C. Nguyen

发表

LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures

L. Nilsson, Y. V. Pabón-Martínez, You Xu, 2017, Scientific Reports.

A Distinct Triplex DNA Unwinding Activity of ChlR1 Helicase*

C. Nguyen, R. Zain, Manhong Guo, 2015, The Journal of Biological Chemistry.

A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors.

C. Nguyen, M. Andreola, V. Dollé, 1995, Journal of medicinal chemistry.

Synthesis and antiviral activity of 4-benzyl pyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors.

C. Nguyen, M. Andreola, V. Dollé, 2000, Journal of medicinal chemistry.

Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains.

Christophe Meyer, Stephen H Hughes, Eddy Arnold, 2005, Journal of medicinal chemistry.

Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase Inhibit Phosphorolysis and Resensitize the 3′-Azido-3′-deoxythymidine (AZT)-resistant Polymerase to AZT-5′-triphosphate*

C. Cruchaga, C. Nguyen, M. Andreola, 2003, Journal of Biological Chemistry.

Ligand binding mode to duplex and triplex dna assessed by combining electrospray tandem mass spectrometry and molecular modeling

E. Pauw, C. Nguyen, F. Rosu, 2007, Journal of the American Society for Mass Spectrometry.

3-iodo-4-phenoxypyridinones (IOPY's), a new family of highly potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.

C. Nguyen, K. Andries, D. Grierson, 2003, Bioorganic & medicinal chemistry letters.

Rational design of a triple helix-specific intercalating ligand.

C. Nguyen, C. Hélène, E. Bisagni, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Binding geometries of triple helix selective benzopyrido [4,3-b]indole ligands complexed with double- and triple-helical polynucleotides

B. Nordén, C. Nguyen, Jian-sheng Sun, 1997 .

Triple helix-specific ligands.

M. Rougée, J. Mergny, C. Nguyen, 1992, Science.

Stabilization of triple helical DNA by a benzopyridoquinoxaline intercalator.

M. Waring, C. Bailly, C. Nguyen, 1996, Biochemistry.

Immunization with the H5N1 Recombinant Vaccine Candidate Induces High Protection in Chickens against Vietnamese Highly Pathogenic Avian Influenza Virus Strains

C. Nguyen, H. Nguyen, Haiyan Chu, 2020, Vaccines.

Delivery, Effect on Cell Viability, and Plasticity of Modified Aptamer Constructs.

K. E. Lundin, C. Nguyen, J. Wengel, 2016, Nucleic acid therapeutics.

Self-association and DNA-binding properties of two triple helix-specific ligands: comparison of a benzo[e]pyridoindole and a benzo[g]pyridoindole

D. S. Pilch, C. Nguyen, Jian-sheng Sun, 1993 .

Stimulation by γ-carboline derivatives (simplified analogues of antitumor ellipticines) of site specific DNA cleavage by calf DNA topoisomerase II

C. Nguyen, C. Paoletti, P. Fossé, 1990 .

Synthesis and evaluation of "AZT-HEPT", "AZT-pyridinone", and "ddC-HEPT" conjugates as inhibitors of HIV reverse transcriptase.

C. Nguyen, C. Monneret, D. Grierson, 2000, Journal of medicinal chemistry.

Benzo[e]pyridoindoles, novel inhibitors of the Aurora kinases

S. Dimitrov, C. Nguyen, T. Hoang, 2009, Cell cycle.

pyridoindoles , novel inhibitors of the aurora kinases

S. Dimitrov, C. Nguyen, T. Hoang, 2022 .

Synthesis and biological evaluation of C-5 methyl substituted 4-arylthio and 4-aryloxy-3-Iodopyridin-2(1H)-one type anti-HIV agents.

K. Hertogs, C. Nguyen, K. Andries, 2009, Journal of medicinal chemistry.

Synthesis and antitumor activity of 1-[[(dialkylamino)alkyl]amino]-4-methyl-5H-pyrido[4,3-b]benzo[e]- and -benzo[g])indoles. A new class of antineoplastic agents.

C. Nguyen, E. Bisagni, F. Lavelle, 1990, Journal of medicinal chemistry.

Intoplicine (RP 60475) and its derivatives, a new class of antitumor agents inhibiting both topoisomerase I and II activities.

C. Nguyen, A. Larsen, J. Riou, 1993, Cancer research.

Nonnucleoside inhibitors of HIV-1 reverse transcriptase inhibit phosphorolysis and resensitize the 3’-azido-3’-deoxythymidine (AZT)-resistant polymerase to AZTTP

C. Cruchaga, C. Nguyen, M. Andreola, 2022 .

Molecular interactions of DNA-topoisomerase I and II inhibitor with DNA and topoisomerases and in ternary complexes: binding modes and biological effects for intoplicine derivatives.

C. Nguyen, M. Manfait, I. Nabiev, 1994, Biochemistry.

BENA435, a new cell-permeant photoactivated green fluorescent DNA probe

C. Nguyen, J. Florent, D. Grierson, 2006, Nucleic acids research.

13H-benzo[6-7]indolo[3,2-c]quinolines(B[6,7]IQ): optimization of their DNA triplex-specific stabilizationproperties

C. Nguyen, Jian-sheng Sun, D. Grierson, 2000 .

Azaindole derivatives are inhibitors of microtubule dynamics, with anti‐cancer and anti‐angiogenic activities

Laurence Lafanechère, Caroline Barette, Anne Martinez, 2013, British journal of pharmacology.

Ligand-induced formation of triple helices with antiparallel third strands containing G and T.

C. Nguyen, E. Bisagni, C. Escudé, 1996, Biochemistry.

Characterization of a triple helix-specific ligand. BePI (3-methoxy-7H-8-methyl-11- [(3'-amino)propylamino]-benzo[e]pyrido[4,3-b]indole) intercalates into both double-helical and triple-helical DNA.

M. Waring, M. Rougée, D. S. Pilch, 1993, Journal of molecular biology.

Triple‐Helix Directed Cleavage of Double‐Stranded DNA by Benzoquinoquinoxaline‐1,10‐phenanthroline Conjugates

C. Nguyen, R. Zain, Jian-sheng Sun, 2004, Chembiochem : a European journal of chemical biology.

Disruption of Higher Order DNA Structures in Friedreich’s Ataxia (GAA)n Repeats by PNA or LNA Targeting

P. Nielsen, C. Nguyen, C. I. Smith, 2016, PloS one.

Structure‐Specific Recognition of Friedreich's Ataxia (GAA)n Repeats by Benzoquinoquinoxaline Derivatives

C. Nguyen, R. Zain, L. Good, 2009, Chembiochem : a European journal of chemical biology.

Benzoquinoquinoxaline derivatives stabilize and cleave H-DNA and repress transcription downstream of a triplex-forming sequence.

C. Nguyen, R. Zain, D. Grierson, 2005, Journal of molecular biology.

Optimization of Triple‐Helix‐Directed DNA Cleavage by Benzoquinoquinoxaline–Ethylenediaminetetraacetic Acid Conjugates

C. Nguyen, R. Zain, Jian-sheng Sun, 2003, Chembiochem : a European journal of chemical biology.

Design of a triple-helix-specific cleaving reagent.

C. Nguyen, R. Zain, C. Marchand, 1999, Chemistry & biology.

A new family of sequence-specific DNA-cleaving agents directed by triple-helical structures: benzopyridoindole-EDTA conjugates.

C. Nguyen, C. Marchand, E. Bisagni, 2000, Chemistry.

Synthesis of 13H-Benzo[6,7]- and 13H-Benzo[4,5]indolo[3,2-c]- quinolines: A New Series of Potent Specific Ligands for Triplex DNA

C. Nguyen, C. Marchand, E. Bisagni, 1998 .

SELECTIVE STABILIZATION OF DNA TRIPLE HELICES BY BENZOPYRIDOINDOLE DERIVATIVES

J. Mergny, C. Nguyen, E. Bisagni, 1995 .

Synthesis and biological evaluation of amino-substituted benzo[f]pyrido[4,3-b] and pyrido[3,4-b]quinoxalines: a new class of antineoplastic agents.

P. Vrignaud, C. Nguyen, J. Riou, 1995, Anti-cancer drug design.

4-benzyl- and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones, a new family of potent anti-HIV agents: optimization and in vitro evaluation against clinically important HIV mutant strains.

R. Pauwels, C. Nguyen, C. Monneret, 2004, Journal of Medicinal Chemistry.

Antiviral activity of 4-benzyl pyridinone derivatives as HIV-1 reverse transcriptase inhibitors

C. Nguyen, M. Andreola, L. Tarrago-Litvak, 2001, Expert opinion on emerging drugs.

Synthesis and Biological Evaluation of 3-Deazacytidine and 3-Deazauridine Derivatives

C. Nguyen, E. Bisagni, M. Legraverend, 1986 .

Ligand-induced formation of hoogsteen-paired parallel DNA.

C. Nguyen, E. Taillandier, J. Liquier, 1996, Chemistry and Biology.

Synthesis and antiviral activity of 4-benzyl pyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors.

C. Nguyen, M. Andreola, V. Dollé, 2000, Journal of medicinal chemistry.

Triple helices formed at oligopyrimidine*oligopurine sequences with base pair inversions: effect of a triplex-specific ligand on stability and selectivity.

D. M. Brown, C. Nguyen, D. Loakes, 1998, Nucleic acids research.

Small-Molecule Inhibition of HIV pre-mRNA Splicing as a Novel Antiretroviral Therapy to Overcome Drug Resistance

J. Tazi, Sophie Maire, B. Chabot, 2007, PLoS pathogens.

Selective modification of alternative splicing by indole derivatives that target serine-arginine-rich protein splicing factors.

M. Gabut, J. Tazi, Sophie Maire, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Stable Triple-Helical DNA Complexes Formed by Benzopyridoindole− and Benzopyridoquinoxaline− Oligonucleotide Conjugates

C. Nguyen, A. Boutorine, C. Hélène, 1997 .

Synthesis of 5H-furo[3′,2′ : 6,7][1]benzopyrano[3,4-c]pyridin-5-ones and 8H-pyrano[3′,2′ : 5,6]benzofuro[3,2-c]pyridin-8-ones (pyridopsoralens)

C. Nguyen, E. Bisagni, J. Morón, 1983 .

Further SAR in the new antitumor 1-amino-substituted gamma-carbolines and 5H-benzo[e]pyrido[4,3-b]indoles series.

C. Nguyen, J. Riou, E. Bisagni, 1992, Anti-cancer drug design.

Inhibition of nonsense-mediated mRNA decay (NMD) by a new chemical molecule reveals the dynamic of NMD factors in P-bodies

J. Tazi, C. Nguyen, N. Cougot, 2007, The Journal of cell biology.

In Vitro High Throughput Screening, What Next? Lessons from the Screening for Aurora Kinase Inhibitors

C. Nguyen, T. Hoang, A. Molla, 2014, Biology.

Antitumor activity of pyridocarbazole and benzopyridoindole derivatives that inhibit protein kinase CK2.

C. Nguyen, J. Florent, V. Moucadel, 2010, Cancer research.

Multi-Kinase Inhibitor C1 Triggers Mitotic Catastrophe of Glioma Stem Cells Mainly through MELK Kinase Inhibition

Kaushal Joshi, I. Nakano, H. Kornblum, 2014, PloS one.

Expression of aryl hydrocarbon receptor, inflammatory cytokines, and incidence of rheumatoid arthritis in Vietnamese dioxin-exposed people

C. Nguyen, T. Kishimoto, N. Nguyen, 2017, Journal of immunotoxicology.

Pharmacological inhibition of LIM kinase stabilizes microtubules and inhibits neoplastic growth.

S. Knapp, A. di Pietro, C. Nguyen, 2012, Cancer research.

Antitumor activity of intoplicine (RP 60475, NSC 645008), a new benzo-pyrido-indole: evaluation against solid tumors and leukemias in mice

P. Vrignaud, C. Nguyen, M. Bissery, 1993, Investigational New Drugs.

Interrelationship between affinity for DNA, cytotoxicity and induction of DNA-breaks in cultured L1210 cells for two series of tricyclic intercalators. Simplified analogues of ellipticine derivatives.

P. Gros, C. Nguyen, E. Bisagni, 1989, Biochemical pharmacology.

1-Amino-substituted 4-methyl-5H-pyrido[3',4':4,5]pyrrolo[3,2-c]pyridines: a new class of antineoplastic agents.

C. Nguyen, E. Bisagni, P. de Cointet, 1987, Journal of medicinal chemistry.

Hydrosoluble Benzo[e]pyridoindolones as Potent Inhibitors of Aurora Kinases

C. Nguyen, A. Molla, Delphine Naud‐Martin, 2013, ChemMedChem.

Synthesis and antitumor properties of new 4-methyl-substituted- pyrido[4,3-b]indoles (gamma-carbolines).

C. Nguyen, E. Bisagni, F. Lavelle, 1992, Anti-cancer drug design.

CD45 phosphatase is crucial for human and murine acute myeloid leukemia maintenance through its localization in lipid rafts

C. Nguyen, A. Hammann, R. Filomenko, 2016, Oncotarget.

1-Amino-substituted 4-methyl-5H-pyrido[4,3-b]indoles (gamma-carbolines) as tricyclic analogues of ellipticines: a new class of antineoplastic agents.

P. Gros, C. Nguyen, E. Bisagni, 1988, Journal of medicinal chemistry.

Aryl hydrocarbon receptor antagonism and its role in rheumatoid arthritis

C. Nguyen, T. Kishimoto, Van-Son Le, 2015, Journal of experimental pharmacology.

Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase.

J. Mergny, C. Nguyen, D. Grierson, 2002, Bioorganic & medicinal chemistry letters.

Pyr1-Mediated Pharmacological Inhibition of LIM Kinase Restores Synaptic Plasticity and Normal Behavior in a Mouse Model of Schizophrenia

C. Nguyen, A. Buisson, Fabien Lanté, 2021, Frontiers in Pharmacology.

Basal aurora kinase B activity is sufficient for histone H3 phosphorylation in prophase

C. Nguyen, A. Molla, Hong-Lien Vu, 2013, Biology Open.

Discovery of benzo[e]pyridoindolones as kinase inhibitors that disrupt mitosis exit while erasing AMPK-Thr172 phosphorylation on the spindle

C. Nguyen, J. Coll, A. Molla, 2015, Oncotarget.

Phencyclidine metabolism in vitro. The formation of a carbinolamine and its metabolites by rabbit liver preparations.

C. Nguyen, A. Cho, D. Schmitz, 1983, Drug metabolism and disposition: the biological fate of chemicals.

Effect of nucleoside analogs and non-nucleoside inhibitors of HIV-1 reverse transcriptase on cell-free virions

H. Fleury, C. Nguyen, V. Dollé, 1999, Archives of Virology.

Complementary advantages of fluorescence and SIMS microscopies in the study of cellular localization of two new antitumor drugs

A. Brunet, C. Nguyen, D. Carrez, 1997, Microscopy research and technique.

Conjugates of Oligonucleotides with Triplex-Specific Intercalating Agents. Stabilization of Triple-Helical DNA in the Promoter Region of the Gene for the α-Subunit of Interleukin 2 (IL-2Rα)

C. Nguyen, A. Boutorine, E. Bisagni, 1997 .