A. Clerk

发表

Regulation of Expression of the Rat Orthologue of Mouse Double Minute 2 (MDM2) by H2O2-induced Oxidative Stress in Neonatal Rat Cardiac Myocytes

S. Pikkarainen, R. Kennedy, A. K. Marshall, 2009, The Journal of Biological Chemistry.

Akt like a woman: gender differences in susceptibility to cardiovascular disease.

A. Clerk, P. Sugden, Peter H. Sugden, 2001, Circulation research.

Phenylephrine promotes phosphorylation of Bad in cardiac myocytes through the extracellular signal-regulated kinases 1/2 and protein kinase A.

S. Cook, A. Clerk, P. Sugden, 2002, Journal of molecular and cellular cardiology.

Activation of protein kinase cascades in the heart by hypertrophic G protein-coupled receptor agonists.

A. Clerk, P. Sugden, 1999, The American journal of cardiology.

Mitogen-Activated Protein Kinases ) in the Myocardium ' ' Stress-Responsive ' ' Mitogen-Activated Protein Kinases ( c-Jun N-Terminal Kinases and

A. Clerk, P. Sugden, 1998 .

Stimulation of “Stress-regulated” Mitogen-activated Protein Kinases (Stress-activated Protein Kinases/c-Jun N-terminal Kinases and p38-Mitogen-activated Protein Kinases) in Perfused Rat Hearts by Oxidative and Other Stresses*

A. Clerk, P. Sugden, S. Fuller, 1998, The Journal of Biological Chemistry.

Integration of protein kinase signaling pathways in cardiac myocytes: signaling to and from the extracellular signal-regulated kinases.

J. G. Harrison, A. Clerk, P. Sugden, 2004, Advances in enzyme regulation.

Regulation of mitogen-activated protein kinase cascade in adult rat heart preparations in vitro.

A. Clerk, P. Sugden, S. Fuller, 1994, Circulation research.

Muscular weakness in the mdx mouse

F. Muntoni, A. Clerk, A. Mateddu, 1993, Journal of the Neurological Sciences.

Regulation of Protein Kinase C δ by Phorbol Ester, Endothelin-1, and Platelet-derived Growth Factor in Cardiac Myocytes*

A. Clerk, P. Sugden, T. Markou, 2006, Journal of Biological Chemistry.

Chemotherapeutic agents and gene expression in cardiac myocytes.

A. Clerk, P. Sugden, Alejandro Giraldo, 2007, Advances in enzyme regulation.

Inflame my heart (by p38-MAPK).

A. Clerk, P. Sugden, 2006, Circulation research.

Activation of c-Jun N-terminal kinases and p38-mitogen-activated protein kinases in human heart failure secondary to ischaemic heart disease.

S. Cook, A. Clerk, P. Sugden, 1999, Journal of molecular and cellular cardiology.

Manifesting carriers of Xp21 muscular dystrophy; Lack of correlation between dystrophin expression and clinical weakness

V. Dubowitz, A. Clerk, C. Sewry, 1993, Neuromuscular Disorders.

The p38‐MAPK inhibitor, SB203580, inhibits cardiac stress‐activated protein kinases/c‐Jun N‐terminal kinases (SAPKs/JNKs)

A. Clerk, P. Sugden, 1998, FEBS letters.

Activation of mitogen‐activated protein kinases (p38‐MAPKs, SAPKs/JNKs and ERKs) by adenosine in the perfused rat heart

A. Clerk, P. Sugden, S. Haq, 1998, FEBS letters.

Regulation of bcl-2 family proteins during development and in response to oxidative stress in cardiac myocytes: association with changes in mitochondrial membrane potential.

S. Cook, A. Clerk, P. Sugden, 1999, Circulation research.

Oxidative stress and growth-regulating intracellular signaling pathways in cardiac myocytes.

A. Clerk, P. Sugden, 2006, Antioxidants & redox signaling.

The radical balance between life and death.

A. Clerk, 2003, Journal of molecular and cellular cardiology.

p90 Ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to Gq-protein-coupled receptor stimuli, endothelin-1 and α1-adrenergic receptor agonists

A. Clerk, P. Sugden, S. Fuller, 2012, The Biochemical journal.

Regulation of mitogen-activated protein kinase cascades in the heart.

A. Clerk, P. Sugden, 1998, Advances in enzyme regulation.

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo

Daniel N. Meijles, O. Rackham, A. Clerk, 2021, bioRxiv.

Regulation of cardiac myocyte protein synthesis through phosphatidylinositol 3' kinase and protein kinase B.

A. Clerk, F. H. Pham, S. Cole, 2001, Advances in Enzyme Regulation.

Regulation of Mitogen-Activated Protein Kinases in Cardiac Myocytes through the Small G Protein Rac1

E. Sahai, C. Marshall, A. Clerk, 2001, Molecular and Cellular Biology.

Clerk and Sugden Small ( 21 kDa ) G Proteins and Cardiac Hypertrophy

A. Clerk, P. Sugden, 2000 .

Activation of the small GTP-binding protein Ras in the heart by hypertrophic agonists.

A. Clerk, P. Sugden, 2000, Trends in cardiovascular medicine.

Small guanine nucleotide-binding proteins and myocardial hypertrophy.

A. Clerk, P. Sugden, 2000, Circulation research.

Regulation of Ras·GTP Loading and Ras-Raf Association in Neonatal Rat Ventricular Myocytes by G Protein-coupled Receptor Agonists and Phorbol Ester

C. Marshall, A. Clerk, P. Sugden, 1999, The Journal of Biological Chemistry.

Are transgenic mice the 'alkahest' to understanding myocardial hypertrophy and failure?

S. Cook, A. Clerk, P. Sugden, 2009, Journal of molecular and cellular cardiology.

SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions.

L. McGuffin, A. Clerk, P. Sugden, 2013, The Biochemical journal.

Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy.

P. Parker, A. Clerk, P. Sugden, 1994, The Journal of biological chemistry.

Stimulation of phosphatidylinositol hydrolysis, protein kinase C translocation, and mitogen-activated protein kinase activity by bradykinin in rat ventricular myocytes: dissociation from the hypertrophic response.

A. Clerk, P. Sugden, S. Fuller, 1996, The Biochemical journal.

Using U0126 to dissect the role of the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade in the regulation of gene expression by endothelin-1 in cardiac myocytes.

R. Kennedy, A. Clerk, P. Sugden, 2006, Journal of molecular and cellular cardiology.

Stimulation of the p38 Mitogen-activated Protein Kinase Pathway in Neonatal Rat Ventricular Myocytes by the G Protein–coupled Receptor Agonists, Endothelin-1 and Phenylephrine: A Role in Cardiac Myocyte Hypertrophy?

A. Clerk, P. Sugden, A. Michael, 1998, The Journal of cell biology.

Glycogen synthase kinases 3alpha and 3beta in cardiac myocytes: regulation and consequences of their inhibition.

A. Clerk, P. Sugden, S. Fuller, 2008, Cellular signalling.

Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: Effects of endothelin-1, oxidative stress and cytokines

E. Tham, A. Clerk, P. Sugden, 2008, Biochimica et biophysica acta.

ERK 1 / 2 signaling dominates over RhoA signaling in regulating early changes in RNA expression induced by endothelin-1 in neonatal rat cardiomyocytes

Oliver P. T. Barrett, A. Clerk, P. Sugden, 2017 .

ERK1/2 Signaling Dominates Over RhoA Signaling in Regulating Early Changes in RNA Expression Induced by Endothelin-1 in Neonatal Rat Cardiomyocytes

Oliver P. T. Barrett, A. Clerk, P. Sugden, 2010, PloS one.

Expression of protein kinase C isoforms during cardiac ventricular development.

P. Parker, A. Clerk, P. Sugden, 1995, The American journal of physiology.

Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts.

A. Clerk, P. Sugden, M. Bogoyevitch, 1994, The Journal of biological chemistry.

Regulation of protein kinase B and 4E-BP1 by oxidative stress in cardiac myocytes.

A. Clerk, P. Sugden, F. H. Pham, 2000, Circulation research.

Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses

S. Pikkarainen, A. Clerk, P. Sugden, 2007, Journal of cellular physiology.

Phenylephrine and endothelin-1 upregulate connective tissue growth factor in neonatal rat cardiac myocytes.

A. Clerk, P. Sugden, T. Kemp, 2004, Journal of molecular and cellular cardiology.

The insulin receptor family in the heart: new light on old insights

A. Clerk, P. Sugden, 2022, Bioscience reports.

Gene expression profiling of human hibernating myocardium: Increased expression of B‐type natriuretic peptide and proenkephalin in hypocontractile vs normally‐contracting regions of the heart

M. Cowie, A. Clerk, T. Kemp, 2008, European journal of heart failure.

Regulation of phospholipases C and D in rat ventricular myocytes: stimulation by endothelin-1, bradykinin and phenylephrine.

A. Clerk, P. Sugden, 1997, Journal of molecular and cellular cardiology.

Brief Communication Phenylephrine and endothelin-1 upregulate connective tissue growth factor in neonatal rat cardiac myocytes

A. Clerk, P. Sugden, T. Kemp, 2004 .

Signaling through the extracellular signal-regulated kinase 1/2 cascade in cardiac myocytes.

A. Clerk, P. Sugden, 2004, Biochemistry and cell biology = Biochimie et biologie cellulaire.

The cardiomyocyte “redox rheostat”: Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death

Daniel N. Meijles, Kenneth Lay, B. Handa, 2019, Journal of molecular and cellular cardiology.

Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart.

A. Clerk, P. Sugden, A. Lazou, 1998, The Biochemical journal.

Endothelin-1 promotes phosphorylation of CREB transcription factor in primary cultures of neonatal rat cardiac myocytes: implications for the regulation of c-jun expression.

J. G. Harrison, A. Clerk, P. Sugden, 2004, Biochimica et biophysica acta.

Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein.

J. G. Harrison, A. Clerk, P. Sugden, 2002, The Biochemical journal.

Cell stress-induced phosphorylation of ATF2 and c-Jun transcription factors in rat ventricular myocytes.

A. Clerk, P. Sugden, 1997, The Biochemical journal.

Untangling the Web: specific signaling from PKC isoforms to MAPK cascades.

A. Clerk, P. Sugden, A Clerk, 2001, Circulation research.

Death by protein kinase C inhibitor: a stressful event.

A. Clerk, 2001, Journal of molecular and cellular cardiology.

Characterisation of dystrophin in carriers of Duchenne muscular dystrophy

V. Dubowitz, A. Clerk, C. Sewry, 1991, Journal of the Neurological Sciences.

The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors

A. Clerk, P. Sugden, S. Fuller, 2021, The Biochemical journal.

Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice

A. Clerk, P. Sugden, S. Fuller, 2022, bioRxiv.

Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension

Daniel N. Meijles, M. Sheppard, A. Clerk, 2020, Hypertension.

Redox regulation of cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) controls p38-MAPK (Mitogen-Activated Protein Kinase) and orchestrates cardiac remodelling to hypertension cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) controls p38-MAPK (Mitogen-Activated Protein Kinase) and orchestrates

Daniel N. Meijles, M. Sheppard, A. Clerk, 2020 .

Activation of the mitogen-activated protein kinase cascade by pertussis toxin-sensitive and -insensitive pathways in cultured ventricular cardiomyocytes.

A. Clerk, P. Sugden, M. Bogoyevitch, 1995, The Biochemical journal.

The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension.

Daniel N. Meijles, M. Sheppard, A. Clerk, 2021, Clinical science.

Dying by the way you live: AIF vs. caspases in apoptosis of hypertrophied cardiomyocytes.

A. Clerk, P. Sugden, 2010, Cardiovascular research.

PKC-dependent activation of p46/p54 JNKs during ischemic preconditioning in conscious rabbits.

P. Ping, R. Bolli, S. Huang, 1999, The American journal of physiology.

The early transcriptomic response to interleukin 1β and interleukin 33 in rat neonatal cardiomyocytes.

Oliver P. T. Barrett, A. Clerk, P. Sugden, 2013, Cytokine.

PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses

Daniel N. Meijles, O. Rackham, A. Clerk, 2022, bioRxiv.

Ras: the stress and the strain.

A. Clerk, P. Sugden, 2006, Journal of molecular and cellular cardiology.

Characterisation of dystrophin in fetuses at risk for Duchenne muscular dystrophy

V. Dubowitz, A. Clerk, C. Sewry, 1992, Journal of the Neurological Sciences.

Regulation of the ERK subgroup of MAP kinase cascades through G protein-coupled receptors.

A. Clerk, P. Sugden, 1997, Cellular signalling.

Kinases as therapeutic targets for heart failure

A. Clerk, C. Vlahos, S. McDowell, 2003, Nature Reviews Drug Discovery.

Modelling Negative Feedback Networks for Activating Transcription Factor 3 Predicts a Dominant Role for miRNAs in Immediate Early Gene Regulation

Marcus J. Tindall, Angela Clerk, A. Clerk, 2014, PLoS Comput. Biol..

Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes: Egr1 is a principal Atf3 target

Oliver P. T. Barrett, A. Clerk, P. Sugden, 2012, The Biochemical journal.

Feedback regulation by Atf 3 in the endothelin-1-responsive transcriptome of cardiomyocytes : Egr 1 is a principal Atf 3 target

Oliver P. T. Barrett, A. Clerk, P. Sugden, 2012 .

Open Access Research Article

E. Tham, A. Clerk, P. Sugden, 2022 .

"Stress-responsive" mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium.

A. Clerk, P. Sugden, 1998, Circulation research.

Activation of mitogen-activated protein kinases ( p 38-MAPKs , SAPKs / JNKs and ERKs ) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart

A. Clerk, P. Sugden, A. Lazou, 1998 .

Regulation of cardiac myocyte cell death.

J. G. Harrison, A. Clerk, D. M. Valks, 2003, Pharmacology & therapeutics.

PKC-dependent activation of p46/p54 JNKs during ischemic preconditioning in conscious rabbits.

Jiahuai Han, Shuang Huang, P. Ping, 1999, American journal of physiology. Heart and circulatory physiology.

Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis

A. Clerk, P. Sugden, S. Fuller, 2008, British journal of pharmacology.

A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3)

Liam J. McGuffin, Angela Clerk, L. McGuffin, 2012, The Biochemical journal.

Cellular mechanisms of cardiac hypertrophy

A. Clerk, P. Sugden, 1998, Journal of Molecular Medicine.

Cardiac myocyte gene expression profiling during H2O2-induced apoptosis.

A. Clerk, P. Sugden, G. Zoumpoulidou, 2007, Physiological genomics.

Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active

E. Tham, A. Clerk, P. Sugden, 2011, Cellular signalling.

Endothelin-1 regulation of immediate early gene expression in cardiac myocytes: negative feedback regulation of interleukin 6 by Atf3 and Klf2.

A. Clerk, P. Sugden, S. Fuller, 2009, Advances in enzyme regulation.

Endothelin Signaling in the Cardiomyocyte

A. Clerk, P. Sugden, 2008 .

Peptide growth factors signal differentially through protein kinase C to extracellular signal-regulated kinases in neonatal cardiomyocytes.

A. Clerk, P. Sugden, K. Stathopoulou, 2006, Cellular signalling.

Alterations in signal transduction

A. Clerk, P. Sugden, 2005 .

Regulation of gene and protein expression in cardiac myocyte hypertrophy and apoptosis.

R. Kennedy, A. Clerk, P. Sugden, 2005, Advances in enzyme regulation.

Adrenergic receptor stimulation of the mitogen-activated protein kinase cascade and cardiac hypertrophy.

A. Clerk, P. Sugden, S. Fuller, 1996, The Biochemical journal.

Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes

L. Game, S. Pikkarainen, A. Clerk, 2008, Genome Biology.

Modulation of interleukin signalling and gene expression in cardiac myocytes by endothelin-1.

E. Tham, A. Clerk, P. Sugden, 2010, The international journal of biochemistry & cell biology.

Dystrophin immunoreactivity in normal and duchenne human fetal neurons in culture

F. Muntoni, A. Clerk, S. Torelli, 1992, Journal of neuroscience research.

Characterisation of dystrophin during development of human skeletal muscle.

A. Clerk, C. Sewry, P. Strong, 1992, Development.

K. Davies, V. Dubowitz, A. Clerk, 1993, The Histochemical Journal.

K. Davies, V. Dubowitz, A. Clerk, 2004, The Histochemical Journal.

A Dystrophin‐Immunoreactive Protein in Mammalian Brain

F. Muntoni, A. Clerk, P. Strong, 1993, Journal of neurochemistry.

Dystrophin abnormalities in polymyositis and dermatomyositis

T. Vyse, V. Dubowitz, A. Clerk, 1991, Neuromuscular Disorders.

Dystrophin analysis using a panel of anti-dystrophin antibodies in Duchenne and Becker muscular dystrophy.

F. Muntoni, C. Cianchetti, A. Clerk, 1993, Journal of neurology, neurosurgery, and psychiatry.

Cardiac protein kinases: the cardiomyocyte kinome and differential kinase expression in human failing hearts.

A. Clerk, P. Sugden, S. Fuller, 2015, Cardiovascular research.

Pro-inflammatory cytokines stimulate mitogen-activated protein kinase subfamilies, increase phosphorylation of c-Jun and ATF2 and upregulate c-Jun protein in neonatal rat ventricular myocytes.

J. G. Harrison, C. Long, A. Clerk, 1999, Journal of molecular and cellular cardiology.

ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models

M. Mayr, S. Heymans, J. Balligand, 2014, European journal of heart failure.

Changes in gene expression induced by H(2)O(2) in cardiac myocytes.

Angela Clerk, Helen C Causton, H. Causton, 2003, Biochemical and biophysical research communications.

Effects of oxidative stress on the cardiac myocyte proteome: modifications to peroxiredoxins and small heat shock proteins.

A. Clerk, P. Sugden, R. Wait, 2006, Journal of molecular and cellular cardiology.

S. Pikkarainen, E. Tham, A. Clerk, 2008, Cellular signalling.

Endothelin-1 and Fibroblast Growth Factors Stimulate the Mitogen-activated Protein Kinase Signaling Cascade in Cardiac Myocytes

C. Marshall, A. Clerk, Péter, 2001 .

Glycogen synthase kinases 3α and 3β in cardiac myocytes: regulation and consequences of their inhibition

A. Clerk, P. Sugden, S. Fuller, 2008 .

Targeting myocardial remodelling to develop novel therapies for heart failure

M. Mayr, S. Heymans, J. Balligand, 2014, European Journal of Heart Failure.

Endothelin signalling in the cardiac myocyte and its pathophysiological relevance.

A. Clerk, P. Sugden, 2005, Current vascular pharmacology.

Mitogen-activated protein kinases are activated by oxidative stress and cytokines in neonatal rat ventricular myocytes.

A. Clerk, P. Sugden, 1997, Biochemical Society transactions.

Regulation of Ras z GTP Loading and Ras-Raf Association in Neonatal Rat Ventricular Myocytes by G Protein-coupled Receptor Agonists and Phorbol Ester ACTIVATION OF THE EXTRACELLULAR SIGNAL-REGULATED KINASE CASCADE BY PHORBOL ESTER IS MEDIATED BY Ras*

C. Marshall, A. Clerk, P. Sugden, 1999 .

MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins

L. McGuffin, A. Clerk, P. Sugden, 2021, The Biochemical journal.

Stimulation of multiple mitogen-activated protein kinase sub-families by oxidative stress and phosphorylation of the small heat shock protein, HSP25/27, in neonatal ventricular myocytes.

A. Clerk, P. Sugden, A. Michael, 1998, The Biochemical journal.

Regulation of Bcl-xL Expression by H2O2 in Cardiac Myocytes*

A. Clerk, D. M. Valks, T. Kemp, 2003, Journal of Biological Chemistry.

Dystrophin and dystrophin-like proteins in muscle and brain of normal and mdx mice.

F. Muntoni, A. Clerk, P. Strong, 1990, Biochemical Society Transactions.