived from uridine 6,2-cyclonucleoside2

M. Ikehara, T. Tezuka, 1974 .

Polynucleotides. XVI. Oligomers of 8,2'-anhydro-8-mercapto-9-( -D-arabinofuranosyl)adennine 5'-monophosphate.

M. Ikehara, S. Uesugi, 1972, Journal of the American Chemical Society.

Studies on Coenzyme Analoges. II. A convenient Synthesis of "Thioinosine."

M. Ikehara, 1960 .

Studies of Nucleosides and Nucleotides. LXXX. Purine Cyclonucleosides. (38). Synthesis of 6-Substituted Purine 2'-Azido-and 2'-Amino-2'-deoxyribofuranosides

M. Ikehara, Y. Takatsuka, 1978 .

SYNTHESIS OF 2′‐ AND 3′‐DEOXYINOSINES

M. Ikehara, A. Yamazaki, I. Kumashiro, 1973 .

Potential antimetabolites. IV. Synthesis of 2,6-bis-alkylthiopurine ribosides and their selective substitution by nucleophilic reagents.

M. Ikehara, A. Yamazaki, T. Ueda, 1962, Chemical & pharmaceutical bulletin.

Synthesis of α-Adenosine 5'-Monophosphate

M. Ikehara, B. Shimizu, T. Nishimura, 1967 .

Studies on transfer ribonucleic acids and related compounds. XXXII. Synthesis of ribonucleotides corresponding to residues 1-5 and 6-10 of tRNAfMet from E. coli and their base conversion analogs.

T. Tanaka, E. Ohtsuka, M. Ikehara, 1979, Nucleic acids research.

Polynucleotides. XXIV. Synthesis and properties of a dinucleoside monophosphate derived from 8,2'-O-cycloadenosine.

M. Ikehara, J. Yano, S. Uesugi, 1974, Journal of the American Chemical Society.

Polynucleotides. XXVI. Complex formation of polynucleotides derived from formycin and laurusin with cyclonucleoside oligonucleotides.

M. Ikehara, T. Tezuka, 1974, Nucleic acids research.

Polynucleotides. LII. Synthesis and properties of poly(2'-deoxy-2'-fluoroadenylic acid).

M. Ikehara, N. Kakiuchi, T. Fukui, 1978, Nucleic acids research.

Protein synthesis using poly(2'-halogeno-2'-deoxyadenylic acids) as messenger.

M. Ikehara, N. Kakiuchi, T. Fukui, 1982, Biochimica et biophysica acta.

Synthesis and characterization of the dinucleoside monophosphates containing 2'-fluoro-2'-deoxyadenosine.

L. Kan, M. Ikehara, S. Uesugi, 1981, Biochemistry.

Studies of Nucleosides and Nucleotides. LXXIX. Purine Cyclonucleosides. (37). The Total Synthesis of an Antibiotic 2'-Amino-2'-deoxyguanosine

M. Ikehara, T. Maruyama, 1978 .

A NEW METHOD FOR THE SYNTHESIS OF 2′-DEOXY-2′-SUBSTITUTED PURINE NUCLEOSIDES. SYNTHESIS OF THE ANTIBIOTIC 2′-DEOXY-2′-AMINOGUANOSINE

M. Ikehara, T. Maruyama, H. Miki, 1978 .

STUDIES OF NUCLEOSIDES AND NUCLEOTIDES. LXIX. PURINE CYCLONUCLEOSIDES. (30). ). ELIMINATION OF THE 8-HYDROXY FUNCTION OF PURINE NUCLEOSIDES

M. Ikehara, T. Maruyama, 1976 .

Molecular cloning and nucleotide sequence of cDNA coding for rat brain cholecystokinin precursor.

K. Araki, R. Kuwano, E. Ohtsuka, 1984, Journal of biochemistry.

Synthesis and expression of a synthetic gene for the activated human c-Ha-ras protein.

E. Ohtsuka, M. Ikehara, S. Iwai, 1986, Japanese journal of cancer research : Gann.

Amino acid sequence of mammalian elongation factor 2 deduced from the cDNA sequence: homology with GTP-binding proteins.

E. Ohtsuka, M. Ikehara, T. Uchida, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Construction of an excretion vector and extracellular production of human growth hormone from Escherichia coli.

E. Ohtsuka, M. Ikehara, T. Kudo, 1987, Gene.

27 amino acid residues can be deleted from the N‐terminus of human lymphotoxin without impairment of its cytotoxic activity

E. Ohtsuka, M. Ikehara, S. Nishikawa, 1990, Journal of molecular recognition : JMR.

Engineering of the hydrophobic segment of the signal sequence for efficient secretion of human lysozyme by Saccharomyces cerevisiae.

M. Ikehara, Y. Yamamoto, Y. Taniyama, 1987, Biochemical and biophysical research communications.

Differences between Saccharomyces cerevisiae and Bacillus subtilis in secretion of human lysozyme.

M. Ikehara, M. Kikuchi, K. Kikuchi, 1987, Biochemical and biophysical research communications.

X-ray structure of T4 endonuclease V: an excision repair enzyme specific for a pyrimidine dimer.

K Morikawa, M Ikehara, K. Morikawa, 1992, Science.

Increase in nucleolytic activity of ribonuclease T1 by substitution of tryptophan 45 for tyrosine 45.

T. Hakoshima, E. Ohtsuka, M. Ikehara, 1988, European journal of biochemistry.

pH-dependent thermostabilization of Escherichia coli ribonuclease HI by histidine to alanine substitutions.

M. Oobatake, H. Nakamura, S. Kanaya, 1993, Journal of biotechnology.

Importance of the positive charge cluster in Escherichia coli ribonuclease HI for the effective binding of the substrate.

M Ikehara, S. Kanaya, M. Ikehara, 1991, The Journal of biological chemistry.

Identification of the amino acid residues involved in an active site of Escherichia coli ribonuclease H by site-directed mutagenesis.

S. Kanaya, E. Ohtsuka, M. Ikehara, 1990, The Journal of biological chemistry.

Molecular cloning and the complete nucleotide sequence of cDNA to mRNA for S-100 protein of rat brain.

R. Kuwano, E. Ohtsuka, M. Ikehara, 1984, Nucleic acids research.

Template activity of poly(2'-fluoro-2'-deoxyinosinic acid) for murine leukemia virus reverse transcriptase.

M. Ikehara, N. Kakiuchi, T. Fukui, 1982, Cancer letters.

Secretion in yeast of human lysozymes with different specific activities created by replacing valine-110 with proline by site-directed mutagenesis.

M. Ikehara, M. Kikuchi, Y. Yamamoto, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Design and creation of a Ca2+ binding site in human lysozyme to enhance structural stability.

M Ikehara, M. Ikehara, R. Kuroki, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Purification of T4 RNA ligase by 2′, 5′‐ADP sepharose chromatography

E. Ohtsuka, M. Ikehara, M. Sugiura, 1979, FEBS letters.

RNA polymerase of influenza virus. II. Influence of oligonucleotide chain length on the priming activity of RNA synthesis by virion-associated RNA polymerase.

A. Ishihama, E. Ohtsuka, M. Ikehara, 1981, Journal of biochemistry.

Base sequence‐specific interactions of operator DNA fragments with the lambda‐cro repressor coupled with changes in their conformations.

M. Shirakawa, Y. Kyōgoku, E. Ohtsuka, 1987, The EMBO journal.

The in vivo stability, maturation and aminoacylation of anticodon-substituted Escherichia coli initiator methionine tRNAs.

R. Cedergren, N. Beauchemin, E. Ohtsuka, 1987, European journal of biochemistry.

Isolation and nucleotide sequence of a partial cDNA clone for bovine opsin.

Y. Nabeshima, S. Koike, E. Ohtsuka, 1983, Biochemical and biophysical research communications.

Effect of mutagenesis at each of five histidine residues on enzymatic activity and stability of ribonuclease H from Escherichia coli.

K. Morikawa, S. Kanaya, E. Ohtsuka, 1991, European journal of biochemistry.

Nuclear magnetic resonance study of the interaction of T4 endonuclease V with DNA.

Y. Kyōgoku, K. Morikawa, E. Ohtsuka, 1994, Biochemistry.

Role of the basic amino acid cluster and Glu-23 in pyrimidine dimer glycosylase activity of T4 endonuclease V.

K. Morikawa, E. Ohtsuka, M. Ikehara, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Participation of glutamic acid 23 of T4 endonuclease V in the beta-elimination reaction of an abasic site in a synthetic duplex DNA.

E. Ohtsuka, M. Ikehara, N. Hori, 1992, Nucleic acids research.

Expression of a synthetic human growth hormone gene in yeast.

E. Ohtsuka, M. Ikehara, S. Iwai, 1985, Gene.

Effect of cavity-modulating mutations on the stability of Escherichia coli ribonuclease HI.

M Ikehara, H. Nakamura, S. Kanaya, 1992, European journal of biochemistry.

Efficient cleavage by α-thrombin of a recombinant fused protein which contains insulin-like growth factor I

E. Ohtsuka, M. Ikehara, S. Nishikawa, 1987 .

2'-Deoxy-2'-azidoadenosine triphosphate and 2'-deoxy-2'-fluoroadenosine triphosphate as substrates and inhibitors for Escherichia coli DNA-dependent RNA polymerase.

A. Ishihama, E. Ohtsuka, M. Ikehara, 1980, Journal of biochemistry.

Inquiries into thestructure-functi

M. Ikehara, S. Nishikawa, Toshiyuki Tanaka, 1986 .

Three-dimensional structure of a mutant ribonuclease T1 (Y45W) complexed with non-cognizable ribonucleotide, 2'AMP, and its comparison with a specific complex with 2'GMP.

T. Hakoshima, E. Ohtsuka, M. Ikehara, 1992, Journal of molecular biology.

Non‐cognizable ribonucleotide, 2′AMP, binds to a mutant ribonuclease T1 (Y45W) at a new base‐binding site but not at the guanine‐recognition site

T. Hakoshima, E. Ohtsuka, M. Ikehara, 1991, FEBS letters.

X-ray diffraction studies of the RNA tetramer GpGpCpUp.

E. Ohtsuka, M. Ikehara, H. Mizuno, 1981, Journal of molecular biology.

Role of cysteine residues in ribonuclease H from Escherichia coli. Site-directed mutagenesis and chemical modification.

S. Kanaya, M. Ikehara, S. Kimura, 1990, The Biochemical journal.

[Polarization of heterocyclic compounds with aromatic characteristics. CX. Synthesis of hydroxy derivatives of morphinan].

M. Ikehara, 1955, Pharmaceutical bulletin.

Binding of nucleic acids to E. coli RNase HI observed by NMR and CD spectroscopy.

H. Nakamura, E. Ohtsuka, M. Ikehara, 1993, Nucleic acids research.

Polynucleotides. LXIII. Solution conformation of oligodeoxyribonucleotides containing an alternating dC-dG sequence which can form a left-handed double helix.

M. Ikehara, S. Uesugi, T. Shida, 1981 .

Polynucleotides. XLVI. 1 Synthesis and properties of poly (2'-amino-2'-deoxyadenylic acid).

M. Ikehara, N. Kakiuchi, T. Fukui, 1977, Nucleic Acids Research.

A hybrid ribonuclease H. A novel RNA cleaving enzyme with sequence-specific recognition.

S. Kanaya, E. Ohtsuka, M. Ikehara, 1992, The Journal of biological chemistry.

Essential structure of E. coli promoter: effect of spacer length between the two consensus sequences on promoter function.

M Ikehara, E. Ohtsuka, M. Ikehara, 1983, Nucleic acids research.

Role of disulfide bonds in folding and secretion of human lysozyme in Saccharomyces cerevisiae.

M. Ikehara, M. Kikuchi, Y. Yamamoto, 1988, Biochemical and biophysical research communications.

Synthesis and properties of ApU analogues containing 2'-halo-2'-deoxyadenosines. Effects of 2' substituents on oligonucleotide conformation.

M. Ikehara, S. Uesugi, T. Kaneyasu, 1982, Biochemistry.

RIBOOLIGONUCLEOTIDES, R(C-G-C-G) ANALOGS CONTAINING 8-SUBSTITUTED GUANOSINE RESIDUES, FORM LEFT-HANDED DUPLEXES WITH Z-FORM-LIKE STRUCTURE

Y. Kyōgoku, M. Ikehara, Yuji Kobayashi, 1984 .

Preparation and characterization of monoclonal antibodies specific for GoCodGdCGoCo duplex with high-anti conformation.

M. Saito, E. Ohtsuka, M. Ikehara, 1987, Biochemical and biophysical research communications.

Studies on the structure and stabilizing factor of the CUUCGG hairpin RNA using chemically synthesized oligonucleotides

Takeshi Sakata, Toshiki Tanaka, Yasushi Oda, 1990, Nucleic Acids Res..

Modification of the anticodon triplet of E.coli tRNAMetf by replacement with trimers complementary to non-sense codons UAG and UAA.

M Ikehara, E. Ohtsuka, M. Ikehara, 1983, Nucleic acids research.

1H‐NMR investigation of the interaction between RNase T1 and a novel substrate analog, 2′‐deoxy‐2′‐fluoroguanylyl‐(3′–5′)uridine

M. Ikehara, I. Shimada, F. Inagaki, 1988, FEBS letters.

Glu 46 of ribonuclease T1 is an essential residue for the recognition of guanine base.

T. Hakoshima, E. Ohtsuka, M. Ikehara, 1988, Biochemical and biophysical research communications.

[Synthesis of polynucleotides. 3].

M. Ikehara, 1967, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

Studies of nucleosides and nucleotides. LVI. A versatile method for the systhesis of 8-mercaptoadenosine nucleotides.

E. Ohtsuka, M. Ikehara, S. Uesugi, 1973, Chemical & pharmaceutical bulletin.

Energy transfer from tryptophan residues to a fluorescent ATP analog, 1,N6-ethenoadenosine triphosphate, bound to H-meromyosin.

Y. Tonomura, M. Ikehara, H. Onishi, 1973, Journal of biochemistry.

Synthesis and Properties of Oligonucleotides

E. Ohtsuka, M. Ikehara, Toshiki Tanaka, 1988 .

Deoxyribonucleic acids and related compounds. XII. Polymer support synthesis of a 46-mer duplex containing the promoter of galactose operon of Escherichia coli.

E. Ohtsuka, M. Ikehara, T. Ohgi, 1985, Chemical & pharmaceutical bulletin.

Replacement and insertion of nucleotides at the anticodon loop of E. coli tRNAMetf by ligation of chemically synthesized ribooligonucleotides.

E. Ohtsuka, M. Ikehara, J. Matsugi, 1985, Nucleic acids research.

Identification of oligonucleotide fragments produced in a strand scission reaction of the d(C-G-C-G-C-G) duplex by bleomycin.

Y. Kyōgoku, M. Ikehara, S. Uesugi, 1984, Nucleic acids research.

Conformation of ribooligonucleotide duplexes containing an alternating C-G sequence which show an unusual circular dichroism spectrum.

G. A. van der Marel, Y. Kyōgoku, E. Ohtsuka, 1984, The Journal of biological chemistry.

Unambiguous assignments of the imino proton resonances of a G ·U wobble base pair

Y. Kyōgoku, M. Kainosho, M. Ikehara, 1982 .

Identification of degradation products of d(C-G) by a 1,10-phenanthroline-copper ion complex

Y. Kyōgoku, M. Ikehara, Yuji Kobayashi, 1982 .

The structure of a dinucleoside monophosphate having a high-anti conformation: 8,2'-S-cyclo-2'-thioadenylyl(3'-5')-8,2'-S-cyclo-2'-thioadenosine (AspAs) hydrochloride

M. Ikehara, S. Fujii, K. Tomita, 1982 .

Studies on Deoxyribonucleic Acids and Related Compounds. II. Synthesis of a Decanucleotide containing a Restriction Enzyme (PstI) Recognition Site

E. Ohtsuka, M. Ikehara, T. Ono, 1981 .

Studies on transfer ribonucleic acids and related compounds. XXXIX. Chemical synthesis of heptadeca- and hexadecaribonucleotides corresponding to the 3'-terminus of the tRNAfMet of E. coli.

E. Ohtsuka, M. Ikehara, K. Fujiyama, 1981, Chemical & pharmaceutical bulletin.

Bacteriorhodopsin: partial sequence of mRNA provides amino acid sequence in the precursor region.

H. Khorana, E. Ohtsuka, M. Ikehara, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Studies on tRNA and Related Compounds. XXXVII. Synthesis and Physical Properties of 2'- or 3'-O-(o-Nitrobenzyl) nucleosides : the Use of o-Nitrophenyldiazomethane as a Synthetic Reagent

E. Ohtsuka, M. Ikehara, A. Hasegawa, 1981 .

Polynucleotides. LXI. Synthesis and Properties of Dinucleoside Monophosphates Containing 8, 2'-S-Cycloadenosine and 8, 2'-S-Cycloinosine Residues. Sequence Dependency of the Stability of the Stacking Conformation

M. Ikehara, S. Uesugi, T. Shida, 1980 .

Comparison of substrate base sequences for RNA ligase reactions in the synthesis of a tetradecanucleotide corresponding to bases 21-34 of E. coli tRNAfMet 1.

E. Ohtsuka, M. Ikehara, Y. Taniyama, 1980, Nucleic acids research.

The spatial configuration of a left-handed base stacked dinucleoside monophosphate

R. Sarma, M. Ikehara, S. Uesugi, 1978 .

Polynecleotides. XXX. Synthesis and properties of oligonucleotides of cyclouridine phosphate. Hybridization with the oligomer of S-cycloadenosine phosphate to form left-handed helical complexes.

M. Ikehara, S. Uesugi, T. Tezuka, 1976, Journal of the American Chemical Society.

Polynucleotides. XXXI1. Synthesis of AUG analogs containing 8,2'-S-cycloadenosine, 8,5'-S-cycloadenosine, 8-bromoadenosin, 8-oxyadenosine and formycin in the first position of the codon.

M. Ikehara, E. Otsuka, T. Nagura, 1975, Nucleic acids research.

A new ribo-oligonucleotide block synthesized by phosphorylation with p-chlorophenyl N-phenylchlorophosphoramidate

E. Ohtsuka, M. Ikehara, Toshiki Tanaka, 1978 .

E. coli initiator tRNA analogs with different nucleotides in the discriminator base position.

D. Söll, E. Ohtsuka, M. Ikehara, 1982, Nucleic acids research.

Activity of artificial mutant variants of human growth hormone deficient in a disulfide bond between Cys53 and Cys165.

T. Hayakawa, M. Ikehara, S. Nishikawa, 1991, Chemical & pharmaceutical bulletin.

How does RNase H recognize a DNA.RNA hybrid?

H. Nakamura, K. Morikawa, S. Kanaya, 1991, Proceedings of the National Academy of Sciences of the United States of America.

1H NMR studies of deuterated ribonuclease HI selectively labeled with protonated amino acids

S. Kanaya, M. Ikehara, K. Nagayama, 1992, Journal of biomolecular NMR.

Bromination of adenine nucleoside and nucleotide

M. Ikehara, S. Uesugi, M. Kaneko, 1967 .

Conformational features of signal sequences and folding of secretory proteins in yeasts.

M. Ikehara, M. Kikuchi, 1991, Trends in biotechnology.

Use of the deoxyinosine-containing probe to isolate and sequence cDNA encoding the fusion (F) glycoprotein of Sendai virus (HVJ).

E. Ohtsuka, M. Ikehara, T. Uchida, 1985, Gene.

Elongation of oligonucleotides in the 3'-direction with activated mononucleotides and their analogs using RNA ligase.

E. Ohtsuka, M. Ikehara, M. Sugiura, 1980, Nucleic acids research.

Expression of human lysozyme in an insoluble form in yeast.

M. Ikehara, M. Kikuchi, K. Nakahama, 1987, Gene.

Phosphorylating agent for the synthesis of oligonucleotide with aliphatic amino group at 5′ end

M. Ikehara, Toshiki Tanaka, S. Tamatsukuri, 1987 .

Interactions between Synthetic Nucleotide Analogs and Snake Venom 5'-Nucleotidase

E. Ohtsuka, M. Ikehara, T. Ueda, 1961 .

Hydrolysis of the secondary phosphate esters of formycin 3'-phosphate by bovine pancreatic ribonuclease.

M. Ikehara, S. Nishimura, K. Murao, 1969, Biochimica et biophysica acta.

Hydrogen exchange kinetics of nucleic acids. Double and triple helices with Hoogsteen-type basepairs.

M Ikehara, M. Ikehara, Y. Inoue, 1982, Biochimica et biophysica acta.

Studies on the interaction between regulatory enzymes and effectors. I. Effect of adenosine 5'-monophosphate analogues on threonine deaminase.

M. Ikehara, A. Nakazawa, O. Hayaishi, 1967, The Journal of biological chemistry.

Stabilization and enhanced enzymatic activities of a mutant human lysozyme C77/95A with a cavity space by amino acid substitution.

E. Kanaya, Y. Ueno, M. Ikehara, 1994, Biological & pharmaceutical bulletin.