P. T. Jørgensen

发表

LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures

L. Nilsson, Y. V. Pabón-Martínez, You Xu, 2017, Scientific Reports.

Synthesis and Biophysical Investigations of Oligonucleotides Containing Galactose-Modified DNA, LNA, and 2'-Amino-LNA Monomers.

P. T. Jørgensen, J. Wengel, T. Kosbar, 2016, The Journal of organic chemistry.

Twisted Intercalating Nucleic Acids – Intercalator Influence on Parallel Triplex Stabilities

P. T. Jørgensen, V. Filichev, E. Pedersen, 2006 .

Synthesis of New MKC-442 Analogues Containing Alkenyl Chains or Reactive Functionalities at C-5

P. T. Jørgensen, C. Nielsen, T. H. Hansen, 2002 .

Unlocked nucleic acid modified primer-based enzymatic polymerization assay: towards allele-specific genotype detection of human platelet antigens

P. T. Jørgensen, J. Wengel, R. Veedu, 2018, RSC advances.

Can Vitamin B12 Assist the Internalization of Antisense LNA Oligonucleotides into Bacteria?

P. T. Jørgensen, J. Wengel, N. Azevedo, 2021, Antibiotics.

Gapmer antisense oligonucleotides containing 2',3'-dideoxy-2'-fluoro-3'-C-hydroxymethyl-β-D-lyxofuranosyl nucleotides display site-specific RNase H cleavage and induce gene silencing.

P. T. Jørgensen, J. Wengel, A. Pasternak, 2020, Chemistry.

Synthesis of locked pyranosyl nucleic acid (LpNA).

P. T. Jørgensen, E. Pedersen, N. Bomholt, 2011, Bioorganic & medicinal chemistry letters.

Alpha-l-Locked Nucleic Acid-Modified Antisense Oligonucleotides Induce Efficient Splice Modulation In Vitro

P. T. Jørgensen, J. Wengel, Tao Wang, 2020, International journal of molecular sciences.

Synthesis of 5-dialkylaminomethyl-3′-azido and 3′-fluoro-2′,3′-dideoxyuridines for evaluation as anti-HIV agents

A. Larnkjær, M. S. Motawia, E. Pedersen, 1993 .

Next-generation bis-locked nucleic acids with stacking linker and 2′-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes

K. E. Lundin, S. Geny, E. Pedersen, 2016, Nucleic acids research.

University of Southern Denmark Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes Geny,

K. E. Lundin, S. Geny, E. Pedersen, 2016 .

Synthesis and Anti‐HIV‐1 Evaluation of New Sonogashira‐Modified Emivirine (MKC‐442) Analogues

P. T. Jørgensen, K. Danel, R. Loddo, 2009 .

Synthesis of novel N-1 (allyloxymethyl) analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine) with improved activity against HIV-1 and its mutants.

P. T. Jørgensen, A. Boel, C. Nielsen, 2002, Journal of medicinal chemistry.

Facile route for the synthesis of the iminosugar nucleoside (3R,4R)-1-(pyren-1-yl)-4-(hydroxymethyl)pyrrolidin-3-ol.

P. T. Jørgensen, P. Stein, I. A. A. El-Gawad, 2004, Carbohydrate research.

Functionalization of 2’’-C-(piperazinomethyl)-2’,3’-BcNA (bicyclic nucleic acids) with pyren-1-ylcarbonyl units

P. T. Jørgensen, J. Wengel, N. K. Andersen, 2014 .

Synthesis of 6‐(3,5‐Dichlorobenzyl) Derivatives as Isosteric Analogues of the HIV Drug 6‐(3,5‐Dimethylbenzyl)‐1‐(ethoxymethyl)‐5‐isopropyluracil (GCA‐186)

P. T. Jørgensen, C. Nielsen, E. Pedersen, 2005, Archiv der Pharmazie.

A NEW AND EASY SYNTHESIS OF SILYLATED FURANOID GLYCALS IN ONE STEP FROM NUCLEOSIDES

E. Pedersen, P. T. Jørgensen, M. Sofan, 1994 .

A New and Easy Synthesis of Silylated Furanoid Glycals, e.g. (III), in One Step from Nucleosides.

E. Pedersen, P. T. Jørgensen, M. Sofan, 1995 .

Synthesis of imidazoles as novel emivirine and S‐DABO analogues

P. T. Jørgensen, C. Nielsen, E. Pedersen, 2002 .

Synthesis and evaluation of double-prodrugs against HIV. Conjugation of D4T with 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine)-type reverse transcriptase inhibitors via the SATE prodrug approach.

P. T. Jørgensen, C. Nielsen, J. Nielsen, 2005, Journal of medicinal chemistry.

Synthesis of annelated analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442) using 1,3-oxazine-2,4(3H)-diones as key intermediates

P. T. Jørgensen, C. Nielsen, E. Pedersen, 2000 .

Convergent synthesis of 2′,3′-dideoxy-3′-methylthio and 2′,3′-dideoxy-3′-mercapto nucleosides and their disulfide analogues — Potential anti-HIV agents

E. Pedersen, P. T. Jørgensen, C. Nielsen, 1993 .

A surprising ring opening mechanism in the formation of α-D-arabinofuranosyl nucleosides from 5-substituted uracils

E. Pedersen, P. T. Jørgensen, C. Nielsen, 1992 .

Using an aryl phenanthroimidazole moiety as a conjugated flexible intercalator to improve the hybridization efficiency of a triplex-forming oligonucleotide.

P. T. Jørgensen, E. Pedersen, N. Bomholt, 2008, Bioorganic & medicinal chemistry.

SYNTHESIS OF 3'-DIALKYLAMINO-2',3'-DIDEOXYNUCLEOSIDES FROM A 2,3'-ANHYDROTHYMIDINE OR AN ALPHA ,BETA -UNSATURATED ALDEHYDE

E. Pedersen, P. T. Jørgensen, R. Gawinecki, 1995 .

New Emivirine (MKC-442) Analogues Containing a Tetrahydronaphthalene at C-6 and their Anti-HIV Activity

P. T. Jørgensen, C. Nielsen, E. Pedersen, 2007 .

Carbazole modified oligonucleotides: synthesis, hybridization studies and fluorescence properties.

P. T. Jørgensen, J. Wengel, Alaa S Gouda, 2020, Organic & biomolecular chemistry.

Synthesis of α-arabinose nucleosides from 6-substituted uracils

E. Pedersen, P. T. Jørgensen, A. El‐Barbary, 1993 .

Polyamine-functionalized 2'-amino-LNA in oligonucleotides: Facile synthesis of novel monomers and high affinity binding towards ssDNA and dsDNA.

P. T. Jørgensen, J. Wengel, K. Jensen, 2020, Chemistry.

Conjugation of a 3-(1H-phenanthro[9,10-d]imidazol-2-yl)-1H-indole intercalator to a triplex oligonucleotide and to a three-way junction.

Y. M. Elkholy, P. T. Jørgensen, N. S. Abbas, 2012, Bioorganic & medicinal chemistry.

Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA

K. E. Lundin, S. Geny, E. Pedersen, 2013, Nucleic acids research.

Antisense locked nucleic acid gapmers to control Candida albicans filamentation.

P. T. Jørgensen, J. Wengel, M. Henriques, 2021, Nanomedicine : nanotechnology, biology, and medicine.

Chemical Modifications and Design Influence the Potency of Huntingtin Anti-Gene Oligonucleotides

K. E. Lundin, P. T. Jørgensen, J. Wengel, 2023, Nucleic acid therapeutics.

Development of an Efficient G‐Quadruplex‐Stabilised Thrombin‐Binding Aptamer Containing a Three‐Carbon Spacer Molecule

Vasanthanathan Poongavanam, N. A. Murugan, P. T. Jørgensen, 2017, Chembiochem : a European journal of chemical biology.

Polyamine–Oligonucleotide Conjugates: 2′-OMe-Triazole-Linked 1,4,7,10-Tetraazacyclododecane and Intercalating Dyes and Their Effect on the Thermal Stability of DNA Duplexes

P. T. Jørgensen, J. Wengel, K. Walczak, 2021, Pharmaceutics.

microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation

P. T. Jørgensen, J. Wengel, H. Jenssen, 2019, Scientific Reports.

microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation

P. T. Jørgensen, J. Wengel, H. Jenssen, 2019, Scientific Reports.

Novel assemblies based on oligonucleotides containing intercalating nucleic acid monomers

P. T. Jørgensen, J. Wengel, Alaa S Gouda, 2020, Nucleosides, nucleotides & nucleic acids.

Synthesis of locked pyranosyl nucleic acid (LpNA).

P. T. Jørgensen, E. Pedersen, N. Bomholt, 2011, Bioorganic & medicinal chemistry letters.

Hoogsteen triplexes stabilized through ethynyl-linked pyrene-indole synthesized by high-temperature Sonogashira coupling.

E. Pedersen, P. T. Jørgensen, Imrich Géci, 2022, Organic & biomolecular chemistry.