G. Mcgown

发表

A previously undescribed mutation within the tetramerisation domain of TP53 in a family with Li-Fraumeni syndrome.

D. Evans, J. Varley, J. Boyle, 1996, Oncogene.

A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours

J. Larkin, M. Gore, P. Lorigan, 2011, British Journal of Cancer.

Germ-line mutations of TP53 in Li-Fraumeni families: an extended study of 39 families.

D. Evans, J. Varley, M. Santibanez-Koref, 1997, Cancer research.

A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li – Fraumeni patients carrying a mutation to the TP53 gene

D. Evans, J. Varley, J. Birch, 1997, Oncogene.

Physical mapping of 43 STSs to human chromosome 6.

M. Santibanez-Koref, Y. Hey, J. Boyle, 1994, Genomics.

Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.

J. Tainer, M. Santibanez-Koref, G. Margison, 2012, Molecular cell.

O6-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib

P. Hersey, R. Kefford, P. Lorigan, 2009, British Journal of Cancer.

Characterization of germline TP53 splicing mutations and their genetic and functional analysis

J. Varley, J. Boyle, J. Birch, 2001, Oncogene.

A novel TP53 splicing mutation in a Li-Fraumeni syndrome family: a patient with Wilms' tumour is not a mutation carrier.

D. Evans, J. Varley, J. Birch, 1998, British Journal of Cancer.

An extended Li-Fraumeni kindred with gastric carcinoma and a codon 175 mutation in TP53.

D. Evans, J. Varley, M. Santibanez-Koref, 1995, Journal of medical genetics.

Proximal 6q, a region showing allele loss in primary breast cancer.

M. Santibanez-Koref, Y. Hey, J. Boyle, 1995, British Journal of Cancer.

Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li–Fraumeni syndrome

J. Varley, J. Birch, G. Mcgown, 1999, British Journal of Cancer.

Tumor O6-methylguanine-DNA Methyltransferase Inactivation by Oral Lomeguatrib

S. Bojanić, G. Margison, G. Mcgown, 2010, Clinical Cancer Research.

A novel deletion within exon 6 of TP53 in a family with Li-Fraumeni-like syndrome, and LOH in a benign lesion from a mutation carrier.

D. Evans, J. Varley, J. Birch, 1996, Cancer genetics and cytogenetics.

Are there low-penetrance TP53 Alleles? evidence from childhood adrenocortical tumors.

D. Evans, J. Varley, G. Margison, 1999, American journal of human genetics.

Quantitative trait locus analysis reveals two intragenic sites that influence O6-alkylguanine-DNA alkyltransferase activity in peripheral blood mononuclear cells.

S. Lewis, P. Barber, M. Santibanez-Koref, 2005, Carcinogenesis.

Quantitative trait locus analysis reveals two intragenic sites that influence O 6-alkylguanine-DNA alkyltransferase activity in peripheral blood mononuclear cells

S. Lewis, P. Barber, G. Margison, 2005 .

Alkylated DNA damage flipping bridges base and nucleotide excision repair

John A Tainer, Oliver Fleck, J. Tainer, 2009, Nature.

Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients.

Aaron S. Gajadhar, K. Aldape, J. Sarkaria, 2012, The Journal of clinical investigation.

Thirteen dinucleotide repeat polymorphisms on chromosome 6.

J. Boyle, G. Mcgown, V. Orphanos, 1993, Human molecular genetics.

Low rate of TP53 germline mutations in breast cancer/sarcoma families not fulfilling classical criteria for Li-Fraumeni syndrome

D. Evans, J. Varley, J. Birch, 2002, Journal of medical genetics.

Allelic imbalance of chromosome 6q in ovarian tumours.

M. Santibanez-Koref, Y. Hey, J. Boyle, 1995, British Journal of Cancer.

Genetic and functional studies of a germline TP53 splicing mutation in a Li–Fraumeni-like family

D. Evans, J. Varley, R. Reddel, 1998, Oncogene.

Temozolomide Pharmacodynamics in Patients with Metastatic Melanoma: DNA Damage and Activity of Repair Enzymes O6-Alkylguanine Alkyltransferase and Poly(ADP-Ribose) Polymerase-1

Adrian L Harris, A. Harris, A. Boddy, 2005, Clinical Cancer Research.

Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation–π interactions

C. Hunter, J. Tainer, G. Margison, 2012, Proceedings of the National Academy of Sciences.

Association between lung cancer risk and single nucleotide polymorphisms in the first intron and codon 178 of the DNA repair gene, O6‐alkylguanine–DNA alkyltransferase

S. Lewis, P. Barber, M. Santibanez-Koref, 2008, International journal of cancer.

Genetic and cytogenetic studies in inherited cancer: Li Fraumeni syndrome

D. Evans, J. Varley, J. Boyle, 2000 .

Significance of intron 6 sequence variations in the TP53 gene in Li-Fraumeni syndrome.

J. Varley, J. Birch, G. Mcgown, 2001, Cancer genetics and cytogenetics.

Short communication Significance of intron 6 sequence variations in the TP53 gene in Li-Fraumeni syndrome

J. Varley, G. Mcgown, M. Thorncroft, 2001 .

Proximal 6q, a region showing allele loss in primary breast cancer.

G. Mcgown, V. Orphanos, Mauro Santibanez-Koref, 1995, British Journal of Cancer.