I. Leigh

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The promoter of a novel human papillomavirus (HPV77) associated with skin cancer displays UV responsiveness, which is mediated through a consensus p53 binding sequence

E. de Villiers, C. Proby, K. Purdie, 1999, The EMBO journal.

Connexin 26 mutations in hereditary non-syndromic sensorineural deafness

D. Kelsell, I. Leigh, J. Dunlop, 1997, nature.

Intermediate filament–membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength

D. Kelsell, B. Gumbiner, I. Leigh, 2002, The Journal of cell biology.

Clinical and genetic heterogeneity of erythrokeratoderma variabilis.

D. Kelsell, I. Leigh, V. Venning, 2005, The Journal of investigative dermatology.

Potential of fibroblast cell therapy for recessive dystrophic epidermolysis bullosa.

J. McGrath, R. Jeffery, G. Elia, 2008, The Journal of investigative dermatology.

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

M. Stratton, L. Alexandrov, C. Chelala, 2018, Nature Communications.

Azathioprine: friend or foe?

G. Inman, C. Proby, I. Leigh, 2019, The British journal of dermatology.

A Surveillance Model for Skin Cancer in Organ Transplant Recipients: A 22‐Year Prospective Study in an Ethnically Diverse Population

M. Raftery, P. Sasieni, J. McGregor, 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Formation of hemidesmosome-like structures in the absence of ligand binding by the (alpha)6(beta)4 integrin requires binding of HD1/plectin to the cytoplasmic domain of the (beta)4 integrin subunit.

A. Sonnenberg, D. Geerts, I. Leigh, 2000, Journal of cell science.

Pre-confluent keratinocyte grafting: the future for cultured skin replacements?

I. Leigh, H. Navsaria, P. Harris, 1998, Burns : journal of the International Society for Burn Injuries.

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma

David Haussler, Nam Huh, Paul T. Spellman, 2011, Proceedings of the National Academy of Sciences.

Detection of basement membrane components and basal cell keratin 14 in noninvasive and invasive carcinomas of the breast.

E. Lane, R. Holland, I. Leigh, 1989, The American journal of pathology.

Plectin defects in epidermolysis bullosa simplex with muscular dystrophy

E. Lane, J. R. McMillan, M. Akiyama, 2007, Muscle & nerve.

Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity

M. Saville, K. Fernandes, C. Proby, 2018, Oncotarget.

Human-Saccharomyces cerevisiae Proliferating Cell Nuclear Antigen Hybrids

B. Stillman, M. McGurk, V. Ellison, 2001, The Journal of Biological Chemistry.

Human Papilloma Viruses and Cancers of the Skin and Oral Mucosa

J. McGregor, C. Proby, I. Leigh, 2000 .

Clinical practice and biological effects of keratinocyte grafting.

I. Leigh, H. Navsaria, I. McKay, 1991, Annals of the Academy of Medicine, Singapore.

Culturing skin in vitro for wound therapy.

S. Myers, I. Leigh, H. Navsaria, 1995, Trends in biotechnology.

Degenerate and Nested PCR: a Highly Sensitive and Specific Method for Detection of Human Papillomavirus Infection in Cutaneous Warts

E. de Villiers, J. Breuer, J. McGregor, 1999, Journal of Clinical Microbiology.

The Role of Human Papillomaviruses in Non-melanoma Skin Cancer

J. McGregor, C. Proby, I. Leigh, 1997 .

Virus infection and cancer risk in transplant recipients.

J. McGregor, C. Proby, I. Leigh, 1996, Trends in microbiology.

Epidermal differentiation and dermal changes in healing following treatment of surgical wounds with sheets of cultured allogeneic keratinocytes.

I. Leigh, H. Navsaria, P. Purkis, 1995, Journal of clinical pathology.

Skin graft storage and keratinocyte viability.

I. Leigh, H. Navsaria, J. Frame, 1993, British journal of plastic surgery.

Ontogenesis of the basement membrane zone after grafting cultured human epithelium: a morphologic and immunoelectron microscopic study.

I. Leigh, A. Mulder, A. Mulder, 1992, The Journal of investigative dermatology.

Cultured epidermal autografts and allografts: a study of differentiation and allograft survival.

B. Gilchrest, I. Leigh, T. Phillips, 1990, Journal of the American Academy of Dermatology.

Cultured keratinocytes and keratinocyte grafts.

I. Leigh, K. Hancock, 1989, BMJ.

Mutations in the plakophilin 1 gene result in ectodermal dysplasia/skin fragility syndrome

E. Lane, J. R. McMillan, J. McGrath, 1997, Nature Genetics.

Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma.

D. Kelsell, I. Leigh, N. Whittock, 2000, Human molecular genetics.

Increased prevalence of dysplastic and malignant lip lesions in renal-transplant recipients.

H. Worthington, C. Healy, I. Leigh, 1995, The New England journal of medicine.

Restoration of basement membrane structure in pigs following keratinocyte autografting.

I. Leigh, C. Green, H. Navsaria, 1993, British journal of plastic surgery.

Missense mutations in fumarate hydratase in multiple cutaneous and uterine leiomyomatosis and renal cell cancer.

A. Rowan, D. Kelsell, I. Tomlinson, 2005, The Journal of molecular diagnostics : JMD.

Epidermolysis bullosa simplex (Dowling-Meara type) is a genetic disease characterized by an abnormal keratin-filament network involving keratins K5 and K14.

E. Lane, A. Ishida-Yamamoto, J. McGrath, 1991, The Journal of investigative dermatology.

Three‐dimensional cultures of keratinocytes and an application to in vitro‐amyloid production of cutaneous amyloidosis

K. Toda, I. Leigh, Y. Horiguchi, 1997, Microscopy research and technique.

Expression of distinct desmocollin isoforms in human epidermis.

I. Leigh, P. Purkis, I. King, 1993, The Journal of investigative dermatology.

Replication of varicella zoster virus in primary human keratinocytes

I. Leigh, H. Navsaria, C. Sexton, 1992, Journal of medical virology.

Revised nomenclature and classification of inherited ichthyoses: results of the First Ichthyosis Consensus Conference in Sorèze 2009.

C. Bodemer, M. Akiyama, H. Shimizu, 2010, Journal of the American Academy of Dermatology.

Prevalence and risk factors associated with leukoplakia, hairy leukoplakia, erythematous candidiasis, and gingival hyperplasia in renal transplant recipients.

C. Healy, I. Leigh, M. Glover, 1994, Oral surgery, oral medicine, and oral pathology.

Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability.

L. Aaltonen, R. Houlston, M. Murdoch, 2003, Cancer genetics and cytogenetics.

Characterization of factors involved in human papillomavirus type 16-mediated immortalization of oral keratinocytes.

L. Banks, C. Proby, I. Leigh, 1993, The Journal of general virology.

Inactivation of TGFb receptors in stem cells drives cutaneous squamous cell carcinoma

H. Clevers, S. Karlsson, G. Sapkota, 2016 .

The classification of inherited epidermolysis bullosa (EB): Report of the Third International Consensus Meeting on Diagnosis and Classification of EB.

E. Bauer, H. Shimizu, J. Uitto, 2008, Journal of the American Academy of Dermatology.

Validation of four cutaneous squamous cell carcinoma staging systems using nationwide data

I. Leigh, T. Nijsten, M. Wakkee, 2021, The British journal of dermatology.

A case of erythrokeratoderma variabilis without mutations in connexin 31

J. Common, D. Kelsell, A. Ishida-Yamamoto, 2000, The British journal of dermatology.

Connexin mutations associated with palmoplantar keratoderma and profound deafness in a single family

D. Kelsell, I. Leigh, C. Munro, 2000, European Journal of Human Genetics.

Defective trafficking and cell death is characteristic of skin disease-associated connexin 31 mutations.

D. Kelsell, J. Monypenny, I. Leigh, 2002, Human molecular genetics.

Multiple epidermal connexins are expressed in different keratinocyte subpopulations including connexin 31.

D. Kelsell, I. Leigh, W. Di, 2001, The Journal of investigative dermatology.

Functional studies of human skin disease- and deafness-associated connexin 30 mutations.

D. Kelsell, I. Leigh, J. Common, 2002, Biochemical and biophysical research communications.

The Role of Allogenic Fibroblasts in an Acute Wound Healing Model

I. Leigh, P. Harris, H. Navsaria, 2004, Plastic and reconstructive surgery.

Culture grafted leg ulcers

I. Leigh, I. Leigh, P. Purkis, 1986, Clinical and experimental dermatology.

Upregulation of integrin expression in benign vulvar warts

I. Leigh, I. Leigh, C. Sexton, 1995, The Journal of pathology.

Role for WNT16B in human epidermal keratinocyte proliferation and differentiation

D. Kelsell, S. Edmunds, I. Leigh, 2007, Journal of Cell Science.

Keratin 17 expression as a marker for epithelial transformation in viral warts.

C. Proby, I. Leigh, M. Glover, 1993, The American journal of pathology.

Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity

M. Saville, K. Fernandes, C. Proby, 2018, Oncotarget.

Morphological changes of neural and vascular peptides in human skin suction blister injury

J. Polak, I. Leigh, D. Price, 1994, The Journal of pathology.

Sporotrichoid spread of cutaneous Mycobacterium chelonei infection

M. Murdoch, I. Leigh, 1989, Clinical and experimental dermatology.

Type VII collagen antibody LH 7.2 identifies basement membrane characteristics of thin malignant melanomas

I. Leigh, N. Kirkham, C. Darley, 1989, The Journal of pathology.

Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix

H. Winter, J. Schweizer, I. Leigh, 1997, Nature Genetics.

Evidence that apoptosis and terminal differentiation of epidermal keratinocytes are distinct processes

L. Goldsmith, F. Watt, I. Leigh, 1999, Experimental dermatology.

Methylated tissue factor pathway inhibitor 2 (TFPI2) DNA in serum is a biomarker of metastatic melanoma.

A. Thompson, T. Crook, G. Inman, 2013, The Journal of investigative dermatology.

High levels of type VII collagen expression in recessive dystrophic epidermolysis bullosa cutaneous squamous cell carcinoma keratinocytes increases PI3K and MAPK signalling, cell migration and invasion

J. McGrath, I. Leigh, Mei Chen, 2014, The British journal of dermatology.

Erratum: Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma (Human Molecular Genetics (1999) 8 (143-148))

I. Leigh, K. Mckenna, R. Eady, 1999 .

Oral keratinocytes immortalized with the early region of human papillomavirus type 16 show elevated expression of interleukin 6, which acts as an autocrine growth factor for the derived T103C cell line.

D. Williams, I. Leigh, I. McKay, 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Antibody markers of basal cells in complex epithelia.

E. Lane, I. Mackenzie, I. Leigh, 1990, Journal of cell science.

Human papillomavirus infection and non‐melanoma skin cancer in immunosuppressed and immunocompetent individuals

J. McGregor, C. Proby, I. Leigh, 2000, Journal of medical virology.

Immunosuppressed Patients Proliferations and Carcinomas of the Skin in Specific Types of Human Papillomavirus Found in Benign

H. Hausen, Christine, I. Leigh, 2006 .

cifieTypes of Human Papillomavirus Found in Benign Proliferations and Carcinomas of the Skin in Iniimmusiippressed Patients 1

H. Hausen, C. Proby, I. Leigh, 2006 .

Epidemiology of basal and cutaneous squamous cell carcinoma in the U.K. 2013–15: a cohort study

S. Langan, J. Rashbass, C. Proby, 2019, The British journal of dermatology.

Skin cancer and warts in immunosuppressed renal transplant recipients.

I. Leigh, M. Glover, 1995, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Comparative study of antiseptic toxicity on basal keratinocytes, transformed human keratinocytes and fibroblasts.

I. Leigh, J. R. Gibson, F. Tatnall, 1990, Skin pharmacology : the official journal of the Skin Pharmacology Society.

Fumarate hydratase mutations and predisposition to cutaneous leiomyomas, uterine leiomyomas and renal cancer

I. Leigh, S. Olpin, N. Alam, 2005, The British journal of dermatology.

Treatment of erythema multiforme secondary to herpes simplex by prophylactic topical acyclovir.

I. Leigh, C. Kennedy, M. Wansbrough-Jones, 1981, British medical journal.

Human monoclonal antibodies to phenolic glycolipid-1 from leprosy patients cross react with poly(ADP-ribose), polynucleotides and tissue bound antigens.

D. Isenberg, Alimuddin Zumla, M. Locniskar, 1988, Autoimmunity.

Keratin expression in pilosebaceous epithelia in truncal skin of acne patients

W. Cunliffe, I. Leigh, I. Leigh, 1996, The British journal of dermatology.

Natural history, management and complications of herpes labialis

I. Leigh, J. Schofield, F. Tatnall, 1993, Journal of medical virology.

Transplantation of keratinocytes in the treatment of wounds.

S. Myers, I. Leigh, C. Green, 1995, American journal of surgery.

The reduction of water-soluble tetrazolium salt reagent on the plasma membrane of epidermal keratinocytes is oxygen dependent.

I. Leigh, A. Panteleyev, L. Weir, 2011, Analytical biochemistry.

Nerve and Blood Vessel Growth in Response to Grafted Dermis and Cultured Keratinocytes

J. Polak, I. Leigh, S. Manek, 1998, Plastic and reconstructive surgery.

Early death from cardiomyopathy in a family with autosomal dominant striate palmoplantar keratoderma and woolly hair associated with a novel insertion mutation in desmoplakin.

D. Kelsell, I. Leigh, C. Munro, 2006, The Journal of investigative dermatology.

Interferon-gamma activates co-ordinate transcription of HLA-DR, DQ, and DP genes in cultured keratinocytes and requires de novo protein synthesis.

K. Welsh, D. Macdonald, I. Leigh, 1990, The Journal of investigative dermatology.

Regeneration pattern of blood vessels and nerves in cultured keratinocyte grafts assessed by confocal laser scanning microscopy

J. Polak, I. Leigh, I. Leigh, 1995, The British journal of dermatology.

Formation of hemidesmosome-like structures in the absence of ligand binding by the α 6 β 4 integrin requires binding of HD 1 / plectin to the cytoplasmic domain of the β 4 integrin subunit

A. Sonnenberg, D. Geerts, I. Leigh, 2022 .

Oral tylosis: a re-appraisal.

I. Leigh, J. Field, A. Ellis, 1997, Oral oncology.

Changing patterns of keratin expression during progression of cervical intraepithelial neoplasia.

F. Smedts, I. Leigh, F. Ramaekers, 1990, The American journal of pathology.

Novel splice site mutation in keratin 1 underlies mild epidermolytic palmoplantar keratoderma in three kindreds.

D. Kelsell, I. Leigh, C. Munro, 2001, The Journal of investigative dermatology.

Novel and recurrent mutations in keratin 10 causing bullous congenital ichthyosiform erythroderma

I. Leigh, M. White, P. Bowden, 1999, Experimental dermatology.

The region coding for the helix termination motif and the adjacent intron 6 of the human type I hair keratin gene hHa2 contains three natural, closely spaced polymorphic sites.

H. Winter, M. Cremer, I. Leigh, 1996, The Journal of investigative dermatology.

Ichthyosis bullosa of Siemens--a disease involving keratin 2e.

E. Lane, I. Leigh, R. Eady, 1994, The Journal of investigative dermatology.

Mutations in the genes for epidermal keratins in epidermolysis bullosa and epidermolytic hyperkeratosis.

E. Lane, I. Leigh, 1993, Archives of dermatology.

Selective involvement of keratins K1 and K10 in the cytoskeletal abnormality of epidermolytic hyperkeratosis (bullous congenital ichthyosiform erythroderma).

E. Lane, A. Ishida-Yamamoto, J. McGrath, 1992, The Journal of investigative dermatology.

A mutation in the conserved helix termination peptide of keratin 5 in hereditary skin blistering

E. Lane, A. Ishida-Yamamoto, I. Leigh, 1992, Nature.

Keratin 14-null cells as a model to test the efficacy of gene therapy approaches in epithelial cells.

E. Lane, M. D'alessandro, I. Leigh, 2011, The Journal of investigative dermatology.

Recessive epidermolysis bullosa simplex associated with plectin mutations: infantile respiratory complications in two unrelated cases

E. Lane, J. R. McMillan, J. Uitto, 1997, The British journal of dermatology.

Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita.

G. Melino, A. Verloes, D. Hohl, 2001, The Journal of investigative dermatology.

Recurrent mutations in kindlin-1, a novel keratinocyte focal contact protein, in the autosomal recessive skin fragility and photosensitivity disorder, Kindler syndrome.

J. McGrath, I. Leigh, R. Eady, 2004, The Journal of investigative dermatology.

Generation and characterization of epidermolysis bullosa simplex cell lines: scratch assays show faster migration with disruptive keratin mutations

M. D'alessandro, D. Hohl, I. Leigh, 2003, The British journal of dermatology.

Diagnosis and confirmation of epidermolytic palmoplantar keratoderma by the identification of mutations in keratin 9 using denaturing high‐performance liquid chromatography

D. Kelsell, I. Leigh, H. Stevens, 2002, The British journal of dermatology.

Ichthyosis bullosa of Siemens and bullous ichthyosiform erythroderma–variants of the same disease?

M. Murdoch, I. Leigh, I. Leigh, 1990, Clinical and experimental dermatology.

Treatment of pachyonychia congenita.

A. Paller, S. Leachman, I. Leigh, 2005, The journal of investigative dermatology. Symposium proceedings.

Keratin 16 and keratin 17 mutations cause pachyonychia congenita

E. Lane, T. Strachan, I. Leigh, 1995, Nature Genetics.

Punctate palmoplantar keratoderma and malignancy in a four‐generation family

I. Leigh, H. Stevens, M. Rustin, 1996, The British journal of dermatology.

Basal-cell keratins in cervical reserve cells and a comparison to their expression in cervical intraepithelial neoplasia.

F. Smedts, I. Leigh, F. Ramaekers, 1992, The American journal of pathology.

Missense mutations in keratin 17 cause either pachyonychia congenita type 2 or a phenotype resembling steatocystoma multiplex.

E. Lane, D. Hohl, I. Leigh, 1997, The Journal of investigative dermatology.

Genomic organization and fine mapping of the keratin 2e gene (KRT2E): K2e V1 domain polymorphism and novel mutations in ichthyosis bullosa of Siemens.

E. Lane, J. Uitto, I. Leigh, 1998, The Journal of investigative dermatology.

Nuclear transcription factors: potential targets for new modes of intervention in skin disease

S. Bustin, I. Leigh, P. Winyard, 1994, The British journal of dermatology.

Close mapping of the focal non-epidermolytic palmoplantar keratoderma (PPK) locus associated with oesophageal cancer (TOC).

J. Weissenbach, D. Bishop, D. Kelsell, 1996, Human molecular genetics.

Most Cited Authors...

A. Enk, H. Williams, D. Schadendorf, 2008 .

MEK Is a Therapeutic and Chemopreventative Target in Squamous Cell Carcinoma.

K. Tsai, C. Coarfa, M. Napoli, 2016, The Journal of investigative dermatology.

Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma.

D. Kelsell, K. Linton, V. Plagnol, 2013, American journal of human genetics.

Association with Keratinocyte Activation, Proliferation, and Keratinization

B. Doğan, I. Leigh, U. Wollina, 2003 .

Loss of plectin causes epidermolysis bullosa with muscular dystrophy: cDNA cloning and genomic organization.

E. Lane, R. Ray, S. DeArmond, 1996, Genes & development.

Envoplakin, a possible candidate gene for focal NEPPK/esophageal cancer (TOC): the integration of genetic and physical maps of the TOC region on 17q25.

D. Bishop, D. Kelsell, F. Watt, 1999, Genomics.

Supplementation of a mutant keratin by stable expression of desmin in cultured human EBS keratinocytes.

E. Lane, I. Leigh, C. Grund, 2000, Journal of cell science.

Temperature sensitivity of the keratin cytoskeleton and delayed spreading of keratinocyte lines derived from EBS patients.

E. Lane, I. Leigh, H. Navsaria, 1995, Journal of cell science.

Whats new in genodermatoses?

D. Kelsell, M. Fear, I. Leigh, 2001, The Keio journal of medicine.

Keratin expression in epidermolysis bullosa simplex (Dowling-Meara).

D. Macdonald, I. Leigh, R. Eady, 1988, Acta dermato-venereologica.

Epidermolysis bullosa: preliminary observations of blister formation in keratinocyte cultures

I. Leigh, I. Leigh, R. Eady, 1984, The British journal of dermatology.

Tylosis oesophageal cancer mapped

D. Bishop, J. Bodmer, I. Leigh, 1994, Nature Genetics.

Epidermolytic acanthomas: clinical characteristics and immunohistochemical features.

Philip R. Cohen, I. Leigh, M. Duvic, 1997, American journal of dermatopathology.

Plectin deficiency results in muscular dystrophy with epidermolysis bullosa

E. Lane, D. Kelsell, J. R. McMillan, 1996, Nature Genetics.

Missing links: Weber–Cockayne keratin mutations implicate the L12 linker domain in effective cytoskeleton function

I. Leigh, H. Navsaria, M. Boxer, 1993, Nature Genetics.

A functional "knockout" of human keratin 14.

E. Lane, J. R. McMillan, I. Leigh, 1994, Genes & development.

The Role of Hyaluronic Acid in Wound Healing

S. Myers, I. Leigh, H. Navsaria, 2005, American journal of clinical dermatology.

A comparative immunohistochemical study of cytokeratin and vimentin expression in middle ear mucosa and cholesteatoma, and in epidermis

I. Leigh, F. Ramaekers, P. Coucke, 2004, Virchows Archiv A.

Recurrent erythema multiforme: tissue typing in a large series of patients

I. Leigh, I. Leigh, J. Schofield, 1994, The British journal of dermatology.

No evidence that human papillomavirus is responsible for the aggressive nature of recessive dystrophic epidermolysis bullosa-associated squamous cell carcinoma.

J. McGrath, C. Proby, H. Pfister, 2010, The Journal of investigative dermatology.

Keratin expression in discoid lupus erythematosus

I. Leigh, D. Dean, S. Burge, 1995, Experimental dermatology.

High frequency and diversity of cutaneous appendageal tumors in organ transplant recipients.

J. McGregor, C. Proby, I. Leigh, 2003, Journal of the American Academy of Dermatology.

A novel lamina lucida component of epithelial and endothelial basement membranes detected by LH39 monoclonal antibody

I. Leigh, S. Challacombe, J. Eveson, 1992, The Journal of pathology.

Recurrent and continuous erythema multiforme– a clinical and immunological study

I. Leigh, I. Leigh, J. Mowbray, 1985, Clinical and experimental dermatology.

In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins.

I. Leigh, J. Sampson, J. Sampson, 2001, Phytomedicine : international journal of phytotherapy and phytopharmacology.

(46) Continuous erythema multiforme treated with azathioprine

C. Proby, I. Leigh, F. Tatnall, 1991 .

Western blot analysis of the antigen in pemphigoid gestationis

I. Leigh, M. Black, F. Wojnarowska, 1990, The British journal of dermatology.

Characterization of LHTric‐1, a new monospecific monoclonal antibody to the trichocyte keratin Ha1

I. Leigh, M. Blount, M. Philpott, 1997, The British journal of dermatology.

Cellular Mechanisms of Mutant Connexins in Skin Disease and Hearing Loss

D. Kelsell, I. Leigh, D. Davies, 2003, Cell communication & adhesion.

Connexin mutations associated with palmoplantar keratoderma and profound deafness in a single family

D. Kelsell, I. Leigh, C. Munro, 2000, European Journal of Human Genetics.

Systemic lupus erythematosus presenting with oral mucosal lesions: easily missed?

I. Leigh, R. Bull, C. Orteu, 2001, The British journal of dermatology.

A comparison of antibodies to type VII and type IV collagen laminin and amnion as epidermal basement membrane markers

I. Leigh, N. Kirkham, M. Price, 1989, The Journal of pathology.

Gamma‐interferon induced human keratinocyte HLA‐DR synthesis: the role of dermal activated T lymphocytes

D. Macdonald, I. Leigh, I. Leigh, 1988, The British journal of dermatology.

Isolation of human tumor-specific antibodies by selection of an antibody phage library on melanoma cells.

I. Leigh, J. N. Newton Bishop, N. Tidman, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Human elastase 1: evidence for expression in the skin and the identification of a frequent frameshift polymorphism.

D. Kelsell, S. Khalaf, I. Leigh, 2000, The Journal of investigative dermatology.

Malignant transformation of cutaneous lesions in renal allograft patients: a role for human papillomavirus.

C. Proby, K. Purdie, I. Leigh, 1993, Cancer research.

Malignant Transformation of Cutaneous Lesions in Renal Allograft Patients: A Role for Human l'a pii loma virus?1

K. Purdie, I. Leigh, M. Glover, 1993 .

Immortalisation of human urothelial cells

J. Masters, I. Leigh, C. Sexton, 2004, Urological Research.

Culture and characterisation of human urothelium in vivo and in vitro

J. Masters, I. Leigh, P. Duffy, 2004, Urological Research.

Basal cell glycoprotein in pig epidermis closely resembles the beta 1 subunit of the integrin family of cell adhesion molecules.

I. Leigh, P. Purkis, P. Fryer, 1991, The Journal of investigative dermatology.

Cytokeratin profiles in dyskeratosis congenita: an immunocytochemical investigation of lingual hyperkeratosis.

E. Lane, G. Ogden, D. Chisholm, 1992, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

(22) Woolly hair naevi with systematized linear epidermal naevus

I. Leigh, I. Leigh, S. Wright, 1991 .

(23) Extensive comedo naevus: benefit from long‐term erythromycin

I. Leigh, I. Leigh, M. Glover, 1991 .

Skin cancer. Introduction.

M. Kripke, I. Leigh, J. N. Newton Bishop, 1996, Cancer surveys.

The retinoid signalling molecule, TRIM16, is repressed during squamous cell carcinoma skin carcinogenesis in vivo and reduces skin cancer cell migration in vitro

J. Wilmott, R. Scolyer, C. Proby, 2011, The Journal of pathology.

Keratins (Kl6 and Kl7) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro

Irene M. Leigh, P. E. Bowden, I. Leigh, 1995 .

Cytokeratins in primary cutaneous amyloidosis

I. Leigh, M. Black, P. Carrington, 1998, The Australasian journal of dermatology.

Psoriasis: maintenance of an intact monolayer basal cell differentiation compartment in spite of hyperproliferation

E. Lane, I. Leigh, K. Pulford, 1985, The British journal of dermatology.

Human papillomavirus infections in nonmelanoma skin cancers from renal transplant recipients and nonimmunosuppressed patients.

E. de Villiers, H. Hausen, G. Plewig, 1996, Journal of the National Cancer Institute.

Altered patterns of keratin expression in oral hairy leukoplakia: prognostic implications.

I. Leigh, J. Greenspan, D. Greenspan, 1991, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

University of Dundee Lysyl hydroxylase 3 localizes to epidermal basement membrane and Is reduced in patients with Recessive Dystrophic Epidermolysis

J. Tolar, J. R. McMillan, J. McGrath, 2017 .

Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessive Dystrophic Epidermolysis Bullosa

J. Tolar, J. R. McMillan, J. McGrath, 2015, PloS one.

Phenotypic/genotypic correlations in patients with epidermolytic hyperkeratosis and the effects of retinoid therapy on keratin expression.

I. Leigh, N. Mørk, M. Virtanen, 2001, Acta dermato-venereologica.

Scleredema of Buschke associated with multiple myeloma

I. Leigh, I. Leigh, J. Salisbury, 1988, Clinical and experimental dermatology.

Keratin expression in cervical cancer.

F. Smedts, I. Leigh, F. Ramaekers, 1992, The American journal of pathology.

Immunosuppression and risk of non-melanoma skin cancer in renal transplant recipients

M. Raftery, J. Deeks, I. Leigh, 1997, The Lancet.

Characteristics of the oral lesions in patients with cutaneous recurrent erythema multiforme.

I. Leigh, D. Williams, P. Farthing, 1995, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

Genetic linkage studies in non-epidermolytic palmoplantar keratoderma: evidence for heterogeneity.

D. Bishop, D. Kelsell, I. Leigh, 1995, Human molecular genetics.

Cytokeratin expression patterns in metastatic transitional cell carcinoma of the urinary tract. An immunohistochemical study comparing local tumor and autologous metastases.

E. Lane, J. Schalken, D. Ruiter, 1991, The American journal of pathology.

Clinical application of skin substitutes

G. Damodaran, S. Myers, I. Leigh, 2008 .

Use of Two Stage Keratinocyte-Dermal Grafting to Treat the Separation Site in Conjoined Twins

M. Stringer, I. Leigh, L. Spitz, 1994, Journal of the Royal Society of Medicine.

SYNTHETIC DRESSINGS

I. Leigh, N. Carver, N. Carver, 1992, International journal of dermatology.

Lamina densa malformation involved in histogenesis of primary localized cutaneous amyloidosis.

I. Leigh, T. Yoshiki, Y. Horiguchi, 1992, The Journal of investigative dermatology.

Expression of intermediate filament proteins in fetal and adult human lung tissues.

E. Lane, S. Wagenaar, I. Leigh, 1989, Differentiation; research in biological diversity.

Clinical features of multiple cutaneous and uterine leiomyomatosis: an underdiagnosed tumor syndrome.

A. Rowan, D. Kelsell, I. Tomlinson, 2005, Archives of dermatology.

Genetic characterization of a human skin carcinoma progression model: from primary tumor to metastasis.

A. Jauch, C. Proby, I. Leigh, 2000, The Journal of investigative dermatology.

Development of a treatment algorithm for actinic keratoses: a European Consensus.

H. Pehamberger, H. Kerl, J. Grob, 2008, European journal of dermatology : EJD.

Patterns of cytokeratin expression in human gingival epithelia.

E. Lane, I. Mackenzie, I. Leigh, 1991, Journal of periodontal research.

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

A. Paetau, L. Aaltonen, R. Houlston, 2002, Nature Genetics.

Keratin Antigens in Differentiating Skin

E. Lane, J. Bartek, I. Leigh, 1985, Annals of the New York Academy of Sciences.

Patterns of keratin-expression in rests of Malassez and periapical lesions.

E. Lane, I. Mackenzie, I. Leigh, 1988, Journal of oral pathology.

Basal cell-specific and hyperproliferation-related keratins in human breast cancer.

E. Lane, R. Holland, I. Leigh, 1991, The American journal of pathology.

Distribution of cytokeratin polypeptides in human transitional cell carcinomas, with special emphasis on changing expression patterns during tumor progression.

D J Ruiter, E. Lane, D. Ruiter, 1990, The American journal of pathology.

The epidermal basement membrane in basal cell carcinoma: an immunohistochemical study

D. Macdonald, I. Leigh, I. Leigh, 1991, The British journal of dermatology.

A comparison of tissue-engineered hyaluronic acid dermal matrices in a human wound model.

I. Leigh, H. Navsaria, R. Price, 2006, Tissue engineering.

Assay of antiseptic agents in cell culture: conditions affecting cytotoxicity.

I. Leigh, J. R. Gibson, F. Tatnall, 1991, The Journal of hospital infection.

Cytokeratin expression of the odontogenic epithelia in dental follicles and developmental cysts.

E. Lane, I. Mackenzie, I. Leigh, 1989, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

Idiopathic scrotal calcinosis is idiopathic.

I. Leigh, H. Navsaria, S. Wright, 1991, Journal of the American Academy of Dermatology.

Treatment of chronic actinic dermatitis with azathioprine

J. Hawk, I. Leigh, 1984, The British journal of dermatology.

Distribution patterns of type VII collagen in normal and malignant human tissues.

H. Schaafsma, I. Leigh, F. Ramaekers, 1991, The American journal of pathology.

Cutaneous warts and tumours in immunosuppressed patients.

I. Leigh, M. Glover, 1995, Journal of the Royal Society of Medicine.

Epidermolysis bullosa acquisita antigen and the carboxy terminus of type VII collagen have a common immunolocalization to anchoring fibrils and lamina densa of basement membrane

H. Shimizu, I. Leigh, I. Leigh, 1990, The British journal of dermatology.

Intra‐epidermal neutrophilic IgA dermatosis with colitis

I. Leigh, I. Leigh, J. Ryan, 1989, The British journal of dermatology.

Keratin expression in the normal nail unit: markers of regional differentiation

I. Leigh, F. Wojnarowska, D. D. de Berker, 2000, The British journal of dermatology.

The clinical expression of bullous pemphigoid is not determined by the specificity of the target antigen

I. Leigh, I. Leigh, F. Wojnarowska, 1991, The British journal of dermatology.

Lichen planus pemphigoides: its relationship to bullous pemphigoid

M. Murdoch, I. Leigh, P. Frith, 1991, The British journal of dermatology.

Identification of the epidermolysis bullosa acquisita antigen by LH 7.2 monoclonal antibody: use in diagnosis *

I. Leigh, M. Black, F. Wojnarowska, 1989, The British journal of dermatology.

Specific types of human papillomavirus found in benign proliferations and carcinomas of the skin in immunosuppressed patients.

E. de Villiers, H. Hausen, C. Proby, 1994, Cancer research.

Potential applications of anti-keratin antibodies in oral diagnosis.

E. Lane, I. Leigh, N. W. Johnson, 2007, Journal of oral pathology.

Oesophageal webs preceding carcinoma and rupture of the oesophagus in cicatricial pemphigoid

I. Leigh, I. Leigh, F. Wojnarowska, 1991, Clinical and experimental dermatology.

Linkage of an American pedigree with palmoplantar keratoderma and malignancy (palmoplantar ectodermal dysplasia type III) to 17q24. Literature survey and proposed updated classification of the keratodermas.

J. Weissenbach, D. Bishop, D. Kelsell, 1996, Archives of dermatology.

Woolly hair naevi with systematized linear epidermal naevus

N. Lemoine, I. Leigh, I. Leigh, 1986, Clinical and experimental dermatology.

Vesicular Langerhans cell histiocytosis—an uncommon variant

I. Leigh, I. Leigh, F. Tatnall, 1994, Clinical and experimental dermatology.

Localization of a gene (MCUL1) for multiple cutaneous leiomyomata and uterine fibroids to chromosome 1q42.3-q43.

R. Houlston, M. Murdoch, D. Kelsell, 2001, American journal of human genetics.

Dermatomyositis pemphigoides: a case with coexistent dermatomyositis and bullous pemphigoid.

I. Leigh, I. Leigh, M. Glover, 1992, Journal of the American Academy of Dermatology.

Inherited epidermolysis bullosa: updated recommendations on diagnosis and classification.

E. Bauer, H. Shimizu, J. Uitto, 2014, Journal of the American Academy of Dermatology.

Recurrent erythema multiforme: clinical features and treatment in a large series of patients

I. Leigh, J. Schofield, F. Tatnall, 1993, The British journal of dermatology.

Permeability barrier properties of oral keratinocyte cultures: a model of intact human oral mucosa.

P. Wertz, I. Leigh, D. Williams, 2001, Oral diseases.

Hereditary ‘white nails’: a genetic and structural study

D. Kelsell, I. Leigh, B. Balme, 2004, The British journal of dermatology.

Cultured keratinocyte allografts and wound healing in severe recessive dystrophic epidermolysis bullosa.

J. McGrath, I. Leigh, R. Eady, 1993, Journal of the American Academy of Dermatology.

Structural variations in anchoring fibrils in dystrophic epidermolysis bullosa: correlation with type VII collagen expression.

J. McGrath, I. Leigh, R. Eady, 1993, The Journal of investigative dermatology.

Intracellular expression of type VII collagen during wound healing in severe recessive dystrophic epidermolysis bullosa and normal human skin

J. McGrath, I. Leigh, I. Leigh, 1992, The British journal of dermatology.

Intraepidermal type VII collagen

I. Leigh, Y. Horiguchi, J. Fine, 1990 .

Type VII collagen is a normal component of epidermal basement membrane, which shows altered expression in recessive dystrophic epidermolysis bullosa.

R. Burgeson, I. Leigh, R. Eady, 1988, The Journal of investigative dermatology.

Non-melanoma skin cancer in renal transplant recipients: the extent of the problem and a strategy for management.

N. Niranjan, I. Leigh, M. Glover, 1994, British journal of plastic surgery.

Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma.

I. Leigh, K. Mckenna, R. Eady, 1999, Human molecular genetics.

Mepacrine pigmentation in systemic lupus erythematosus

J. Ramsey, I. Leigh, I. Leigh, 1979, The British journal of dermatology.

Keratinocyte differentiation in psoriatic scalp: morphology and expression of epithelial keratins

E. Lane, I. Leigh, D. Dean, 1994, The British journal of dermatology.

A double‐blind, placebo‐controlled trial of continuous acyclovir therapy in recurrent erythema multiforme

I. Leigh, J. Schofield, F. Tatnall, 1995, The British journal of dermatology.

Nationwide Incidence of Metastatic Cutaneous Squamous Cell Carcinoma in England

Katherine E Henson, S. Langan, J. Rashbass, 2019, JAMA dermatology.

Patients with recessive dystrophic epidermolysis bullosa develop squamous-cell carcinoma regardless of type VII collagen expression.

J. McGrath, I. Leigh, H. Fassihi, 2007, The Journal of investigative dermatology.

Metastatic cutaneous squamous cell carcinoma shows frequent deletion in the protein tyrosine phosphatase receptor Type D gene

Irene M. Leigh, Catherine A. Harwood, David P. Kelsell, 2012, International journal of cancer.

Detection of a novel basement membrane antigen by GDA‐J/F3 anti‐human sperm fibrous sheath monoclonal antibody

I. Leigh, R. Eady, P. Purkis, 1991, The British journal of dermatology.

Development of autologous human dermal–epidermal composites based on sterilized human allodermis for clinical use

S. Mac Neil, I. Leigh, R. Dawson, 1999, The British journal of dermatology.

Survival of cultured allogeneic keratinocytes transplanted to deep dermal bed assessed with probe specific for Y chromosome.

I. Leigh, M. Hackett, H. Navsaria, 1989, BMJ.

Kerato-dermal grafts: the importance of dermis for the in vivo growth of cultured keratinocytes.

I. Leigh, S. Manek, C. Green, 1993, British journal of plastic surgery.

The Role of the Immune System in Cutaneous Squamous Cell Carcinoma

M. Bottomley, I. Leigh, C. Harwood, 2019, International journal of molecular sciences.

A novel human papillomavirus identified in epidermodysplasia verruciformis

I. Leigh, C. Proby, K. Purdie, 1997, The British journal of dermatology.

Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling

R. Hamoudi, C. Proby, K. Purdie, 2013, British Journal of Cancer.

Keratinocyte Grafts and Skin Equivalents

I. Leigh, N. Carver, 1991, International journal of dermatology.

External anogenital premalignant and malignant disease.

I. Leigh, K. Gibbon, A. Ekeowa‐Anderson, 2009, Cancer treatment and research.

Development and characterization of a novel xenograft model permissive for human papillomavirus DNA amplification and late gene expression.

R. Shaw, I. Leigh, C. Lovegrove, 1995, The Journal of general virology.

Epidermal cytokines and their roles in cutaneous wound healing

I. Leigh, I. McKay, I. Mckay, 1991, The British journal of dermatology.

Increased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin

P. Sasieni, J. McGregor, C. Proby, 2004, The British journal of dermatology.

E2 represses the late gene promoter of human papillomavirus type 8 at high concentrations by interfering with cellular factors

F. Stubenrauch, H. Pfister, I. Leigh, 1996, Journal of virology.

Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis.

D. Kelsell, E. Sprecher, C. Mein, 2005, American journal of human genetics.

A porcine model using skin graft chambers for studies on cultured keratinocytes.

I. Leigh, S. Manek, C. Green, 1993, British journal of plastic surgery.

Altered laminin 5 expression due to mutations in the gene encoding the beta 3 chain (LAMB3) in generalized atrophic benign epidermolysis bullosa.

J. Uitto, J. McGrath, A. Christiano, 1995, The Journal of investigative dermatology.

Intracytoplasmic retention of type VII collagen and dominant dystrophic epidermolysis bullosa: reversal of defect following cessation of or marked improvement in disease activity.

I. Leigh, J. T. Wright, R. Briggaman, 1993, The Journal of investigative dermatology.

Intraepidermal type VII collagen. Evidence for abnormal intracytoplasmic processing of a major basement membrane protein in rare patients with dominant and possibly localized recessive forms of dystrophic epidermolysis bullosa.

I. Leigh, Y. Horiguchi, J. Fine, 1990, Journal of the American Academy of Dermatology.

Type VII collagen regulates tumour expression of organic anion transporting polypeptide OATP 1 B 3 , promotes front to rear polarity and increases structural organisation in 3 D spheroid cultures of recessive dystrophic epidermolysis bullosa tumour keratinocytes

J. McGrath, I. Leigh, D. Murrell, 2017 .

Type VII collagen regulates expression of OATP1B3, promotes front-to-rear polarity and increases structural organisation in 3D spheroid cultures of RDEB tumour keratinocytes

J. McGrath, I. Leigh, D. Murrell, 2014, Journal of Cell Science.

Detection and typing of human papillomaviruses in mucosal and cutaneous biopsies from immunosuppressed and immunocompetent patients and patients with epidermodysplasia verruciformis: a unified diagnostic approach.

J. Breuer, J. McGregor, C. Proby, 1998, Journal of clinical pathology.

Role of a p53 polymorphism in the development of human papilloma-virus-associated cancer

Irene M. Leigh, Catherine A. Harwood, Judith Breuer, 1998, Nature.

Linkage of autosomal dominant dystrophic epidermolysis bullosa in three British families to the marker D3S2 close to the COL7A1 locus.

M. Farrall, I. Leigh, R. Eady, 1992, Journal of medical genetics.

A Case of Pretibial Dystrophic Epidermolysis Bullosa: Decreased Expression of the Non‐helical Domain of Type VII Collagen Molecule

I. Leigh, Y. Horiguchi, Toshihiro Tanaka, 1993, The Journal of dermatology.

Treatment of chronic venous ulcers with sheets of cultured allogenic keratinocytes

I. Leigh, H. Navsaria, P. Purkis, 1987, The British journal of dermatology.

Clinicopathologic features of skin cancer in organ transplant recipients: a retrospective case-control series.

J. McGregor, C. Proby, I. Leigh, 2006, Journal of the American Academy of Dermatology.

Single nucleotide polymorphism array analysis defines a specific genetic fingerprint for well-differentiated cutaneous SCCs.

C. Proby, K. Purdie, I. Leigh, 2009, The Journal of investigative dermatology.

Mutations in the rod 1A domain of keratins 1 and 10 in bullous congenital ichthyosiform erythroderma (BCIE).

E. Lane, J. R. McMillan, I. Leigh, 1994, The Journal of investigative dermatology.

Vulval intraepithelial neoplasia and periungual Bowen's disease concordant for mucosal (HPV‐34) and epidermodysplasia verruciformis (HPV‐21) human papillomavirus types

I. Leigh, C. Harwood, K. Gibbon, 2007, Clinical and experimental dermatology.

p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis

A. Costanzo, C. Proby, I. Leigh, 2013, The Journal of experimental medicine.

p 63 is an alternative p 53 repressor in melanoma that confers chemoresistance and a poor prognosis

A. Costanzo, C. Proby, I. Leigh, 2013 .

British cosmetic regulations inadequate.

I. Leigh, C. Ridley, S. Adams, 1984, British medical journal.

Reepithelialisation of Wounds

I. Leigh, 1995 .

Keratin expression in human mammary epithelial cells cultured from normal and malignant tissue: relation to in vivo phenotypes and influence of medium.

E. Lane, J. Bartek, J. Taylor‐Papadimitriou, 1989, Journal of cell science.

Expression of beta human chorionic gonadotrophin by non-trophoblastic non-endocrine 'normal' and malignant epithelial cells.

T. Chard, I. Leigh, R. Oliver, 1990, British Journal of Cancer.

Expression ofbetahumanchorionic gonadotrophin bynon-trophoblasti c non-endocrine 'normal' andmalignant epithelial cells

T. Chard, I. Leigh, R. Oliver, 1990 .

Altered keratinocyte growth and differentiation in psoriasis.

I. Leigh, I. McKay, I. Mckay, 1995, Clinics in dermatology.

Activated keratinocytes in the epidermis of hypertrophic scars.

I. Leigh, M. Machesney, A. Waseem, 1998, The American journal of pathology.

Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency.

N P Burrows, M Keefe, A. Rowan, 2003, Human molecular genetics.

Treatment of post‐transplant premalignant skin disease: a randomized intrapatient comparative study of 5‐fluorouracil cream and topical photodynamic therapy

P. Karran, J. McGregor, C. Proby, 2007, The British journal of dermatology.

Abnormal expression of wild type p53 protein in normal cells of a cancer family patient

D. Lane, L. Bobrow, B. Vojtesek, 1992, The Lancet.

Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis

D. Kelsell, C. Proby, K. Purdie, 2007, Genes, chromosomes & cancer.

Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry

G. Pinkus, J. Aster, L. Chirieac, 2013, PloS one.

Detection of human papillomavirus DNA in PUVA-associated non-melanoma skin cancers.

J. McGregor, C. Proby, I. Leigh, 1998, The Journal of investigative dermatology.

Expression of keratin K2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation, and keratinization.

B. Doğan, I. Leigh, U. Wollina, 2003, The American journal of pathology.

Mena regulates the LINC complex to control actin–nuclear lamina associations, trans-nuclear membrane signalling and cancer gene expression

J. Armstrong, A. von Kriegsheim, W. Bickmore, 2021, bioRxiv.

Spectrum of dominant mutations in the desmosomal cadherin desmoglein 1, causing the skin disease striate palmoplantar keratoderma

D. Kelsell, H. Hennies, I. Leigh, 2001, European Journal of Human Genetics.

N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma.

D. Kelsell, I. Leigh, R. Eady, 1999, Human molecular genetics.

Linkage of monilethrix to the trichocyte and epithelial keratin gene cluster on 12q11-q13.

D. Bishop, D. Kelsell, I. Leigh, 1996, The Journal of investigative dermatology.

Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16

D. Kelsell, M. Freeman, I. Leigh, 2017, Nature Communications.

The Genomic Landscape of Actinic Keratosis

G. Inman, C. Proby, K. Purdie, 2021, The Journal of investigative dermatology.

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

H. Clevers, S. Karlsson, G. Sapkota, 2016, Nature Communications.

An investigation of cytokeratin expression in skin epithelial cysts and some uncommon types of cystic tumours using chain-specific antibodies

E. Lane, I. Leigh, F. Ramaekers, 2004, Archives of Dermatological Research.

Immunohistochemical Analysis of the Cytokeratin Expression in Middle Ear Cholesteatoma and Related Epithelial Tissues

Paul Coucke, I. Leigh, F. Ramaekers, 1992, The Annals of otology, rhinology, and laryngology.

High-resolution genomic profiling of human papillomavirus-associated vulval neoplasia

C. Proby, K. Purdie, I. Leigh, 2010, British Journal of Cancer.

Identification of the familial cylindromatosis tumour-suppressor gene

A. Ashworth, S. Seal, M. Stratton, 2000, Nature Genetics.

Spontaneous keratinocyte cell lines representing early and advanced stages of malignant transformation of the epidermis

C. Proby, K. Purdie, I. Leigh, 2000, Experimental dermatology.

Retention of low copy number human papillomavirus DNA in cultured cutaneous and mucosal wart keratinocytes.

K. Purdie, I. Leigh, D. Williams, 1994, The Journal of general virology.

Changes in type I keratin expression associated with HPV16 transformation of human epidermal keratinocytes.

F. Watt, I. Leigh, X. Pei, 1992, Epithelial cell biology.

NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis

S. Arron, J. Aster, M. Dimon, 2014, The Journal of investigative dermatology.

Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis

F. Watt, U. Jensen, I. Leigh, 2003, Development.

Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes.

S. Bustin, I. Leigh, I. McKay, 1994, DNA and cell biology.

Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa.

J. McGrath, I. Leigh, F. Hogg, 2012, Cancer research.

ARNT controls the expression of epidermal differentiation genes through HDAC- and EGFR-dependent pathways

I. Leigh, A. Panteleyev, M. Romanowska, 2012, Journal of Cell Science.

Isolation, sequence and expression of the gene encoding human keratin 13.

B. Doğan, I. Leigh, A. Waseem, 1998, Gene.

Two Mechanisms Regulate Keratin K15 Expression In Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signalling

I. Leigh, M. Teh, A. Waseem, 2012, PloS one.

Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes.

B. Doğan, I. Leigh, M. Machesney, 1999, The Journal of investigative dermatology.

Epidermal and hair follicle progenitor cells express melanoma-associated chondroitin sulfate proteoglycan core protein.

I. Leigh, A. Quinn, M. Philpott, 2004, The Journal of investigative dermatology.

Characterization of a 500 kb region on 17q25 and the exclusion of candidate genes as the familial Tylosis Oesophageal Cancer (TOC) locus

J. E. Langan, D. Kelsell, I. Leigh, 2002, Oncogene.

Localization of the Netherton syndrome gene to chromosome 5q32, by linkage analysis and homozygosity mapping.

L. Cardon, C. Bodemer, D. Kelsell, 2000, American Journal of Human Genetics.

A novel human type II cytokeratin, K6hf, specifically expressed in the companion layer of the hair follicle.

H. Winter, J. Schweizer, I. Leigh, 1998, The Journal of investigative dermatology.

Subtle Early Features of Onchocerciasis in a European

I. Leigh, M. Glover, M. Murdoch, 1991, Journal of the Royal Society of Medicine.

A hyaluronic acid membrane delivery system for cultured keratinocytes: clinical "take" rates in the porcine kerato-dermal model.

C. Soranzo, S. Myers, I. Leigh, 1997, The Journal of burn care & rehabilitation.

An animal model to study the significance of dermis for grafting cultured keratinocytes on full thickness wounds.

I. Leigh, S. Manek, C. Green, 1994, Burns : journal of the International Society for Burn Injuries.

The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions

M. Feltkamp, G. Inman, C. Proby, 2018, Front. Microbiol..

Novel CARD11 Mutations in Human Cutaneous Squamous Cell Carcinoma Lead to Aberrant NF-κB Regulation.

S. Arron, M. Dimon, C. Proby, 2015, The American journal of pathology.

The Identification of Potential Therapeutic Targets for Cutaneous Squamous Cell Carcinoma

M. Saville, K. Fernandes, C. Proby, 2019, The Journal of investigative dermatology.

An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity.

E. K. Parkinson, I. Leigh, M. Teh, 2008, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

The distribution of LH39 basement membrane epitope in the tumour stroma of oral squmaous cell carcinomas

I. Leigh, S. Challacombe, J. Eveson, 1992, The Journal of pathology.

HPV8 early genes modulate differentiation and cell cycle of primary human adult keratinocytes

B. Akgül, H. Pfister, I. Leigh, 2007, Experimental dermatology.

An immunohistochemical and histochemical study of cytokeratin, involucrin and transglutaminase in seborrhoeic keratosis

E. Lane, I. Leigh, F. Ramaekers, 2004, Archives of Dermatological Research.

Keratin expression in cutaneous lichen planus

I. Leigh, P. Marren, A. Milligan, 1995, Histopathology.

Keratin expression in the normal anal canal

I. Talbot, I. Leigh, J. Northover, 1995, Histopathology.

Keratinocyte alterations in skin tumour development.

E. Lane, C. Proby, I. Leigh, 1993, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Keratin expression in basal cell carcinomas

E. Lane, D. Macdonald, I. Leigh, 1992, The British journal of dermatology.

Expression of simple epithelial keratins 8 and 18 in epidermal neoplasia.

E. Lane, D. Macdonald, I. Leigh, 1991, The Journal of investigative dermatology.

Keratin 19: predicted amino acid sequence and broad tissue distribution suggest it evolved from keratinocyte keratins.

I. Leigh, P. Purkis, P. Stasiak, 1989, The Journal of investigative dermatology.

Relationship Between p 53 Codon 72 Polymorphism and Susceptibility to Sunburn and Skin Cancer

S. Fisher, C. Lewis, J. McGregor, 2010 .

Relationship between p53 codon 72 polymorphism and susceptibility to sunburn and skin cancer.

S. Fisher, C. Lewis, J. McGregor, 2002, The Journal of investigative dermatology.

Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma

S. Bray, G. Inman, P. Coates, 2018, Oncotarget.

Reduced SMAD 2 / 3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma

S. Bray, G. Inman, P. Coates, 2018 .

Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability

J. McGrath, I. Leigh, R. Eady, 2003, Journal of Cell Science.

Genomic analysis of atypical fibroxanthoma

Namita Ravi, S. Arron, C. Proby, 2017, PloS one.

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

P. Cole, C. Proby, I. Leigh, 2019, PloS one.

Cutaneous Squamous Cell Carcinoma (SCC) and the DNA Damage Response: pATM Expression Patterns in Pre-Malignant and Malignant Keratinocyte Skin Lesions

K. Purdie, I. Leigh, A. Storey, 2011, PloS one.

Vascular patterns in reactive lymphoid tissue and in non-Hodgkin's lymphoma

K. Gatter, G. Pillai, F. Pezzella, 2003, British Journal of Cancer.

Growth and Viability of Cutaneous Squamous Cell Carcinoma Cell Lines Display Different Sensitivities to Isoform-Specific Phosphoinositide 3-Kinase Inhibitors

I. Leigh, D. Bergamaschi, T. Maffucci, 2021, International journal of molecular sciences.

Vascular phenotype in angiogenic and non-angiogenic lung non-small cell carcinomas

A. Nicholson, P. Granone, P. Goldstraw, 2002, British Journal of Cancer.

WNT Signaling in Cutaneous Squamous Cell Carcinoma: A Future Treatment Strategy?

I. Leigh, V. Sherwood, 2016, The Journal of investigative dermatology.

Low-dose retinoids in the prevention of cutaneous squamous cell carcinomas in organ transplant recipients: a 16-year retrospective study.

C. Proby, I. Leigh, C. Harwood, 2005, Archives of dermatology.

Immunohistochemical analysis of burn depth.

J. Frame, I. Leigh, I M Leigh, 1999, The Journal of burn care & rehabilitation.

Anticardiolipin and antinuclear antibodies in discoid lupus erythematosus‐their clinical significance

I. Leigh, F. Wojnarowska, C. Lovell, 1988, Clinical and experimental dermatology.

Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma

J. McGrath, C. Mein, J. Bourdon, 2011, Oncogene.

Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis.

F. Watt, I. Leigh, M. Hertle, 1992, The Journal of clinical investigation.

The effect of backing materials on keratinocyte autograft take.

I. Leigh, C. Green, H. Navsaria, 1993, British journal of plastic surgery.

The Promise of Genomics and the Development of Targeted Therapies for Cutaneous Squamous Cell Carcinoma.

G. Inman, C. Proby, I. Leigh, 2016, Acta dermato-venereologica.

Identification of a novel mutation R42P in the gap junction protein beta-3 associated with autosomal dominant erythrokeratoderma variabilis.

D. Kelsell, I. Leigh, R. Eady, 1999, The Journal of investigative dermatology.

Cytokeratin expression in pili annulati hair follicles

I. Leigh, F. Wojnarowska, K. Giehl, 2005, Clinical and experimental dermatology.

Patterns and composition of basement membranes in colon adenomas and adenocarcinomas

J. Arends, F. Bosman, I. Leigh, 1993, The Journal of pathology.

Immunohistochemical localization of basement membrane type VII collagen and laminin in neoplasms of the head and neck

H. Schaafsma, I. Leigh, F. Ramaekers, 1992, Histopathology.

Imiquimod cream 5% for recalcitrant cutaneous warts in immunosuppressed individuals

J. McGregor, I. Leigh, C. Harwood, 2005, The British journal of dermatology.

Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates

H. Hennies, I. Leigh, P. Nürnberg, 2002, Human Genetics.

Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours

C. Proby, I. Leigh, A. Storey, 2006, British Journal of Cancer.

Binding of Integrin α6β4 to Plectin Prevents Plectin Association with F-Actin but Does Not Interfere with Intermediate Filament Binding

E. Lane, A. Sonnenberg, G. Wheeler, 1999, The Journal of cell biology.

Cyclic adenosine monophosphate-phosphodiesterase activity in cultured keratinocytes from patients with atopic eczema.

I. Leigh, H. Navsaria, S. Wright, 1991, Journal of dermatological science.

Tylosis associated with carcinoma of the oesophagus and oral leukoplakia in a large Liverpool family--a review of six generations.

I. Leigh, A. Fryer, J. Field, 1994, European journal of cancer. Part B, Oral oncology.

Adducin expression in cutaneous and oral lesions: α‐ and β‐adducin transcripts down‐regulate with keratinocyte differentiation in stratified epithelia

I. Leigh, A. Waseem, S. L. Bowen, 2003 .

RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome.

D. Bishop, D. Kelsell, V. Plagnol, 2012, American journal of human genetics.

Mena regulates nesprin-2 to control actin–nuclear lamina associations, trans-nuclear membrane signalling and gene expression

J. Armstrong, A. von Kriegsheim, W. Bickmore, 2023, Nature Communications.

Two siblings with harlequin ichthyosis, clinical and molecular findings

D. Kelsell, I. Leigh, R. Mak, 2006 .

Linkage and LOH studies in 19 cylindromatosis families show no evidence of genetic heterogeneity and refine the CYLD locus on chromosome 16q12–q13

S. Seal, M. Stratton, R. Siebert, 2000, Human Genetics.

Severe cutaneous papillomavirus disease after haematopoietic stem‐cell transplantation in patients with severe combined immunodeficiency

H. Bobby Gaspar, I. Leigh, A. Thrasher, 2004, British journal of haematology.

Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro.

I. Leigh, P. Riddle, H. Navsaria, 1995, The British journal of dermatology.

Localisation of a gene for Papillon-Lefèvre syndrome to chromosome 11q14–q21 by homozygosity mapping

Irene M. Leigh, Howard P. Stevens, André Reis, 1997, Human Genetics.

Adducin expression in cutaneous and oral lesions: alpha- and beta-adducin transcripts down-regulate with keratinocyte differentiation in stratified epithelia.

I. Leigh, A. Waseem, B. K. Bloor, 2003, The Journal of pathology.

Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability.

E. Lane, I. Leigh, A. Waseem, 2004, Biochemistry.

Phosphorylated human keratinocyte ornithine decarboxylase is preferentially associated with insoluble cellular proteins.

O. Jänne, I. Leigh, R. Tuan, 1999, Molecular biology of the cell.

A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing

G. Inman, K. Blyth, C. Proby, 2019, International journal of molecular sciences.

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity

A. Thompson, T. Crook, P. Szlosarek, 2012, British Journal of Cancer.

Hypoxia-mediated control of HIF/ARNT machinery in epidermal keratinocytes.

J. Vass, I. Leigh, A. Panteleyev, 2011, Biochimica et biophysica acta.

Advanced cutaneous squamous cell carcinoma – a pressing case for treatment

I. Leigh, 2019, Journal of the European Academy of Dermatology and Venereology : JEADV.

Recurrent erythema multiforme. An immune complex-mediated vasculitis?

I. Leigh, G. Levene, J. Mowbray, 1983 .

Role of human papillomaviruses in cutaneous and oral manifestations of immunosuppression.

I. Leigh, A. Storey, C. Harwood, 1999, Journal of acquired immune deficiency syndromes.

Exfoliative cytology of normal oral mucosa. Assessing the basal cell keratin phenotype.

E. Lane, G. Ogden, D. Chisholm, 1996, Acta cytologica.

Nerve growth factor levels in cultured human skin cells: effect of gestation and viral transformation

I. Leigh, H. Navsaria, D. Sinicropi, 1995, Neuroscience Letters.

HLA antigen frequencies in renal transplant recipients and non-immunosuppressed patients with non-melanoma skin cancer.

J. Bodmer, W. Bodmer, I. Leigh, 1993, European journal of cancer.

Linear IgA disease: cylindroma demonstrates heterogeneity of the target antigens.

I. Leigh, F. Wojnarowska, J. Allen, 1994, Dermatology.

Generation and selection of monoclonal antibodies, single‐chain Fv and antibody fusion phage specific for human melanoma‐associated antigens

I. Leigh, J. N. Newton Bishop, N. Tidman, 1995, Melanoma research.

Loss of desmoplakin isoform I causes early onset cardiomyopathy and heart failure in a Naxos-like syndrome

D. Kelsell, H. Kayserili, I. Leigh, 2005, Journal of Medical Genetics.

Systemic sclerosis with subcutaneous nodules *

I. Leigh, Cameron Kennedy, 1979, The British journal of dermatology.

The keratins and their disorders

I. Leigh, E. Rugg, 2004, American journal of medical genetics. Part C, Seminars in medical genetics.

Wnt5a inhibits the CpG oligodeoxynucleotide‐triggered activation of human plasmacytoid dendritic cells

C. Proby, I. Leigh, J. Foerster, 2012, Clinical and experimental dermatology.

Non‐Hodgkin's lymphoma associated with long‐term azathioprine therapy

I. Leigh, J. Salisbury, T. Phillips, 1987, Clinical and experimental dermatology.

Progress in skin cancer: the U.K. experience

I. Leigh, 2014, The British journal of dermatology.

Extensive variant of cutaneous amyloidosis: report of a case with electron-microscopic and immunohistochemical studies of the basement membrane zone at sites of amyloid production.

K. Danno, I. Leigh, Y. Horiguchi, 1992, Dermatology.

Ultrastructural changes resulting from keratin-9 gene mutations in two families with epidermolytic palmoplantar keratoderma.

E. Lane, I. Leigh, M. Shamsher, 1995, The Journal of investigative dermatology.

Prophylactic topical acyclovir for frequent recurrent herpes simplex infection with and without erythema multiforme.

I. Leigh, A. E. Clark, M. Wansbrough-Jones, 1983, British medical journal.

Management of non-genital herpes simplex virus infections in immunocompetent patients.

I. Leigh, 1988, The American journal of medicine.

Tyrosine dephosphorylation is required for Bak activation in apoptosis

I. Leigh, A. Storey, B. Kessler, 2010, The EMBO journal.

Epidermal repair results from activation of follicular and epidermal progenitor keratinocytes mediated by a growth factor cascade

S. Myers, I. Leigh, H. Navsaria, 2007, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

Cutaneous squamous cell carcinoma derived cell lines are more sensitive to the proteasome inhibitor bortezomib than normal skin cells

M. Saville, I. Leigh, A. South, 2013 .

Inflammation induced by tumor-associated nerves promotes resistance to anti-PD-1 therapy in cancer patients and is targetable by IL-6 blockade

K. Tsai, N. Ajami, G. Calin, 2023, Research square.

Laminin and type VII collagen distribution in different types of human lung carcinoma: correlation with expression of keratins 14, 16, 17 and 18

E. Lane, S. Wagenaar, H. Schaafsma, 1992, Histopathology.

Acute rejection of cultured keratinocyte allografts in nonimmunosuppressed pigs.

I. Leigh, C. Green, H. Navsaria, 1991, Transplantation.

Growth factors : a practical approach

I. Leigh, I. McKay, I. Mckay, 1993 .

Foetal antigen 2 (FA2) in relation to wound healing and fibroblast proliferation

I. Leigh, J. Andersen, B. Teisner, 1992, The British journal of dermatology.