H. Xin

发表

The Gene Encoding p202, an Interferon-inducible Negative Regulator of the p53 Tumor Suppressor, Is a Target of p53-mediated Transcriptional Repression*

S. D’Souza, H. Xin, S. Walter, 2001, The Journal of Biological Chemistry.

Registered report: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

Lindsey T. Brinton, H. Xin, Erin M. Griner, 2015, eLife.

Replication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

Timothy M. Errington, T. Errington, H. Xin, 2019, eLife.

Study 9: Replication of Vermeulen et al., 2010 (Nature Cell Biology)

James A. Evans, T. Errington, H. Xin, 2013 .

The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors.

Hua Yu, Hong Xin, Minwei Ye, 2009, Cancer cell.

Cutting Edge: A Critical Functional Role for IL-23 in Psoriasis

T. Mcclanahan, F. Nestle, R. Kastelein, 2010, The Journal of Immunology.

Integrin α6 signaling induces STAT3-TET3-mediated hydroxymethylation of genes critical for maintenance of glioma stem cells

Hua Yu, A. Herrmann, P. Chu, 2019, Oncogene.

CHIP Mediates Degradation of Smad Proteins and Potentially Regulates Smad-Induced Transcription

Xin-Yuan Fu, H. Xin, Yue Chen, 2004, Molecular and Cellular Biology.

Isoform-specific and cell/tissue-dependent effects of p38 MAPKs in regulating inflammation and inflammation-associated oncogenesis.

H. Xin, J. Qin, Xiaomei Qi, 2022, Frontiers in bioscience.

Glutaredoxin 2 protects cardiomyocytes from hypoxia/reoxygenation-induced injury by suppressing apoptosis, oxidative stress, and inflammation via enhancing Nrf2 signaling.

J. Mu, H. Xin, Chengliang Li, 2021, International immunopharmacology.

Inhibition of PAX3 by TGF-beta modulates melanocyte viability.

Yinshi Guo, Rutao Cui, H. Xin, 2008, Molecular cell.

Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressor

Julie A. Brown, J. Gnarra, H. Xin, 2010, Oncogene.

3-Bromopyruvate induces necrotic cell death in sensitive melanoma cell lines.

H. Xin, B. Nickoloff, J. Qin, 2010, Biochemical and biophysical research communications.

Suppression of surfactant protein A by an epidermal growth factor receptor tyrosine kinase inhibitor exacerbates lung inflammation

H. Xin, M. Maemondo, T. Nukiwa, 2008, Cancer science.

Association of the von Hippel–Lindau Protein with AUF1 and Posttranscriptional Regulation of VEGFA mRNA

Julie A. Brown, J. Gnarra, H. Fan, 2011, Molecular Cancer Research.

Association of the von Hippel-Lindau protein with AUF 1 and post-transcriptional regulation of Vascular Endothelial Growth Factor A mRNA

Julie A. Brown, J. Gnarra, H. Fan, 2011 .

Expression of an IFN-Inducible Cellular Senescence Gene, IFI16, Is Up-Regulated by p53

F. Alimirah, H. Xin, D. Choubey, 2008, Molecular Cancer Research.

2-deoxyglucose sensitizes melanoma cells to TRAIL-induced apoptosis which is reduced by mannose.

H. Xin, B. Nickoloff, J. Qin, 2010, Biochemical and biophysical research communications.

Paracrine factors of multipotent stromal cells ameliorate lung injury in an elastase-induced emphysema model.

H. Xin, Ruowen Sun, T. Nukiwa, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways

H. Xin, N. Ferrara, B. Choudhury, 2020, Nature Communications.

IL-23 in Psoriasis Cutting Edge: A Critical Functional Role for

T. Mcclanahan, H. Xin, C. Conrad, 2010 .

Ligand-Activated Peroxisome Proliferator-Activated Receptor β/δ Modulates Human Endometrial Cancer Cell Survival

J. Coon, H. Xin, D. Chakravarti, 2013, Hormones and Cancer.

Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells

Huqun, T. Honjo, H. Xin, 2005, European journal of immunology.

Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: new insights into molecular mechanisms for the disease

Shuhan Sun, G. Xue, H. Xin, 2012, Journal of cellular and molecular medicine.

Androgen receptor auto‐regulates its expression by a negative feedback loop through upregulation of IFI16 protein

F. Alimirah, H. Xin, D. Choubey, 2006, FEBS letters.

Intratracheal Delivery of CX3CL1-Expressing Mesenchymal Stem Cells to Multiple Lung Tumors

H. Mizuguchi, H. Xin, Ruowen Sun, 2009, Molecular medicine.

Dendritic cells modified to express fractalkine/CX3CL1 in the treatment of preexisting tumors

H. Mizuguchi, T. Hayakawa, H. Xin, 2006, European journal of immunology.

Involvement of Fractalkine/CX3CL1 Expression by Dendritic Cells in the Enhancement of Host Immunity against Legionella pneumophila

T. Honjo, H. Xin, T. Nukiwa, 2005, Infection and Immunity.

CHIP functions an E3 ubiquitin ligase of Runx1.

H. Xin, Yonggong Zhai, Xialian Xu, 2009, Biochemical and biophysical research communications.

Knockdown of TRIM24 suppresses growth and induces apoptosis in acute myeloid leukemia through downregulation of Wnt/GSK-3β/β-catenin signaling

J. Mu, H. Xin, C. Li, 2020, Human & experimental toxicology.

Consensus guidelines for the use and interpretation of angiogenesis assays

Robert J. Griffin, Federico Bussolino, Mark J. Post, 2018, Angiogenesis.

p202 levels are negatively regulated by serum growth factors.

S. D’Souza, H. Xin, S. Walter, 2000, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Levels Are Negatively Regulated by Serum Growth Factors 1

S. D’Souza, H. Xin, S. Walter, 2000 .

p202, an interferon-inducible negative regulator of cell growth, is a target of the adenovirus E1A protein

P. Lengyel, S. D’Souza, H. Xin, 2001, Oncogene.

Disruption of Mutually Negative Regulatory Feedback Loop between Interferon-Inducible p202 Protein and the E2F Family of Transcription Factors in Lupus-Prone Mice1

H. Xin, D. Choubey, R. Panchanathan, 2008, The Journal of Immunology.

LncRNA CCDC26 Interacts with CELF2 Protein to Enhance Myeloid Leukemia Cell Proliferation and Invasion via the circRNA_ANKIB1/miR-195-5p/PRR11 Axis

J. Mu, H. Xin, Chengliang Li, 2021, Cell transplantation.

Interleukin-6 Induces Expression of Ifi202, an Interferon-inducible Candidate Gene for Lupus Susceptibility*

H. Xin, D. Choubey, B. Kotzin, 2004, Journal of Biological Chemistry.

Heparin-binding VEGFR1 variants as long-acting VEGF inhibitors for treatment of intraocular neovascular disorders

H. Xin, N. Ferrara, Cuiling Zhong, 2021, Proceedings of the National Academy of Sciences.

The cytokine and chemokine network in psoriasis.

Hong Xin, F. Nestle, H. Xin, 2007, Clinics in dermatology.

Targeted Delivery of CX3CL1 to Multiple Lung Tumors by Mesenchymal Stem Cells

H. Mizuguchi, T. Hayakawa, H. Xin, 2007, Stem cells.

Evidence for Pro-angiogenic Functions of VEGF-Ax

H. Xin, N. Ferrara, Cuiling Zhong, 2016, Cell.

Up‐regulation of microRNA‐145 promotes differentiation by repressing OCT4 in human endometrial adenocarcinoma cells

Shuhan Sun, H. Xin, Shupeng Liu, 2011, Cancer.

Subcellular localization and mechanisms of nucleocytoplasmic distribution of p202, an interferon‐inducible candidate for lupus susceptibility

H. Xin, D. Choubey, R. Pramanik, 2003, FEBS letters.

DU‐145 and PC‐3 human prostate cancer cell lines express androgen receptor: Implications for the androgen receptor functions and regulation

Hong Xin, F. Alimirah, H. Xin, 2006, FEBS letters.

A naturally occurring p73 mutation in a p73‐p53 double‐mutant lung cancer cell line encodes p73α protein with a dominant‐negative function

Huqun, H. Xin, T. Nukiwa, 2003, Cancer science.

The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival

R. Jove, Y. Yen, A. Scuto, 2011, Leukemia.

TLR9 is critical for glioma stem cell maintenance and targeting.

G. Gallia, Hua Yu, R. Jove, 2014, Cancer research.

Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation

A. Riggs, Hua Yu, R. Jove, 2012, Proceedings of the National Academy of Sciences.

Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment.

C. Drake, Hua Yu, M. Kortylewski, 2009, Cancer cell.

Cytoplasmic localization of the interferon‐inducible protein that is encoded by the AIM2 (absent in melanoma) gene from the 200‐gene family

H. Xin, S. Walter, D. Choubey, 2000, FEBS letters.

Icaritin Inhibits JAK/STAT3 Signaling and Growth of Renal Cell Carcinoma

Jia-Bin Huang, Hua Yu, H. Xin, 2013, PloS one.

Ligand Binding to the Androgen Receptor Induces Conformational Changes That Regulate Phosphatase Interactions

H. Xin, D. Brautigan, B. Paschal, 2007, Molecular and Cellular Biology.

LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy

Ruikang K. Wang, G. Paternostro, C. Piermarocchi, 2021, EMBO molecular medicine.

CHIP Controls the Sensitivity of Transforming Growth Factor-β Signaling by Modulating the Basal Level of Smad3 through Ubiquitin-mediated Degradation*

Xin-Yuan Fu, H. Xin, Xialian Xu, 2005, Journal of Biological Chemistry.

LncRNA SNHG1 contributes to the regulation of acute myeloid leukemia cell growth by modulating miR‐489‐3p/SOX12/Wnt/β‐catenin signaling

H. Xin, Q. Gao, Minjuan Wang, 2020, Journal of cellular physiology.

Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells.

R. Figlin, Hua Yu, A. Herrmann, 2009, Cancer research.

Targeted delivery of NK4 to multiple lung tumors by bone marrow-derived mesenchymal stem cells

K. Matsumoto, T. Nakamura, H. Mizuguchi, 2007, Cancer Gene Therapy.

Androgen receptor levels are increased by interferons in human prostate stromal and epithelial cells

F. Alimirah, H. Xin, D. Choubey, 2006, Oncogene.

Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence

R. Johnstone, H. Xin, D. Choubey, 2003, Oncogene.

Sunitinib Induces Apoptosis and Growth Arrest of Medulloblastoma Tumor Cells by Inhibiting STAT3 and AKT Signaling Pathways

Hua Yu, Fan Yang, H. Xin, 2010, Molecular Cancer Research.

Therapeutics , Targets , and Chemical Biology TLR 9 Is Critical for Glioma Stem Cell Maintenance and Targeting

G. Gallia, Hua Yu, R. Jove, 2014 .

G-protein-coupled Receptor Agonist BV8/Prokineticin-2 and STAT3 Protein Form a Feed-forward Loop in Both Normal and Malignant Myeloid Cells*

Hua Yu, R. Jove, Chunyan Zhang, 2013, The Journal of Biological Chemistry.

CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer.

Hua Yu, R. Jove, H. Xin, 2016, Immunity.

Moesin-dependent cytoskeleton remodelling is associated with an anaplastic phenotype of pancreatic cancer

H. Friess, J. Kleeff, K. Felix, 2009, Journal of cellular and molecular medicine.

Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors.

Charles Y. Lin, S. Knapp, T. Westbrook, 2020, Cell chemical biology.

The Anthelmintic Flubendazole Blocks Human Melanoma Growth and Metastasis and Suppresses Programmed Cell Death Protein-1 and Myeloid-Derived Suppressor Cell Accumulation.

H. Xin, L. Khachigian, Grishma Acharya, 2019, Cancer letters.

Induction of p202, a modulator of apoptosis, during oncogenic transformation of NIH 3T3 cells by activated H‐Ras (Q61L) contributes to cell survival

H. Xin, D. Choubey, R. Pramanik, 2003, Journal of cellular biochemistry.

Role of IFI 16 in cellular senescence of human fibroblasts

O. Pereira-smith, H. Xin, D. Choubey, 2004, Oncogene.

Factors in Lupus-Prone Mice p 202 Protein and the E 2 F Family of Feedback Loop between Interferon-Inducible Disruption of Mutually Negative Regulatory

H. Xin, D. Choubey, R. Panchanathan, 2008 .

THE ACTIVATING ACTION OF LOW LEVEL HELIUM NEON LASER RADIATION ON MACROPHAGES IN THE MOUSE MODEL

Hong Xin, H. Xin, J. Qin, 1992 .

Increased Expression of Ifi202, an IFN-Activatable Gene, in B6.Nba2 Lupus Susceptible Mice Inhibits p53-Mediated Apoptosis1

P. Lengyel, A. Vaughan, S. D’Souza, 2006, The Journal of Immunology.

Apoptosis Susceptible Mice Inhibits p 53-Mediated IFN-Activatable Gene , in B 6 . Nba 2 Lupus , an Ifi 202 Increased Expression of

P. Lengyel, A. Vaughan, S. D’Souza, 2006 .

Targeting glutamine metabolism sensitizes melanoma cells to TRAIL-induced death.

H. Xin, B. Nickoloff, J. Qin, 2010, Biochemical and biophysical research communications.

Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480.

R. Figlin, Hua Yu, R. Jove, 2011, Cancer research.

Specifically targeting ERK1 or ERK2 kills Melanoma cells

H. Xin, B. Nickoloff, J. Qin, 2012, Journal of Translational Medicine.

Cutting Edge: An In Vivo Requirement for STAT3 Signaling in TH17 Development and TH17-Dependent Autoimmunity1

Hua Yu, Drew M. Pardoll, Charles G. Drake, 2007, The Journal of Immunology.

A requirement of STAT3 DNA binding precludes Th-1 immunostimulatory gene expression by NF-κB in tumors.

Hua Yu, D. Pardoll, H. Xin, 2011, Cancer research.

Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA.

H. Xin, B. Nickoloff, M. Denning, 2006, Cancer research.

CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells.

Hua Yu, A. Herrmann, M. Kortylewski, 2015, The Journal of clinical investigation.

CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells.

Hua Yu, A. Herrmann, M. Kortylewski, 2014, The Journal of clinical investigation.

A Requirement of STAT 3 DNA Binding Precludes Th1 Immunostimulatory Gene Expression by NFk B in Tumors

Hua Yu, D. Pardoll, H. Xin, 2011 .

Microenvironment and Immunology Antiangiogenic and Antimetastatic Activity of JAK Inhibitor AZD 1480

R. Figlin, Hua Yu, R. Jove, 2011 .

Retinoblastoma (Rb) protein upregulates expression of the Ifi202 gene encoding an interferon-inducible negative regulator of cell growth

H. Xin, D. Choubey, R. Pramanik, 2003, Oncogene.

Correction: A requirement of STAT3 DNA binding precludes Th-1 immunostimulatory gene expression by NF-κB in tumors (Cancer Research (2011) 71, (3772-3880))

H. Xin, H. Yu, A. Pardoll, 2011 .

Circ_CHFR Promotes Platelet-Derived Growth Factor-BB–Induced Proliferation, Invasion, and Migration in Vascular Smooth Muscle Cells via the miR-149-5p/NRP2 Axis

H. Xin, Chengliang Li, Jinlong Cao, 2021, Journal of cardiovascular pharmacology.

Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis

Hua Yu, R. Jove, Fan Yang, 2012, Cancer biology & therapy.

SOSTDC1 acts as a tumor inhibitor in acute myeloid leukemia by downregulating the Wnt/β‐catenin pathway

H. Xin, Minjuan Wang, Chengliang Li, 2022, Environmental toxicology.

CaMKK2 alleviates myocardial ischemia/reperfusion injury by inhibiting oxidative stress and inflammation via the action on the AMPK-AKT-GSK-3β/Nrf2 signaling cascade

H. Xin, Chengliang Li, Huichang Qiu, 2023, Inflammation Research.

Long noncoding RNA colon cancer associated transcript‑1 promotes the proliferation, migration and invasion of cervical cancer.

H. Xin, Y. Zhang, F. Tian, 2017, Molecular medicine reports.

Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation

A. Riggs, Hua Yu, R. Jove, 2012, Proceedings of the National Academy of Sciences.

CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer.

Hua Yu, R. Jove, H. Xin, 2016, Immunity.

TLR9 is critical for glioma stem cell maintenance and targeting.

G. Gallia, Hua Yu, R. Jove, 2014, Cancer research.

Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells.

R. Figlin, Hua Yu, A. Herrmann, 2009, Cancer research.

Estrogen receptor β agonist diarylpropionitrile inhibits lipopolysaccharide-induced regulated on activation normal T cell expressed and secreted (RANTES) production in macrophages by repressing nuclear factor κB activation.

H. Xin, Jing Sun, Rui Li, 2013, Fertility and sterility.