J. Herkel

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Activation of the AktCREB signaling axis by a prolinerich heptapeptide confers resistance to stressinduced celldeath and inflammation

I. Cohen, N. Erez, J. Herkel, 2017 .

Activation of the Akt–CREB signalling axis by a proline‐rich heptapeptide confers resistance to stress‐induced cell death and inflammation

I. Cohen, N. Erez, J. Herkel, 2017, Immunology.

Autoimmunity to the p53 protein is a feature of systemic lupus erythematosus (SLE) related to anti-DNA antibodies.

V. Rotter, I. Cohen, N. Erez, 2001, Journal of autoimmunity.

P38 MAP Kinase Signaling Is Required for the Conversion of CD4+CD25− T Cells into iTreg

A. Waisman, M. Blessing, J. Herkel, 2008, PloS one.

Cell-autonomous hepatocyte-specific GP130 signalling is sufficient to trigger a robust innate immune response in mice.

T. Renné, P. Rosenstiel, H. Schlüter, 2020, Journal of hepatology.

Dietary and metabolic modulators of hepatic immunity

J. Herkel, A. Carambia, 2017, Seminars in Immunopathology.

TGF-β-dependent induction of CD4⁺CD25⁺Foxp3⁺ Tregs by liver sinusoidal endothelial cells.

T. Korn, J. Herkel, A. Lohse, 2014, Journal of hepatology.

Liver sinusoidal cells collecting MHC-I molecules: you can't get enough of a good thing.

J. Herkel, A. Carambia, 2014, Journal of hepatology.

Inhibition of inflammatory CD4 T cell activity by murine liver sinusoidal endothelial cells.

Oliver T. Bruns, J. Herkel, A. Lohse, 2013, Journal of hepatology.

IL‐6 trans‐signaling is essential for the development of hepatocellular carcinoma in mice

D. Schmidt-Arras, S. Rose-John, J. Herkel, 2017, Hepatology.

Expression of the 60 kDa heat shock protein in normal and inflamed liver.

W. van Eden, H. Dienes, J. Herkel, 1993, Journal of hepatology.

Scavenger receptor CD36 mediates uptake of high density lipoproteins in mice and by cultured cells[S]

K. Moore, J. Herkel, J. Heeren, 2011, Journal of Lipid Research.

Characterization of human gene encoding SLA/LP autoantigen and its conserved homologs in mouse, fish, fly, and worm.

P. Galle, A. Teufel, J. Herkel, 2006, World journal of gastroenterology.

Response to Dr. Granito et al.

J. Herkel, A. Lohse, C. Frenzel, 2007, The American Journal of Gastroenterology.

Aryl Hydrocarbon Receptor Activity in Hepatocytes Sensitizes to Hyperacute Acetaminophen-Induced Hepatotoxicity in Mice

A. Ghallab, J. Herkel, A. Lohse, 2020, Cellular and molecular gastroenterology and hepatology.

Harnessing the liver to induce antigen-specific immune tolerance

J. Herkel, A. Carambia, C. Gottwick, 2022, Seminars in Immunopathology.

CD4 T cells in hepatic immune tolerance.

J. Herkel, A. Carambia, 2010, Journal of autoimmunity.

Hepatic over-expression of TGF-beta1 promotes LPS-induced inflammatory cytokine secretion by liver cells and endotoxemic shock.

P. Galle, J. Herkel, A. Lohse, 2005, Immunology letters.

Reply to: “T regulatory cell number and function: The autoimmune traits in liver diseases”

J. Herkel, C. Schramm, M. Sebode, 2012 .

CCL21‐expression and accumulation of CCR7+ NK cells in livers of patients with primary sclerosing cholangitis

M. Altfeld, J. Herkel, K. Oldhafer, 2019, European journal of immunology.

CCL21â•’expression and accumulation of CCR7⁺ NK cells in livers of patients with primary sclerosing cholangitis

M. Altfeld, J. Herkel, K. Oldhafer, 2019 .

Regulatory T Cells in Hepatic Immune Tolerance and Autoimmune Liver Diseases

J. Herkel, 2015, Digestive Diseases.

TNF-Producing Th1 Cells Are Selectively Expanded in Liver Infiltrates of Patients with Autoimmune Hepatitis

J. Herkel, A. Lohse, R. Zenouzi, 2019, The Journal of Immunology.

Identification of CD4 T-cell epitopes in soluble liver antigen/liver pancreas autoantigen in autoimmune hepatitis.

G. Ahlenstiel, J. Herkel, A. Lohse, 2008, Gastroenterology.

Transgenic overproduction of murine 60 kDa heat shock protein in the liver does not prevent type I diabetes in NOD mice

J. Herkel, A. Lohse, S. Lüth, 2006, Diabetologia.

Autoimmune hepatitis: Possible triggers, potential treatments.

J. Herkel, A. Lohse, A. Carambia, 2020, Journal of hepatology.

Review article: unanswered clinical and research questions in autoimmune hepatitis‐conclusions of the International Autoimmune Hepatitis Group Research Workshop

J. Herkel, A. Lohse, J. Drenth, 2019, Alimentary pharmacology & therapeutics.

Murine liver antigen presenting cells control suppressor activity of CD4+CD25+ regulatory T cells

J. Herkel, A. Lohse, E. Schmitt, 2005, Hepatology.

HSP60 and CpG-DNA-oligonucleotides differentially regulate LPS-tolerance of hepatic Kupffer cells.

P. Galle, J. Herkel, A. Lohse, 2004, Immunology letters.

TUMOR DORMANCY IN BONE MARROW

V. Rotter, I. Cohen, A. Waisman, 2006 .

CXCR3 Deficiency Exacerbates Liver Disease and Abrogates Tolerance in a Mouse Model of Immune-Mediated Hepatitis

U. Panzer, J. Herkel, H. Mittrücker, 2011, The Journal of Immunology.

CXCR3 Deficiency Exacerbates Liver Disease

U. Panzer, J. Herkel, H. Mittrücker, 2011 .

Immune-Mediated Hepatitis Abrogates Tolerance in a Mouse Model of CXCR3 Deficiency Exacerbates Liver Disease and

U. Panzer, J. Herkel, G. Tiegs, 2011 .

of Immune-Mediated Hepatitis and Abrogates Tolerance in a Mouse Model CXCR3 Deficiency Exacerbates Liver Disease

U. Panzer, J. Herkel, H. Mittrücker, 2011 .

IL-17A/F enable cholangiocytes to restrict T cell-driven experimental cholangitis via PD-1/PD-L1 interaction

Christoph, J Wagner, T. Krech, 2022 .

Th17 cells bound for the liver: group tourists or private travellers?

J. Herkel, A. Carambia, 2012, Journal of hepatology.

Defective T helper response of hepatocyte-stimulated CD4 T cells impairs antiviral CD8 response and viral clearance.

A. Oxenius, J. Herkel, A. Lohse, 2007, Gastroenterology.

Chronic liver inflammation dominated by interferon-γ can prevent hepatocarcinogenesis

J. Herkel, J. Schrader, 2012, Oncoimmunology.

Inflammatory type 2 conventional dendritic cells contribute to murine and human cholangitis.

M. Altfeld, P. Rosenstiel, J. Herkel, 2022, Journal of hepatology.

Identification of target antigen for SLA/LP autoantibodies in autoimmune hepatitis

J. Herkel, A. Lohse, S. Kanzler, 2000, The Lancet.

Monocytes as Potential Mediators of Pathogen-Induced T-Helper 17 Differentiation in Patients With Primary Sclerosing Cholangitis (PSC).

A. Franke, J. Herkel, A. Lohse, 2020, Hepatology.

J. Herkel, J. Schrader, 2012 .

Selenocysteine, soluble liver antigen/liver‐pancreas, and autoimmune hepatitis

M. Manns, J. Herkel, A. Lohse, 2007, Hepatology.

CD4+ T-Cell Help Is Required for Effective CD8+ T Cell-Mediated Resolution of Acute Viral Hepatitis in Mice

A. Oxenius, J. Herkel, A. Lohse, 2014, PloS one.

Evaluation of F-Actin ELISA for the Diagnosis of Autoimmune Hepatitis

P. Galle, J. Herkel, A. Lohse, 2006, The American Journal of Gastroenterology.

Pregnancy in Autoimmune Hepatitis: Outcome and Risk Factors

P. Galle, J. Herkel, A. Lohse, 2006, The American Journal of Gastroenterology.

Establishment of standardised SLA/LP immunoassays: specificity for autoimmune hepatitis, worldwide occurrence, and clinical characteristics

J. Herkel, A. Lohse, M. Nishioka, 2002, Gut.

Fine specificity of autoantibodies to soluble liver antigen and liver/pancreas

J. Herkel, A. Lohse, B. Heidrich, 2002, Hepatology.

Immune-mediated liver injury.

J. Herkel, A. Lohse, G. Tiegs, 2005, Journal of hepatology.

Nanoparticle‐mediated targeting of autoantigen peptide to cross‐presenting liver sinusoidal endothelial cells protects from CD8 T‐cell‐driven autoimmune cholangitis

J. Herkel, A. Lohse, R. Digigow, 2020, Immunology.

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice.

Stefan Lüth, Harald Ittrich, Christian Waurisch, 2015, Journal of hepatology.

Idiotypic immunization induces immunity to mutated p53 and tumor rejection

V. Rotter, I. Cohen, H. Garren, 1998, Nature Medicine.

Inflammatory Phenotype of Intrahepatic Sulfatide-Reactive Type II NKT Cells in Humans With Autoimmune Hepatitis

T. Krech, J. Herkel, A. Lohse, 2019, Front. Immunol..

Phenotypic alterations of regulatory T cells in autoimmune hepatitis: Causal or associated with treatment and remission?

J. Herkel, A. Lohse, C. Schramm, 2015, Hepatology.

FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency.

A. Quaas, J. Herkel, A. Lohse, 2012, Journal of hepatology.

Multiplex neuritis in a patient with autoimmune hepatitis: a case report.

J. Herkel, C. Schramm, F. Birklein, 2006, World journal of gastroenterology.

Liver infiltrating T cells regulate bile acid metabolism in experimental cholangitis.

A. Franke, J. Herkel, A. Lohse, 2019, Journal of hepatology.

Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice.

P. Schirmacher, P. Galle, J. Herkel, 2006, Journal of hepatology.

Significance of autoantibodies

J. Herkel, A. Lohse, 2008, Hepatology.

IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo

Francis J. Huber, Anastasios D. Giannou, E. Esplugues, 2017, The Journal of Immunology.

Activin A Promotes the TGF-β-Induced Conversion of CD4+CD25− T Cells into Foxp3+ Induced Regulatory T Cells 1

S. Werner, R. Flavell, M. Blessing, 2009, The Journal of Immunology.

Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3+ Regulatory T Cells

Francis J. Huber, R. Flavell, U. Panzer, 2018, The Journal of Immunology.

Mouse Models of Liver Fibrosis

J. Herkel, A. Lohse, C. Weiler-Normann, 2007, Zeitschrift fur Gastroenterologie.

Immunity to p53 induced by an idiotypic network of anti-p53 antibodies: generation of sequence-specific anti-DNA antibodies and protection from tumor metastasis.

V. Rotter, I. Cohen, A. Waisman, 1998, Cancer research.

Induction of the anti-ergotypic response.

I. Cohen, J. Herkel, A. Lohse, 1993, International immunology.

Dysfunction of hepatic regulatory T cells in experimental sclerosing cholangitis is related to IL-12 signaling.

A. Quaas, J. Herkel, A. Lohse, 2017, Journal of hepatology.

Dysfunction of hepatic regulatory T cells in experimental sclerosing cholangitis is related with IL-12 signaling Short title : Hepatic Treg failure to suppress sclerosing cholangitis

A. Quaas, J. Herkel, A. Lohse, 2016 .

Reduced FOXP3(+) regulatory T cells in patients with primary sclerosing cholangitis are associated with IL2RA gene polymorphisms.

A. Quaas, J. Herkel, A. Lohse, 2014, Journal of hepatology.

Prevalence of Autoantibodies to the p53 Protein in Autoimmune Hepatitis

V. Rotter, I. Cohen, J. Herkel, 2002, Autoimmunity.

T-cell repertoire profiling by next-generation sequencing reveals tissue migration dynamics of TRBV13-family clonotypes in a common experimental autoimmune encephalomyelitis mouse model

N. Akyüz, J. Herkel, S. Schliffke, 2019, Journal of Neuroimmunology.

Chronic inflammatory IFN-γ signaling suppresses hepatocarcinogenesis in mice by sensitizing hepatocytes for apoptosis.

P. Schirmacher, K. Yamamura, K. Reifenberg, 2011, Cancer research.

Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs.

W. Brück, C. Stadelmann, J. Herkel, 2008, The Journal of clinical investigation.

MHC class II‐expressing hepatocytes function as antigen‐presenting cells and activate specific CD4 T lymphocyutes

M. Blessing, J. Herkel, A. Lohse, 2003, Hepatology.

Failure of thymic deletion and instability of autoreactive Tregs drive autoimmunity in immune-privileged liver

J. Herkel, A. Lohse, C. Schramm, 2021, JCI Insight.

36 – p53 AUTOANTIBODIES

I. Cohen, J. Herkel, 2007 .

Monoclonal antibody to a DNA‐binding domain of p53 mimics charge structure of DNA: anti‐idiotypes to the anti‐p53 antibody are anti‐DNA

V. Rotter, M. Eisenstein, I. Cohen, 2004, European journal of immunology.

Systemic lupus erythematosus in mice, spontaneous and induced, is associated with autoimmunity to the C‐terminal domain of p53 that recognizes damaged DNA

V. Rotter, I. Cohen, R. Wolkowicz, 2000, European journal of immunology.

Characteristics and Long-term Prognosis of the Autoimmune Hepatitis/Primary Sclerosing Cholangitis Overlap Syndrome

P. Galle, H. Dienes, J. Herkel, 2009, Journal of clinical gastroenterology.

Testosterone Suppresses Hepatic Inflammation by the Downregulation of IL-17, CXCL-9, and CXCL-10 in a Mouse Model of Experimental Acute Cholangitis

T. Krech, A. Quaas, J. Herkel, 2015, The Journal of Immunology.

Estimation of the frequency of self-reactive T cells in health and inflammatory diseases by limiting dilution analysis and single cell cloning.

J. Herkel, A. Lohse, K. Meyer zum Büschenfelde, 1996, Journal of autoimmunity.

Increased T helper type 17 response to pathogen stimulation in patients with primary sclerosing cholangitis

M. Neurath, E. Burandt, A. Quaas, 2013, Hepatology.

[Presence of SLA/LP autoantibodies in patients with primary biliary cirrhosis as a marker for secondary autoimmune hepatitis (overlap syndrome)].

H. Dienes, J. Herkel, S. Kanzler, 2001, Deutsche medizinische Wochenschrift.

Monocytes as Potential Mediators of Pathogen‐Induced T‐Helper 17 Differentiation in Patients With Primary Sclerosing Cholangitis (PSC)

A. Franke, J. Herkel, A. Lohse, 2020, Hepatology.

Can Understanding the Pathogenesis of Autoimmune Hepatitis Lead to Rational Therapy?

J. Herkel, A. Lohse, C. Weiler-Normann, 2017, Digestive Diseases.

Serologic Markers Compared With Liver Biopsy for Monitoring Disease Activity in Autoimmune Hepatitis

Stefan Lüth, Christian Frenzel, Stephan Kanzler, 2008, Journal of clinical gastroenterology.

Deciphering the highway code for lymphocyte traffic along the gut - liver axis.

J. Herkel, A. Carambia, 2014, Journal of hepatology.

Reply to: "anti-TNF-induced autoimmune hepatitis".

J. Herkel, A. Lohse, C. Schramm, 2014, Journal of hepatology.

Model of Experimental Acute Cholangitis IL-17, CXCL-9, and CXCL-10 in a Mouse Inflammation by the Downregulation of Testosterone Suppresses Hepatic

T. Krech, A. Quaas, J. Herkel, 2015 .

Autoantigen‐selected B cells are bystanders in spontaneous T cell‐driven experimental autoimmune hepatitis

J. Herkel, S. Weidemann, M. Binder, 2023, Immunology.

Attenuated viral hepatitis in Trem1−/− mice is associated with reduced inflammatory activity of neutrophils

T. Krech, J. Herkel, J. Heeren, 2016, Scientific Reports.

CD4+ T cells from patients with primary sclerosing cholangitis exhibit reduced apoptosis and down‐regulation of proapoptotic Bim in peripheral blood

A. Franke, J. Herkel, A. Lohse, 2017, Journal of leukocyte biology.

IL-17A/F enable cholangiocytes to restrict T cell-driven experimental cholangitis by upregulating PD-L1 expression.

J Wagner, T. Krech, J. Herkel, 2020, Journal of hepatology.

Human SepSecS or SLA/LP: selenocysteine formation and autoimmune hepatitis

D. Söll, J. Herkel, A. Lohse, 2010, Biological chemistry.

Reply to: “Regulatory T cell defects in autoimmune hepatitis”

J. Herkel, C. Schramm, M. Sebode, 2012 .

Reply to: “Regulatory T cells in autoimmune hepatitis”

J. Herkel, C. Schramm, M. Sebode, 2012 .

Mediators of liver inflammation and carcinogenesis

D. Schmidt-Arras, J. Herkel, 2021, Seminars in Immunopathology.

Lack of requirement for CD8+ cells in recovery from and resistance to experimental autoimmune encephalomyelitis.

J. Herkel, A. Lohse, K. Meyer zum Büschenfelde, 1995, Journal of autoimmunity.

Reduced FOXP3(+) regulatory T cells in patients with primary sclerosing cholangitis are associated with IL2RA gene polymorphisms.

A. Quaas, J. Herkel, A. Lohse, 2014, Journal of hepatology.

Monoclonal antibody to a DNA‐binding domain of p53 mimics charge structure of DNA: anti‐idiotypes to the anti‐p53 antibody are anti‐DNA

V. Rotter, M. Eisenstein, I. Cohen, 2004, European Journal of Immunology.

CXCR3 Deficiency Exacerbates Liver Disease and Abrogates Tolerance in a Mouse Model of Immune-Mediated Hepatitis

U. Panzer, J. Herkel, H. Mittrücker, 2011, The Journal of Immunology.

IFNγ and CTLA-4 Drive Hepatic CD4 T-Cell Tolerance and Protection From Autoimmunity in Mice

J. Herkel, S. Huber, S. Weidemann, 2023, Cellular and molecular gastroenterology and hepatology.

Let it B in viral hepatitis?

J. Herkel, A. Carambia, 2011, Journal of hepatology.