V. Kähäri

发表

R. Ala-aho, V. Kähäri, R. Ala‐aho, 2005, Biochimie.

Adenoviral delivery of p53 gene suppresses expression of collagenase-3 (MMP-13) in squamous carcinoma cells

R. Grenman, P. Seth, R. Ala-aho, 2002, Oncogene.

Enhancement of Fibroblast Collagenase (Matrix Metalloproteinase-1)Gene Expression by Ceramide Is Mediated by Extracellular Signal-regulated and Stress-activated Protein Kinase Pathways*

J. Westermarck, J. Eriksson, V. Kähäri, 1998, The Journal of Biological Chemistry.

Enhancement of fibroblast collagenase-1 (MMP-1) gene expression by tumor promoter okadaic acid is mediated by stress-activated protein kinases Jun N-terminal kinase and p38.

J. Westermarck, J. Eriksson, V. Kähäri, 1998, Matrix biology : journal of the International Society for Matrix Biology.

Matrix metalloproteinases in cancer: Prognostic markers and therapeutic targets

V. Kähäri, P. Vihinen, Pia Vihinen, 2002, International journal of cancer.

Targeting Degradome Genes via Engineered Viral Vectors

R. Ala-aho, V. Kähäri, A. Baker, 2008 .

Matrix metalloproteinase (MMP)-7 in salivary gland cancer

T. Vahlberg, V. Kähäri, H. Luukkaa, 2010, Acta oncologica.

Significant Role of Collagen XVII And Integrin β4 in Migration and Invasion of The Less Aggressive Squamous Cell Carcinoma Cells

T. Salo, V. Kähäri, K. Tasanen, 2017, Scientific Reports.

Expression of collagenase-3 (matrix metalloproteinase-13) in squamous cell carcinomas of the head and neck.

R. Grenman, V. Kähäri, U. Saarialho-Kere, 1997, The American journal of pathology.

Expression of collagenase‐3 (matrix metalloproteinase‐13) in transitional‐cell carcinoma of the urinary bladder

P. Boström, V. Kähäri, M. Laato, 2000, International journal of cancer.

p38alpha and p38delta mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells.

J. Westermarck, P. Jaakkola, R. Grenman, 2007, Oncogene.

p38α and p38δ mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells

J. Westermarck, P. Jaakkola, R. Grenman, 2007, Oncogene.

Transforming growth factor-beta up-regulates elastin gene expression in human skin fibroblasts. Evidence for post-transcriptional modulation.

J. Uitto, V. Kähäri, Y. Chen, 1992, Laboratory investigation; a journal of technical methods and pathology.

Collagen Turnover in Wound Repair--A Macrophage Connection.

V. Kähäri, L. Nissinen, 2015, The Journal of investigative dermatology.

Integrin α2β1 Is a Positive Regulator of Collagenase (MMP-1) and Collagen α1(I) Gene Expression (*)

J. Heino, J. Westermarck, V. Kähäri, 1995, The Journal of Biological Chemistry.

Matrix metalloproteinase-19 expression in dermal wounds and by fibroblasts in culture.

C. López-Otín, V. Kähäri, U. Saarialho-Kere, 2003, The Journal of investigative dermatology.

Expression of human macrophage metalloelastase (MMP-12) by tumor cells in skin cancer.

S. Shapiro, R. Grenman, R. Ala-aho, 2000, The Journal of investigative dermatology.

Expression of matrix metalloproteinase (MMP)‐7 and MMP‐13 and loss of MMP‐19 and p16 are associated with malignant progression in chronic wounds

B. Baldursson, S. Syrjänen, V. Kähäri, 2005, The British journal of dermatology.

Matrix metalloproteinase‐19 is expressed by proliferating epithelium but disappears with neoplastic dedifferentiation

R. Grenman, V. Kähäri, M. Toriseva, 2003, International journal of cancer.

Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas.

S. Grénman, S. Hietanen, V. Kähäri, 1999, The American journal of pathology.

Expression of matrix metalloproteinase‐1, ‐7, ‐9, ‐13, Ki‐67, and HER‐2 in epithelial‐myoepithelial salivary gland cancer

R. Gilbert, T. Vahlberg, A. Mäkitie, 2009, Head & neck.

Accelerated Up‐Regulation of L‐Sox5, Sox6, and Sox9 by BMP‐2 Gene Transfer During Murine Fracture Healing *

V. Lefebvre, E. Vuorio, V. Kähäri, 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Induction of periosteal callus formation by bone morphogenetic protein-2 employing adenovirus-mediated gene delivery.

E. Vuorio, V. Kähäri, H. Aro, 2001, Matrix biology : journal of the International Society for Matrix Biology.

αV integrin promotes in vitro and in vivo survival of cells in metastatic melanoma

J. Heino, V. Kähäri, M. Ahonen, 2004, International journal of cancer.

Tumor cell-specific Serpin A1 expression in vulvar squamous cell carcinoma

V. Kähäri, L. Nissinen, E. Snellman, 2019, Archives of Gynecology and Obstetrics.

Antitumor activity and bystander effect of adenovirally delivered tissue inhibitor of metalloproteinases-3.

R. Grenman, R. Ala-aho, V. Kähäri, 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

Differential modulation of basement membrane gene expression in human fibrosarcoma HT-1080 cells by transforming growth factor-beta 1. Enhanced type IV collagen and fibronectin gene expression correlates with altered culture phenotype of the cells.

J. Uitto, V. Kähäri, J. Peltonen, 1991, Laboratory investigation; a journal of technical methods and pathology.

p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2.

Jiahuai Han, J. Westermarck, V. Kähäri, 2020, Cancer research.

Mitogen-activated Protein/extracellular Signal-regulated Cell Survival by Inducing Dephosphorylation of P38 Mitogen-activated Protein Kinase Pathway Suppresses Updated Version Cited Articles Citing Articles E-mail Alerts P38 Mitogen-activated Protein Kinase Pathway Suppresses Cell Survival by Induci

Jiahuai Han, J. Westermarck, V. Kähäri, 2013 .

Hypoxia-activated Smad3-specific Dephosphorylation by PP2A*

S. Leivonen, J. Westermarck, P. Jaakkola, 2009, The Journal of Biological Chemistry.

Activation of Smad signaling enhances collagenase-3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells

S. Leivonen, R. Grenman, R. Ala-aho, 2006, Oncogene.

Isoform-specific regulation of the actin-organizing protein palladin during TGF-beta1-induced myofibroblast differentiation.

B. Hinz, S. Leivonen, M. Rönty, 2006, The Journal of investigative dermatology.

Smad3 and extracellular signal-regulated kinase 1/2 coordinately mediate transforming growth factor-beta-induced expression of connective tissue growth factor in human fibroblasts.

S. Leivonen, V. Kähäri, L. Häkkinen, 2005, The Journal of investigative dermatology.

Increased type I collagen mRNA levels in cultured scleroderma fibroblasts.

E. Vuorio, V. Kähäri, K. Näntö-Salonen, 1984, Biochimica et biophysica acta.

European dermatology forum S1‐guideline on the diagnosis and treatment of sclerosing diseases of the skin, Part 2: Scleromyxedema, scleredema and nephrogenic systemic fibrosis

A. Gabrielli, L. Rudnicka, P. Wolf, 2017, Journal of the European Academy of Dermatology and Venereology : JEADV.

Keratinocyte Growth Factor Induces Gene Expression Signature Associated with Suppression of Malignant Phenotype of Cutaneous Squamous Carcinoma Cells

R. Grenman, R. Ala-aho, V. Kähäri, 2012, PloS one.

Expression of extracellular matrix genes: transforming growth factor (TGF)-beta1 and ras in tibial fracture healing of lathyritic rats.

V. Kähäri, P. Paavolainen, R. Penttinen, 2000, Bone.

Differential regulation of interstitial collagenase (MMP-1) gene expression by ETS transcription factors

J. Westermarck, V. Kähäri, A. Seth, 1997, Oncogene.

High-efficiency gene transfer to primary T lymphocytes by recombinant adenovirus vectors.

R. Lahesmaa, V. Kähäri, J. Bergelson, 2002, Journal of immunological methods.

Transforming growth factor‐β signaling in cancer invasion and metastasis

S. Leivonen, V. Kähäri, 2007, International journal of cancer.

Adenovirus mediated intra-articular expression of collagenase-3 (MMP-13) induces inflammatory arthritis in mice

E. Vuorio, R. Ala-aho, V. Kähäri, 2004, Annals of the rheumatic diseases.

Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human chondrosarcomas Note

E. Vuorio, T. Ekfors, V. Kähäri, 2001, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate.

J. Westermarck, V. Kähäri, J. Keski‐Oja, 1996, European journal of biochemistry.

Differential regulation of decorin and biglycan gene expression by dexamethasone and retinoic acid in cultured human skin fibroblasts.

H. Larjava, J. Westermarck, V. Kähäri, 1995, The Journal of investigative dermatology.

Okadaic acid-elicited transcriptional activation of collagenase gene expression in HT-1080 fibrosarcoma cells is mediated by JunB.

J. Westermarck, V. Kähäri, J. Keski‐Oja, 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Cyclosporin A enhances cytokine and phorbol ester-induced fibroblast collagenase expression.

V. Kähäri, J. Keski‐Oja, J. Lohi, 1994, The Journal of investigative dermatology.

Human recombinant interleukin-1 beta up-regulates elastin gene expression in dermal fibroblasts. Evidence for transcriptional regulation in vitro and in vivo.

J. Uitto, L. Rudnicka, V. Kähäri, 1993, The Journal of biological chemistry.

High expression levels of collagenase‐1 and stromelysin‐1 correlate with shorter disease‐free survival in human metastatic melanoma

V. Kähäri, P. Vihinen, T. Vlaykova, 2002, International journal of cancer.

CIP2A Inhibits PP2A in Human Malignancies

R. Sears, J. Westermarck, R. Grenman, 2007, Cell.

Activation of p38α MAPK Enhances Collagenase-1 (Matrix Metalloproteinase (MMP)-1) and Stromelysin-1 (MMP-3) Expression by mRNA Stabilization*

Jiahuai Han, V. Kähäri, Song-ping Li, 2002, The Journal of Biological Chemistry.

Interleukin-1 increases collagen production and mRNA levels in cultured skin fibroblasts.

J. Heino, E. Vuorio, V. Kähäri, 1987, Biochimica et biophysica acta.

Natural killer cells in wound healing

V. Kähäri, M. Toriseva, J. Liippo, 2010 .

Collagenase-3 (matrix metalloproteinase-13) expression is induced in oral mucosal epithelium during chronic inflammation.

C. López-Otín, V. Kähäri, J. Firth, 1998, The American journal of pathology.

Differential regulation of the AP-1 family members by UV irradiation in vitro and in vivo.

J. Westermarck, V. Kähäri, K. Punnonen, 1998, Cellular signalling.

Leukoregulin, A T‐cell derived cytokine, upregulates stromelysin‐1 gene expression in human dermal fibroblasts: Evidence for the role of AP‐1 in transcriptional activiation

J. Uitto, V. Kähäri, A. Mauviel, 1992, Journal of cellular biochemistry.

Eosinophilic Fasciitis: Increased Collagen Production and Type I Procollagen Messenger RNA Levels in Fibroblasts Cultured From Involved Skin

L. Niskanen, J. Heino, J. Uitto, 1990 .

Characterization of One Phenotype of Human Periodontal Granulation-tissue Fibroblasts

H. Larjava, J. Heino, E. Vuorio, 1989, Journal of dental research.

Gene expression of fibroblast matrix proteins is altered by indomethacin

D. Hartmann, J. Heino, V. Kähäri, 1988, FEBS letters.

Elevated proα2(I) collagen mRNA levels in cultured scleroderma fibroblasts result from an increased transcription rate of the corresponding gene

E. Vuorio, V. Kähäri, P. Multimäki, 1987, FEBS letters.

Collagen synthesis in the vaginal connective tissue of patients with and without uterine prolapse.

E. Vuorio, V. Kähäri, J. Mäkinen, 1987, European journal of obstetrics, gynecology, and reproductive biology.

Integrin α2β1 Mediates Isoform-Specific Activation of p38 and Upregulation of Collagen Gene Transcription by a Mechanism Involving the α2 Cytoplasmic Tail

J. Heino, J. Westermarck, V. Kähäri, 1999, The Journal of cell biology.

Modulation of Tight Junctions and the Permeability Barrier in Betaine-Treated Keratinocyte Cultures

J. Hakkarainen, V. Kähäri, S. Peltonen, 2021 .

Collagens XV and XVIII show different expression and localisation in cutaneous squamous cell carcinoma: type XV appears in tumor stroma, while XVIII becomes upregulated in tumor cells and lost from microvessels

V. Kähäri, K. Tasanen, T. Pihlajaniemi, 2016, Experimental dermatology.

Molecular biology and pathology of human elastin.

J. Rosenbloom, J. Uitto, A. Christiano, 1991, Biochemical Society transactions.

Eosinophilia-myalgia syndrome, eosinophilic fasciitis, and related fibrosing disorders.

V. Kähäri, J. Varga, 1997, Current opinion in rheumatology.

Expression of human collagenase‐3 (MMP‐13) by fetal skin fibroblasts is induced by transforming growth factor‐β via p38 mitogen‐activated protein kinase

Jiahuai Han, T. Crombleholme, V. Kähäri, 2001 .

Expression of human collagenase-3 (MMP-13) by fetal skin fibroblasts is induced by transforming growth factor beta via p38 mitogen-activated protein kinase.

T. Crombleholme, V. Kähäri, M. Foschi, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Tissue inhibitor of metalloproteinases-3 induces apoptosis in melanoma cells by stabilization of death receptors

J. Eriksson, V. Kähäri, M. Ahonen, 2003, Oncogene.

Activation of fibroblast collagenase-1 expression by tumor cells of squamous cell carcinomas is mediated by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase-2.

J. Westermarck, P. Jaakkola, R. Grenman, 2000, Cancer research.

Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptional levels.

J. Uitto, V. Kähäri, F. Ramirez, 1990, The Journal of clinical investigation.

Tumor necrosis factor-alpha down-regulates human elastin gene expression. Evidence for the role of AP-1 in the suppression of promoter activity.

J. Rosenbloom, J. Uitto, V. Kähäri, 1992, The Journal of biological chemistry.

Expression of claudin‐11 by tumor cells in cutaneous squamous cell carcinoma is dependent on the activity of p38δ

V. Kähäri, S. Peltonen, J. Peltonen, 2017, Experimental dermatology.

Identification of metastatic primary cutaneous squamous cell carcinoma utilizing artificial intelligence analysis of whole slide images

L. Talve, V. Kähäri, L. Nissinen, 2022, Scientific Reports.

Super Enhancer-Regulated LINC00094 (SERLOC) Upregulates the Expression of MMP-1 and MMP-13 and Promotes Invasion of Cutaneous Squamous Cell Carcinoma

V. Kähäri, L. Nissinen, M. Kallajoki, 2022, Cancers.

Requirements for Receptor Engagement during Infection by Adenovirus Complexed with Blood Coagulation Factor X

V. Kähäri, N. Van Rooijen, A. Parker, 2010, PLoS pathogens.

Dasatinib promotes apoptosis of cutaneous squamous carcinoma cells by regulating activation of ERK1/2

R. Grenman, V. Kähäri, L. Nissinen, 2017, Experimental dermatology.

Efficient infection of tumor endothelial cells by a capsid-modified adenovirus

V. Kähäri, S. Woo, A. Lieber, 2006, Gene Therapy.

Stromal collagenase in melanoma: a vascular connection.

R. Ala-aho, V. Kähäri, R. Ala‐aho, 2009, The Journal of investigative dermatology.

Human nidogen gene: structural and functional characterization of the 5'-flanking region.

J. Uitto, V. Kähäri, B. Saitta, 1991, The Journal of investigative dermatology.

Activation of dermal connective tissue in scleroderma.

V. Kähäri, 1993, Annals of medicine.

High collagenase-1 expression correlates with a favourable chemoimmunotherapy response in human metastatic melanoma

V. Kähäri, P. Vihinen, T. Vlaykova, 2001, Melanoma research.

Expression of collagenase‐3 (MMP‐13) enhances invasion of human fibrosarcoma HT‐1080 cells

R. Ala-aho, V. Kähäri, N. Johansson, 2002, International journal of cancer.

Potential applications of tissue inhibitor of metalloproteinase (TIMP) overexpression for cancer gene therapy.

V. Kähäri, M. Ahonen, A. Baker, 2000, Advances in experimental medicine and biology.

Transforming growth factor-beta-induced alpha-smooth muscle cell actin expression in renal proximal tubular cells is regulated by p38beta mitogen-activated protein kinase, extracellular signal-regulated protein kinase1,2 and the Smad signalling during epithelial-myofibroblast transdifferentiation.

S. Leivonen, V. Kähäri, I. Mucsi, 2008, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Matrix metalloproteinase (MMP)-1, -9 and -13 as prognostic factors in salivary gland cancer

T. Vahlberg, V. Kähäri, H. Luukkaa, 2008, Acta oto-laryngologica.

Regulation of elastin gene expression: evidence for functional promoter activity in the 5'-flanking region of the human gene.

J. Rosenbloom, J. Uitto, V. Kähäri, 1990, The Journal of investigative dermatology.

Activation of Extracellular Signal-regulated Kinase 1/2 Inhibits Type I Collagen Expression by Human Skin Fibroblasts*

Jiahuai Han, V. Kähäri, M. Foschi, 2000, The Journal of Biological Chemistry.

Activation of extracellular signal-regulated protein kinase1,2 results in down-regulation of decorin expression in fibroblasts.

V. Kähäri, R. Iozzo, M. Foschi, 2000, The Biochemical journal.

Fibroblast activation in scleroderma.

E. Vuorio, V. Kähäri, A. Lehtonen, 1984, Scandinavian journal of rheumatology.

Evaluation of transforming growth factor beta and type I procollagen gene expression in fibrotic skin diseases by in situ hybridization.

S. Jimenez, J. Uitto, V. Kähäri, 1990, The Journal of investigative dermatology.

Expression of collagenase-3 (MMP-13) by tumor cells in squamous cell carcinomas of the head and neck.

R. Grenman, V. Kähäri, U. Saarialho-Kere, 1998, Advances in experimental medicine and biology.

Oncolytic capacity of attenuated replicative semliki forest virus in human melanoma xenografts in severe combined immunodeficient mice.

V. Kähäri, M. Vähä-Koskela, A. Hinkkanen, 2006, Cancer research.

Immunodeficient Mice Virus in Human Melanoma Xenografts in Severe Combined Oncolytic Capacity of Attenuated Replicative Semliki Forest

V. Kähäri, M. Vähä-Koskela, A. Hinkkanen, 2006 .

Identification of fibroblasts responsible for increased collagen production in localized scleroderma by in situ hybridization.

E. Vuorio, V. Kähäri, H. Kalimo, 1988, The Journal of investigative dermatology.

Interferon-α and interferon-γ reduce excessive collagen synthesis and procollagen mRNA levels of scleroderma fibroblasts in culture

J. Heino, E. Vuorio, V. Kähäri, 1988 .

TIMP‐3 promotes apoptosis in nonadherent small cell lung carcinoma cells lacking functional death receptor pathway

V. Kähäri, S. Hopkins-Donaldson, J. Kallio, 2011, International journal of cancer.

High level expression of tissue inhibitors of metalloproteinases-1,-2 and -3 in melanoma cells achieved by adenovirus mediated gene transfer.

V. Kähäri, M. Ahonen, A. Baker, 1998, Advances in experimental medicine and biology.

Coordinated regulation of type I and type III collagen production and mRNA levels of pro alpha 1(I) and pro alpha 2(I) collagen in cultured morphea fibroblasts.

E. Vuorio, V. Kähäri, T. Vuorio, 1987, Archives of dermatological research.

Epidermal growth factor increases collagen production in granulation tissue by stimulation of fibroblast proliferation and not by activation of procollagen genes.

E. Vuorio, V. Kähäri, M. Laato, 1987, The Biochemical journal.

Protodynamic intracellular acidification by cis-urocanic acid promotes apoptosis of melanoma cells in vitro and in vivo.

P. Taimen, V. Kähäri, H. Kujari, 2010, The Journal of investigative dermatology.

Retrospective, Registry-based, Cohort Investigation of Clinical Outcomes in Patients with Cutaneous Squamous Cell Carcinoma and Basal Cell Carcinoma in Finland

L. Ukkola-Vuoti, V. Kähäri, L. Vassilev, 2022, Acta dermato-venereologica.

Proteinases in cutaneous wound healing

V. Kähäri, M. Toriseva, 2008, Cellular and Molecular Life Sciences.

Differential regulation of extracellular matrix proteoglycan (PG) gene expression. Transforming growth factor-beta 1 up-regulates biglycan (PGI), and versican (large fibroblast PG) but down-regulates decorin (PGII) mRNA levels in human fibroblasts in culture.

H. Larjava, J. Uitto, V. Kähäri, 1991, The Journal of biological chemistry.

Human recombinant interleukin-1 regulates cellular mRNA levels of dermatan sulphate proteoglycan core protein.

J. Heino, V. Kähäri, A. Mauviel, 1988, The Biochemical journal.

High Serum Levels of Matrix Metalloproteinase-9 and Matrix Metalloproteinase-1 Are Associated with Rapid Progression in Patients with Metastatic Melanoma

P. Kellokumpu-Lehtinen, V. Kähäri, P. Vihinen, 2005, Clinical Cancer Research.

A Role for Decorin in the Structural Organization of Periodontal Ligament

Paul G Scott, Renato V Iozzo, H. Larjava, 2000, Laboratory Investigation.

Human collagenase-3 is expressed in malignant squamous epithelium of the skin.

V. Kähäri, U. Saarialho-Kere, N. Johansson, 1997, The Journal of investigative dermatology.

Matrix metalloproteinases in skin

V. Kähäri, U. Saarialho-Kere, U. Saarialho‐kere, 1997, Experimental dermatology.

European Dermatology Forum S1‐guideline on the diagnosis and treatment of sclerosing diseases of the skin, Part 1: localized scleroderma, systemic sclerosis and overlap syndromes

A. Gabrielli, L. Rudnicka, P. Wolf, 2017, Journal of the European Academy of Dermatology and Venereology : JEADV.

Expression and activity of matrix metalloproteinase‐2 and ‐9 in experimental granulation tissue

V. Kähäri, L. Ravanti, J. Ahonen, 2000, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

Risk Factors and Prognosis for Metastatic Cutaneous Squamous Cell Carcinoma: A Cohort Study

V. Kähäri, L. Nissinen, S. Kurki, 2020, Acta dermato-venereologica.

Complement System in Cutaneous Squamous Cell Carcinoma

V. Kähäri, L. Nissinen, P. Riihilä, 2019, International journal of molecular sciences.

Human Granulation-tissue Fibroblasts Show Enhanced Proteoglycan Gene Expression and Altered Response to TGF-β1

H. Larjava, J. Westermarck, V. Kähäri, 1996, Journal of dental research.

1 β Response to TGF-Human Granulation-tissue Fibroblasts Show Enhanced Proteoglycan Gene Expression and Altered

H. Larjava, J. Westermarck, V. Kähäri, 2022 .

Matrix metalloproteinases in inflammation.

V. Kähäri, L. Nissinen, Veli-Matti Kähäri, 2014, Biochimica et biophysica acta.

Epidermal growth factor (EGF) prevents methylprednisolone-induced inhibition of wound healing.

J. Heino, V. Kähäri, M. Laato, 1989, The Journal of surgical research.

The Role of p53 in Progression of Cutaneous Squamous Cell Carcinoma

V. Kähäri, L. Nissinen, P. Riihilä, 2021, Cancers.

Matrix metalloproteinase‐7 activates heparin‐binding epidermal growth factor‐like growth factor in cutaneous squamous cell carcinoma

J. McGrath, R. Grenman, R. Ala-aho, 2010, The British journal of dermatology.

Matrix metalloproteinases in keratinocyte carcinomas

V. Kähäri, L. Nissinen, P. Riihilä, 2020, Experimental dermatology.

p38 Mitogen-Activated Protein Kinase-Dependent Activation of Protein Phosphatases 1 and 2A Inhibits MEK1 and MEK2 Activity and Collagenase 1 (MMP-1) Gene Expression

Jiahuai Han, J. Westermarck, V. Kähäri, 2001, Molecular and Cellular Biology.

Distinct populations of stromal cells express collagenase-3 (MMP-13) and collagenase-1 (MMP-1) in chronic ulcers but not in normally healing wounds.

M. Karjalainen‐Lindsberg, V. Kähäri, U. Saarialho-Kere, 1997, The Journal of investigative dermatology.

Comparative effects of interleukin-1 and tumor necrosis factor-alpha on collagen production and corresponding procollagen mRNA levels in human dermal fibroblasts.

D. Hartmann, J. Heino, E. Vuorio, 1991, The Journal of investigative dermatology.

Induction of Collagenase-3 (MMP-13) Expression in Human Skin Fibroblasts by Three-dimensional Collagen Is Mediated by p38 Mitogen-activated Protein Kinase*

C. López-Otín, J. Heino, V. Kähäri, 1999, The Journal of Biological Chemistry.

MicroRNA-203 Inversely Correlates with Differentiation Grade, Targets c-MYC, and Functions as a Tumor Suppressor in cSCC.

J. Lapins, J. Lovén, D. Grandér, 2016, The Journal of investigative dermatology.

Association between high collagenase‐3 expression levels and poor prognosis in patients with head and neck cancer

P. Kronqvist, T. Vahlberg, V. Kähäri, 2006, Head & neck.

p53-regulated long non-coding RNA PRECSIT promotes progression of cutaneous squamous cell carcinoma via STAT3 signaling.

V. Kähäri, S. Peltonen, J. Peltonen, 2019, The American journal of pathology.

Long non-coding RNAs in cutaneous biology and keratinocyte carcinomas

V. Kähäri, L. Nissinen, M. Piipponen, 2020, Cellular and Molecular Life Sciences.

Expression Profiles and Clinical Correlations of Degradome Components in the Tumor Microenvironment of Head and Neck Squamous Cell Carcinoma

Y. Okada, R. Ala-aho, V. Kähäri, 2010, Clinical Cancer Research.

Coordinated regulation of type I and type III collagen production and mRNA levels of pro α1(I) and pro α2(I) collagen in cultured morphea fibroblasts

E. Vuorio, V. Kähäri, T. Vuorio, 2004, Archives of Dermatological Research.

MAPK/ERK Overrides the Apoptotic Signaling from Fas, TNF, and TRAIL Receptors*

S. E. F. Tran, J. Eriksson, V. Kähäri, 2001, The Journal of Biological Chemistry.

Complement Factor D Is a Novel Biomarker and Putative Therapeutic Target in Cutaneous Squamous Cell Carcinoma

S. Meri, V. Kähäri, S. Peltonen, 2022, Cancers.

Transformation‐specific matrix metalloproteinases (MMP)‐7 and MMP‐13 are expressed by tumour cells in epidermolysis bullosa‐associated squamous cell carcinomas

H. Shimizu, J. McGrath, V. Kähäri, 2008, The British journal of dermatology.

MMP-13 Regulates Growth of Wound Granulation Tissue and Modulates Gene Expression Signatures Involved in Inflammation, Proteolysis, and Cell Viability

S. Krane, V. Kähäri, M. Laato, 2012, PloS one.

Hypoxic conversion of SMAD7 function from an inhibitor into a promoter of cell invasion.

P. Jaakkola, V. Kähäri, T. Jokilehto, 2010, Cancer research.

Transforming growth factor-beta signaling in cancer invasion and metastasis.

S. Leivonen, V. Kähäri, 2007, International journal of cancer.

Collagenase‐3 (MMP‐13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development

J. Heino, E. Vuorio, J. Westermarck, 1997, Developmental dynamics : an official publication of the American Association of Anatomists.

Transcription of alpha2 integrin gene in osteosarcoma cells is enhanced by tumor promoters.

J. Heino, J. Westermarck, V. Kähäri, 1998, Experimental cell research.

Diagnostic and prognostic role of matrix metalloproteases in cancer.

R. Ala-aho, V. Kähäri, P. Vihinen, 2008, Expert opinion on medical diagnostics.

Inhibition of c-Abl Kinase Activity Renders Cancer Cells Highly Sensitive to Mitoxantrone

S. Hietanen, V. Kähäri, M. Kallio, 2014, PloS one.

Matrix Metalloproteinase-13 Promotes Recovery from Experimental Liver Cirrhosis in Rats

R. Ala-aho, V. Kähäri, J. Itoh, 2011, Pathobiology.

Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1.

G. Evan, H. Joensuu, J. Marine, 2013, Cancer discovery.

Endothelial cell–Matrix interactions

J. Heino, V. Kähäri, K. Elenius, 2003, Microscopy research and technique.

CCHCR1 Is Up-Regulated in Skin Cancer and Associated with EGFR Expression

Leena Latonen, Juha Kere, Jenita Pärssinen, 2009, PloS one.

Regulation of matrix metalloproteinase expression in tumor invasion

J. Westermarck, V. Kähäri, 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Serpin peptidase inhibitor clade A member 1 (SerpinA1) is a novel biomarker for progression of cutaneous squamous cell carcinoma.

R. Ala-aho, V. Kähäri, J. Peltonen, 2011, The American journal of pathology.

Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinases-3 inhibits invasion and induces apoptosis in melanoma cells.

V. Kähäri, M. Ahonen, A. Baker, 1998, Cancer research.

Matrix metalloproteinases in tumor invasion

V. Kähäri, M. Ahonen, N. Johansson, 2000, Cellular and Molecular Life Sciences CMLS.

New perspectives on role of tumor microenvironment in progression of cutaneous squamous cell carcinoma

V. Kähäri, L. Nissinen, P. Riihilä, 2016, Cell and Tissue Research.

The Viability and Growth of HaCaT Cells After Exposure to Bioactive Glass S53P4-Containing Cell Culture Media

V. Kähäri, L. Nissinen, P. Boström, 2021, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

Long Noncoding RNA PICSAR Promotes Growth of Cutaneous Squamous Cell Carcinoma by Regulating ERK1/2 Activity.

V. Kähäri, S. Peltonen, J. Peltonen, 2016, The Journal of investigative dermatology.

Long non-coding RNA PICSAR decreases adhesion and promotes migration of squamous carcinoma cells by downregulating α2β1 and α5β1 integrin expression

J. Heino, V. Kähäri, L. Nissinen, 2018, Biology Open.

Matrix metalloproteinases in squamous cell carcinoma.

V. Kähäri, N. Johansson, 2000, Histology and histopathology.

Signaling pathways in human osteoclasts differentiation: ERK1/2 as a key player

V. Kähäri, S. Peltonen, J. Peltonen, 2021, Molecular Biology Reports.

EGF‐R regulates MMP function in fibroblasts through MAPK and AP‐1 pathways

S. Leivonen, M. Birrer, V. Kähäri, 2007, Journal of cellular physiology.

Discovery of NOvel CIP2A VAriant (NOCIVA) and its clinical relevance in myeloid leukemias

R. Clark, J. Westermarck, V. Kähäri, 2020, bioRxiv.

Role of thymic peptides as transmitters between the neuroendocrine and immune systems.

V. Kähäri, U. Saarialho-Kere, U. Saarialho‐kere, 1999 .

Matrix metalloproteinases and their inhibitors in tumour growth and invasion.

V. Kähäri, U. Saarialho-Kere, V. Kahari, 1999, Annals of medicine.

2 F 1-CIP 2 A feedback loop prevents senescence induction in breast cancer cells with inactive p 53

G. Evan, H. Joensuu, J. Marine, 2012 .

Transcriptional targeting of adenoviral gene delivery into migrating wound keratinocytes using FiRE, a growth factor-inducible regulatory element

P. Jaakkola, V. Kähäri, M. Ahonen, 2000, Gene Therapy.

TGF-β-Elicited Induction of Tissue Inhibitor of Metalloproteinases (TIMP)-3 Expression in Fibroblasts Involves Complex Interplay between Smad3, p38α, and ERK1/2

S. Leivonen, V. Kähäri, D. Edwards, 2013, PloS one.

New prognostic factors and developing therapy of cutaneous melanoma

V. Kähäri, P. Vihinen, S. Pyrhönen, 2003, Annals of medicine.

Complement factor H: a biomarker for progression of cutaneous squamous cell carcinoma.

S. Meri, R. Ala-aho, V. Kähäri, 2014, The Journal of investigative dermatology.

Loss of the laminin subunit alpha‐3 induces cell invasion and macrophage infiltration in cutaneous squamous cell carcinoma *

V. Kähäri, L. Nissinen, E. Jones, 2020, The British journal of dermatology.

Clinical and Pathological Aspects of Melanoma among Children in Finland.

V. Kähäri, M. Kääriäinen, I. Koskivuo, 2016, Acta dermato-venereologica.

Integrin α2β1 Promotes Activation of Protein Phosphatase 2A and Dephosphorylation of Akt and Glycogen Synthase Kinase 3β

J. Heino, J. Eriksson, V. Kähäri, 2002, Molecular and Cellular Biology.

Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.

J. Heino, J. Eriksson, V. Kähäri, 2002, Molecular and cellular biology.

Serum VEGF-C is associated with metastatic site in patients with malignant melanoma

K. Syrjänen, V. Kähäri, P. Vihinen, 2007, Acta oncologica.

Matrix metalloproteinases in wound repair (review).

V. Kähäri, V M Kähäri, L Ravanti, 2000, International journal of molecular medicine.

Different expression of BRAFV600E, ALK and PD-L1 in melanoma in children and adolescents: a nationwide retrospective study in Finland in 1990–2014

L. Talve, V. Kähäri, P. Vihinen, 2020, Acta oncologica.

Increased incidence of melanoma in children and adolescents in Finland in 1990–2014: nationwide re-evaluation of histopathological characteristics

L. Talve, V. Kähäri, P. Vihinen, 2022, Annals of medicine.

Complement factor I promotes progression of cutaneous squamous cell carcinoma.

S. Meri, R. Ala-aho, V. Kähäri, 2015, The Journal of investigative dermatology.

Interferon-gamma-induced inhibition of wound healing in vivo and in vitro.

J. Heino, V. Kähäri, M. Laato, 2001, Annales chirurgiae et gynaecologiae. Supplementum.

Tumor cell-specific AIM2 regulates growth and invasion of cutaneous squamous cell carcinoma

V. Kähäri, S. Peltonen, J. Peltonen, 2017, Oncotarget.

Collagenase 3 (matrix metalloproteinase 13) gene expression by HaCaT keratinocytes is enhanced by tumor necrosis factor alpha and transforming growth factor beta.

C. López-Otín, J. Heino, J. Westermarck, 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC.

J. McGrath, V. Kähäri, D. Murrell, 2016, Journal of the National Cancer Institute.

Upregulation of Collagen Gene Transcription by a Mechanism Involving the a 2 Cytoplasmic Tail

J. Heino, J. Westermarck, V. Kähäri, 1999 .

Targeted inhibition of human collagenase-3 (MMP-13) expression inhibits squamous cell carcinoma growth in vivo

R. Ala-aho, V. Kähäri, M. Ahonen, 2004, Oncogene.

Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase.

C. López-Otín, N. Fusenig, R. Ala-aho, 2000, Journal of cell science.

Activation of tissue inhibitor of metalloproteinases-3 (TIMP-3) mRNA expression in scleroderma skin fibroblasts.

V. Kähäri, M. Ahonen, U. Saarialho-Kere, 1998, The Journal of investigative dermatology.

Expression of osteonectin, decorin, and transforming growth factor-beta 1 genes in fibroblasts cultured from patients with systemic sclerosis and morphea.

E. Vuorio, V. Kähäri, C. Black, 1991, The Journal of rheumatology.

EphB2 Promotes Progression of Cutaneous Squamous Cell Carcinoma.

R. Ala-aho, V. Kähäri, S. Peltonen, 2015, Journal of Investigative Dermatology.

Squamous cell carcinoma of the skin: Emerging need for novel biomarkers.

V. Kähäri, A. Kivisaari, 2013, World journal of clinical oncology.

Inhibition of collagenase-3 (MMP-13) expression in transformed human keratinocytes by interferon-γ is associated with activation of extracellular signal-regulated kinase-1,2 and STAT1

C. López-Otín, N. Fusenig, R. Ala-aho, 2000, Oncogene.

Human TIMP-3 Is Expressed During Fetal Development, Hair Growth Cycle, and Cancer Progression

J. Kere, P. Heikkilä, V. Kähäri, 1998, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Metalloelastase (MMP‐12) expression by tumour cells in squamous cell carcinoma of the vulva correlates with invasiveness, while that by macrophages predicts better outcome

S. Shapiro, S. Grénman, R. Ala-aho, 2002, The Journal of pathology.

A metaphyseal defect model of the femur for studies of murine bone healing.

E. Vuorio, V. Kähäri, M. Ahonen, 2001, Bone.

Collagenase-1, stromelysin-1 and 92 kDa gelatinase are associated with tumor necrosis factor-alpha induced morphological change of human endothelial cells in vitro.

V. Kähäri, S. Nikkari, H. Järveläinen, 1998, Matrix biology : journal of the International Society for Matrix Biology.

Complement Component C3 and Complement Factor B Promote Growth of Cutaneous Squamous Cell Carcinoma.

S. Meri, V. Kähäri, S. Peltonen, 2017, The American journal of pathology.

TUMORIGENESIS AND NEOPLASTIC PROGRESSION Complement Component C 3 and Complement Factor B Promote Growth of Cutaneous Squamous Cell Carcinoma

S. Meri, V. Kähäri, S. Peltonen, 2022 .

C1r Upregulates Production of Matrix Metalloproteinase-13 and Promotes Invasion of Cutaneous Squamous Cell Carcinoma.

J. Heino, S. Meri, V. Kähäri, 2021, The Journal of investigative dermatology.

Tumour‐cell‐derived complement components C1r and C1s promote growth of cutaneous squamous cell carcinoma†

S. Meri, V. Kähäri, S. Peltonen, 2019, The British journal of dermatology.

p38δ mitogen-activated protein kinase regulates the expression of tight junction protein ZO-1 in differentiating human epidermal keratinocytes

V. Kähäri, S. Peltonen, J. Peltonen, 2014, Archives of Dermatological Research.

Identification of metastatic primary cutaneous squamous cell carcinoma utilizing artificial intelligence analysis of whole slide images

L. Talve, V. Kähäri, L. Nissinen, 2022, Scientific Reports.

266 Identification of metastatic primary cutaneous squamous cell carcinoma using artificial intelligence analysis of whole slide images

L. Talve, V. Kähäri, L. Nissinen, 2021, Journal of Investigative Dermatology.

Transforming Growth Factor-β Induces Collagenase-3 Expression by Human Gingival Fibroblasts via p38 Mitogen-activated Protein Kinase*

Jiahuai Han, H. Larjava, V. Kähäri, 1999, The Journal of Biological Chemistry.

Matrix metalloproteinases as therapeutic targets in cancer.

R. Ala-aho, V. Kähäri, P. Vihinen, 2005, Current cancer drug targets.

Temporospatial expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in mouse antigen-induced arthritis

E. Vuorio, V. Kähäri, K. Joronen, 2005, Histochemistry and Cell Biology.

Extended release of adenovirus from silica implants in vitro and in vivo

U. Stenman, R. Ala-aho, V. Kähäri, 2009, Gene Therapy.

Collagenase-3 (MMP-13) enhances remodeling of three-dimensional collagen and promotes survival of human skin fibroblasts.

J. Heino, R. Ala-aho, V. Kähäri, 2007, The Journal of investigative dermatology.

Interferon-alpha and interferon-gamma reduce excessive collagen synthesis and procollagen mRNA levels of scleroderma fibroblasts in culture.

J. Heino, E. Vuorio, V. Kähäri, 1988, Biochimica et biophysica acta.

TNF-R55-specific form of human tumor necrosis factor-alpha induces collagenase gene expression by human skin fibroblasts.

W. Fiers, J. Westermarck, V. Kähäri, 1995, The Journal of investigative dermatology.

Deletion analyses of 5'-flanking region of the human elastin gene. Delineation of functional promoter and regulatory cis-elements.

J. Rosenbloom, J. Uitto, V. Kähäri, 1990, The Journal of biological chemistry.

H-Ras activation and fibroblast-induced TGF-β signaling promote laminin-332 accumulation and invasion in cutaneous squamous cell carcinoma.

J. Heino, V. Kähäri, L. Nissinen, 2020, Matrix biology : journal of the International Society for Matrix Biology.

Complement factor I upregulates expression of matrix metalloproteinase‐13 and ‐2 and promotes invasion of cutaneous squamous carcinoma cells

S. Meri, V. Kähäri, L. Nissinen, 2021, Experimental dermatology.

Discovery of a Novel CIP2A Variant (NOCIVA) with Clinical Relevance in Predicting TKI Resistance in Myeloid Leukemias

L. Elo, R. Clark, J. Westermarck, 2021, Clinical Cancer Research.

Integrin alpha 2 beta 1 is a positive regulator of collagenase (MMP-1) and collagen alpha 1(I) gene expression.

J. Heino, J. Westermarck, V. Kähäri, 1995, The Journal of biological chemistry.

Suprabasal expression of epidermal alpha 2 beta 1 and alpha 3 beta 1 integrins in skin treated with topical retinoic acid.

J. Heino, J. Westermarck, V. Kähäri, 1998, The British journal of dermatology.

ADAMTS5: A New Player in the Vascular Field.

V. Kähäri, L. Nissinen, 2012, The American journal of pathology.

Dexamethasone suppresses elastin gene expression in human skin fibroblasts in culture.

V. Kähäri, 1994, Biochemical and biophysical research communications.

ADAMTS5: A New Player in the Vascular Field.

V. Kähäri, L. Nissinen, 2012, The American journal of pathology.

Characterization of One Phenotype of Human Periodontal Granulation-tissue Fibroblasts

J. Heino, V. Kähäri, T. Krusius, 1989, Journal of dental research.

Targeting Myofibroblasts in Dermal Fibrosis: A Retinoid Connection.

V. Kähäri, L. Nissinen, 2023, The Journal of investigative dermatology.

Inhibition of TGF-β signaling, invasion, and growth of cutaneous squamous cell carcinoma by PLX8394

V. Kähäri, L. Nissinen, M. Kallajoki, 2023, Oncogene.

Skin type VII collagen acts as a tumor suppressor by regulating TGF and angiogenesis

J. McGrath, V. Kähäri, D. Murrell, 2017 .

Activation of extracellular signal-regulated protein kinase1,2 results in down-regulation of decorin expression in fibroblasts.

V. Kähäri, M. Foschi, N. Reunanen, 2000, The Biochemical journal.

EphB2 Promotes Progression of Cutaneous Squamous Cell Carcinoma.

V. Kähäri, S. Peltonen, J. Peltonen, 2015, The Journal of investigative dermatology.

European Dermatology Forum S1‐guideline on the diagnosis and treatment of sclerosing diseases of the skin, Part 1: localized scleroderma, systemic sclerosis and overlap syndromes

A. Gabrielli, L. Rudnicka, P. Wolf, 2017, Journal of the European Academy of Dermatology and Venereology : JEADV.

Cancer-associated fibroblast activation predicts progression, metastasis, and prognosis of cutaneous squamous cell carcinoma.

T. Pellinen, V. Kähäri, L. Nissinen, 2024, International Journal of Cancer.