C. Brinckerhoff

发表

p53 Down-regulates Human Matrix Metalloproteinase-1 (Collagenase-1) Gene Expression*

Y. Sun, L. Wenger, H. Cheung, 1999, The Journal of Biological Chemistry.

Potential for the 2G single nucleotide polymorphism in the promoter of matrix metalloproteinase to enhance gene expression in normal stromal cells.

C. Brinckerhoff, Colby A. Wyatt, C. I. Coon, 2002, Cancer research.

Fra-1 targets the AP-1 site/2G single nucleotide polymorphism (ETS site) in the MMP-1 promoter.

C. Brinckerhoff, C. I. Coon, K. Belguise, 2003, European journal of biochemistry.

Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors

C. Brinckerhoff, M. Vincenti, Matthew P Vincenti, 2001, Arthritis Research & Therapy.

Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts.

C. Brinckerhoff, C. I. Coon, M. Vincenti, 1998, Arthritis and rheumatism.

A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates an Ets binding site and augments transcription.

J. Gusella, L. Ozelius, J. Rutter, 1998, Cancer research.

Loss of heterozygosity on chromosome 11q22-23 in melanoma is associated with retention of the insertion polymorphism in the matrix metalloproteinase-1 promoter.

A. Schned, M. Ernstoff, J. Rutter, 2001, The American journal of pathology.

Early response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin-1beta

C. Brinckerhoff, M. Vincenti, Matthew P Vincenti, 2001, Arthritis research.

Cell‐type specific regulation of human interstitial collagenase‐1 gene expression by interleukin‐1β (IL‐1β) in human fibroblasts and BC‐8701 breast cancer cells

J. Rutter, C. Brinckerhoff, C. I. Coon, 1997 .

Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2α in von Hippel–Lindau renal cell carcinoma

C. Brinckerhoff, J. Lohi, B. Petrella, 2005, Oncogene.

Interstitial collagenases as markers of tumor progression.

J. Rutter, C. Brinckerhoff, U. Benbow, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Identification of a cigarette smoke-responsive region in the distal MMP-1 promoter.

J. D’Armiento, C. Brinckerhoff, B. Mercer, 2009, American journal of respiratory cell and molecular biology.

Collagenase immunolocalization in cultures of rheumatoid synovial cells.

D. Woolley, C. Brinckerhoff, E. D. Harris, 1978, Science.

Collagenase production by synovial fibroblasts treated with phorbol myristate acetate.

C. Brinckerhoff, E. D. Harris, R. McMillan, 1979, Arthritis and rheumatism.

Collagenase production by rheumatoid synovial cells: morphological and immunohistochemical studies of the dendritic cell.

D. Woolley, C. Brinckerhoff, C. Vater, 1979, Annals of the rheumatic diseases.

A precursor form of latent collagenase produced in a cell-free system with mRNA from rabbit synovial cells.

R. Jackson, C. Brinckerhoff, C. Vater, 1981, The Journal of biological chemistry.

A Matrix Metalloproteinase-1/Protease Activated Receptor-1 signaling axis promotes melanoma invasion and metastasis

C. Brinckerhoff, C. I. Coon, Jessica S. Blackburn, 2009, Oncogene.

BRAFV600E melanoma cells secrete factors that activate stromal fibroblasts and enhance tumourigenicity

C. Brinckerhoff, C. Whipple, 2014, British Journal of Cancer.

Analysis of Matrix Metalloproteinase-1 Gene Polymorphisms and Expression in Benign and Malignant Breast Tumors

R. Mural, S. Somiari, C. Brinckerhoff, 2011, Cancer investigation.

Differential mechanisms of tumor progression in clones from a single heterogeneous human melanoma

C. Brinckerhoff, W. Croteau, Molly H. Jenkins, 2013, Journal of cellular physiology.

Overexpression of Collagenase 1 (MMP-1) Is Mediated by the ERK Pathway in Invasive Melanoma Cells

C. Der, C. Slingluff, J. M. Shields, 2004, Journal of Biological Chemistry.

Short hairpin RNA-mediated inhibition of matrix metalloproteinase-1 in MDA-231 cells: effects on matrix destruction and tumor growth.

C. Brinckerhoff, Colby A. Wyatt, James C. Geoghegan, 2005, Cancer research.

Peroxisome proliferator-activated receptor-gamma-independent repression of collagenase gene expression by 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and prostaglandin 15-deoxy-delta(12,14) J2: a role for Smad signaling.

M. Sporn, E. Rosen, C. Brinckerhoff, 2004, Molecular pharmacology.

High levels of MMP‐1 expression in the absence of the 2G single nucleotide polymorphism is mediated by p38 and ERK1/2 mitogen‐activated protein kinases in VMM5 melanoma cells

C. Brinckerhoff, Colby A. Wyatt, G. B. Tower, 2002, Journal of cellular biochemistry.

A Novel Host/Tumor Cell Interaction Activates Matrix Metalloproteinase 1 and Mediates Invasion through Type I Collagen*

J. Rutter, C. Brinckerhoff, K. Shimokawa, 1999, The Journal of Biological Chemistry.

Morphologic and mitogenic responses of rabbit synovial fibroblasts to transforming growth factor beta require transforming growth factor alpha or epidermal growth factor.

C. Brinckerhoff, 1983, Arthritis and rheumatism.

Matrix metalloproteinases: a tail of a frog that became a prince

Constance E. Brinckerhoff, L. Matrisian, C. Brinckerhoff, 2002, Nature Reviews Molecular Cell Biology.

Editorial The 'RASor's' edge: Ras proteins and matrix destruction in

C. Brinckerhoff, 2009 .

The 'RASor's' edge: Ras proteins and matrix destruction in arthritis

C. Brinckerhoff, Adam C Schmucker, 2009, Arthritis research & therapy.

Wild‐type versus mutant MMP‐8 in melanoma: ‘When you come to a fork in the road, take it’ *

C. Brinckerhoff, Jessica S. Blackburn, J. Blackburn, 2009, Pigment cell & melanoma research.

Site controlled transgenic mice validating increased expression from human matrix metalloproteinase (MMP-1) promoter due to a naturally occurring SNP.

J. Gaudet, S. Fiering, C. Brinckerhoff, 2009, Matrix biology : journal of the International Society for Matrix Biology.

Potential for the 2 G Single Nucleotide Polymorphism in the Promoter of Matrix Metalloproteinase to Enhance Gene Expression in Normal Stromal Cells 1

C. Brinckerhoff, Colby A. Wyatt, C. I. Coon, 2002 .

Effect of a Single Nucleotide Polymorphism (NP) on Breast Cancer Invasion

C. Brinckerhoff, Colby A. Wyatt, 2001 .

Isolation of a collagenase cDNA clone and measurement of changing collagenase mRNA levels during induction in rabbit synovial fibroblasts.

R. H. Gross, C. Fletcher, C. Brinckerhoff, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition by retinoic acid of collagenase production in rheumatoid synovial cells.

C. Brinckerhoff, J. Dayer, E. D. Harris, 1980, The New England journal of medicine.

Rat collagenase. Cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells.

L. Matrisian, C. Brinckerhoff, D. Scott, 1990, The Journal of biological chemistry.

Regulating expression of the gene for matrix metalloproteinase-1 (collagenase): mechanisms that control enzyme activity, transcription, and mRNA stability.

C. Brinckerhoff, M. Vincenti, U. Benbow, 1996, Critical reviews in eukaryotic gene expression.

Erk 1/2 differentially regulates the expression from the 1G/2G single nucleotide polymorphism in the MMP-1 promoter in melanoma cells.

C. Brinckerhoff, G. B. Tower, M. Vincenti, 2002, Biochimica et biophysica acta.

Post‐Transcriptional regulationa of collagenase and stromelysin gene expression by epidermal growth factor and dexamethasone in cultured human fibroblasts

C. Brinckerhoff, A. Delany, 1992 .

C. Brinckerhoff, C. I. Coon, M. Vincenti, 1996, Arthritis and rheumatism.

Posttranscriptional regulation of collagenase-1 gene expression in synoviocytes by adenosine receptor stimulation.

G. Firestein, J. Rutter, C. Brinckerhoff, 1997, Arthritis and rheumatism.

Saturable, high affinity binding of serum amyloid A (SAA3) to rabbit fibroblasts

C. Brinckerhoff, T. Mitchell, 1995 .

Serum amyloid A (SAA3) produced by rabbit synovial fibroblasts treated with phorbol esters or interleukin 1 induces synthesis of collagenase and is neutralized with specific antiserum.

C. Brinckerhoff, C. I. Coon, T. Mitchell, 1991, The Journal of clinical investigation.

Molecular cloning of human synovial cell collagenase and selection of a single gene from genomic DNA.

M. Fini, C. Brinckerhoff, P. Ruby, 1987, The Journal of clinical investigation.

The 2G Single Nucleotide Polymorphism (SNP) in the MMP-1 Promoter Contributes to High Levels of MMP-1 Transcription in MCF-7/ADR Breast Cancer Cells

C. Brinckerhoff, C. I. Coon, G. B. Tower, 2003, Breast Cancer Research and Treatment.

Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts.

C. Brinckerhoff, K. L. Sirum, 1989, Biochemistry.

Cell-type specific regulation of human interstitial collagenase-1 gene expression by interleukin-1 beta (IL-1 beta) in human fibroblasts and BC-8701 breast cancer cells.

J. Rutter, C. Brinckerhoff, C. I. Coon, 1997, Journal of Cellular Biochemistry.

Nuclear hormone receptors inhibit matrix metalloproteinase (MMP) gene expression through diverse mechanisms.

C. Brinckerhoff, D. Schroen, 1996, Gene expression.

Inhibition of rabbit collagenase (matrix metalloproteinase‐1; MMP‐1) transcription by retinoid receptors: Evidence for binding of RARs/RXRs to the −77 AP‐1 site through interactions with c‐Jun

C. Brinckerhoff, D. Schroen, Constance E. Brinckerhoff, 1996, Journal of cellular physiology.

Regulation of metalloproteinase gene expression: implications for osteoarthritis.

C. Brinckerhoff, Constance E. Brinckerhoff, 1992, Critical reviews in eukaryotic gene expression.

Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3.

C. Brinckerhoff, C. I. Coon, M. Vincenti, 2000, Arthritis and rheumatism.

Suppression of collagenase gene expression by all‐trans and 9‐cis retinoic acid is ligand dependent and requires both RARs and RXRs

C. Brinckerhoff, C. Eckhoff, L. Pan, 1995, Journal of cellular biochemistry.

Modulation by retinoic acid and corticosteroids of collagenase production by rabbit synovial fibroblasts treated with phorbol myristate acetate or poly(ethylene glycol).

C. Brinckerhoff, E. D. Harris, 1981, Biochimica et biophysica acta.

The potential of signal transduction inhibitors for the treatment of arthritis: Is it all just JNK?

C. Brinckerhoff, M. Vincenti, 2001, The Journal of clinical investigation.

Confocal assay for invasion: use of propidium iodide fluorescence and laser reflectance to quantify the rate of migration of cells through a matrix.

A. Givan, C. Brinckerhoff, U. Benbow, 2000, Cytometry.

Rabbit procollagenase synthesized and secreted by a high-yield mammalian expression vector requires stromelysin (matrix metalloproteinase-3) for maximal activation.

R. Palmiter, K. Suzuki, C. Brinckerhoff, 1990, The Journal of biological chemistry.

Specificity of glucocorticoid inhibition of synovial prostaglandin synthesis

C. Brinckerhoff, E. D. Harris, R. McMillan, 1980 .

Human Metalloproteinase‐1 (Collagenase‐1) Is a Tumor Suppressor Protein p53 Target Gene

Y. Sun, Yubo Sun, L. Wenger, 1999, Annals of the New York Academy of Sciences.

Autocrine induction of collagenase by serum amyloid A-like and beta 2-microglobulin-like proteins.

M. Benson, C. Brinckerhoff, B. Kluve-Beckerman, 1989, Science.

Cloning of a complementary DNA for rabbit proactivator. A metalloproteinase that activates synovial cell collagenase, shares homology with stromelysin and transin, and is coordinately regulated with collagenase.

M. Fini, C. Brinckerhoff, M. Karmilowicz, 1987, Arthritis and rheumatism.

Effects of all-trans-retinoic acid (retinoic acid) and 4-hydroxyphenylretinamide on synovial cells and articular cartilage.

C. Brinckerhoff, E. D. Harris, H. Nagase, 1982, Journal of the American Academy of Dermatology.

Interstitial Collagenases as Markers of Tumor Progression 1

J. Rutter, C. Brinckerhoff, U. Benbow, 2000 .

Joint destruction in arthritis: metalloproteinases in the spotlight.

C. Brinckerhoff, 1991, Arthritis and rheumatism.

Interleukin-1 or phorbol induction of the stromelysin promoter requires an element that cooperates with AP-1.

C. Brinckerhoff, K. Sirum-Connolly, Karen Sirum-Connolly, 1991, Nucleic acids research.

Retinoids and rheumatoid arthritis: modulation of extracellular matrix by controlling expression of collagenase.

C. Brinckerhoff, 1990, Methods in enzymology.

Heat shock of rabbit synovial fibroblasts increases expression of mRNAs for two metalloproteinases, collagenase and stromelysin

C. Brinckerhoff, B. A. Vance, B. Vance, 1989, The Journal of cell biology.

Biosynthesis and secretion of procollagenase by rabbit synovial fibroblasts. Inhibition of procollagenase secretion by monensin and evidence for glycosylation of procollagenase.

C. Brinckerhoff, C. Vater, E. D. Harris, 1983, The Biochemical journal.

Increased level of translatable collagenase messenger ribonucleic acid in rabbit synovial fibroblasts treated with phorbol myristate acetate or crystals of monosodium urate monohydrate.

R. H. Gross, R. Jackson, C. Brinckerhoff, 1982, Biochemistry.

Differential regulation of collagenase gene expression by retinoic acid receptors—α, β and γ

D. Auble, C. Brinckerhoff, L. Pan, 1992 .

Differential regulation of collagenase gene expression by retinoic acid receptors--alpha, beta and gamma.

D. Auble, C. Brinckerhoff, L. Pan, 1992, Nucleic acids research.

Retinoid‐Mediated Suppression of Tumor Invasion and Matrix Metalloproteinase Synthesis

J. Rutter, C. Brinckerhoff, P. Reczek, 1999, Annals of the New York Academy of Sciences.

Regulation of collagenase gene expression by IL-1 beta requires transcriptional and post-transcriptional mechanisms.

C. Brinckerhoff, C. I. Coon, M. Vincenti, 1994, Nucleic acids research.

Collagenase release from synovial fibroblasts: relationship to fatty acid release and prostaglandin synthesis

C. Brinckerhoff, E. D. Harris, R. McMillan, 1980 .

Synthesis of PGE2, collagenase and tissue factor by fibroblast substrains: substrains are differentially activated for different metabolic products.

C. Brinckerhoff, J. Korn, R. Edwards, 1985, Collagen and related research.

Collagenase production by cloned populations of rabbit synovial fibroblasts.

C. Brinckerhoff, J. Nagel, 1981, Collagen and related research.

Matrix metalloproteinases as therapeutic targets in arthritic diseases: bull's-eye or missing the mark?

C. Brinckerhoff, K. Mix, J. A. Mengshol, 2002, Arthritis and rheumatism.

Retinoids and rexinoids for the 21st century: a brave new world for arthritis.

M. Sporn, C. Brinckerhoff, 2003, The Journal of rheumatology.

Autoregulation of collagenase production by a protein synthesized and secreted by synovial fibroblasts: cellular mechanism for control of collagen degradation.

C. Brinckerhoff, W. Culp, M. Benoit, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Induction of collagenase mRNA in lapine articular chondrocytes by synovial factors and interleukin-1.

G. Bandara, C. Brinckerhoff, C. Evans, 1988, Archives of biochemistry and biophysics.

Matrix metalloproteinases: role in arthritis.

C. Brinckerhoff, P. Burrage, K. Mix, 2006, Frontiers in bioscience : a journal and virtual library.

Effect of retinoids on rheumatoid arthritis, a proliferative and invasive non-malignant disease.

C. Brinckerhoff, L. Sheldon, R. Wilder, 2008, Ciba Foundation symposium.

Regulation of Collagenase Gene Expression in Synovial Fibroblasts a

D. Auble, C. Brinckerhoff, 1990, Annals of the New York Academy of Sciences.

A gene for rabbit synovial cell collagenase: member of a family of metalloproteinases that degrade the connective tissue matrix.

R. H. Gross, M. Fini, C. Brinckerhoff, 1987, Biochemistry.

Iron increases collagenase production by rabbit synovial fibroblasts.

C. Brinckerhoff, P. Sinclair, I. Okazaki, 1981, The Journal of laboratory and clinical medicine.

Use of agarose culture to measure the effect of transforming growth factor beta and epidermal growth factor on rabbit articular chondrocytes.

C. Brinckerhoff, K. Skantze, J. Collier, 1985, Cancer research.

Characterization of rabbit genes for synovial cell collagenase.

R. H. Gross, M. Fini, C. Brinckerhoff, 1986, Arthritis and rheumatism.

Homology between exon-containing portions of rabbit genomic clones for synovial cell collagenase and human foreskin and synovial cell mRNAs.

R. H. Gross, M. Fini, C. Brinckerhoff, 1986, Collagen and related research.

Morphologic and mitogenic responses of rabbit synovial fibroblasts to transforming growth factor β require transforming growth factor α or epidermal growth factor

C. Brinckerhoff, 1983 .

Collagen production by cultures containing multinucleated cells derived from synovial fibroblasts.

C. Brinckerhoff, E. D. Harris, 1978, Arthritis and rheumatism.

Novel inhibitors of matrix metalloproteinase gene expression as potential therapies for arthritis.

M. Sporn, D. Schurman, C. Brinckerhoff, 2004, Clinical orthopaedics and related research.

Increased tumor immunity in mice inoculated with muconomycin A-treated B16 melanoma cells.

C. Brinckerhoff, M. Lubin, 1978, Cancer Research.

Multiple murine BRafV600E melanoma cell lines with sensitivity to PLX4032

J. Fisher, M. Ernstoff, C. Brinckerhoff, 2014, Pigment cell & melanoma research.

Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses

N. Hacohen, L. Garraway, G. Freeman, 2021, Science Translational Medicine.

Prolonged inhibition of protein and glycoprotein synthesis in tumor cells treated with muconomycin A.

C. Brinckerhoff, M. Lubin, 1977, Journal of the National Cancer Institute.

Sialic acid-deficient tumor cells: inhibition of sialoglycoprotein synthesis by emetine.

C. Brinckerhoff, M. Lubin, 1974, Journal of the National Cancer Institute.

The AP-1 site and MMP gene regulation: what is all the fuss about?

C. Brinckerhoff, C E Brinckerhoff, U Benbow, 1997, Matrix biology : journal of the International Society for Matrix Biology.

Survival of rheumatoid synovium implanted into nude mice.

C. Brinckerhoff, E. D. Harris, E. Constance, 1981, The American journal of pathology.

Autocrine control of collagenase synthesis by synovial fibroblasts

C. Brinckerhoff, T. Mitchell, 1988, Journal of cellular physiology.

PTEN suppression of YY1 induces HIF-2 activity in von hippel lindau null renal cell carcinoma

C. Brinckerhoff, B. Petrella, 2009, Cancer biology & therapy.

Matrix metalloproteinase and G protein coupled receptors: co-conspirators in the pathogenesis of autoimmune disease and cancer.

C. Brinckerhoff, P. Burrage, Jessica S. Blackburn, 2009, Journal of autoimmunity.

Matrix metalloproteinase-1 and thrombin differentially activate gene expression in endothelial cells via PAR-1 and promote angiogenesis.

C. Brinckerhoff, Jessica S. Blackburn, J. Blackburn, 2008, The American journal of pathology.

A TLR7 agonist strengthens T and NK cell function during BRAF‐targeted therapy in a preclinical melanoma model

G. Cappellano, C. Brinckerhoff, L. Bellmann, 2019, International journal of cancer.

Chapter 15 – Transcriptional Regulation of Matrix Metalloproteinases

C. Brinckerhoff, U. Benbow, 2003 .

ETS sites in the promoters of the matrix metalloproteinases collagenase (MMP-1) and stromelysin (MMP-3) are auxiliary elements that regulate basal and phorbol-induced transcription.

C. Brinckerhoff, C. Maute, L. White, 1997, Connective tissue research.

Human breast cancer cells activate procollagenase-1 and invade type I collagen: invasion is inhibited by all-trans retinoic acid

A. Givan, C. Brinckerhoff, U. Benbow, 1999, Clinical & Experimental Metastasis.

Transcriptional repression of the human collagenase-1 (MMP-1) gene in MDA231 breast cancer cells by all-trans-retinoic acid requires distal regions of the promoter

J. Rutter, C. Brinckerhoff, C. Lowrey, 1999, British Journal of Cancer.

Induction of collagenase and stromelysin gene expression by mechanical injury in a vascular smooth muscle‐derived cell line

C. Brinckerhoff, R. Zwolak, L. A. White, 1993, Journal of cellular physiology.

The synthetic retinoid (4-hydroxyphenyl)retinamide decreases collagen expression in vitro and in the tight-skin mouse.

C. Brinckerhoff, A. Delany, 1993, Arthritis and rheumatism.

Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase

C. Brinckerhoff, B. Petrella, 2006, Molecular Cancer.

Role of serum amyloid A as an intermediate in the IL-1 and PMA-stimulated signaling pathways regulating expression of rabbit fibroblast collagenase.

M. Fini, K. Strissel, J. West-Mays, 1997, Experimental cell research.

Synergistic induction of matrix metalloproteinase 1 by interleukin-1alpha and oncostatin M in human chondrocytes involves signal transducer and activator of transcription and activator protein 1 transcription factors via a novel mechanism.

J. Rutter, C. Brinckerhoff, A. Rowan, 2001, Arthritis and rheumatism.

CXCR4 and Matrix Metalloproteinase-1 Are Elevated in Breast Carcinoma–Associated Fibroblasts and in Normal Mammary Fibroblasts Exposed to Factors Secreted by Breast Cancer Cells

C. Brinckerhoff, W. Winkelman, Anik L. Côté, 2009, Molecular Cancer Research.

CXCR 4 and Matrix Metalloproteinase-1 Are Elevated in Breast Carcinoma – Associated Fibroblasts and in Normal Mammary Fibroblasts Exposed to Factors Secreted by Breast Cancer Cells

C. Brinckerhoff, W. Winkelman, Anik L. Côté, 2009 .

Diesel Exhaust Particles Activate the Matrix-Metalloproteinase-1 Gene in Human Bronchial Epithelia in a β-Arrestin–Dependent Manner via Activation of RAS

C. Brinckerhoff, S. Simon, A. Ghio, 2008, Environmental health perspectives.

Basic Calcium Phosphate Crystals Induce Matrix Metalloproteinase-1 through the Ras/Mitogen-activated Protein Kinase/c-Fos/AP-1/Metalloproteinase 1 Pathway

Yubo Sun, L. Wenger, H. Cheung, 2002, The Journal of Biological Chemistry.

The BRAFV600E inhibitor, PLX4032, increases type I collagen synthesis in melanoma cells

C. Brinckerhoff, W. Croteau, Molly H. Jenkins, 2015, Matrix biology : journal of the International Society for Matrix Biology.

Selective modulation of collagenase 1 gene expression by the chemotherapeutic agent doxorubicin.

C. Brinckerhoff, J. Hamilton, R. Maitra, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

The Collagenases: Novel Roles for Matrix Metalloproteinases (MMPS) in Invasion and Metastasis

C. Brinckerhoff, U. Benbow, Grant B. Tower, 2002 .

Manganese Superoxide Dismutase Signals Matrix Metalloproteinase Expression via H2O2-dependent ERK1/2 Activation*

C. Epstein, J. Rutter, C. Brinckerhoff, 2001, The Journal of Biological Chemistry.

Consequences of altered TGF-β expression and responsiveness in breast cancer: evidence for autocrine and paracrine effects

C. Brinckerhoff, B. Arrick, V. Memoli, 2002, Oncogene.

Using inhibitors of metalloproteinases to treat arthritis. Easier said than done?

C. Brinckerhoff, M. Vincenti, I. Clark, 1994, Arthritis and rheumatism.

The AP-1 sequence is necessary but not sufficient for phorbol induction of collagenase in fibroblasts.

D. Auble, C. Brinckerhoff, Constance E. Brinckerhoff, 1991, Biochemistry.

What are the therapeutic implications of increased collagen expression in melanoma cells treated with vemurafenib?

C. Brinckerhoff, 2016, Melanoma management.

Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression

M. Sporn, C. Brinckerhoff, P. Burrage, 2008, Arthritis research & therapy.

Increased proliferation of human synovial fibroblasts treated with recombinant immune interferon.

C. Brinckerhoff, P M Guyre, C E Brinckerhoff, 1985, Journal of immunology.

CXCR3 Signaling in BRAFWT Melanoma Increases IL-8 Expression and Tumorigenicity

C. Brinckerhoff, Molly H. Jenkins, D. Mullins, 2015, PloS one.

The nuclear receptor corepressor SMRT inhibits interstitial collagenase (MMP-1) transcription through an HRE-independent mechanism.

C. Brinckerhoff, M. Vincenti, J. Chen, 1997, Biochemical and biophysical research communications.

The mitogen-activated protein kinase pathway plays a critical role in regulating immunological properties of BRAF mutant cutaneous melanoma cells

J. Fisher, M. Ernstoff, C. Fadul, 2016, Melanoma research.

BRAF Inhibition Alleviates Immune Suppression in Murine Autochthonous Melanoma

M. Ernstoff, M. Bosenberg, C. Brinckerhoff, 2014, Cancer Immunology Research.

Activation of the MMP-1 promoter by cigarette smoke in human small airway epithelial cells requires ERK MAP kinase signaling: differential response of the 1G and 2G promoter sequences.

J. D’Armiento, C. Brinckerhoff, B. Mercer, 2006, Proceedings of the American Thoracic Society.

Signal transduction and cell‐type specific regulation of matrix metalloproteinase gene expression: Can MMPs be good for you?

C. Brinckerhoff, M. Vincenti, 2007, Journal of cellular physiology.

IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: requirement for Runx-2 and activation by p38 MAPK and JNK pathways.

C. Brinckerhoff, M. Vincenti, C E Brinckerhoff, 2001, Nucleic acids research.

Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization.

P. Libby, C. Brinckerhoff, M. Aikawa, 1998, Circulation.

Relationship of procollagenase activator, stromelysin and matrix metalloproteinase 3.

C. Brinckerhoff, H. Nagase, G. Murphy, 1988, Collagen and related research.

Regulation of matrix metalloproteinase gene expression by a retinoid X receptor-specific ligand.

M. Sporn, C. Brinckerhoff, P. Burrage, 2007, Arthritis and rheumatism.

Transcriptional Repression of Matrix Metalloproteinase Gene Expression by the Orphan Nuclear Receptor NURR1 in Cartilage*

S. Abramson, C. Brinckerhoff, M. Attur, 2007, Journal of Biological Chemistry.

Post-transcriptional regulation of collagenase and stromelysin gene expression by epidermal growth factor and dexamethasone in cultured human fibroblasts.

C. Brinckerhoff, A. Delany, 1992, Journal of cellular biochemistry.

Cloning of the gene for interstitial collagenase-3 (matrix metalloproteinase-13) from rabbit synovial fibroblasts: differential expression with collagenase-1 (matrix metalloproteinase-1).

C. Brinckerhoff, C. I. Coon, M. Vincenti, 1998, The Biochemical journal.

Transforming growth factor beta inhibitory element in the rabbit matrix metalloproteinase-1 (collagenase-1) gene functions as a repressor of constitutive transcription.

C. Brinckerhoff, L A White, C E Brinckerhoff, 2000, Biochimica et biophysica acta.

Half-life of synovial cell collagenase mRNA is modulated by phorbol myristate acetate but not by all-trans-retinoic acid or dexamethasone.

G. O'Connor, C. Brinckerhoff, L. Sheldon, 1986, Biochemistry.

A synthetic triterpenoid selectively inhibits the induction of matrix metalloproteinases 1 and 13 by inflammatory cytokines.

M. Sporn, C. Brinckerhoff, M. Vincenti, 2001, Arthritis and rheumatism.

Regulation of Extrahepatic Apolipoprotein Serum Amyloid A (ApoSAA) Gene Expression by Interleukin‐1α Alone: Synthesis and Secretion of ApoSAA by Cultured Aortic Smooth Muscle Cells

B. Schreiber, C. Brinckerhoff, J. Sipe, 1997, Scandinavian journal of immunology.

Matrix metalloproteinase-1 promotes breast cancer angiogenesis and osteolysis in a novel in vivo model

C. Brinckerhoff, C. I. Coon, B. Petrella, 2009, Breast Cancer Research and Treatment.

RNA interference inhibition of matrix metalloproteinase-1 prevents melanoma metastasis by reducing tumor collagenase activity and angiogenesis.

C. Brinckerhoff, C. I. Coon, C. Rhodes, 2007, Cancer research.

The acute phase reactant serum amyloid A (SAA3) is a novel substrate for degradation by the metalloproteinases collagenase and stromelysin.

R. Palmiter, C. Brinckerhoff, T. Mitchell, 1993, Biochimica et biophysica acta.

Molecular targets in osteoarthritis: metalloproteinases and their inhibitors.

C. Brinckerhoff, P. Burrage, 2007, Current drug targets.

Patterns of regulation of collagen breakdown in articular cartilage

C. Brinckerhoff, C. Vater, E. D. Harris, 1981 .

Elevated levels of collagenase and prostaglandin e2 from synovium associated with chronic lyme arthritis

A. Steere, S. Malawista, C. Brinckerhoff, 1980 .

Collagenase Activity and Angiogenesis Prevents Melanoma Metastasis by Reducing Tumor RNA Interference Inhibition of Matrix Metalloproteinase-1

C. Brinckerhoff, C. I. Coon, C. Rhodes, 2007 .

Two activator protein-1 elements in the matrix metalloproteinase-1 promoter have different effects on transcription and bind Jun D, c-Fos, and Fra-2.

C. Brinckerhoff, L A White, C E Brinckerhoff, 1995, Matrix biology : journal of the International Society for Matrix Biology.

v‐src activation of the collagenase‐1 (matrix metalloproteinase‐1) promoter through PEA3 and STAT: Requirement of extracellular signal‐regulated kinases and inhibition by retinoic acid receptors

C. Brinckerhoff, C. I. Coon, M. Vincenti, 1998, Molecular carcinogenesis.

Cancer Stem Cells (CSCs) in melanoma: There's smoke, but is there fire?

C. Brinckerhoff, Constance E. Brinckerhoff, 2017, Journal of cellular physiology.

Inhibition of Collagenase Gene Expression in Synovial Fibroblasts by All‐trans and 9‐cis Retinoic Acid a

C. Brinckerhoff, L. Pan, 1994, Annals of the New York Academy of Sciences.

Novel phorbol ester response region in the collagenase promoter binds Fos and Jun

C. Brinckerhoff, R. Hemmer, Constance E. Brinckerhoff, 1993, Journal of cellular biochemistry.

Selective retinoic acid receptor ligands for rheumatoid arthritis.

C. Brinckerhoff, J. Ostrowski, B. Beehler, 2004, Current opinion in investigational drugs.

A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates an Ets binding site and augments transcription.

J. Gusella, L. Ozelius, J. Rutter, 1998, Cancer research.

Elevated levels of collagenase and prostaglandin E2 from synovium associated with erosion of cartilage and bone in a patient with chronic Lyme arthritis.

A. Steere, S. Malawista, C. Brinckerhoff, 1980, Arthritis and rheumatism.

Matrix metalloproteinase-1 and thrombin differentially activate gene expression in endothelial cells via PAR-1 and promote angiogenesis.

C. Brinckerhoff, Jessica S. Blackburn, 2008, The American journal of pathology.

Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase

C. Brinckerhoff, B. Petrella, 2006, Molecular Cancer.

Transforming growth factor beta inhibitory element in the rabbit matrix metalloproteinase-1 (collagenase-1) gene functions as a repressor of constitutive transcription.

C. Brinckerhoff, T. Mitchell, L. White, 2000, Biochimica et biophysica acta.