R. Pardossi-Piquard

发表

p53‐Dependent control of cell death by nicastrin: lack of requirement for presenilin‐dependent γ‐secretase complex

P. S. St George-Hyslop, J. Dunys, F. Checler, 2009, Journal of neurochemistry.

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

K. Lunetta, R. Green, You-Qiang Song, 2007, Nature Genetics.

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP.

F. Checler, C. A. D. Alves da Costa, C. Sunyach, 2005, Neuron.

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.

P. S. St George-Hyslop, D. Westaway, P. Fraser, 2006, Nature.

The gamma/epsilon-secretase-derived APP intracellular domain fragments regulate p53.

P. S. St George-Hyslop, F. Checler, C. Sunyach, 2007, Current Alzheimer research.

Neprilysin activity and expression are controlled by nicastrin

P. S. St George-Hyslop, J. Dunys, F. Checler, 2006, Journal of neurochemistry.

The Transcription Factor EB Reduces the Intraneuronal Accumulation of the Beta-Secretase-Derived APP Fragment C99 in Cellular and Mouse AD Models

Qingli Xiao, E. Duplan, I. Lauritzen, 2020 .

The Transcription Factor EB Reduces the Intraneuronal Accumulation of the Beta-Secretase-Derived APP Fragment C99 in Cellular and Mouse Alzheimer’s Disease Models

Qingli Xiao, E. Duplan, I. Lauritzen, 2020, Cells.

γ-Secretase-mediated regulation of neprilysin: influence of cell density and aging and modulation by imatinib.

J. Dunys, F. Checler, R. Pardossi-Piquard, 2011, Journal of Alzheimer's disease : JAD.

TMP21 Transmembrane Domain Regulates γ-Secretase Cleavage

P. S. St George-Hyslop, P. Fraser, Fusheng Chen, 2009, The Journal of Biological Chemistry.

Presenilin-Dependent (cid:1) -Secretase-Mediated Control of p53-Associated Cell Death in Alzheimer’s Disease

P. George-Hyslop, F. Checler, C. Sunyach, 2006 .

APH1 Polar Transmembrane Residues Regulate the Assembly and Activity of Presenilin Complexes

P. Wong, P. S. St George-Hyslop, P. Fraser, 2009, The Journal of Biological Chemistry.

p53 Is Regulated by and Regulates Members of the γ-Secretase Complex

J. Dunys, F. Checler, C. A. D. Alves da Costa, 2010, Neurodegenerative Diseases.

Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains

L. Buée, J. Cazareth, I. Lauritzen, 2020, Acta Neuropathologica.

Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?

I. Lauritzen, F. Checler, R. Pardossi-Piquard, 2021, The Journal of biological chemistry.

Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP

F. Checler, C. Sunyach, C. A. D. Costa, 2005, Neuron.

TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity

D. Westaway, P. Fraser, E. Rogaeva, 2006, Nature.

The γ /η-Secretase-Derived APP Intracellular Domain Fragments Regulate p53

P. George-Hyslop, F. Checler, C. Sunyach, 2007 .

Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models

I. Lauritzen, F. Checler, R. Pardossi-Piquard, 2019, Translational Neurodegeneration.

The physiology of the β‐amyloid precursor protein intracellular domain AICD

F. Checler, R. Pardossi-Piquard, 2012, Journal of neurochemistry.

β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog–Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models

T. Goiran, E. Duplan, Lila Rouland, 2017, Biological Psychiatry.

Presenilin-Dependent γ-Secretase-Mediated Control of p53-Associated Cell Death in Alzheimer's Disease

P. S. St George-Hyslop, F. Checler, C. Sunyach, 2006, The Journal of Neuroscience.

Does Intraneuronal Accumulation of Carboxyl-terminal Fragments of the Amyloid Precursor Protein Trigger Early Neurotoxicity in Alzheimer's Disease?

I. Lauritzen, F. Checler, R. Pardossi-Piquard, 2019, Current Alzheimer research.

Intraneuronal accumulation of C99 contributes to synaptic alterations, apathy-like behavior, and spatial learning deficits in 3×TgAD and 2×TgAD mice

I. Lauritzen, F. Checler, R. Pardossi-Piquard, 2018, Neurobiology of Aging.

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

W. Klein, I. Lauritzen, F. Checler, 2016, Acta Neuropathologica.

Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α.

J. Delgado-García, A. Gruart, L. Velloso, 2020, Cell reports.

The η-secretase-derived APP fragment ηCTF is localized in Golgi, endosomes and extracellular vesicles and contributes to Aβ production

E. Duplan, Wejdane El Manaa, I. Lauritzen, 2023, Cellular and Molecular Life Sciences.

Influence of Genetic Background on Apathy-Like Behavior in Triple Transgenic AD Mice.

P. Robert, I. Lauritzen, F. Checler, 2016, Current Alzheimer research.

The β-Secretase-Derived C-Terminal Fragment of βAPP, C99, But Not Aβ, Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus

P. Fraser, I. Lauritzen, J. Dunys, 2012, The Journal of Neuroscience.

Evidence that the amyloid-β protein precursor intracellular domain, AICD, derives from β-secretase-generated C-terminal fragment.

I. Lauritzen, F. Checler, R. Pardossi-Piquard, 2012, Journal of Alzheimer's disease : JAD.

A novel presenilin 2 mutation (V393M) in early‐onset dementia with profound language impairment

P. S. St George-Hyslop, G. Waldemar, N. Heegaard, 2008, European journal of neurology.

p53-dependent control of transactivation of the Pen2 promoter by presenilins

M. Vitek, Huaxi Xu, J. Dunys, 2009, Journal of Cell Science.

Response to Correspondence: Pardossi-Piquard et al., “Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP.” Neuron 46, 541–554

P. George-Hyslop, J. Dunys, F. Checler, 2007, Neuron.

The η-secretase-derived APP fragment ηCTF is localized in Golgi, endosomes and extracellular vesicles and contributes to Aβ production

E. Duplan, Wejdane El Manaa, I. Lauritzen, 2023, Cellular and Molecular Life Sciences.

Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.

P. S. St George-Hyslop, F. Checler, C. Sunyach, 2006, The Journal of neuroscience : the official journal of the Society for Neuroscience.

p53, a Molecular Bridge Between Alzheimer’s Disease Pathology and Cancers?

J. Dunys, F. Checler, R. Pardossi-Piquard, 2011 .

Ectodomain shedding of PLA2R1 is mediated by the metalloproteases ADAM10 and ADAM17

R. Pardossi-Piquard, C. Payré, Joana Justino, 2024, Journal of Biological Chemistry.

p53 Is Regulated by and Regulates Members of the γ-Secretase Complex

J. Dunys, F. Checler, R. Pardossi-Piquard, 2010, Neurodegenerative Diseases.