J. Calvet

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MAP/ERK Kinase Kinase 1 (MEKK1) Mediates Transcriptional Repression by Interacting with Polycystic Kidney Disease-1 (PKD1) Promoter-bound p53 Tumor Suppressor Protein*

S. Puri, C. Widmann, M. R. Islam, 2010, The Journal of Biological Chemistry.

Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator/Na(+),K(+),2Cl(-) Co-transporter-dependent cystic dilation.

B. Magenheimer, R. Maser, J. Calvet, 2006, Journal of the American Society of Nephrology : JASN.

PPAR-gamma agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease.

James P Calvet, H. Kurahashi, J. Calvet, 2011, American journal of physiology. Renal physiology.

Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation.

B. Magenheimer, J. Calvet, Xiaogang Li, 2012, Kidney international.

The Role of Calcium and Cyclic AMP in PKD

J. Calvet, 2015 .

PPAR- (cid:1) agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease

H. Kurahashi, J. Calvet, S. Nagao, 2011 .

Strategies to inhibit cyst formation in ADPKD.

J. Calvet, 2008, Clinical journal of the American Society of Nephrology : CJASN.

Calcium Restriction Allows cAMP Activation of the B-Raf/ERK Pathway, Switching Cells to a cAMP-dependent Growth-stimulated Phenotype*

James P Calvet, B. Magenheimer, J. Calvet, 2004, Journal of Biological Chemistry.

Phosphodiesterase Isoform Regulation of Cell Proliferation and Fluid Secretion in Autosomal Dominant Polycystic Kidney Disease.

B. Magenheimer, J. Calvet, D. Wallace, 2016, Journal of the American Society of Nephrology : JASN.

Integrin-Linked Kinase Signaling Promotes Cyst Growth and Fibrosis in Polycystic Kidney Disease.

J. Calvet, D. Wallace, Xiaogang Li, 2017, Journal of the American Society of Nephrology : JASN.

The Future of Polycystic Kidney Disease Research--As Seen By the 12 Kaplan Awardees.

G. Germino, S. Somlo, C. Antignac, 2015, Journal of the American Society of Nephrology : JASN.

Aberrant Regulation of Notch3 Signaling Pathway in Polycystic Kidney Disease

B. Magenheimer, R. Maser, J. Calvet, 2018, Scientific Reports.

Defective epidermal growth factor gene expression in mice with polycystic kidney disease.

J. Calvet, V. Gattone, G. Andrews, 1990, Developmental biology.

Murine infantile polycystic kidney disease: a role for reduced renal epidermal growth factor.

J. Calvet, V. Gattone, 1991, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Renal cysts in transgenic mice expressing transforming growth factor-alpha.

G. Merlino, G. Lindemann, J. Calvet, 1994, The Journal of laboratory and clinical medicine.

Transient transfection assays for analysis of signal transduction in renal cells.

B. Magenheimer, R. Maser, J. Calvet, 2003, Methods in molecular medicine.

The genetics and physiology of polycystic kidney disease.

J. Calvet, J. Grantham, 2001, Seminars in nephrology.

Polycystic kidney disease: In danger of being X-rated?

J. Calvet, J. Grantham, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Development of autosomal recessive polycystic kidney disease in BALB/c-cpk/cpk mice.

J. Calvet, V. Gattone, J. Ricker, 2000, Journal of the American Society of Nephrology : JASN.

Cilia in PKD--letting it all hang out.

J. Calvet, 2002, Journal of the American Society of Nephrology : JASN.

Renal epithelial fluid secretion and cyst growth: the role of cyclic AMP

J. Calvet, J. Grantham, C. Park, 1989, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Epithelial Vasopressin Type-2 Receptors Regulate Myofibroblasts by a YAP-CCN2-Dependent Mechanism in Polycystic Kidney Disease.

J. Calvet, D. Wallace, T. Fields, 2020, Journal of the American Society of Nephrology : JASN.

Kid-1 expression is high in differentiated renal proximal tubule cells and suppressed in cyst epithelia.

N. Gretz, J. Calvet, J. Bonventre, 1998, American journal of physiology. Renal physiology.

Quinomycin A reduces cyst progression in polycystic kidney disease

W. Wang, B. Magenheimer, J. Calvet, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Intraflagellar transport-A deficiency attenuates ADPKD in a renal tubular- and maturation-dependent manner

J. Calvet, D. Wallace, C. Slawson, 2020, bioRxiv.

Quinomycin A reduces cyst progression in polycystic kidney disease

B. Magenheimer, J. Calvet, D. Wallace, 2020, bioRxiv.

Elevated c-myc protooncogene expression in autosomal recessive polycystic kidney disease.

J. Calvet, J. Grantham, B. Cowley, 1987, Proceedings of the National Academy of Sciences of the United States of America.

pathwaysmodels via cAMP and EGFR-Src-MEK stimulate fluid secretion and cyst growth of in vitro Endogenous concentrations of ouabain act as a cofactor to

B. Magenheimer, J. Calvet, D. Wallace, 2016 .

Ouabain Regulates CFTR-Mediated Anion Secretion and Na,K-ATPase Transport in ADPKD Cells

B. Magenheimer, J. Calvet, D. Wallace, 2015, The Journal of Membrane Biology.

Overexpression of the Polycystin-1 C-Tail Enhances Sensitivity of M-1 Cells to Ouabain

B. Magenheimer, R. Maser, J. Calvet, 2013, The Journal of Membrane Biology.

Endogenous concentrations of ouabain act as a cofactor to stimulate fluid secretion and cyst growth of in vitro ADPKD models via cAMP and EGFR-Src-MEK pathways.

B. Magenheimer, J. Calvet, D. Wallace, 2012, American journal of physiology. Renal physiology.

Developmental signaling: does it bridge the gap between cilia dysfunction and renal cystogenesis?

J. Calvet, Xiaogang Li, Madhulika Sharma, 2014, Birth defects research. Part C, Embryo today : reviews.

Autosomal recessive polycystic kidney disease in a murine model. A gross and microscopic description.

A. Evan, J. Calvet, V. Gattone, 1988, Laboratory investigation; a journal of technical methods and pathology.

Human-Specific Abnormal Alternative Splicing of Wild-Type PKD1 Induces Premature Termination of Polycystin-1.

J. Calvet, C. Ward, D. Wallace, 2018, Journal of the American Society of Nephrology : JASN.

Ttc21b deficiency attenuates autosomal dominant polycystic kidney disease in a kidney tubular- and maturation-dependent manner.

J. Calvet, D. Wallace, T. Fields, 2022, Kidney international.

MEK inhibition holds promise for polycystic kidney disease.

J. Calvet, 2006, Journal of the American Society of Nephrology : JASN.

A hereditary model of slowly progressive polycystic kidney disease in the mouse.

J. Calvet, H. Takahashi, V. Gattone, 1991, Journal of the American Society of Nephrology : JASN.

Heterogeneous nuclear RNA double-stranded regions probed in living HeLa cells by crosslinking with the psoralen derivative aminomethyltrioxsalen.

J. Calvet, T. Pederson, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Targeting the Vasopressin Type 2 Receptor for Renal Cell Carcinoma Therapy

R. Weiss, J. Calvet, N. Dwivedi, 2019, Oncogene.

SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1.

J. Calvet, Xiaogang Li, Lucy X. Fan, 2014, Human molecular genetics.

Molecular approaches for analyzing differential gene expression: differential cDNA library construction and screening

J. Calvet, 1991, Pediatric Nephrology.

Localization of overexpressed c-myc mRNA in polycystic kidneys of the cpk mouse.

J. Calvet, V. Gattone, V. Gattone, 1992, Kidney international.

Elevated proto-oncogene expression in polycystic kidneys of the C57BL/6J (cpk) mouse.

J. Calvet, J. Grantham, B. Cowley, 1991, Journal of the American Society of Nephrology : JASN.

A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD

B. Magenheimer, R. Maser, J. Calvet, 2018, Human molecular genetics.

Sulfated glycoprotein-2 (Sgp-2) maps to mouse Chromosome 14

W. Frankel, B. Magenheimer, J. Calvet, 2004, Mammalian Genome.

The SGP-2 gene is developmentally regulated in the mouse kidney and abnormally expressed in collecting duct cysts in polycystic kidney disease.

J. Calvet, V. Gattone, V. Gattone, 1991, Developmental biology.

In-vivo secondary structure analysis of the small nuclear RNA U1 using psoralen cross-linking.

J. Calvet, J. A. Myers, 1987, Journal of molecular biology.

J. Calvet, E. Falvey, T. Pederson, 1983, Journal of molecular biology.

Small nuclear RNA U2 is base-paired to heterogeneous nuclear RNA.

J. Calvet, T. Pederson, L. M. Meyer, 1982, Science.

Nucleoprotein organization of inverted repeat DNA transcripts in heterogeneous nuclear RNA-ribonucleoprotein particles from HeLa cells.

J. Calvet, T. Pederson, 1978, Journal of molecular biology.

Primary and secondary genetic responses after folic acid-induced acute renal injury in the mouse.

J. Calvet, L. Chadwick, 1994, Journal of the American Society of Nephrology : JASN.

Vasopressin Receptor Type-2 Mediated Signaling in Renal Cell Carcinoma Stimulates Stromal Fibroblast Activation

J. Calvet, N. Dwivedi, S. Thomas, 2022, International journal of molecular sciences.

Matrix metalloproteinase-2 in a murine model of infantile-type polycystic kidney disease.

J. Calvet, V. Gattone, C. Tian, 1999, Journal of the American Society of Nephrology : JASN.

Antioxidant enzyme peroxiredoxin 5 regulates cyst growth and ciliogenesis via modulating Plk1 stability

J. Calvet, Xiaogang Li, J. Zhou, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The GPCR properties of polycystin-1- A new paradigm

R. Maser, J. Calvet, S. Parnell, 2022, Frontiers in Molecular Biosciences.

Renal expression of a transforming growth factor-alpha transgene accelerates the progression of inherited, slowly progressive polycystic kidney disease in the mouse.

G. Lindemann, X. Lu, J. Calvet, 1996, The Journal of laboratory and clinical medicine.

RNA helicase p68 inhibits the transcription and post-transcription of Pkd1 in ADPKD

J. Calvet, P. Harris, Xiaogang Li, 2020, Theranostics.

Overexpression of the Polycystin-1 C-Tail Enhances Sensitivity of M-1 Cells to Ouabain

B. Magenheimer, R. Maser, J. Calvet, 2013, The Journal of Membrane Biology.

Molecular genetics of polycystic kidney disease.

J. Calvet, 1998, JN. Journal of Nephrology (Milano. 1992).

Polycystin-1 Activates the Calcineurin/NFAT (Nuclear Factor of Activated T-cells) Signaling Pathway*

S. Puri, B. Magenheimer, R. Maser, 2004, Journal of Biological Chemistry.

Ciclopirox olamine induces ferritinophagy and reduces cyst burden in polycystic kidney disease

B. Magenheimer, J. Calvet, D. Wallace, 2021, JCI insight.

Ciclopirox Olamine Induces Ferritinophagy and Ameliorates Disease Progression in Polycystic Kidney Disease

B. Magenheimer, J. Calvet, D. Wallace, 2020 .

Immersion refractometric analysis of culturedHyalophora cecropia hemocytes

J. Calvet, R. M. Clark, R. Clark, 2005, Protoplasma.

Global gene expression profiling in early-stage polycystic kidney disease in the Han:SPRD Cy rat identifies a role for RXR signaling.

H. Kurahashi, J. Calvet, S. Nagao, 2011, American journal of physiology. Renal physiology.

Base-pairing interactions between small nuclear RNAs and nuclear RNA precursors as revealed by psoralen cross-linking in vivo

J. Calvet, T. Pederson, 1981, Cell.

Secondary structure of heterogeneous nuclear RNA: two classes of double-stranded RNA in native ribonucleoprotein.

J. Calvet, T. Pederson, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Sequence analysis of the glutamate tRNA family: evidence for pseudogenes.

J. Calvet, F. L. Smardo, 1987, Gene.

A tumor necrosis factor-α–mediated pathway promoting autosomal dominant polycystic kidney disease

B. Magenheimer, J. Calvet, D. Wallace, 2008, Nature Medicine.

Lysine methyltransferase SMYD2 promotes triple negative breast cancer progression

A. Godwin, J. Calvet, R. Jensen, 2018, Cell Death & Disease.

Sequential protooncogene expression in regenerating kidney following acute renal injury.

J. Calvet, J. Grantham, B. Cowley, 1989, The Journal of biological chemistry.

Molecular Biology, Gene Expression, and Medicine

J. Calvet, 1990 .

Cross-talk between CDK4/6 and SMYD2 regulates gene transcription, tubulin methylation, and ciliogenesis

Xiaodong Wang, J. Calvet, P. Harris, 2020, Science Advances.

Oxidant stress and reduced antioxidant enzyme protection in polycystic kidney disease.

B. Magenheimer, R. Maser, J. Calvet, 2002, Journal of the American Society of Nephrology : JASN.

Remarkable sequence conservation of the last intron in the PKD1 gene.

M. R. Islam, M. Rodova, J. Calvet, 2003, Molecular biology and evolution.

Deregulated expression of the homeobox gene Cux-1 in transgenic mice results in downregulation of p27(kip1) expression during nephrogenesis, glomerular abnormalities, and multiorgan hyperplasia.

P. Igarashi, M. Rodova, J. Calvet, 2002, Developmental biology.

Aberrant Polycystin-1 Expression Results in Modification of Activator Protein-1 Activity, whereas Wnt Signaling Remains Unaffected*

Marc van de Wetering, Ngoc Hang Le, Paola van der Bent, 2004, Journal of Biological Chemistry.

Polycystin-1 Activation of c-Jun N-terminal Kinase and AP-1 Is Mediated by Heterotrimeric G Proteins*

James P Calvet, Anna-Maria Frischauf, A. Frischauf, 2002, The Journal of Biological Chemistry.

Lysine methyltransferase SMYD 2 promotes cyst growth in autosomal dominant polycystic kidney disease

J. Sage, J. Calvet, J. Grantham, 2019 .

Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease

J. Sage, J. Calvet, J. Grantham, 2017, The Journal of clinical investigation.

The Polycystic Kidney Disease-1 Protein, Polycystin-1, Binds and Activates Heterotrimeric G-Proteinsin Vitro

T. Okamoto, B. Magenheimer, R. Maser, 1998 .

Sorafenib inhibits cAMP-dependent ERK activation, cell proliferation, and in vitro cyst growth of human ADPKD cyst epithelial cells.

J. Calvet, D. Wallace, Tamio Yamaguchi, 2010, American journal of physiology. Renal physiology.

Adhesion GPCRs as a paradigm for understanding polycystin-1 G protein regulation.

R. Maser, J. Calvet, 2020, Cellular signalling.

Nuclear Localization Signal and p53 Binding Site in MAP/ERK Kinase Kinase 1 (MEKK1)

M. R. Islam, J. Calvet, Elizabeth Chipps, 2015, Journal of cellular biochemistry.

The Polycystic Kidney Disease-1 Gene Is a Target for p53-mediated Transcriptional Repression*

S. Puri, Z. Saifudeen, S. El-Dahr, 2006, Journal of Biological Chemistry.

Acetylation of β-Catenin by CREB-binding Protein (CBP)*

E. Miska, T. Kouzarides, M. Rodova, 2002, The Journal of Biological Chemistry.

Single-Cell and CellChat Resolution Identifies Collecting Duct Cell Subsets and Their Communications with Adjacent Cells in PKD Kidneys

J. Calvet, Xiaogang Li, J. Zhou, 2022, Cells.

A cAMP and CREB-mediated feed-forward mechanism regulates GSK3β in polycystic kidney disease.

J. Calvet, Xiaogang Li, A. Yu, 2016, Journal of molecular cell biology.

Strategies for folding of affinity tagged proteins using GroEL and osmolytes

Mitchell R. McGill, J. Calvet, T. Holyoak, 2008, Journal of Structural and Functional Genomics.

Acetylation of beta-catenin by CREB-binding protein (CBP).

E. Miska, T. Kouzarides, M. Rodova, 2002, The Journal of biological chemistry.

The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease

B. Magenheimer, J. Calvet, D. Wallace, 2020, bioRxiv.

C‐Fos expression is hypersensitive to serum‐stimulation in cultured cystic kidney cells from the C57BL/6J‐cpk mouse

J. Calvet, J. Grantham, C. A. Rankin, 1992, Journal of cellular physiology.

Polycystic kidney disease in Han:SPRD Cy rats is associated with elevated expression and mislocalization of SamCystin.

H. Kurahashi, J. Calvet, S. Nagao, 2010, American journal of physiology. Renal physiology.

Autosomal-dominant polycystic kidney disease in the rat.

J. Calvet, V. Gattone, V. Gattone, 1993, Kidney international.

Polycystic kidney disease: primary extracellular matrix abnormality or defective cellular differentiation?

J. Calvet, 1993, Kidney international.

A fast and efficient method of DNA fragment isolation from agarose gels without using commercial kits

M. R. Islam, M. Rodova, J. Calvet, 2002 .

Injury and development in polycystic kidney disease.

J. Calvet, 1994, Current opinion in nephrology and hypertension.

Retinoic acid-dependent activation of the polycystic kidney disease-1 (PKD1) promoter.

S. Puri, M. R. Islam, M. Rodova, 2008, American journal of physiology. Renal physiology.

Ets factors regulate the polycystic kidney disease-1 promoter.

S. Puri, M. R. Islam, M. Rodova, 2006, Biochemical and biophysical research communications.

The Polycystic Kidney Disease-1 Promoter Is a Target of the β-Catenin/T-cell Factor Pathway*

M. R. Islam, M. Rodova, R. Maser, 2002, The Journal of Biological Chemistry.

Calcium channel inhibition accelerates polycystic kidney disease progression in the Cy/+ rat.

H. Kurahashi, J. Calvet, S. Nagao, 2008, Kidney international.

Aberrant Regulation of Notch3 Signaling Pathway in Polycystic Kidney Disease

B. Magenheimer, R. Maser, J. Calvet, 2018, Scientific Reports.

The heat shock response in HeLa cells is accompanied by elevated expression of the c-fos proto-oncogene

J. Calvet, E. Adamson, G. Andrews, 1987, Molecular and cellular biology.

Protein Phosphatase-1α Interacts with and Dephosphorylates Polycystin-1

S. Puri, J. Calvet, D. Wallace, 2012, PloS one.

Cilia-like Structures and Polycystin-1 in Osteoblasts/Osteocytes and Associated Abnormalities in Skeletogenesis and Runx2 Expression*

Shiqin Zhang, James P Calvet, Lynda Bonewald, 2006, Journal of Biological Chemistry.

Chapter Aberrant Polycystin-1 Expression results in Modifi cation of AP-1 Activity , whereas Wnt Signaling remains unaffected 2

H. Clevers, M. Wetering, J. Calvet, 2006 .

tubule cells and suppressed in cyst epithelia Kid-1 expression is high in differentiated renal proximal

N. Gretz, J. Calvet, J. Bonventre, 2016 .

Kid-1 expression is high in differentiated renal proximal tubule cells and suppressed in cyst epithelia.

N. Gretz, J. Calvet, J. Bonventre, 1998, The American journal of physiology.

Matrix metalloproteinases and TIMPS in cultured C57BL/6J-cpk kidney tubules.

K. Suzuki, J. Calvet, J. Grantham, 1996, Kidney international.

Polycystic kidney disease and cancer after renal transplantation.

B. Kasiske, J. Calvet, A. Yu, 2014, Journal of the American Society of Nephrology : JASN.

Global Gene Expression Profiling in PPAR-γ Agonist-Treated Kidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease

T. Abe, H. Kurahashi, J. Calvet, 2012, PPAR research.

Ouabain Regulates CFTR-Mediated Anion Secretion and Na,K-ATPase Transport in ADPKD Cells

B. Magenheimer, J. Calvet, D. Wallace, 2015, The Journal of Membrane Biology.

Growth characteristics of cells cultured from two murine models of polycystic kidney disease

R. Maser, J. Calvet, C. A. Rankin, 1996, In Vitro Cellular & Developmental Biology - Animal.

The tyrosine-kinase inhibitor Nintedanib ameliorates autosomal-dominant polycystic kidney disease

J. Calvet, D. Wallace, T. Fields, 2021, Cell Death & Disease.

A One Health overview, facilitating advances in comparative medicine and translational research

Dongsheng Duan, Ubadah Sabbagh, James P. Calvet, 2016, Clinical and Translational Medicine.

Hormonal effects on chromosomal puffs and insect development

J. Calvet, H. Laufer, 1972 .

Metanephric organ culture.

B. Magenheimer, R. Maser, J. Calvet, 2019, Methods in Cell Biology.

TNFα Signaling Regulates Cystic Epithelial Cell Proliferation through Akt/mTOR and ERK/MAPK/Cdk2 Mediated Id2 Signaling

J. Calvet, Xiaogang Li, Lucy X. Fan, 2015, PloS one.

The cystic fibrosis transmembrane conductance regulator mediates transepithelial fluid secretion by human autosomal dominant polycystic kidney disease epithelium in vitro.

L. Rome, R. Maser, J. Calvet, 1996, Kidney international.

A mouse kidney- and liver-expressed cDNA having homology with a prokaryotic parathion hydrolase (phosphotriesterase)-encoding gene: abnormal expression in injured and polycystic kidneys.

B. Magenheimer, R. Maser, J. Calvet, 1996, Gene.

U3 small nuclear RNA can be psoralen-cross-linked in vivo to the 5' external transcribed spacer of pre-ribosomal-RNA.

R. Maser, J. Calvet, J. Calvet, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Mouse plasma glutathione peroxidase. cDNA sequence analysis and renal proximal tubular expression and secretion.

B. Magenheimer, R. Maser, J. Calvet, 1994, The Journal of biological chemistry.

Polycystin-1 Interacting Protein-1 (CU062) Interacts with the Ectodomain of Polycystin-1 (PC1).

J. Calvet, C. Ward, D. Wallace, 2023, Cells.

Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation.

B. Magenheimer, J. Calvet, Xiaogang Li, 2012, Kidney international.

Ciliary signaling goes down the tubes

J. Calvet, 2003, Nature Genetics.

Overexpression of SMYD3 Promotes Autosomal Dominant Polycystic Kidney Disease by Mediating Cell Proliferation and Genome Instability

J. Calvet, J. Zhou, Ewud Agborbesong, 2024, Biomedicines.

Polycystic kidney disease in Han:SPRD Cy rats is associated with elevated expression and mislocalization of SamCystin.

H. Kurahashi, J. Calvet, S. Nagao, 2010, American journal of physiology. Renal physiology.