Yiguo Hu

发表

Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia

D. Fabbro, M. Warmuth, M. Hallek, 2004, Nature Genetics.

Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia

C. Peng, Yiguo Hu, Shaoguang Li, 2009, Nature Genetics.

Purinostat Mesylate Is a Uniquely Potent and Selective Inhibitor of HDACs for the Treatment of BCR-ABL–Induced B-Cell Acute Lymphoblastic Leukemia

Fang Wang, Yiguo Hu, Zhuang Yang, 2019, Clinical Cancer Research.

Genetic Modeling of Human Blood Cancers in Mice

Yiguo Hu, Shaoguang Li, 2008 .

Small Molecule Multi-Targeted Kinase Inhibitor RGB-286638 Triggers P53-Dependent and -Independent Anti-Multiple Myeloma Activity through Inhibition of Transcriptional CDKs

K. Anderson, N. Munshi, Yiguo Hu, 2013, Leukemia.

A deep learning diagnostic platform for diffuse large B-cell lymphoma with high accuracy across multiple hospitals

Yiguo Hu, Shaoguang Li, Jacob R. Bledsoe, 2020, Nature Communications.

Preclinical pharmacodynamic evaluation of drug candidate SKLB-178 in the treatment of non-small cell lung cancer

Yiguo Hu, Xin Chen, L. Zhong, 2017, Oncotarget.

The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells

Michael R. Green, Xueqing Zhang, A. Higgins, 2012, Nature Genetics.

Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I-induced leukemia and suppresses leukemic stem cells.

C. Peng, Yiguo Hu, Shaoguang Li, 2007, Blood.

Lack of the adhesion molecules P-selectin and intercellular adhesion molecule-1 accelerate the development of BCR/ABL-induced chronic myeloid leukemia-like myeloproliferative disease in mice.

Yiguo Hu, Yuhua Liu, Shawn D. Pelletier, 2004, Blood.

Molecular Pathogenesis of Polycythemia Induced in Mice by JAK2 V617F.

Yiguo Hu, R. A. Etten, Shaoguang Li, 2005 .

DEPTOR Is a Regulator of Response to mTOR Kinase Inhibitors in Multiple Myeloma

S. Guichard, Yiguo Hu, N. Raje, 2011 .

Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma.

Michael A. Sellitto, D. Carrasco, Jian-jun Zhao, 2012, Blood.

therapeutic option in multiple myeloma is a promising α Blockade of XBP1 splicing by inhibition of IRE1

N. Munshi, P. Richardson, Yiguo Hu, 2013 .

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma.

N. Munshi, P. Richardson, Yiguo Hu, 2011, Blood.

The bromodomain protein BRD4 positively regulates necroptosis via modulating MLKL expression

Yuquan Wei, Shile Huang, Yiguo Hu, 2019, Cell Death & Differentiation.

Functional Ramifications for the Loss of P-Selectin Expression on Hematopoietic and Leukemic Stem Cells

C. Peng, Yiguo Hu, Shaoguang Li, 2011, PloS one.

Cancer Therapy : Preclinical Dual Inhibition of Canonical and Noncanonical NFk B Pathways Demonstrates Signi fi cant Antitumor Activities in Multiple Myeloma

P. Richardson, Yiguo Hu, T. Hideshima, 2012 .

Small Molecule Therapeutics Delineating themTORKinasePathwayUsingaDual TORC 1 / 2 Inhibitor , AZD 8055 , in Multiple Myeloma

S. Guichard, Yiguo Hu, N. Raje, 2014 .

CML Mouse Model Generated from Leukemia Stem Cells.

Yiguo Hu, 2016, Methods in molecular biology.

Inhibitory Effects of Omacetaxine on Leukemic Stem Cells and BCR-ABL-Induced Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia in Mice

Yiguo Hu, Shaoguang Li, Dennis M. Brown, 2009, Leukemia.

SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model

Yuquan Wei, Yiguo Hu, Sheng-yong Yang, 2021 .

SKLB060 Reversibly Binds to Colchicine Site of Tubulin and Possesses Efficacy in Multidrug-Resistant Cell Lines

Yiguo Hu, Sheng-yong Yang, Peng Bai, 2018, Cellular Physiology and Biochemistry.

SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model

Yuquan Wei, Yiguo Hu, Sheng-yong Yang, 2021, Science.

Genome-scale screens identify factors regulating tumor cell responses to natural killer cells

Jordan G Bryan, Michal Sheffer, Vasilis Syrgkanis, 2021, Nature Genetics.

Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement

Yong Liu, Wei Peng, Yiguo Hu, 2022, Nature Communications.

Characterizing dedifferentiation of thyroid cancer by integrated analysis

C. Gong, Wei Cheng, C. Caulin, 2021, Science Advances.

Discovery of New SIRT2 Inhibitors by Utilizing a Consensus Docking/Scoring Strategy and Structure-Activity Relationship Analysis

Lin-Li Li, Rong Xiang, Sheng-Yong Yang, 2017, J. Chem. Inf. Model..

Beta-catenin Is Essential for Survival of Leukemia Stem Cells Insensitive to Kinase Inhibition in Mice with BCR-ABL Induced Chronic Myeloid Leukemia.

Yiguo Hu, Shaoguang Li, Yaoyu Chen, 2008 .

Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells.

Jian-jun Zhao, P. Richardson, A. Berger, 2012, Blood.

High‐dose vitamin D metabolite delivery inhibits breast cancer metastasis

Yiguo Hu, Dongsheng He, Q. Pan, 2021, Bioengineering & translational medicine.

A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma.

Jeffrey Ecsedy, Loredana Santo, Paul Richardson, 2009, Blood.

Dual Inhibition of Canonical and Noncanonical NF-κB Pathways Demonstrates Significant Antitumor Activities in Multiple Myeloma

P. Richardson, Yiguo Hu, T. Hideshima, 2012, Clinical Cancer Research.

Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice

F. Lee, Yiguo Hu, Shaoguang Li, 2006, Proceedings of the National Academy of Sciences.

Survival regulation of leukemia stem cells

Yiguo Hu, Shaoguang Li, 2016, Cellular and Molecular Life Sciences.

Antimyeloma Activity of a Multitargeted Kinase Inhibitor, AT9283, via Potent Aurora Kinase and STAT3 Inhibition Either Alone or in Combination with Lenalidomide

N. Munshi, S. Rodig, Yiguo Hu, 2011, Clinical Cancer Research.

Molecular Pathogenesis and Therapy of Polycythemia Induced in Mice by JAK2 V617F

R. V. van Etten, Yiguo Hu, Shaoguang Li, 2006, PloS one.

Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins.

Christopher J. Ott, W. Hahn, Michal Sheffer, 2021, Cell reports.

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance.

P. Richardson, Yiguo Hu, D. Chauhan, 2014, Blood.

Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma.

N. Munshi, P. Richardson, G. Görgün, 2009, Blood.

The suppressive functions of Rora in B lineage cell proliferation and BCR/ABL1-induced B-ALL pathogenesis

Yiguo Hu, Haojian Zhang, Zhihui Li, 2022, International journal of biological sciences.

myeloma interaction of tumor and bone marrow accessory cells in multiple Immunomodulatory effects of lenalidomide and pomalidomide on

N. Munshi, P. Richardson, Yiguo Hu, 2012 .

Targeting glutaminase1 and synergizing with clinical drugs achieved more promising antitumor activity on multiple myeloma

F. Wang, Yiguo Hu, Sheng-yong Yang, 2019, Oncotarget.

Survival regulation of leukemia stem cells

Yiguo Hu, Shaoguang Li, 2015, Cellular and Molecular Life Sciences.

Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations

Rong Xiang, Shen-Zhen Huang, Sheng-Yong Yang, 2017, Chemical biology & drug design.

Differential m6A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function.

Yiguo Hu, Shaoguang Li, Yuhuan Zheng, 2021, Cell stem cell.

A tumor suppressor function of the Msr1 gene in leukemia stem cells of chronic myeloid leukemia.

Cong Peng, Dongguang Li, Con Sullivan, 2011, Blood.

Tmem30a Plays Critical Roles in Ensuring the Survival of Hematopoietic Cells and Leukemia Cells in Mice.

Xianjun Zhu, Yiguo Hu, Lijuan Chen, 2018, The American journal of pathology.

Novel recurrent altered genes in Chinese patients with anaplastic thyroid cancer.

Yiguo Hu, Wei Zhang, Yong Peng, 2021, The Journal of clinical endocrinology and metabolism.

AT9283, a Small Molecule Multi-Targeted Kinase Inhibitor with Potent Activity Against Aurora Kinase and STAT3 In Combination with Lenalidomide Results In Synergistic Anti-Myeloma Activity

N. Munshi, Yiguo Hu, D. Chauhan, 2010 .

ALCAM-EGFR interaction regulates myelomagenesis

M. Gou, Yiguo Hu, Yuhuan Zheng, 2021, Blood advances.

Delineating the mTOR Kinase Pathway Using a Dual TORC1/2 Inhibitor, AZD8055, in Multiple Myeloma

S. Guichard, Yiguo Hu, N. Raje, 2014, Molecular Cancer Therapeutics.

Inhibitory Effects of Homoharringtonine on Leukemic Stem Cells and BCR-ABL Induced Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia in Mice.

Yiguo Hu, Shaoguang Li, Yaoyu Chen, 2007 .

Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias

Joshua M. Dempster, Christopher J. Ott, James M. McFarland, 2023, Nature Cancer.

Targeting BCR-ABL Kinase Activity-Independent Signaling Pathways and Leukemia Stem Cells Is Essential for Curative Therapy of Philadelphia Chromosome Positive (Ph+) Leukemia.

F. Lee, Yiguo Hu, Shaoguang Li, 2005 .

SKLB-23bb, A HDAC6-Selective Inhibitor, Exhibits Superior and Broad-Spectrum Antitumor Activity via Additionally Targeting Microtubules

Yuquan Wei, Yiguo Hu, F. Wang, 2018, Molecular Cancer Therapeutics.

Atp8a1 deletion increases the proliferative activity of hematopoietic stem cells by impairing PTEN function

Xianjun Zhu, Yiguo Hu, Congbin Pan, 2023, Cellular Oncology.

A novel rapid-onset high-penetrance plasmacytoma mouse model driven by deregulation of cMYC cooperating with KRAS12V in BALB/c mice

K. Anderson, N. Munshi, G. Görgün, 2013, Blood Cancer Journal.