V. Kinzel

发表

Influence of myristoylation, phosphorylation, and deamidation on the structural behavior of the N-terminus of the catalytic subunit of cAMP-dependent protein kinase.

A. Tholey, R. Pipkorn, D. Bossemeyer, 2001, Biochemistry.

Crystal Structures of Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Isoquinolinesulfonyl Protein Kinase Inhibitors H7, H8, and H89

R. Huber, R. Engh, D. Bossemeyer, 1996, The Journal of Biological Chemistry.

Phosphoproteins of the cell surface as generated by endogenous or exogenous protein kinase: stability of the 32P-labelled product.

V. Kinzel, E. Rozengurt, A. Mastro, 1976, Biochimica et biophysica acta.

Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.

R. Huber, H. Hidaka, R. Engh, 2003, Structure.

Phosphotransferase and substrate binding mechanism of the cAMP‐dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5‐24).

R. Huber, R. Engh, D. Bossemeyer, 1993, The EMBO journal.

Physiological Aspects of Surface Protein Kinase Activity

V. Kinzel, W. Pyerin, D. Kübler, 1986 .

Protein kinase activity and substrates at the surface of intact HeLa cells.

V. Kinzel, W. Pyerin, D. Kübler, 1982, The Journal of biological chemistry.

Lens culinaris lectin immobilized on sepharose: binding and sugar-specific release of intact tissue culture cells

V. Kinzel, D. Kubler, J. Richards, 1976, Science.

Phorbol esters as a tool in cell research?

G. Kreibich, V. Kinzel, R. Süss, 1972, European journal of cancer.

Protein Kinases in HeLa Cells and in Human Cervix Carcinoma

V. Kinzel, W. Pyerin, D. Kübler, 1981, Zeitschrift fur Naturforschung. Section C, Biosciences.

Biosynthesis and membrane topography of the neural cell adhesion molecule L1.

D. Teplow, V. Kinzel, A. Faissner, 1985, The EMBO journal.

Cell surface protein kinases and extracellular phosphorylation

D. Bossemeyer, V. Kinzel, D. Kübler, 2003 .

Analysis of isoaspartate in peptides by electrospray tandem mass spectrometry

W. Lehmann, R. Pipkorn, D. Bossemeyer, 2000, Protein science : a publication of the Protein Society.

Downregulation of protein phosphatase 2A activity in HeLa cells at the G2-mitosis transition and unscheduled reactivation induced by 12-O-tetradecanoyl phorbol-13-acetate (TPA).

V. Kinzel, H. Barth, M. Klingler-Hoffmann, 2005, European journal of cell biology.

Radiomimetic activity of phorbol esters exerted in HeLa cells in comparison with their tumor-promoting capacity.

F. Marks, V. Kinzel, G. Fürstenberger, 1984, Cancer research.

Stimulation of choline incorporation in cell cultures by phorbol derivatives and its correlation with their irritant and tumor-promoting activity.

G. Kreibich, V. Kinzel, E. Hecker, 1979, Cancer research.

Variation and adaptation of Pseudomonas aeruginosa toxicity to HeLa cells and fibroblasts

V. Kinzel, H. Sonntag, G. Keilich, 1986, Journal of clinical microbiology.

Inhibitors of the conformational switch involved in CD4 binding by the env glycoprotein gp120 from human immunodeficiency virus type 1 (HIV1).

V. Kinzel, J. Reed, 1994, Biochemistry.

Cocarcinogenic croton oil factor A1 stimulates lipid synthesis in cell cultures

G. Kreibich, V. Kinzel, R. Süss, 1971, Experientia.

A conserved deamidation site at asn 2 in the catalytic subunit of mammalian cAMP‐dependent protein kinase detected by capillary LC‐MS and tandem mass spectrometry

A. Tholey, D. Bossemeyer, V. Kinzel, 1998, Protein science : a publication of the Protein Society.

Clostridium botulinum C2 Toxin Delays Entry into Mitosis and Activation of p34cdc2Kinase and cdc25-C Phosphatase in HeLa cells

V. Kinzel, K. Aktories, H. Barth, 1999, Infection and Immunity.

Volker HeLa cells Kinase and cdc 25C Phosphatase in cdc 2 Entry into Mitosis and Activation of p 34 C 2 Toxin Delays Clostridium botulinum

V. Kinzel, K. Aktories, H. Barth, 1999 .

Phorbol ester TPA rapidly prevents activation of p34cdc2 histone H1 kinase and concomitantly the transition from G2 phase to mitosis in synchronized HeLa cells.

V. Kinzel, H. Barth, H. Barth, 1994, Experimental cell research.

Phorbol ester-induced G2 delay in HeLa cells analyzed by time lapse photography.

V. Kinzel, J. Richards, G. Bonheim, 1988, Cancer research.

Responses of synchronized HeLa cells to the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate as evaluated by flow cytometry.

V. Kinzel, M. Stöhr, J. Richards, 1981, Cancer research.

Induced Release of Cell Surface Protein Kinase Yields CK1- and CK2-like Enzymes in Tandem (*)

V. Kinzel, J. Walter, M. Schnölzer, 1996, The Journal of Biological Chemistry.

Evidence for ecto-protein kinase activity that phosphorylates Kemptide in a cyclic AMP-dependent mode.

V. Kinzel, W. Pyerin, D. Kübler, 1989, The Journal of biological chemistry.

Substrate-effected release of surface-located protein kinase from intact cells.

V. Kinzel, W. Pyerin, D. Kübler, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Chalones and Cancer: Melanoma Regression induced by “Chalone”: a New Tumour Inhibiting Principle acting in vivo

V. Kinzel, U. Mohr, R. Süss, 1968, Nature.

Early changes in the arachidonic acid metabolism of HeLa cells in response to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and related compounds

F. Marks, V. Kinzel, G. Fürstenberger, 2004, Journal of Cancer Research and Clinical Oncology.

Cloning of the Cα catalytic subunit of the bovine cAMP-dependent protein kinase

S. Wiemann, V. Kinzel, W. Pyerin, 1992 .

Role of arachidonic acid release in the G2 delay induced by tumor promoter TPA in HeLa cells.

V. Kinzel, G. Fürstenberger, J. Richards, 1987, Experimental cell research.

Accumulation of ester- and ether-linked phosphatidates by HeLa cells in response to ionophore A23187 through activation of phospholipase D.

V. Kinzel, M. Kaszkin, P. Plein, 1992, Biological chemistry Hoppe-Seyler.

Detection and Biochemistry of Cell Surface Protein Kinase

V. Kinzel, W. Pyerin, D. Kübler, 1986 .

A rapid assay for the localization of protein kinase modulator (inhibitor) in complete polyacrylamide gels

V. Kinzel, M. Gagelmann, 1980, Experientia.

Chromatographic separation of two heterogeneous forms of the catalytic subunit of cyclic AMP-dependent protein kinase holoenzyme type I and type II from striated muscle of different mammalian species.

F. Hofmann, V. Kinzel, J. Reed, 1987, Archives of biochemistry and biophysics.

Protein kinase activities in mammalian blood fluid.

V. Kinzel, W. Pyerin, D. Kübler, 1985, Biochemical and biophysical research communications.

Interaction of protease inhibitors with the catalytic subunit of cAMP-dependent protein kinase.

V. Kinzel, N. König, 1980, Biochemical and biophysical research communications.

Single step purification of the catalytic subunit(s) of cyclic 3', 5'-adenosine monophosphate-dependent protein kinase(s) from rat muscle.

V. Kinzel, D. Kübler, 1976, Biochemical and biophysical research communications.

Atrial natriuretic peptide is phosphorylated by intact cells through cAMP-dependent ecto-protein kinase.

D. Reinhardt, V. Kinzel, J. Reed, 1992, European Journal of Biochemistry.

Phosphorylation by cell surface protein kinase of bovine and human fibrinogen and fibrin.

V. Kinzel, D. Kübler, J. Sonka, 1989, Biochimica et biophysica acta.

Phosphorylation of cytochrome-P-450-dependent monooxygenase components.

F. Oesch, C. Wolf, V. Kinzel, 1983, Carcinogenesis.

Interference of xanthate compounds with phorbol ester TPA-induced changes of phospholipid metabolism: inhibition of prostaglandin production.

V. Kinzel, G. Fürstenberger, M. Kaszkin, 1991, Biochemical pharmacology.

Dual effect of the phorbol ester TPA on arachidonic acid release from HeLa cells

V. Kinzel, M. Kaszkin, U. Espe, 1988, FEBS letters.

Catalytic subunit of cAMP-dependent protein kinase from bovine heart: several isoforms demonstrated by high resolution focusing in immobilized pH gradient.

V. Kinzel, J. Chrivia, H. Taniguchi, 1989, Biochemical and biophysical research communications.

Protein kinase assay on isoelectric focusing gels: evaluation of its quantitative potentials.

V. Kinzel, W. Pyerin, D. Kübler, 1979, Analytical biochemistry.

Cancer: Experiments and Concepts

V. Kinzel, J. Scribner, R. Süss, 1977 .

Circular dichroic investigations of secondary structure in synthetic peptide inhibitors of cAMP-dependent protein kinase: a model for inhibitory potential.

H. Cheng, D. Walsh, V. Kinzel, 1987, Biochemistry.

Near- and far-ultraviolet circular dichroism of the catalytic subunit of adenosine cyclic 5'-monophosphate dependent protein kinase.

V. Kinzel, J. Reed, 1984, Biochemistry.

Investigation of the structural components governing the polarity-dependent refolding of a CD4-binding peptide from gp120.

R. Pipkorn, V. Kinzel, J. Reed, 1995, Journal of molecular biology.

Primary structure elements responsible for the conformational switch in the envelope glycoprotein gp120 from human immunodeficiency virus type 1: LPCR is a motif governing folding.

V. Kinzel, J. Reed, 1993, Proceedings of the National Academy of Sciences of the United States of America.

A conformational switch is associated with receptor affinity in peptides derived from the CD4-binding domain of gp120 from HIV I.

V. Kinzel, J. Reed, 1991, Biochemistry.

The human papillomavirus type 16 E5 protein modulates phospholipase C-γ-1 activity and phosphatidyl inositol turnover in mouse fibroblasts

V. Kinzel, A. Alonso, K. Crusius, 1999, Oncogene.

International Symposium: Skin Carcinogenesis in Man and in Experimental Models

R. MacKie, M. Ichihashi, E. Jung, 1992, Journal of Cancer Research and Clinical Oncology.

Nosematosis as an accompanying infection of plasmacytoma ascites in Syrian golden hamsters.

V. Kinzel, O. Jírovec, J. Meiser, 1971, Pathologia et microbiologia.

On the biochemical mechanism of tumorigenesis in mouse skin. V. studies of the metabolism of tumor promoting and non promoting phorbol derivatives in vivo and in vitro

G. Kreibich, V. Kinzel, R. Süss, 2004, Zeitschrift für Krebsforschung.

[Electron microscope study of the origin of premelanosomes in melanoma cells in vitro].

V. Kinzel, U. Mohr, P. Stanka, 1969, Virchows Archiv. B, Cell pathology.

Measurement of the response of HELA cells towards the radiomimetic activity of 12-O-tetradecanoylphorbol-13-acetate.

V. Kinzel, J. Richards, F. Düzgün, 1982, Cancer letters.

Phorbol ester stimulates choline incorporation

G. Kreibich, V. Kinzel, E. Hecker, 1971, Naturwissenschaften.

Thymidine incorporation into HeLa cells increased by tumor-promoting croton oil factor TPA

G. Kreibich, V. Kinzel, R. Süss, 1970, Naturwissenschaften.

Early effects of the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate on the cell cycle traverse of asynchronous HeLa cells.

V. Kinzel, J. Richards, M. Stöhr, 1981, Cancer research.

Tumor promoter TPA mimics irradiation effects on the cell cycle of HeLa cells.

V. Kinzel, J. Richards, M. Stöhr, 1980, Science.

Severe chromosomal damage in mammalian cells induced by pulse labeling with small amounts of [3H]thymidine.

V. Kinzel, B. Färber, 1990, Mutation research.

Chromosomenstudien am in vivo und in vitro gehaltenen Walkercarcinom 256

V. Kinzel, U. Mohr, O. Wieser, 2004, Zeitschrift für Krebsforschung.

Proposed role of phosphatidic acid in the extracellular control of the transition from G2 phase to mitosis exerted by epidermal growth factor in A431 cells.

V. Kinzel, J. Richards, M. Kaszkin, 1992, Cancer research.

On the biochemical mechanism of tumorigenesis in mouse skin

G. Kreibich, V. Kinzel, E. Hecker, 2004, Zeitschrift für Krebsforschung.

Biochemical mechanism of tumorigenesis in mouse skin. 3. Decrease in tumor yields by poly I-C administered during initiation of skin b y and intragastric dose of 7,12-dimethyl-benz(a)anthracene.

G. Kreibich, V. Kinzel, E. Hecker, 1970, Zeitschrift fur Krebsforschung.

Variation andAdaptation ofPseudomonas aeruginosa Toxicity to HeLaCells andFibroblasts

V. Kinzel, H. Sonntag, G. Keilich, 1986 .

Intracellular Distribution of Mammalian Protein Kinase a Catalytic Subunit Altered by Conserved Asn2 Deamidation

R. Pepperkok, A. Hotz-Wagenblatt, D. Bossemeyer, 2000, The Journal of cell biology.

Biosynthesis andmembranetopography oftheneural celladhesion molecule Li

D. Teplow, V. Kinzel, A. Faissner, 1985 .

Mobilization of diacylglycerol in intact HeLa cells by exogenous phospholipase C from Cl. perfringens is accompanied by release of fatty acids including arachidonic acid.

V. Kinzel, P. Jordan, M. Kaszkin, 1992, Biochimica et biophysica acta.

Serum proteins associated with tissue culture cells as demonstrated by the use of enzymatically radio-phosphorylated serum.

V. Kinzel, D. Kübler, 1978, Experimental cell research.

Phosphorylation of surface proteins of HeLa cells using an exogenous protein kinase and (gamma-32P)ATP.

V. Kinzel, G. Mueller, 1973, Biochimica et biophysica acta.

Direct effects of phosphorylation on the preferred backbone conformation of peptides: a nuclear magnetic resonance study.

A. Tholey, V. Kinzel, J. Reed, 1999, Biophysical journal.

Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential.

R. Huber, R. Engh, D. Bossemeyer, 1997, Structure.

In vivo activation of recombinant cAPK catalytic subunit active site mutants by coexpression of the wild‐type enzyme, evidence for intermolecular cotranslational phosphorylation

D. Bossemeyer, V. Kinzel, A. Girod, 1996, FEBS letters.

Major cell surface-located protein substrates of an ecto-protein kinase are homologs of known nuclear proteins.

V. Kinzel, P. Jordan, D. Kübler, 1994, Biochemistry.

Role of cdc25‐C phosphatase in the immediate G2 delay induced by the exogenous factors epidermal growth factor and phorbolester

V. Kinzel, I. Hoffmann, J. Richards, 1996, Journal of cellular physiology.

Suppression of the first stage of phorbol 12-tetradecanoate 13-acetate-effected tumor promotion in mouse skin by nontoxic inhibition of DNA synthesis.

F. Marks, V. Kinzel, K. Goerttler, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Secondary structure of the Arg-Gly-Asp recognition site in proteins involved in cell-surface adhesion. Evidence for the occurrence of nested beta-bends in the model hexapeptide GRGDSP.

S. Suhai, V. Kinzel, J. Reed, 1988, European journal of biochemistry.

"Geography" of Mitoses and Cell Divisions in the Basal Cell Layer of Mouse Epidermis

V. Kinzel, K. Goerttler, R. Süss, 1971 .

Epidermal Growth Factor Inhibits Transiently the Progression from G2-Phase to Mitosis: A Receptor-mediated Phenomenon in Various Cells1

V. Kinzel, J. Richards, A. Blume, 2006 .

Epidermal Growth Factor Inhibits Transiently the Progression from G 2-Phase to Mitosis : A Receptor-mediated Phenomenon in Various Cells 1

Marietta, V. Kinzel, J. Richards, 2006 .

Epidermal growth factor rapidly impairs activation of p34cdc2 protein kinase in HeLa cells at the G2‐M boundary

V. Kinzel, H. Barth, 1995, Journal of cellular physiology.

Role of Phospholipid Metabolites in the Cell Cycle Delay Caused by Epidermal Growth Factor at the Transition from G2-Phase to Mitosis in A431 Cells

V. Kinzel, M. Kaszkin, 1993 .

Epidermal growth factor inhibits transiently the progression from G2-phase to mitosis: a receptor-mediated phenomenon in various cells.

V. Kinzel, J. Richards, M. Kaszkin, 1990, Cancer research.

Three-stage tumorigenesis in mouse skin: DNA synthesis as a prerequisite for the conversion stage induced by TPA prior to initiation.

F. Marks, V. Kinzel, G. Fürstenberger, 1986, Carcinogenesis.

Primary alcohols and phosphatidylcholine metabolism in rat brain synaptosomal membranes via phospholipase D.

V. Kinzel, M. Kaszkin, L. Seidler, 1996, Pharmacology & toxicology.

The protein kinase A catalytic subunit Cbeta2: molecular characterization and distribution of the splice variant.

S. Wiemann, D. Bossemeyer, V. Kinzel, 2000, The Biochemical journal.

Catalytic and molecular properties of highly purified phosvitin/casein kinase type II from human epithelial cells in culture (HeLa) and relation to ecto protein kinase.

V. Kinzel, W. Pyerin, D. Kübler, 1987, Biological chemistry Hoppe-Seyler.

Isoform C beta 2, an unusual form of the bovine catalytic subunit of cAMP-dependent protein kinase.

S. Wiemann, V. Kinzel, W. Pyerin, 1991, The Journal of biological chemistry.

The amino terminus of PKA catalytic subunit—A site for introduction of posttranslation heterogeneities by deamidation: D‐Asp2 and D‐isoAsp2 containing isozymes

W. Lehmann, R. Pipkorn, D. Bossemeyer, 2000, Protein science : a publication of the Protein Society.

Radiation with 1 Gy prevents the activation of the mitotic inducers mitosis-promoting factor (MPF) and cdc25-C in HeLa cells.

V. Kinzel, I. Hoffmann, H. Barth, 1996, Cancer research.

Conformational analysis of PKI(5-22)amide, the active inhibitory fragment of the inhibitor protein of the cyclic AMP-dependent protein kinase.

J. Trewhella, D. Walsh, V. Kinzel, 1989, The Biochemical journal.

Circular dichroic evidence for an ordered sequence of ligand/binding site interactions in the catalytic reaction of the cAMP-dependent protein kinase.

H. Cheng, B. Kemp, D. Walsh, 1985, Biochemistry.

Evidence for a "mute" catalytic subunit of cyclic AMP-dependent protein kinase from rat muscle and its mode of activation.

V. Kinzel, J. Reed, W. Pyerin, 1980, Proceedings of the National Academy of Sciences of the United States of America.

The typically disordered N-terminus of PKA can fold as a helix and project the myristoylation site into solution.

R. Huber, R. Engh, D. Bossemeyer, 2004, Biochemistry.

Lectin receptor sites at the cell surface employed for affinity separation of tissue culture cells. Basic requirements as realized by lens culinaris lectin (LCL) immobilized on 2tb-sepharose.

V. Kinzel, D. Kübler, J. Richards, 1977, Experimental cell research.

Solvent polarity‐dependent structural refolding: A CD and NMR study of a 15 residue peptide

V. Kinzel, J. Reed, M. Jiménez, 1995, Proteins.

Differential sensitivity of monolayer cells compared with suspension cell cultures to treatment with high concentrations of croton oil factor (TPA) and the surfactants tween 80 and triton X-100.

G. Kreibich, V. Kinzel, E. Schmid, 1973, Biochemical pharmacology.

Phosphatidic acid mobilized by phospholipase D is involved in the phorbol 12-myristate 13-acetate-induced G2 delay of A431 cells.

V. Kinzel, J. Richards, M. Kaszkin, 1996, The Biochemical journal.

A proposed common mechanism by which phorbol esters and epidermal growth factor delay the progression from G2 phase to mitosis of HeLa cells through phospholipid metabolites.

V. Kinzel, G. Fürstenberger, J. Richards, 1991, Cancer research.

Epidermal-growth-factor-induced production of phosphatidylalcohols by HeLa cells and A431 cells through activation of phospholipase D.

V. Kinzel, M. Kaszkin, R. Kast, 1992, The Biochemical journal.

Ligand binding site interaction in adenosine cyclic 3',5'-monophosphate dependent protein kinase catalytic subunit: circular dichroic evidence for intramolecular transmission of conformational change.

V. Kinzel, J. Reed, 1984, Biochemistry.

Signal transduction through epidermal growth factor receptor is altered in HeLa monolayer cells during mitosis.

V. Kinzel, H. Barth, M. Kaszkin, 1997, The Biochemical journal.

Mechanistic aspects of the delay in the G2 phase of the cell cycle caused by tumor promoter 12-O-tetradecanoylphorbol-13-acetate in HeLa cells.

F. Marks, V. Kinzel, G. Fürstenberger, 1985, Carcinogenesis.

A sequence variant in the N‐terminal region of the catalytic subunit of the cAMP‐dependent protein kinase

V. Kinzel, H. Ponstingl, G. Maier, 1989 .

The inhibitor protein of the cyclic AMP-dependent protein kinase-catalytic subunit interaction. Composition of multiple complexes.

S. M. Van Patten, D. Walsh, V. Kinzel, 1988, The Biochemical journal.

Assays of cell surface protein kinase: importance of selecting cytophilic substrates.

V. Kinzel, W. Pyerin, D. Kübler, 1982, European journal of cell biology.

Phospho-accepting proteins in bovine sera

V. Kinzel, D. Kübler, 1976, Blut.

Partial inversion of the initiation-promotion sequence of multistage tumorigenesis in the skin of NMRI mice.

F. Marks, M. Schwarz, V. Kinzel, 1985, Science.

Structure of the LAV6 peptide: A nucleation site for the correct receptor‐induced refolding of the CD4‐binding domain of HIV1 gp 120

V. Kinzel, J. Reed, P. Rösch, 1997, Proteins: Structure, Function, and Bioinformatics.