J. Schuetz

Ji-Young Lee, J. Schuetz, Ajay C Donepudi, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Differential effects of thiopurine methyltransferase (TPMT) and multidrug resistance-associated protein gene 4 (MRP4) on mercaptopurine toxicity

M. Relling, W. Evans, J. Schuetz, 2017, Cancer Chemotherapy and Pharmacology.

Protection against chemotherapy-induced alopecia: targeting ATP-binding cassette transporters in the hair follicle?

R. Paus, J. Schuetz, I. Haslam, 2013, Trends in pharmacological sciences.

The MYND Motif Is Required for Repression of Basal Transcription from the Multidrug Resistance 1 Promoter by the t(8;21) Fusion Protein

J. Schuetz, S. Hiebert, B. Lutterbach, 1998, Molecular and Cellular Biology.

ATP-dependent Mitochondrial Porphyrin Importer ABCB6 Protects against Phenylhydrazine Toxicity*

J. Rehg, P. Potter, J. Schuetz, 2012, The Journal of Biological Chemistry.

Use of human hepatocytes to study P450 gene induction.

S. Strom, E. Schuetz, J. Schuetz, 1996, Methods in enzymology.

Bromocriptine Transcriptionally Activates the Multidrug Resistance Gene (pgp2/mdr1b) by a Novel Pathway*

M. Sharif, E. Schuetz, J. Schuetz, 1997, The Journal of Biological Chemistry.

Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line.

J. Schuetz, L. Matherly, I. Goldman, 1988, The Journal of biological chemistry.

Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat.

J. Boyer, J. Schuetz, C. Soroka, 2004, Journal of hepatology.

Interactions between Hepatic Mrp4 and Sult2a as Revealed by the Constitutive Androstane Receptor and Mrp4 Knockout Mice*

R. Evans, D. Moore, G. Reid, 2004, Journal of Biological Chemistry.

A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer

J. Schuetz, T. Nakanishi, M. Oshima, 2017, Scientific Reports.

Regulation of cytochrome P-450b/e and P-450p gene expression by growth hormone in adult rat hepatocytes cultured on a reconstituted basement membrane.

E. Schuetz, J. Schuetz, P. Guzelian, 1990, The Journal of biological chemistry.

Induction of P‐Glycorprotein mRNA by protein synthesis inhibition is not controlled by a transcriptional repressor protein in rat and human liver cells

S. Strom, E. Schuetz, J. Schuetz, 1995 .

Divergent effects of cycloheximide on the induction of class II and class III cytochrome P450 mRNAs in cultures of adult rat hepatocytes.

E. Schuetz, J. Schuetz, P. Guzelian, 1990, Archives of biochemistry and biophysics.

Involvement of Multiple Efflux Transporters in Hepatic Disposition of Fexofenadine

K. Maeda, H. Kusuhara, Y. Sugiyama, 2008, Molecular Pharmacology.

Biology of Mitochondrial ABCs and Their Contribution to Pathology

J. Schuetz, John Lynch, Y. Fukuda, 2016 .

Evaluation of the Role of Breast Cancer Resistance Protein (BCRP/ABCG2) and Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) in The Urinary Excretion of Sulfate and Glucuronide Metabolites of Edaravone (MCI-186; 3-Methyl-1-phenyl-2-pyrazolin-5-one)

Yuichi Sugiyama, Hiroyuki Kusuhara, H. Kusuhara, 2007, Drug Metabolism and Disposition.

Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy

P. Wielinga, J. Panetta, J. Schuetz, 2004, Molecular and Cellular Biology.

Multidrug resistance-associated protein 4 is involved in the urinary excretion of hydrochlorothiazide and furosemide.

Yuichi Sugiyama, Hiroyuki Kusuhara, Kenji Takeuchi, 2007, Journal of the American Society of Nephrology : JASN.

Investigation of the Importance of Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4) in the Active Efflux of Anionic Drugs Across the Blood-Brain Barrier.

H. Kusuhara, Y. Sugiyama, J. Schuetz, 2017, Journal of pharmaceutical sciences.

Limited Brain Distribution of [3R,4R,5S]-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate Phosphate (Ro 64-0802), a Pharmacologically Active Form of Oseltamivir, by Active Efflux across the Blood-Brain Barrier Mediated by Organic Anion Transporter 3 (Oat3/Slc22a8) and Multidrug Res

H. Kusuhara, Y. Sugiyama, M. Kanai, 2009, Drug Metabolism and Disposition.

Unimpaired immune functions in the absence of Mrp4 (Abcc4).

T. D. de Gruijl, J. Schuetz, G. Scheffer, 2009, Immunology letters.

Multiple Human Isoforms of Drug Transporters Contribute to the Hepatic and Renal Transport of Olmesartan, a Selective Antagonist of the Angiotensin II AT1-Receptor

Kazuya Maeda, Yuichi Sugiyama, Teruo Okano, 2007, Drug Metabolism and Disposition.

Increasing Systemic Exposure of Methotrexate by Active Efflux Mediated by Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3)

H. Kusuhara, Y. Sugiyama, J. Schuetz, 2008, Journal of Pharmacology and Experimental Therapeutics.

Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein.

R. Kim, E. Schuetz, J. Schuetz, 2000, Molecular pharmacology.

Functional Involvement of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) in the Renal Elimination of the Antiviral Drugs Adefovir and Tenofovir

Yuichi Sugiyama, Hiroyuki Kusuhara, Kenji Takeuchi, 2007, Molecular Pharmacology.

Human Immunodeficiency Virus Protease Inhibitors Interact with ATP Binding Cassette Transporter 4/Multidrug Resistance Protein 4: A Basis for Unanticipated Enhanced Cytotoxicity

S. Ekins, J. Schuetz, S. Ambudkar, 2013, Molecular Pharmacology.

Human Immunodeficiency Virus Protease Inhibitors Interact with ATP Binding Cassette Transporter 4 / Multidrug Resistance Protein 4 : A Basis for Unanticipated Enhanced Cytotoxicity s

S. Ekins, J. Schuetz, S. Ambudkar, 2013 .

Expression of the Pregnane X Receptor in Mice Antagonizes the Cholic Acid–Mediated Changes in Plasma Lipoprotein Profile

E. Schuetz, J. Schuetz, P. Gambert, 2005, Arteriosclerosis, thrombosis, and vascular biology.

Tobacco carcinogen NNK transporter MRP2 regulates CFTR function in lung epithelia: implications for lung cancer.

J. Schuetz, A. Naren, Chunying Li, 2010, Cancer letters.

Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in vivo.

F. Saletta, J. Schuetz, J. Fletcher, 2017, European journal of cancer.

Compartmentalized Accumulation of cAMP near Complexes of Multidrug Resistance Protein 4 (MRP4) and Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Contributes to Drug-induced Diarrhea*

J. Schuetz, H. D. de Jonge, R. Buddington, 2015, The Journal of Biological Chemistry.

p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents.

E. Schuetz, G. Zambetti, J. Schuetz, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Advances in Brief Imatinib Mesylate Is a Potent Inhibitor of the ABCG 2 ( BCRP ) Transporter and Reverses Resistance to Topotecan and SN-38 in Vitro

P. Houghton, P. Traxler, E. Buchdunger, 2004 .

Imatinib Mesylate Is a Potent Inhibitor of the ABCG2 (BCRP) Transporter and Reverses Resistance to Topotecan and SN-38 in Vitro

P. Houghton, P. Traxler, E. Buchdunger, 2004, Cancer Research.

CHARACTERIZATION OF TRANSPORT PROTEIN EXPRESSION IN MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN (MRP) 2-DEFICIENT RATS

Peijin Zhang, K. Brouwer, J. Schuetz, 2006, Drug Metabolism and Disposition.

An unexpected protein interaction promotes drug resistance in leukemia

J. Downing, Jing Ma, Taosheng Chen, 2017, Nature Communications.

Induction of Mdr1b expression by tumor necrosis factor‐α in rat liver cells is independent of p53 but requires NF‐κB signaling

M. Manns, C. Trautwein, J. Schuetz, 2001 .

Abcb11 Deficiency Induces Cholestasis Coupled to Impaired β-Fatty Acid Oxidation in Mice*

G. Neale, J. Schuetz, F. Gonzalez, 2012, The Journal of Biological Chemistry.

Deregulated Hepatic Metabolism Exacerbates Impaired Testosterone Production in Mrp4-deficient Mice*

G. Neale, J. Schuetz, K. Boyd, 2012, The Journal of Biological Chemistry.

Lack of multidrug resistance-associated protein 4 (Mrp4) alters the kinetics of acetaminophen toxicity

J. Schuetz, Ajay C Donepudi, Michael J Goedken, 2019, Toxicology reports.

Multidrug-resistance-associated protein 1 (Mrp1) is probably not required for murine Th cell activation.

J. Schuetz, M. Huber, M. Lohoff, 2006, International immunology.

Renal and hepatic family 3A cytochromes P450 (CYP3A) in spontaneously hypertensive rats.

L. Kramer, J. Schuetz, W. Grogan, 1995, Biochemical pharmacology.

ABCB6, an ABC Transporter Impacting Drug Response and Disease

J. Schuetz, Y. Fukuda, Rebba C. Boswell-Casteel, 2017, The AAPS Journal.

Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene.

E. Schuetz, J. Schuetz, K. Yasuda, 1998, Archives of biochemistry and biophysics.

Extracellular matrix regulation of multidrug resistance in primary monolayer cultures of adult rat hepatocytes.

E. Schuetz, J. Schuetz, 1993, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy.

M. Roussel, A. Shelat, D. Kawauchi, 2015, Cancer research.

A method for the synchronization of cultured cells with aphidicolin: application to the large-scale synchronization of L1210 cells and the study of the cell cycle regulation of thymidylate synthase and dihydrofolate reductase.

J. Schuetz, L. Matherly, I. Goldman, 1989, Analytical biochemistry.

Isolation of CYP3A5P cDNA from human liver: a reflection of a novel cytochrome P-450 pseudogene.

J. Schuetz, P. Guzelian, 1995, Biochimica et biophysica acta.

Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death

Jie J. Zheng, J. Opferman, D. Green, 2015, Scientific Reports.

Divergent regulation of the class II P-glycoprotein gene in primary cultures of hepatocytes versus H35 hepatoma by glucocorticoids.

E. Schuetz, J. Schuetz, J. Thottassery, 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

IDH1 and IDH2 mutations in pediatric acute leukemia

S. Shurtleff, I. Radtke, C. Mullighan, 2011, Leukemia.

Prostaglandin signaling regulates ciliogenesis by modulating intraflagellar transport

Terri T. Ni, Bin Zhou, J. Schuetz, 2014, Nature Cell Biology.

Morphogen Directed Coordination of GPCR Activity Promotes Primary Cilium Function for Downstream Signaling

Elaine L. Shelton, Yan Zhang, S. Ogden, 2022, bioRxiv.

Creation of Polarized Cells Coexpressing CYP3A4, NADPH Cytochrome P450 Reductase and MDR1/P-glycoprotein

M. Relling, E. Schuetz, J. Schuetz, 2004, Pharmaceutical Research.

University of Groningen Expression and regulation of ABC transporter genes during liver regeneration

M. Manns, C. Trautwein, J. Schuetz, 2017 .

Chapter 5 Induction of Mdr 1 b expression by tumor necrosis factor-α in rat liver cells is independent of p 53 but requires NF-κ B signaling

M. Manns, C. Trautwein, J. Schuetz, 2002 .

Maternal bile acid transporter deficiency promotes neonatal demise

C. Rock, Fei Li, G. Neale, 2015, Nature Communications.

Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes.

M. Relling, L. Nguyen, E. Schuetz, 2000, Molecular pharmacology.

The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6

E. Rampersaud, M. Weiss, P. Bond, 2016, Nature Communications.

Regulation of gene expression by miR-144/451 during mouse erythropoiesis.

Z. Mourelatos, Gang Wu, M. Weiss, 2019, Blood.

Zebrafish abcb11b mutant reveals strategies to restore bile excretion impaired by bile salt export pump deficiency

E. Schuetz, J. Schuetz, Chunyue Yin, 2018, Hepatology.

Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells.

S. Strom, E. Schuetz, J. Schuetz, 1996, Molecular pharmacology.

Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes.

E. Schuetz, J. Schuetz, P. Guzelian, 1992, Proceedings of the National Academy of Sciences of the United States of America.

DMD057539 541..545

D. Tweedie, P. Swaan, J. Schuetz, 2014 .

Impaired 2',3'-dideoxy-3'-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11.

C. Scagnolari, O. Turriziani, G. Antonelli, 2002, The Biochemical journal.

Profiling placental DNA methylation associated with maternal SSRI treatment during pregnancy

C. Marsit, E. Portales-Casamar, T. Oberlander, 2022, Scientific Reports.

Development and Validation of a Sensitive and Specific LC-MS/MS Method for IWR-1-Endo, a Wnt Signaling Inhibitor: Application to a Cerebral Microdialysis Study

J. Schuetz, C. Stewart, O. Campagne, 2022, Molecules.

The ABCC4 membrane transporter modulates platelet aggregation.

J. Schuetz, Y. Fukuda, T. Pestina, 2015, Blood.

Linker Domains: Why ABC Transporters 'Live in Fragments no Longer'.

J. Schuetz, R. Ford, Dominic Marshall-Sabey, 2019, Trends in biochemical sciences.

Heme-Sensing Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics

Shondra M. Pruett-Miller, J. Opferman, C. Mullighan, 2020, bioRxiv.

Dihydrofluorouracil, a fluorouracil catabolite with antitumor activity in murine and human cells.

R. Diasio, J. Schuetz, J. Sommadossi, 1985, Cancer research.

Deficiency of ATP binding cassette transporter b6 in megakaryocyte progenitors accelerates atherosclerosis in mice

A. Murphy, J. Schuetz, C. Welch, 2014 .

Reduced folate carrier expression in acute lymphoblastic leukemia: a mechanism for ploidy but not lineage differences in methotrexate accumulation.

S. Raimondi, M. Relling, C. Pui, 1999, Blood.

The effect of 5-fluorouracil on DNA chain elongation in intact bone marrow cells.

R. Diasio, J. Schuetz, 1985, Biochemical and biophysical research communications.

Promoter and Intronic Sequences of the Human Thiopurine S-Methyltransferase (TPMT) Gene Isolated from a Human Pacl Genomic Library

J. Schuetz, W. Evans, C. R. Yates, 1997, Pharmaceutical Research.

A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase.

M. Relling, C. Pui, W. Evans, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Heterogeneity of cytochrome P450IIIA expression in rat gut epithelia

J. Kolars, P. Watkins, S. Wrighton, 1992 .

Structural and functional analysis of the human TPMT gene promoter.

J. Schuetz, W. Evans, M. Fessing, 1998, Advances in experimental medicine and biology.

PPIX-binding Proteins Reveal Porphyrin Synthesis and Ferroptosis Link

J. Schuetz, Junmin Peng, John Lynch, 2022, bioRxiv.

PLATELETS AND THROMBOPOIESIS The ABCC 4 membrane transporter modulates platelet aggregation

J. Schuetz, Y. Fukuda, T. Pestina, 2015 .

ABCC 4 , a plasma membrane transporter modulating platelet aggregation

J. Schuetz, Y. Fukuda, T. Pestina, 2015 .

The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma

Shondra M. Pruett-Miller, Samuel W. Brady, M. Babu, 2021, Nature Communications.

Forskolin modifies retinal vascular development in Mrp4-knockout mice.

K. Maruyama, H. Kusuhara, J. Schuetz, 2012, Investigative ophthalmology & visual science.

Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms.

M. Relling, J. Schuetz, M. Relling, 1996, Pharmacogenetics.

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

Ann Daly, Jatinder Lamba, M. Boguski, 2001, Nature Genetics.

Nonsense mediated decay downregulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons.

E. Schuetz, J. Schuetz, R. Allikmets, 2003, Human molecular genetics.

Involvement of MRP4 (ABCC4) in the Luminal Efflux of Ceftizoxime and Cefazolin in the Kidney

H. Kusuhara, Y. Sugiyama, J. Schuetz, 2007, Molecular Pharmacology.

The ABC Transporter Abcg2/Bcrp: Role in Hypoxia Mediated Survival

J. Schuetz, P. Krishnamurthy, Partha Krishnamurthy, 2005, Biometals.

Identification of a new P-glycoprotein-like ATP-binding cassette transporter gene that is overexpressed during hepatocarcinogenesis.

E. Schuetz, J. Schuetz, K. Furuya, 1997, Cancer research.

Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters

S. Ekins, T. Shaw, D. Finkelstein, 2021, PloS one.

The effects of prolonged treatment with zidovudine, lamivudine, and abacavir on a T-lymphoblastoid cell line.

O. Turriziani, A. Pierangeli, G. Antonelli, 2006, AIDS research and human retroviruses.

MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

J. Schuetz, Alok Kumar, M. Connelly, 1999, Nature Medicine.

Alteration of the secondary structure of newly synthesized DNA from murine bone marrow cells by 5-fluorouracil.

R. Diasio, J. Schuetz, J. Collins, 1986, Cancer research.

DNA repair following incorporation of 5-fluorouracil into DNA of mouse bone marrow cells

R. Diasio, J. Schuetz, H. Wallace, 1988, Cancer Chemotherapy and Pharmacology.

The Stem Cell Marker Bcrp/ABCG2 Enhances Hypoxic Cell Survival through Interactions with Heme*

J. Schuetz, D. Ross, T. Nakanishi, 2004, Journal of Biological Chemistry.

ABC transporters and their role in nucleoside and nucleotide drug resistance.

J. Schuetz, Y. Fukuda, John D Schuetz, 2012, Biochemical pharmacology.

Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells.

J. Wijnholds, R. D. De Abreu, J. Beijnen, 2002, Molecular pharmacology.

Sp1 and Egr-1 Have Opposing Effects on the Regulation of the RatPgp2/mdr1b Gene*

V. Sukhatme, E. Schuetz, G. Zambetti, 1999, The Journal of Biological Chemistry.

The role of transporters in cellular heme and porphyrin homeostasis.

J. Schuetz, P. Krishnamurthy, Tao Xie, 2007, Pharmacology & therapeutics.

Obstacles to Brain Tumor Therapy: Key ABC Transporters

J. Schuetz, Y. Fukuda, J. Wijaya, 2017, International journal of molecular sciences.

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration

Daniel P. Stewart, D. Green, J. Opferman, 2012, Nature Cell Biology.

Development and validation of an LC-MS/MS method to quantify the bromodomain and extra-terminal (BET) inhibitor JQ1 in mouse plasma and brain microdialysate: Application to cerebral microdialysis study.

J. Schuetz, C. Stewart, O. Campagne, 2021, Journal of Pharmaceutical and Biomedical Analysis.

Phenotypic variability in induction of p‐glycoprotein mrna by aromatic hydrocarbons in primary human hepatocytes

S. Strom, E. Schuetz, J. Schuetz, 1995, Molecular carcinogenesis.

Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans

M. Relling, P. Watkins, Xin Chen, 2006, Pharmacogenetics & Genomics.

Using Pharmacology to Squeeze the Life Out of Childhood Leukemia, and Potential Strategies to Achieve Breakthroughs in Medulloblastoma Treatment

J. Schuetz, T. Gose, J. Wijaya, 2020, Pharmacological Reviews.

Isolation of a genomic clone containing the promoter region of the human ATP binding cassette (ABC) transporter, ABCB6.

J. Schuetz, Hui Zhang, K. Furuya, 2002, Biochimica et biophysica acta.

The Arachidonic Acid Metabolome Serves as a Conserved Regulator of Cholesterol Metabolism

A. Moschen, W. März, M. Kleber, 2014, Cell metabolism.

Isolation of rat pgp3 cDNA: evidence for gender and zonal regulation of expression in the liver.

E. Schuetz, J. Schuetz, K. Furuya, 1994, Biochimica et biophysica acta.

Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

E. Schuetz, W. T. Beck, J. Schuetz, 1996, Molecular pharmacology.

cGMP transport by vesicles from human and mouse erythrocytes

Piet Borst, Jan Wijnholds, J. Wijnholds, 2007, The FEBS journal.

Heterogeneity of cytochrome P450IIIA expression in rat gut epithelia.

J. Kolars, P. Watkins, S. Wrighton, 1992, Gastroenterology.

Expression of cytochrome P450 3A in amphibian, rat, and human kidney.

E. Schuetz, J. Schuetz, A. Náray-Fejes-Tóth, 1992, Archives of biochemistry and biophysics.

Multi-drug Resistance Protein 4 (MRP4)-mediated Regulation of Fibroblast Cell Migration Reflects a Dichotomous Role of Intracellular Cyclic Nucleotides*

J. Schuetz, K. Arora, A. Naren, 2012, The Journal of Biological Chemistry.

Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis.

M. Roussel, G. Neale, G. Grosveld, 2017, JCI Insight.

Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction.

J. Opferman, J. Rehg, J. Schuetz, 2013, Genes & development.

Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure Service Email

J. Opferman, J. Rehg, J. Schuetz, 2013 .

Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver.

J. Schuetz, P. Guzelian, P. Guzelian, 1989, Archives of biochemistry and biophysics.

Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo

J. Schuetz, B. Sorrentino, Sheng Zhou, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Identification of rifampin-inducible P 450 IIIA 4 ( CYP 3 A 4 ) in human small bowel enterocytes

J. Kolars, P. Watkins, J. Schuetz, 2013 .

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.

J. Kolars, P. Watkins, J. Schuetz, 1992, The Journal of clinical investigation.

Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine.

E. Schuetz, J. Schuetz, K. Thummel, 2003, Pharmacogenetics.

Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo.

P. Houghton, J. Panetta, J. Schuetz, 2006, Cancer research.

Gefitinib Enhances the Antitumor Activity and Oral Bioavailability of Irinotecan in Mice

Peter J Houghton, P. Houghton, R. Gilbertson, 2004, Cancer Research.

Identification of functionally variant MDR1 alleles among European Americans and African Americans

R. Kim, E. Schuetz, J. Schuetz, 2001, Clinical pharmacology and therapeutics.

Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12.

A. Hutchinson, A. Rzhetsky, J. Schuetz, 2001, Gene.

P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans.

M. Relling, E. Schuetz, J. Schuetz, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Beyond Competitive Inhibition: Regulation of ABC Transporters by Kinases and Protein-Protein Interactions as Potential Mechanisms of Drug-Drug Interactions

E. Schuetz, J. Schuetz, P. Potukuchi, 2018, Drug Metabolism and Disposition.

ABCG2 requires a single aromatic amino acid to “clamp” substrates and inhibitors into the binding pocket

Taosheng Chen, A. Shelat, J. Schuetz, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4.

M. Relling, E. Schuetz, K. Korzekwa, 1994, Molecular pharmacology.

Metabolic switching in pluripotent stem cells reorganizes energy metabolism and subcellular organelles.

Ji-Hoon Cho, J. Schuetz, Junmin Peng, 2019, Experimental cell research.

Identification of a mammalian mitochondrial porphyrin transporter

Daxi Sun, J. Schuetz, B. Sosa-Pineda, 2006, Nature.

Transporter-mediated protection against thiopurine-induced hematopoietic toxicity.

M. Relling, W. Evans, H. Nakauchi, 2008, Cancer research.

Role of MRP4 and MRP5 in biology and chemotherapy

L. Naesens, J. Schuetz, L. Matherly, 2008, AAPS PharmSci.

Cyclic nucleotide compartmentalization: contributions of phosphodiesterases and ATP-binding cassette transporters.

J. Hulot, J. Schuetz, A. Naren, 2013, Annual review of pharmacology and toxicology.

The Role of Transporters in Toxicity and Disease

Peter W Swaan, D. Tweedie, P. Swaan, 2014, Drug Metabolism and Disposition.

Induction of Mdr1b expression by tumor necrosis factor-alpha in rat liver cells is independent of p53 but requires NF-kappaB signaling.

M. Manns, C. Trautwein, J. Schuetz, 2001, Hepatology.

Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice.

D. Green, T. Prolla, J. Opferman, 2015, Blood.

Mrp4−/− mice have an impaired cytoprotective response in obstructive cholestasis

J. Boyer, J. Schuetz, M. Adachi, 2006, Hepatology.

The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics

Shondra M. Pruett-Miller, J. Opferman, C. Mullighan, 2020, Molecular Cancer Research.

Induction of cytochrome P4503A by taxol in primary cultures of human hepatocytes.

S. Wrighton, S. Strom, E. Schuetz, 1998, Archives of biochemistry and biophysics.

Mdr1b facilitates p53-mediated cell death and p53 is required for Mdr1b upregulation in vivo

E. Schuetz, G. Zambetti, J. Schuetz, 2001, Oncogene.

Mutant p53 Cooperates with ETS and Selectively Up-regulates Human MDR1 Not MRP1*

Daxi Sun, Qingjian Wang, Linda H. Shapiro, 2001, The Journal of Biological Chemistry.

Regulation of human liver cytochromes P‐450 in family 3A in primary and continuous culture of human hepatocytes

R. Fisher, S. Strom, E. Schuetz, 1993, Hepatology.

Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents.

R. Kim, S. Strom, E. Schuetz, 2002, Molecular pharmacology.

17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA.

E. Schuetz, J. Schuetz, L. Kaminsky, 1992, Archives of biochemistry and biophysics.

Repression of Human Reduced Folate Carrier Gene Expression by Wild Type p53*

T. L. Witt, J. Whetstine, J. Schuetz, 2001, The Journal of Biological Chemistry.

Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice.

K. Zatloukal, H. Denk, J. Schuetz, 2003, Gastroenterology.

Differential effect of allopurinol (hpp) on incorporation of 5-fluorouracil (fu) into rna of tumor and host cells isolated from cf1 mice bearing ehrlich ascites tumor (et). Abstr.

M. E. Wilburn, R. Diasio, J. Schuetz, 1981 .

Crucial Role for Phylogenetically Conserved Cytoplasmic Loop 3 in ABCC4 Protein Expression*

Jie J. Zheng, J. Schuetz, T. Zhong, 2013, The Journal of Biological Chemistry.

HIV protease inhibitors interact with ABCC4/MRP4: a basis for unanticipated enhanced cytotoxicity

S. Ekins, J. Schuetz, S. Ambudkar, 2013 .

The Absence of Mrp4 Has No Effect on the Recruitment of Neutrophils and Eosinophils into the Lung after LPS, Cigarette Smoke or Allergen Challenge

J. Schuetz, F. Gantner, H. Mayer, 2013, PloS one.

Conserved Intramolecular Disulfide Bond Is Critical to Trafficking and Fate of ATP-binding Cassette (ABC) Transporters ABCB6 and Sulfonylurea Receptor 1 (SUR1)/ABCC8*

J. Bryan, L. Aguilar-Bryan, M. Vaxillaire, 2011, The Journal of Biological Chemistry.

Spatiotemporal Coupling of cAMP Transporter to CFTR Chloride Channel Function in the Gut Epithelia

M. Zaccolo, J. Schuetz, K. Jalink, 2007, Cell.

Deficiency of ATP-Binding Cassette Transporter B6 in Megakaryocyte Progenitors Accelerates Atherosclerosis in Mice

A. Murphy, J. Schuetz, M. Westerterp, 2014, Arteriosclerosis, thrombosis, and vascular biology.

Transient inhibition of DNA synthesis by 5-fluorodeoxyuridine leads to overexpression of dihydrofolate reductase with increased frequency of methotrexate resistance.

J. Schuetz, I. Goldman, E. Westin, 1988, The Journal of biological chemistry.

Influence of ABC transporters on the excretion of ciprofloxacin assessed with PET imaging in mice.

J. Schuetz, O. Langer, R. Karch, 2021, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Disrupted Bile Acid Homeostasis Reveals an Unexpected Interaction among Nuclear Hormone Receptors, Transporters, and Cytochrome P450*

Jatinder Lamba, Erin G. Schuetz, Frank J. Gonzalez, 2001, The Journal of Biological Chemistry.

Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms.

E. Schuetz, J. Schuetz, K. Furuya, 1995, The Journal of pharmacology and experimental therapeutics.

PharmGKB Update: II. CYP3A5, Cytochrome P450, Family 3, Subfamily A, Polypeptide 5

E. Cook, M. Boguski, F. Behm, 2004, Pharmacological Reviews.

Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver.

J. Schuetz, P. Guzelian, D. L. Beach, 1994, Pharmacogenetics.

Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta.

J. Schuetz, P. Guzelian, S. Kauma, 1993, The Journal of clinical investigation.

Variability in human cytochrome P450 paclitaxel metabolism.

M. Relling, E. Schuetz, A. Pappo, 1995, The Journal of pharmacology and experimental therapeutics.

Development of A Real-Time in Vivo Transcription Assay : Application Reveals Pregnane X Receptor-Mediated Induction of CYP 3 A 4 by Cancer Chemotherapeutic Agents

R. Kim, S. Strom, E. Schuetz, 2002 .

Influence of Multidrug Resistance-Associated Proteins on the Excretion of the ABCC1 Imaging Probe 6-Bromo-7-[11C]Methylpurine in Mice

C. Kuntner, J. Schuetz, O. Langer, 2018, Molecular Imaging and Biology.

Deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity.

J. Schuetz, A. Sparreboom, K. Takenaka, 2011, Cancer research.

An unexpected protein interaction promotes drug resistance in leukemia

J. Downing, Jing Ma, Taosheng Chen, 2017, Nature Communications.

TNF-alpha mediated up-regulation of the multidrug resistance gene mdr1b but not of mrp1 in rat hepatocytes is dependent on NF-kappa B activation

M. Manns, C. Trautwein, J. Schuetz, 1999 .

An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling

M. Roussel, Jingjing Liu, Beisi Xu, 2020, Cancer Research.

Contribution of Abcc4-Mediated Gastric Transport to the Absorption and Efficacy of Dasatinib

S. Baker, A. Gibson, R. Williams, 2013, Clinical Cancer Research.

A PPIX-binding probe facilitates discovery of PPIX-induced cell death modulation by peroxiredoxin

J. Schuetz, J. Peng, John Lynch, 2023, Communications biology.

A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer

J. Schuetz, T. Nakanishi, M. Oshima, 2017, Scientific Reports.

How Cryo-EM Has Expanded Our Understanding of Membrane Transporters

J. Schuetz, T. Gose, S. Baril, 2023, Drug Metabolism and Disposition.

Induction of P-glycoprotein mRNA by protein synthesis inhibition is not controlled by a transcriptional repressor protein in rat and human liver cells.

S. Strom, E. Schuetz, J. Schuetz, 1995, Journal of cellular physiology.

Allopurinol inhibits de novo purine synthesis in lymphoblasts of children with acute lymphoblastic leukemia.

C. Pui, J. Schuetz, M. Relling, 1996, Leukemia.

A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression.

Wooin Lee, Catia Marzolini, Guillermo Gervasini, 2007, Molecular endocrinology.

Sonic Hedgehog Activates Prostaglandin Signaling to Stabilize Primary Cilium Length

Elaine L. Shelton, S. Ogden, J. Schuetz, 2023, bioRxiv.

PKA and actin play critical roles as downstream effectors in MRP4-mediated regulation of fibroblast migration.

J. Schuetz, A. Ziady, Songbai Lin, 2015, Cellular signalling.

Leukemia and ABC transporters.

J. Schuetz, Y. Fukuda, Shangli Lian, 2015, Advances in cancer research.

Transcriptional Control of Intestinal Cytochrome P-4503A by 1 (cid:1) ,25-Dihydroxy Vitamin D 3

E. Schuetz, J. Schuetz, E. Kharasch, 2001 .

The role of ABCG2 and ABCB6 in porphyrin metabolism and cell survival.

J. Schuetz, P. Krishnamurthy, 2011, Current pharmaceutical biotechnology.

Compartmentalization: Contributions of Phosphodiesterases and ATP-Binding Cassette Transporters

J. Hulot, J. Schuetz, A. Naren, 2013 .

Unimpaired immune functions in the absence of Mrp4 (Abcc4).

T. D. de Gruijl, J. Schuetz, G. Scheffer, 2009, Immunology letters.

Deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity.

J. Schuetz, A. Sparreboom, K. Takenaka, 2011, Cancer research.

ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity.

J. Schuetz, A. Naren, S. Cheepala, 2023, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Developing Inhibitors that Exploit ABCG2 and Cancer Dependencies to Improve Therapeutic Outcome

Taosheng Chen, J. Schuetz, Y. Fukuda, 2019, The FASEB Journal.

Exploiting ABCG2 Inhibition to Improve Cancer Therapy

Taosheng Chen, J. Schuetz, Y. Fukuda, 2018 .

The net electrostatic potential and hydration of ABCG2 affect substrate transport

E. Rampersaud, A. Shelat, J. Schuetz, 2023, Nature communications.

The Role of Transporters in Toxicity and Disease

D. Tweedie, P. Swaan, J. Schuetz, 2014, Drug Metabolism and Disposition.

Membrane protein changes in an L1210 leukemia cell line with a translocation defect in the methotrexate-tetrahydrofolate cofactor transport carrier.

J. Schuetz, P. Swerdlow, L. Matherly, 1989, The Journal of biological chemistry.

Sonic Hedgehog activates prostaglandin signaling to stabilize primary cilium length

Shondra M. Pruett-Miller, S. Ogden, J. Schuetz, 2024, The Journal of cell biology.

Understanding How Cellular Metabolism Affects Clofarabine Treatment in Acute Myeloid Leukemia

J. Opferman, J. Schuetz, A. Budhraja, 2023, ASPET 2023 Annual Meeting Abstract - Cancer Pharmacology.