C. Whitelaw

发表

p21(Waf1/Cip1) as a molecular sensor for BoHV-4 replication.

A. Capocefalo, V. Franceschi, C. Whitelaw, 2009, Journal of virological methods.

CRISPR/Cas9 mediated generation of an ovine model for infantile neuronal ceroid lipofuscinosis (CLN1 disease)

C. Whitelaw, S. Lillico, J. Cooper, 2019, Scientific Reports.

C. Whitelaw, S. Lillico, D. F. Carlson, 2014, Transgenic Research.

Using standard nomenclature to adequately name transgenes, knockout gene alleles and any mutation associated to a genetically modified mouse strain

C. Whitelaw, L. Montoliu, 2011, Transgenic Research.

Novel GM animal technologies and their governance

J. Tait, C. Whitelaw, D. Castle, 2013, Transgenic Research.

Engineering large animal models of human disease

Timothy P. Sheets, C. Whitelaw, S. Lillico, 2015, The Journal of pathology.

Pigs Lacking the Scavenger Receptor Cysteine-Rich Domain 5 of CD163 Are Resistant to Porcine Reproductive and Respiratory Syndrome Virus 1 Infection

T. Opriessnig, T. Stadejek, A. Archibald, 2018, Journal of Virology.

Edinburgh Research Explorer Pigs lacking the scavenger receptor cysteine-rich domain 5 of CD163 are resistant to PRRSV-1 infection

T. Opriessnig, T. Stadejek, A. Archibald, 2018 .

Novel combination of CRISPR-based gene drives eliminates resistance and localises spread

B. Whitelaw, C. Whitelaw, R. Gaynor, 2020, Scientific Reports.

Milk Lacking α-Casein Leads to Permanent Reduction in Body Size in Mice

C. Whitelaw, S. Lillico, A. Carlisle, 2011, PloS one.

Chromosomal position effects and the modulation of transgene expression.

C. Whitelaw, S. Damak, F. Yull, 1994, Reproduction, fertility, and development.

Efficient generation of transgenic pigs using equine infectious anaemia virus (EIAV) derived vector

A. Clark, C. Whitelaw, T. King, 2004, FEBS letters.

Production of pharmaceutical proteins in milk

A. Archibald, I. Wilmut, A. Clark, 1991, Experientia.

Biosynthesis of Milk Proteins

C. Whitelaw, J. Vilotte, D. Shennan, 2003 .

Genetics and Biosynthesis of Milk Proteins

C. Whitelaw, J. Vilotte, D. Shennan, 2013 .

Edinburgh Explorer Swine ANP32A supports avian influenza virus polymerase

D. Goldhill, C. Whitelaw, S. Lillico, 2020 .

Swine ANP32A Supports Avian Influenza Virus Polymerase

D. Goldhill, C. Whitelaw, S. Lillico, 2020, Journal of Virology.

Transgenic sheep designed for transplantation studies

C. Whitelaw, S. Lillico, G. Mclachlan, 2009, Molecular reproduction and development.

Producing recombinant human milk proteins in the milk of livestock species.

C. Whitelaw, M. Baranyi, Z. Bösze, 2008, Advances in experimental medicine and biology.

Live lambs born from zona-pellucida denuded embryos.

I. Wilmut, J. Gardner, C. Whitelaw, 2005, Cloning and Stem Cells.

Generation of functional neurons from feeder-free, keratinocyte-derived equine induced pluripotent stem cells.

C. Whitelaw, C. Proudfoot, D. Wyllie, 2014, Stem cells and development.

Control of mammary involution by insulin-like growth factor binding proteins: role of prolactin

D. Flint, C. Whitelaw, C. Knight, 2001 .

Simulating the Commercial Implementation of Gene-Editing for Influenza A Virus Resistance in Pigs: An Economic and Genetic Analysis

C. Whitelaw, F. Hely, T. Byrne, 2022, Genes.

Edinburgh Explorer Simulating the Commercial Implementation of Gene-Editing for Influenza A Virus Resistance in Pigs: An Economic and Genetic Analysis

C. Whitelaw, F. Hely, T. Byrne, 2022 .

Animal productivity and genetic diversity: cloned and transgenic animals - animal agriculture's future through biotechnology, Part 8.

C. Whitelaw, R. Wall, G. Laible, 2009 .

Insulin-like growth factor binding protein-5 (IGFBP-5) potentially regulates programmed cell death and plasminogen activation in the mammary gland.

D. Flint, L. Shkreta, C. Whitelaw, 2000, Advances in experimental medicine and biology.

Insulin-like growth factor binding proteins initiate cell death and extracellular matrix remodeling in the mammary gland.

J. Beattie, D. Flint, W. Hurley, 2005, Domestic animal endocrinology.

The changing role of cell culture in the generation of transgenic livestock

C. Whitelaw, J. Webster, E. Farini, 1999, Cytotechnology.

The developmental regulation of the human ζ-globin gene in transgenic mice employing β-galactosidase as a reporter gene

N. Proudfoot, C. Whitelaw, M. Pondel, 1992 .

A Strategy To Exploit Surrogate Sire Technology in Livestock Breeding Programs

C. Whitelaw, J. Hickey, M. Battagin, 2017, G3: Genes, Genomes, Genetics.

Mammalian interspecies substitution of immune modulatory alleles by genome editing

David E. Paschon, Lei Zhang, E. Rebar, 2016, Scientific Reports.

Live pigs produced from genome edited zygotes

B. Whitelaw, C. Whitelaw, S. Lillico, 2013, Scientific Reports.

Transgenic Mice Secreting Coronavirus Neutralizing Antibodies into the Milk

B. Pintado, A. Clark, C. Whitelaw, 1998, Journal of Virology.

Duplication of Stat5-binding sites within the beta-lactoglobulin promoter compromises transcription in vivo.

R. Pena, C. Whitelaw, 2005, Biochimie.

CMV enhancer–promoter is preferentially active in exocrine cells in vivo

H. Sang, C. Whitelaw, D. Vasey, 2009, Transgenic Research.

Modelling Neurological Diseases in Large Animals: Criteria for Model Selection and Clinical Assessment

C. Whitelaw, S. Lillico, J. Cooper, 2022, Cells.

A virus-neutralising antibody is not cytotoxic in vitro.

C. Whitelaw, A. Kolb, 2006, Molecular immunology.

The majority of G0 transgenic mice are derived from mosaic embryos

C. Whitelaw, John Clark, A. Springbett, 2005, Transgenic Research.

Matrix attachment region regulates basal β-lactoglobulin transgene expression

C. Whitelaw, G. Donofrio, P. Accornero, 2000 .

Matrix attachment region regulates basal beta-lactoglobulin transgene expression.

C. Whitelaw, G. Donofrio, P. Accornero, 2000, Gene.

Expression of c-myc is down-regulated as mouse mammary epithelial cells become confluent.

C. Whitelaw, G. Donofrio, P. Accornero, 1997, Biochemical and biophysical research communications.

Expression of Human Anti-Hemophilic Factor IX in the Milk of Transgenic Sheep

R. Lathe, C. Prowse, I. Wilmut, 1989, Bio/Technology.

Production of Human α 1 -Antitrypsin in The Milk of Transgenic Sheep and Mice: Targeting Expression of cDNA Sequences to The Mammary Gland

A. Archibald, I. Wilmut, A. Clark, 1991 .

Targeting expression to the mammary gland: intronic sequences can enhance the efficiency of gene expression in transgenic mice

A. Archibald, A. Clark, C. Whitelaw, 1991, Transgenic Research.

Mono-allelic Expression of Variegating Transgene Locus in the Mouse

R. Lathe, C. Whitelaw, A. Colman, 2003, Transgenic Research.

Species-Specific Variation in RELA Underlies Differences in NF-κB Activity: a Potential Role in African Swine Fever Pathogenesis

B. Whitelaw, C. Whitelaw, S. Lillico, 2011, Journal of Virology.

Dolly for dinner? Assessing commercial and regulatory trends in cloned livestock

C. Warkup, C. Whitelaw, A. Braun, 2007, Nature Biotechnology.

Current and prospective control strategies of influenza A virus in swine

C. Whitelaw, Hamish A. Salvesen, 2021, Porcine Health Management.

Species-Speciﬁc Variation in RELA Underlies Differences in NF- (cid:1) B Activity: a Potential Role in African Swine Fever Pathogenesis (cid:1)

C. Whitelaw, S. Lillico, C. Palgrave, 2011 .

Edinburgh Research Explorer Species-specific variation in RELA underlies differences in NF-B activity

C. Whitelaw, S. Lillico, C. Palgrave, 2011 .

Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 gene

Ki-Eun Park, A. Tibary, L. Blomberg, 2017, Scientific Reports.

Comparison of CRISPR/Cas9 and TALENs on editing an integrated EGFP gene in the genome of HEK293FT cells

C. Whitelaw, S. Lillico, C. Proudfoot, 2016, SpringerPlus.

Comparison of CRISPR / Cas 9 and TALENs on editing an integrated EGFP gene in the genome of HEK 293 FT cells

C. Whitelaw, S. Lillico, C. Proudfoot, 2016 .

Stat5 as a Target for Regulation by Extracellular Matrix (*)

C. Watson, C. Schindler, C. Whitelaw, 1995, The Journal of Biological Chemistry.

The future of animal production: improving productivity and sustainability

David A. Hume, Christopher Bruce Alexander Whitelaw, Alan Archibald, 2011, The Journal of Agricultural Science.

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity

P. Kind, C. Shaw, Colin Smith, 2018, Nature Communications.

Strain-specific copy number variation in the intelectin locus on the 129 mouse chromosome 1

C. Whitelaw, P. Knight, A. Pemberton, 2011, BMC Genomics.

p21WAF1 is component of a positive feedback loop that maintains the p53 transcriptional program

T. Hupp, L. Pang, C. Whitelaw, 2011, Cell cycle.

An animal model to evaluate the function and regulation of the adaptively evolving stress protein SEP53 in oesophageal bile damage responses

A. Archibald, Jill K Thompson, T. Hupp, 2008, Cell Stress and Chaperones.

Position-independent expression of the ovine beta-lactoglobulin gene in transgenic mice.

C. Whitelaw, J. Simons, M. McClenaghan, 1992, The Biochemical journal.

Multiple Copies of β-Lactoglobulin Promoter Do Not Function as LCR

A. Clark, C. Whitelaw, C. Neil, 2000 .

CRISPR/Cas9 mediated generation of an ovine model for infantile neuronal ceroid lipofuscinosis (CLN1 disease)

C. Whitelaw, S. Lillico, J. Cooper, 2019, Scientific Reports.

Derivation and characterization of induced pluripotent stem cells from equine fibroblasts.

C. Whitelaw, E. Milne, Amandine Breton, 2013, Stem cells and development.

Potential of gene drives with genome editing to increase genetic gain in livestock breeding programs

C. Whitelaw, J. Hickey, A. Mileham, 2017, Genetics Selection Evolution.

USP18 restricts PRRSV growth through alteration of nuclear translocation of NF-κB p65 and p50 in MARC-145 cells

A. Archibald, C. Whitelaw, S. Lillico, 2012, Virus research.

Comparable processing ofβ-lactoglobulin pre-mRNA in cell culture and transgenic mouse models

A. Clark, C. Whitelaw, G. Donofrio, 1996, Molecular and General Genetics MGG.

Intronic sequences modulate the sensitivity of beta-lactoglobulin transgenes to position effects.

A. Clark, C. Whitelaw, G. Donofrio, 1997, Gene.

Enhancing the efficiency of transgene expression.

A. Archibald, A. Clark, C. Whitelaw, 1993, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Methods of gene transfer and their potential use to modify milk composition

A. Archibald, I. Wilmut, A. Clark, 1990 .

Cross-species efficacy of enzyme replacement therapy for CLN1 disease in mice and sheep

S. Ekins, C. Whitelaw, S. Lillico, 2022, The Journal of clinical investigation.

Efficient TALEN-mediated gene knockout in livestock

Daniel F. Voytas, Scott C. Fahrenkrug, Wenfang Tan, 2012, Proceedings of the National Academy of Sciences.

Production of transgenic farm animals by viral vector-mediated gene transfer.

C. Whitelaw, S. Lillico, T. King, 2008, Reproduction in domestic animals = Zuchthygiene.

Edinburgh Research Explorer p21 (WAF1) is component of a positive feedback loop that maintains the p53 transcriptional program

T. Hupp, L. Pang, C. Whitelaw, 2011 .

337 NONMEIOTIC INTROGRESSION OF QUANTITATIVE TRAIT NUCLEOTIDES AND CORRECTION OF CONGENITAL MUTATIONS IN LIVESTOCK WITH TRANSCRIPTION ACTIVATOR-LIKE EFFECTOR NUCLEASES

C. Whitelaw, S. Lillico, D. F. Carlson, 2013 .

Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function

A. Archibald, C. Whitelaw, S. Lillico, 2017, PLoS pathogens.

Genome-wide CRISPR knockout screen reveals membrane tethering complexes EARP and GARP important for Bovine Herpes Virus Type 1 replication

C. Whitelaw, S. Lillico, R. Dalziel, 2020, bioRxiv.

Spatial p21 expression profile in the mid-term mouse embryo

C. Whitelaw, C. Roland Wolf, K. Brown, 2011, Transgenic Research.

New insights and current tools for genetically engineered (GE) sheep and goats.

C. Whitelaw, I. Anegon, M. Crispo, 2016, Theriogenology.

Reprogramming pig fetal fibroblasts reveals a functional LIF signaling pathway.

T. Freeman, R. Talbot, A. Archibald, 2012, Cellular reprogramming.

Large animal models of cardiovascular disease

C. Whitelaw, V. Macrae, K. Summers, 2016, Cell biochemistry and function.

Prolactin inhibits cell loss and decreases matrix metalloproteinase expression in the involuting mouse mammary gland but fails to prevent cell loss in the mammary glands of mice expressing IGFBP-5 as a mammary transgene.

D. Flint, C. Whitelaw, M. Boutinaud, 2006, Journal of molecular endocrinology.

Nucleosome Organisation of the β-Lactoglobulin Gene

C. Whitelaw, 2002 .

Rapid Cohort Generation and Analysis of Disease Spectrum of Large Animal Model of Cone Dystrophy

J. Mallet, C. Kostic, Y. Arsenijévic, 2013, PloS one.

Multiple effects of genetic background on variegated transgene expression in mice.

R. Lathe, S. Reid, C. Whitelaw, 2002, Genetics.

Mammary gland development is delayed in mice deficient for aminopeptidase N

C. Whitelaw, S. Lillico, D. Sorrell, 2012, Transgenic Research.

Insulin-like growth factor binding protein-5 (IGFBP-5) induces premature cell death in the mammary glands of transgenic mice.

J. Beattie, D. Flint, C. Whitelaw, 2002, Development.

Livestock 2.0 – genome editing for fitter, healthier, and more productive farmed animals

A. Archibald, M. Watson, H. Sang, 2018, Genome Biology.

Mammary gland differentiation inversely correlates with GDF‐8 expression

R. Pena, C. Whitelaw, Ravikumar Manickam, 2008, Molecular reproduction and development.

Gene targeting, genome editing: from Dolly to editors

B. Whitelaw, C. Whitelaw, S. Lillico, 2016, Transgenic Research.

Distal Transgene Insertion Affects CpG Island Maintenance during Differentiation*

A. Clark, C. Whitelaw, D. Strathdee, 2008, Journal of Biological Chemistry.

Temporal profiles of appearance of DNase I hypersensitive sites associated with the ovine b-lactoglobulin gene differ in sheep and transgenic mice

C. Whitelaw, J. Webster, 1998, Molecular and General Genetics MGG.

Modification of milk composition.

A. Archibald, I. Wilmut, A. Clark, 1990, Journal of reproduction and fertility. Supplement.

On the Use of Post-Transcriptional Processing Elements in Transgenes

C. Whitelaw, Z. Bősze, L. Hiripi, 2004, Transgenic Research.

Rescue of an MMTV transgene by co-integration reveals novel locus control properties of the ovine β-lactoglobulin gene that confer locus commitment to heterogeneous tissues

B. Langley, C. Whitelaw, P. L'huillier, 1998, Transgenic Research.

Genetically engineering milk

C. Whitelaw, S. Lillico, Satish Kumar, 2016, Journal of Dairy Research.

Welfare assessment in transgenic pigs expressing green fluorescent protein (GFP)

P. Sandøe, C. Whitelaw, S. Lillico, 2012, Transgenic research.

Potential of promotion of alleles by genome editing to improve quantitative traits in livestock breeding programs

J. Woolliams, R. Varshney, B. Whitelaw, 2015, Genetics Selection Evolution.

Comparison of surrogate reporter systems for enrichment of cells with mutations induced by genome editors.

C. Whitelaw, S. Lillico, Meirui Liu, 2016, Journal of biotechnology.

Strategies for production of pharmaceutical proteins in milk.

I. Wilmut, C. Whitelaw, 1994, Reproduction, fertility, and development.

Comparative analysis on the structural features of the 5' flanking region of κ-casein genes from six different species

Endre Barta, E. Barta, C. Whitelaw, 2002, Genetics Selection Evolution.

The molecular manipulation of milk composition.

C. Prowse, A. Archibald, A. Clark, 1989, Genome.

Relative transgene expression frequencies in homozygous versus hemizygous transgenic mice

C. Whitelaw, J. West, S. Morley, 2013, Transgenic Research.

Virus-Neutralizing Monoclonal Antibody Expressed in Milk of Transgenic Mice Provides Full Protection against Virus-Induced Encephalitis

S. Perlman, C. Whitelaw, S. Siddell, 2001, Journal of Virology.

A virus-neutralising monoclonal antibody expressed in the milk of transgenic mice.

C. Whitelaw, S. Siddell, A. Kolb, 2001, Advances in experimental medicine and biology.

Gene Drive: Past, Present and Future Roads to Vertebrate Biocontrol

C. Whitelaw, S. Lillico, Gus R. Mcfarlane, 2023, Applied Biosciences.

CRISPR-Based Gene Drives for Pest Control.

C. Whitelaw, S. Lillico, Gus R. Mcfarlane, 2018, Trends in biotechnology.

Substitution of warthog NF-κB motifs into RELA of domestic pigs is not sufficient to confer resilience to African swine fever virus

C. Whitelaw, S. Lillico, H. Crooke, 2020, Scientific Reports.

Highly efficient targeted chromosome deletions using CRISPR/Cas9.

C. Whitelaw, S. Lillico, C. Proudfoot, 2015, Biotechnology and bioengineering.

Optimisation of Transgene Expression in the Mammary Gland

A. Clark, C. Whitelaw, 1999 .

Ovine-induced pluripotent stem cells can contribute to chimeric lambs.

C. Whitelaw, S. Lillico, T. Burdon, 2012, Cellular Reprogramming.

Toward ovine iPSCs.

C. Whitelaw, 2013, Cellular reprogramming.

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity

P. Kind, C. Shaw, S. Chandran, 2018, Nature Communications.

Transgenic embryos and mice produced from low titre lentiviral vectors

C. Whitelaw, T. King, W. Ritchie, 2007, Transgenic Research.

Tissue-specific, temporally regulated expression mediated by the proximal ovine beta-lactoglobulin promoter in transgenic mice.

A. Clark, C. Whitelaw, R. Wallace, 1995, Cellular & molecular biology research.

Regulation of ovine beta-lactoglobulin gene expression during the first stage of lactogenesis.

C. Whitelaw, 1995, Biochemical and biophysical research communications.

Unexpected mutations were expected and unrelated to CRISPR-Cas9 activity

C. Whitelaw, L. Montoliu, 2018, Transgenic research.

CRISPR/Cas9 mediated generation of an ovine model for infantile neuronal ceroid lipofuscinosis (CLN1 disease)

C. Whitelaw, S. Lillico, J. Cooper, 2019, Scientific Reports.

Tissue-specific and expression of porcine growth hormone gene in BAC transgenic mice

Ning Li, C. Whitelaw, S. Lillico, 2011, Transgenic Research.

Erratum to: Potential of promotion of alleles by genome editing to improve quantitative traits in livestock breeding programs

J. Woolliams, R. Varshney, C. Whitelaw, 2015, Genetics Selection Evolution.

Severe perinatal hydrops fetalis in genome edited pigs with a biallelic five base pair deletion of the Marfan syndrome gene, FBN1

Mary E. B. McCulloch, C. Whitelaw, S. Lillico, 2020, bioRxiv.

Mammary gland development is delayed in mice deficient for aminopeptidase N

C. Whitelaw, S. Lillico, D. Sorrell, 2012, Transgenic Research.

Efficient TALEN-mediated gene knockout in livestock

D. Voytas, C. Whitelaw, S. Lillico, 2012, Proceedings of the National Academy of Sciences.

Transgenic sheep designed for transplantation studies

C. Whitelaw, S. Lillico, G. Mclachlan, 2009, Molecular reproduction and development.

Engineering large animal models of human disease

Timothy P. Sheets, C. Whitelaw, S. Lillico, 2015, The Journal of pathology.

Substitution of warthog NF-κB motifs into RELA of domestic pigs is not sufficient to confer resilience to African swine fever virus

C. Whitelaw, S. Lillico, H. Crooke, 2020, Scientific Reports.