B. M. Forman

发表

Two distinct dimerization interfaces differentially modulate target gene specificity of nuclear hormone receptors.

K. Umesono, P. Rangarajan, R. Evans, 1996, Molecular endocrinology.

Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice

B. M. Forman, Wendong Huang, Wei-Dong Chen, 2012, Hepatology.

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

K. Umesono, Jasmine Chen, R. Evans, 1995, Cell.

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta.

Jasmine Chen, R. Evans, B. M. Forman, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

Barry M. Forman, Jasmine Chen, R. Evans, 1997 .

FXR-mediated down-regulation of CYP7A1 dominates LXRalpha in long-term cholesterol-fed NZW rabbits.

F. Suchy, B. M. Forman, A. Honda, 2003, Journal of lipid research.

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

K. Umesono, S. Kliewer, R. Evans, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Peptide Mimetic HIV Protease Inhibitors Are Ligands for the Orphan Receptor SXR*

B. M. Forman, Min Lin, T. Synold, 2001, The Journal of Biological Chemistry.

Stereoselective synthesis, biological evaluation, and modeling of novel bile acid-derived G-protein coupled bile acid receptor 1 (GP-BAR1, TGR5) agonists.

Nagarajan Vaidehi, N. Vaidehi, B. M. Forman, 2015, Bioorganic & medicinal chemistry.

Novel FXR (farnesoid X receptor) modulators: Potential therapies for cholesterol gallstone disease.

B. M. Forman, Donna D. Yu, Wendong Huang, 2016, Bioorganic & medicinal chemistry.

An improved synthesis of 6α-ethylchenodeoxycholic acid (6ECDCA), a potent and selective agonist for the Farnesoid X Receptor (FXR)

B. M. Forman, D. Mattern, Donna D. Yu, 2012, Steroids.

Identification of an agonist ligand for estrogen-related receptors ERRbeta/gamma.

B. M. Forman, Donna D. Yu, 2005, Bioorganic & medicinal chemistry letters.

Half-site spacing and orientation determines whether thyroid hormone and retinoic acid receptors and related factors bind to DNA response elements as monomers, homodimers, or heterodimers.

B. Raaka, H. Samuels, B. M. Forman, 1992, Molecular endocrinology.

pEXPRESS: a family of expression vectors containing a single transcription unit active in prokaryotes, eukaryotes and in vitro.

H. Samuels, B. M. Forman, 1991, Gene.

Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo.

B. M. Forman, Wendong Huang, Wei-Dong Chen, 2008, Molecular endocrinology.

Polymorphisms in promiscuous PXR: an explanation for interindividual differences in drug clearance?

B. M. Forman, 2001, Pharmacogenetics.

Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR.

S. Kitareewan, L. Deterding, K. Tomer, 1996, Molecular biology of the cell.

Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance

B. M. Forman, E. Wang, Min Lin, 2003, Proceedings of the National Academy of Sciences of the United States of America.

CHAPTER 277 – Orphan Nuclear Receptors

B. M. Forman, 2003 .

The PPARs 2001: it's not over 'til the fat lady sings. 4-10 February 2001.

B. M. Forman, 2001, Trends in molecular medicine.

Nuclear Hormone Receptors Activate Direct, Inverted, and Everted Repeats a

R. Evans, B. M. Forman, R. Evans, 1995, Annals of the New York Academy of Sciences.

Regulation of the Farnesoid X Receptor (FXR) by Bile Acid Flux in Rabbits*

B. M. Forman, Guorong Xu, G. Tint, 2002, The Journal of Biological Chemistry.

Laminar Flow Activates Peroxisome Proliferator–Activated Receptor-&ggr; in Vascular Endothelial Cells

S. Chien, B. M. Forman, J. Shyy, 2004, Circulation.

Insufficient bile acid signaling impairs liver repair in CYP27(-/-) mice.

B. M. Forman, Z. Meng, Wendong Huang, 2011, Journal of hepatology.

Farnesoid X receptor alleviates age‐related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription

B. M. Forman, Donna D. Yu, Wendong Huang, 2009, Hepatology.

FXR-activatingg ligands inhibit rabbit ASBT expression viaa FXR-SHP-FTF cascade

B. M. Forman, J. Chiang, M. Ananthanarayanan, 2007 .

Identification of a nuclear receptor that is activated by farnesol metabolites

Jasmine Chen, R. Evans, D. Noonan, 1995, Cell.

Removal of the bile acid pool upregulates cholesterol 7alpha-hydroxylase by deactivating FXR in rabbits.

F. Suchy, B. M. Forman, M. Ananthanarayanan, 2002, Journal of lipid research.

Specific bile acids inhibit hepatic fatty acid uptake in mice

B. M. Forman, J. Maher, H. Park, 2012, Hepatology.

A retinoic acid response element is part of a pleiotropic domain in the phosphoenolpyruvate carboxykinase gene.

R. O’Brien, H. Samuels, B. M. Forman, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of gene expression by thyroid hormone.

H. Samuels, B. M. Forman, Z. Ye, 1988, The Journal of clinical investigation.

Peroxisome proliferator-activated receptor gamma inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells.

E. Fleck, Jasmine Chen, T. Kiyono, 2003, Molecular endocrinology.

Constitutive Activation of Peroxisome Proliferator-activated Receptor-γ Suppresses Pro-inflammatory Adhesion Molecules in Human Vascular Endothelial Cells*

Jasmine Chen, B. M. Forman, Hongling Li, 2002, The Journal of Biological Chemistry.

Identification of an Endogenous Ligand Bound to a Native Orphan Nuclear Receptor

Eugene Bolotin, F. Sladek, B. M. Forman, 2009, PloS one.

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR.

Jasmine Chen, Haibo Wang, B. M. Forman, 1999, Molecular cell.

FXR protects lung from lipopolysaccharide-induced acute injury.

B. M. Forman, Donna D. Yu, Wendong Huang, 2012, Molecular endocrinology.

Rat growth hormone gene expression. Both cell-specific and thyroid hormone response elements are required for thyroid hormone regulation.

H. Samuels, Á. Pascual, B. M. Forman, 1988, The Journal of biological chemistry.

Effects of varying the position of thyroid hormone response elements within the rat growth hormone promoter: implications for positive and negative regulation by 3,5,3'-triiodothyronine.

J. Harney, P. Larsen, H. Samuels, 1991, Molecular endocrinology.

Are those phospholipids in your pocket?

B. M. Forman, 2005, Cell metabolism.

Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response

B. M. Forman, Donna D. Yu, Wendong Huang, 2008, Hepatology.

15-Deoxy-Δ 12,14-Prostaglandin J 2 is a ligand for the adipocyte determination factor PPARγ

B. Spiegelman, Jasmine Chen, R. Evans, 1995, Cell.

Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor.

Taosheng Chen, B. M. Forman, Donna D. Yu, 2014, Bioorganic & medicinal chemistry.

Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors.

S. Kliewer, Jasmine Chen, R. Evans, 1994, Molecular endocrinology.

Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor.

B. Spiegelman, J. Fletcher, S. Singer, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Vitamin K2 Regulation of Bone Homeostasis Is Mediated by the Steroid and Xenobiotic Receptor SXR*

B. Blumberg, B. M. Forman, M. M. Tabb, 2003, Journal of Biological Chemistry.

The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism.

Jasmine Chen, R. Evans, B. M. Forman, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery.

Taosheng Chen, B. M. Forman, Donna D. Yu, 2013, Bioorganic & medicinal chemistry.

Structure of the murine constitutive androstane receptor complexed to androstenol: a molecular basis for inverse agonism.

E. Fernandez, B. M. Forman, M. Sherman, 2004, Molecular cell.

Androstane metabolites bind to and deactivate the nuclear receptor CAR-β

David D. Moore, Barry M. Forman, Jasmine Chen, 1998, Nature.

Prostaglandins and fatty acids regulate transcriptional signaling via the peroxisome proliferator activated receptor nuclear receptors.

B. M. Forman, I. Dussault, Isabelle Dussault, 2000, Prostaglandins & other lipid mediators.

Orphan Nuclear Receptors and Their Ligands

B. M. Forman, 1998 .

The Peroxisome Proliferator‐activated Receptors: Ligands and Activators a

Jasmine Chen, B. M. Forman, R. Evans, 1996, Annals of the New York Academy of Sciences.

Differential activation of adipogenesis by multiple PPAR isoforms.

B. Spiegelman, Jasmine Chen, R. Evans, 1996, Genes & development.

15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma.

B. Spiegelman, R. Evans, B. M. Forman, 1995, Cell.

The Antidiabetic Agent LG100754 Sensitizes Cells to Low Concentrations of Peroxisome Proliferator-activated Receptor γ Ligands*

B. M. Forman, 2002, The Journal of Biological Chemistry.

Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model.

H. Samuels, B. M. Forman, H. H. Samuels, 1990, Molecular endocrinology.

Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation.

B. Blumberg, B. M. Forman, E. Nelson, 2006, The Journal of clinical investigation.

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

B. M. Forman, T. Synold, I. Dussault, 2001, Nature Medicine.

c-erbA protooncogenes mediate thyroid hormone-dependent and independent regulation of the rat growth hormone and prolactin genes.

H. Samuels, B. M. Forman, F. Stanley, 1988, Molecular endocrinology.

Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1α regulation of FXR expression.

Y. Yen, Xiyong Liu, B. M. Forman, 2012, Molecular endocrinology.

Identification of the cis-acting elements and trans-acting factors that mediate cell-specific and thyroid hormone stimulation of growth hormone gene expression.

H. Samuels, Á. Pascual, B. M. Forman, 1988, Recent progress in hormone research.

The nuclear receptor PXR: a master regulator of "homeland" defense.

B. M. Forman, I. Dussault, 2002, Critical reviews in eukaryotic gene expression.

Bioimaging Real-Time PXR-Dependent mdr1a Gene Regulation in mdr1a.fLUC Reporter Mice

Jasmine Chen, S. Kane, B. M. Forman, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Linking lipids, Alzheimer's and LXRs?

B. M. Forman, N. Patel, 2004, Nuclear Receptor Signaling.

The G‐Protein‐coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light‐chain enhancer of activated B cells (NF‐κB) in mice

B. M. Forman, Donna D. Yu, Wendong Huang, 2011, Hepatology.

Functional ecdysone receptor is the product of EcR and Ultraspiracle genes

M. Mckeown, R. Evans, T. Yao, 1993, Nature.

FXR regulates liver repair after CCl4-induced toxic injury.

H. Pan, B. M. Forman, Z. Meng, 2010, Molecular endocrinology.

A domain containing leucine-zipper-like motifs mediate novel in vivo interactions between the thyroid hormone and retinoic acid receptors.

H. Samuels, B. M. Forman, J. Ghysdael, 1989, Molecular endocrinology.

Conformational changes in chicken thyroid hormone receptor alpha 1 induced by binding to ligand or to DNA.

H. Samuels, G. Sanyal, B. M. Forman, 1993, Biochemistry.

Capacity for cooperative binding of thyroid hormone (T3) receptor dimers defines wild type T3 response elements.

J. Harney, P. Larsen, H. Samuels, 1992, Molecular endocrinology.

Oligomeric binding of T3 receptor is required for maximal T3 response.

J. Harney, H. Samuels, B. M. Forman, 1991, The Journal of biological chemistry.

Regulation of the Growth Arrest and DNA Damage-Inducible Gene 45 (GADD45) by Peroxisome Proliferator-Activated Receptor &ggr; in Vascular Smooth Muscle Cells

E. Fleck, T. Sakai, B. M. Forman, 2003, Circulation research.

Deficiency of G‐protein‐coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesis

B. M. Forman, Donna D. Yu, Wendong Huang, 2013, Hepatology.

Simple and efficient production of (Z)-4-hydroxytamoxifen, a potent estrogen receptor modulator.

B. M. Forman, Donna D. Yu, 2003, The Journal of organic chemistry.

Specificity of a retinoic acid response element in the phosphoenolpyruvate carboxykinase gene promoter: consequences of both retinoic acid and thyroid hormone receptor binding.

H. Samuels, B. M. Forman, P. Lucas, 1991, Molecular and cellular biology.

Dimerization among nuclear hormone receptors.

H. Samuels, B. M. Forman, 1990, The New biologist.

Detection of designer steroids

B. M. Forman, Xiaohui Yuan, 2005, Nuclear receptor signaling.

Peroxisome proliferator-activated receptor γ inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells

E. Fleck, Jasmine Chen, T. Kiyono, 2003 .

Identification of Gene-selective Modulators of the Bile Acid Receptor FXR*

Jasmine Chen, B. M. Forman, R. Chandraratna, 2003, The Journal of Biological Chemistry.

Identification of novel inverse agonists of estrogen-related receptors ERRγ and ERRβ.

Hongzhi Li, B. M. Forman, J. Huss, 2017, Bioorganic & medicinal chemistry.

A Structural Model of the Constitutive Androstane Receptor Defines Novel Interactions That Mediate Ligand-Independent Activity

B. M. Forman, J. Termini, M. Sherman, 2002, Molecular and Cellular Biology.

Discovery of novel modulators for the PPARα (peroxisome proliferator activated receptor α): Potential therapies for nonalcoholic fatty liver disease.

B. M. Forman, B. Stoltz, Donna D. Yu, 2021, Bioorganic & medicinal chemistry.

Regulation of gene expression by thyroid hormone.

H. Samuels, B. M. Forman, Z. Ye, 1989, Annual review of physiology.

Specificity of a retinoic acid response element in the phosphoenolpyruvate carboxykinase gene promoter: consequences of both retinoic acid and thyroid hormone receptor binding

H. Samuels, B. M. Forman, P. Lucas, 1991, Molecular and cellular biology.

Specificity ofa Retinoic AcidResponse Element inthe Phosphoenolpyruvate Carboxykinase GenePromoter: Consequences ofBothRetinoic Acidand Thyroid HormoneReceptor Binding

B. M. Forman, 1991 .

Characterization of the domain structure of chick c-erbA by deletion mutation: in vitro translation and cell transfection studies.

H. Samuels, B. M. Forman, J. Casanova, 1989, Molecular endocrinology.

FXR-activatingg ligands inhibit rabbit ASBT expression viaa FXR-SHP-FTF cascade

B. M. Forman, J. Chiang, M. Ananthanarayanan, 2007 .

Crystallographic analysis of murine constitutive androstane receptor ligand-binding domain complexed with 5α-androst-16-en-3α-ol

E. Fernandez, B. M. Forman, J. Brunzelle, 2005 .

Novel FXR (farnesoid X receptor) modulators: Potential therapies for cholesterol gallstone disease.

B. M. Forman, Donna D. Yu, Wendong Huang, 2016, Bioorganic & medicinal chemistry.

Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor.

Taosheng Chen, B. M. Forman, Donna D. Yu, 2014, Bioorganic & medicinal chemistry.

An improved synthesis of 6α-ethylchenodeoxycholic acid (6ECDCA), a potent and selective agonist for the Farnesoid X Receptor (FXR)

B. M. Forman, D. Mattern, Donna D. Yu, 2012, Steroids.

Regulation of gene expression by thyroid hormone.

H. Samuels, B. M. Forman, Z. Ye, 1988, The Journal of clinical investigation.