Thilo Werner

发表

Tracking cancer drugs in living cells by thermal profiling of the proteome

G. Drewes, B. Kuster, P. Nordlund, 2014, Science.

Computational prediction of proteotypic peptides for quantitative proteomics

Daniel B. Martin, R. Aebersold, B. Kuster, 2007, Nature Biotechnology.

Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry

G. Drewes, W. Huber, M. Bantscheff, 2015, Nature Protocols.

Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP

W. Huber, M. Bantscheff, M. Savitski, 2018 .

High-resolution enabled TMT 8-plexing.

M. Bantscheff, M. Savitski, G. Sweetman, 2012, Analytical chemistry.

The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains.

Carsten Hopf, Chun-Wa Chung, Marcus Bantscheff, 2014, ACS chemical biology.

Application of Atypical Acetyl-Lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains.

Melanie V. Leveridge, P. Grandi, A. Michon, 2020, Journal of medicinal chemistry.

Meltome atlas—thermal proteome stability across the tree of life

Thomas A. Hopf, B. Kuster, Mathias Wilhelm, 2020, Nature Methods.

Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors.

P. Grandi, A. Michon, Christina Rau, 2015, Journal of medicinal chemistry.

Identifying drug targets in tissues and whole blood with thermal-shift profiling

Douglas W. Thomson, W. Huber, Christina Rau, 2020, Nature Biotechnology.

Differential Kinobeads Profiling for Target Identification of Irreversible Kinase Inhibitors.

M. Bantscheff, Thilo Werner, M. Muelbaier, 2017, ACS chemical biology.

Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors.

P. Grandi, A. Michon, Christina Rau, 2018, Journal of medicinal chemistry.

Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation

P. Grandi, A. Michon, G. Drewes, 2020, Science.

GSK789: A Selective Inhibitor of the First Bromodomains (BD1) of the Bromo and Extra Terminal Domain (BET) Proteins.

P. Grandi, P. Bamborough, R. Prinjha, 2020, Journal of medicinal chemistry.

A Selective Inhibitor Reveals Pi3Kgamma Dependence of T(H)17 Cell Differentiation.

G. Drewes, G. Neubauer, Christina Rau, 2012 .

Proteome thermal stability reflects organ physiology and identifies drug-target engagement in vivo

Douglas W. Thomson, W. Huber, Christina Rau, 2018 .

Improved Proteomics-Based Drug Mechanism-of-Action Studies Using 16-Plex Isobaric Mass Tags.

M. Bantscheff, Toby Mathieson, N. Zinn, 2021, Journal of proteome research.

Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia

Peter A. Jones, Philip J. Chapman, P. Grandi, 2021, Nature Cancer.

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B

Stefan Knapp, Susanne Müller, Chun-Wa Chung, 2015, Journal of medicinal chemistry.

BRD4 methylation by the methyltransferase SETD6 regulates selective transcription to control mRNA translation

P. Grandi, M. Bantscheff, V. Chalifa-Caspi, 2021, Science Advances.

Selectively Targeting the Kinome-Conserved Lysine of PI3Kδ as a General Approach to Covalent Kinase Inhibition.

M. Bantscheff, Thilo Werner, M. Convery, 2018, Journal of the American Chemical Society.

Chemical proteomics reveals target selectivity of clinical Jak inhibitors in human primary cells

Douglas W. Thomson, G. Drewes, M. Bantscheff, 2019, Scientific Reports.

Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP

W. Huber, M. Bantscheff, M. Savitski, 2018, Nature Communications.

Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis

P. Grandi, M. Bantscheff, M. Savitski, 2018, Cell.

Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat.

M. Bantscheff, M. Savitski, Carola Doce, 2016, Nature chemical biology.

Ion coalescence of neutron encoded TMT 10-plex reporter ions.

Marcus Bantscheff, Mikhail M Savitski, M. Bantscheff, 2014, Analytical chemistry.

Click chemistry enables preclinical evaluation of targeted epigenetic therapies

P. Grandi, G. Drewes, S. Dawson, 2017, Science.

Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease.

G. Neubauer, N. Ramsden, G. Bergamini, 2012, Bioorganic & medicinal chemistry letters.

A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation.

G. Drewes, G. Neubauer, M. Bantscheff, 2012, Nature chemical biology.

Thermal proteome profiling monitors ligand interactions with cellular membrane proteins

G. Drewes, W. Huber, M. Bantscheff, 2015, Nature Methods.

proteome Tracking cancer drugs in living cells by thermal profiling of the

G. Drewes, B. Kuster, P. Nordlund, 2014 .

Meltome atlas—thermal proteome stability across the tree of life

Thomas A. Hopf, B. Kuster, Mathias Wilhelm, 2020, Nature Methods.

Corrigendum: A selective inhibitor reveals PI3Kγ dependence of T H 17 cell differentiation

G. Drewes, G. Neubauer, M. Bantscheff, 2012 .

Affinity Enrichment for Target Deconvolution and

M. Bantscheff, H. Eberl, Thilo Werner, 2021, Methods in Molecular Biology.

A Modular Probe Strategy for Drug Localization, Target Identification and Target Occupancy Measurement on Single Cell Level.

Douglas W. Thomson, Marcus Bantscheff, Anna Rutkowska, 2016, ACS chemical biology.

A Proteome-wide Approach Identifies Sumoylated Substrate Proteins in Yeast*

Bernhard Kuster, V. G. Panse, Ed Hurt, 2004, Journal of Biological Chemistry.

Identifying drug targets in tissues and whole blood with thermal-shift profiling

Douglas W. Thomson, W. Huber, M. Bantscheff, 2020, Nature Biotechnology.

A Novel Acyl-CoA: Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor, GSK2973980A, Inhibits Postprandial Triglycerides and Reduces Body Weight in a Rodent Diet-induced Obesity Model

Douglas W. Thomson, G. Bergamini, A. Awasthi, 2017 .

Integration of Thermal Proteome Profiling with phosphoproteomic and transcriptomic data via mechanistic network models decodes the molecular response to PARP inhibition

P. Grandi, M. Bantscheff, J. Saez-Rodriguez, 2023, bioRxiv.

Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells

G. Drewes, M. Bantscheff, D. Eberhard, 2011, Leukemia.

Selectively Targeting the Kinome-Conserved Lysine of PI3Kδ as a General Approach to Covalent Kinase Inhibition.

M. Bantscheff, Thilo Werner, M. Convery, 2018, Journal of the American Chemical Society.

Affinity Enrichment Chemoproteomics for Target Deconvolution and Selectivity Profiling.

M. Bantscheff, H. Eberl, Thilo Werner, 2021, Methods in molecular biology.

Tracking cancer drugs in living cells by thermal profiling of the proteome

G. Drewes, B. Kuster, P. Nordlund, 2014, Science.

The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains.

P. Grandi, G. Drewes, G. Neubauer, 2014, ACS chemical biology.