A. Astanehe

发表

Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer

David J. Arenillas, Gordon B Mills, Wyeth W Wasserman, 2008, Journal of Cell Science.

The transcriptional induction of PIK3CA in tumor cells is dependent on the oncoprotein Y-box binding protein-1

W. Lam, A. Astanehe, S. Dunn, 2009, Oncogene.

The expression of activated Y-box binding protein-1 serine 102 mediates trastuzumab resistance in breast cancer cells by increasing CD44+ cells

A. Astanehe, S. Dunn, A. Fotovati, 2010, Oncogene.

Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy

T. Nielsen, W. Lam, M. Marra, 2007, Breast Cancer Research.

Extracutaneous melanoma epidemiology in British Columbia

Tim K. Lee, A. Astanehe, S. Kalia, 2014, Melanoma research.

An Enhanced Recovery after Surgery Pathway for Microvascular Breast Reconstruction Is Safe and Effective

Christiaan H. Schrag, A. Astanehe, C. Temple-Oberle, 2018, Plastic and reconstructive surgery. Global open.

Non-Invasive Imaging of Phosphoinositide-3-Kinase-Catalytic-Subunit-Alpha (PIK3CA) Promoter Modulation in Small Animal Models

S. Gambhir, A. Astanehe, P. Ray, 2013, PloS one.

YB-1 is a Transcription/Translation Factor that Orchestrates the Oncogenome by Hardwiring Signal Transduction to Gene Expression

A. Astanehe, S. Dunn, A. Stratford, 2007, Translational oncogenomics.

MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition

M. Krzywinski, G. Mills, M. Marra, 2012, Oncogene.

Role of Y-box binding protein-1 (YB-1) in breast cancer

A. Astanehe, 2011 .

Profiling YB-1 target genes uncovers a new mechanism for MET receptor regulation in normal and malignant human mammary cells

C. Eaves, P. Comoglio, A. Astanehe, 2009, Oncogene.

Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance.

C. Eaves, Jing Wang, A. Astanehe, 2010, Cancer research.

Molecular Decoy to the Y-Box Binding Protein-1 Suppresses the Growth of Breast and Prostate Cancer Cells whilst Sparing Normal Cell Viability

M. Gleave, Steven J. M. Jones, C. Eaves, 2010, PloS one.

YB‐1 Transforms Human Mammary Epithelial Cells Through Chromatin Remodeling Leading to the Development of Basal‐Like Breast Cancer

G. Mills, C. Maxwell, A. Astanehe, 2014, Stem cells.

Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice.

C. Eaves, M. Hung, A. Astanehe, 2008, Cancer research.

Suppresses Tumor Growth in Mice Cells Induces Apoptosis via the mTOR / STAT 3 Pathway and Targeting YB-1 in HER-2 Overexpressing Breast Cancer

C. Eaves, M. Hung, A. Astanehe, 2008 .

Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy.

T. Nielsen, W. Lam, M. Marra, 2007, Breast cancer research : BCR.