E. Giaime

发表

Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6

P. Heutink, J. Pouysségur, G. Pagès, 2010, Cell Death and Differentiation.

p53‐Dependent control of cell death by nicastrin: lack of requirement for presenilin‐dependent γ‐secretase complex

P. S. St George-Hyslop, J. Dunys, F. Checler, 2009, Journal of neurochemistry.

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice

R. J. Kelleher, Raphael Kopan, E. Giaime, 2010, Proceedings of the National Academy of Sciences.

Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease

T. Meitinger, R. Krüger, D. Berg, 2009, neurogenetics.

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

H. Cai, E. Giaime, J. Bonventre, 2012, Molecular Neurodegeneration.

ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1

A. Brice, H. Ariga, E. Duplan, 2013, Journal of Cell Science.

Loss of DJ-1 Does Not Affect Mitochondrial Respiration but Increases ROS Production and Mitochondrial Permeability Transition Pore Opening

E. Giaime, Jie Shen, T. Kitada, 2012, PloS one.

Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice

Guodong Huang, E. Giaime, Jie Shen, 2017, Neuron.

Huntington’s disease phenotypes are improved via mTORC1 modulation by small molecule therapy

B. Davidson, E. Giaime, E. Saiah, 2022, PloS one.

Study on the Putative Contribution of Caspases and the Proteasome to the Degradation of Aph-1a and Pen-2

P. S. St George-Hyslop, J. Dunys, F. Checler, 2007, Neurodegenerative Diseases.

A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics

Xuedong Liu, Jie Shen, E. Giaime, 2014, Cell Research.

Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease

Patrick M. Abou-Sleiman, Nicholas W. Wood, Andrew West, 2009, Nature Cell Biology.

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1.

Liewei Wang, J. Jen, Y. Pang, 2015, Molecular cell.

Parkin Regulates Mitosis a nd Genomic Stability through Cdc 20 / Cdh 1 Graphical Abstract Highlights

Boqin, Liewei Wang, J. Jen, 2015 .

PINK1 Triggers Autocatalytic Activation of Parkin to Specify Cell Fate Decisions

Xuedong Liu, Xuedong Liu, E. Giaime, 2014, Current Biology.

Caspase-3-derived C-terminal Product of Synphilin-1 Displays Antiapoptotic Function via Modulation of the p53-dependent Cell Death Pathway*

P. McLean, F. Checler, E. Giaime, 2006, Journal of Biological Chemistry.

p53-dependent control of transactivation of the Pen2 promoter by presenilins

M. Vitek, Huaxi Xu, J. Dunys, 2009, Journal of Cell Science.

Regulation of mitochondrial permeability transition pore by PINK1

E. Giaime, Jie Shen, D. Chan, 2012, Molecular Neurodegeneration.

Discovery of NV-5138, the first selective Brain mTORC1 activator

E. Giaime, Shomit Sengupta, E. Saiah, 2019, Scientific Reports.

Discovery of NV-5138, the first selective Brain mTORC1 activator

E. Giaime, Shomit Sengupta, E. Saiah, 2019, Scientific Reports.