Shuling Guo

M. Benson, Shuling Guo, B. Monia, 2016, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Evaluation of Therapeutic Oligonucleotides for Familial Amyloid Polyneuropathy in Patient-Derived Hepatocyte-Like Cells

Shuling Guo, B. Monia, J. Gollob, 2016, PloS one.

A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions

J. Martín-Subero, Maite Huarte, Ivan Raimondi, 2020, Nature Communications.

Antisense oligonucleotide treatment ameliorates IFN-γ-induced proteinuria in APOL1-transgenic mice.

Christopher E. Hart, S. Kuntz, Shuling Guo, 2019, JCI insight.

Novel Targeted Therapy for Precursor B-Cell Acute Lymphoblastic Leukemia: Anti-CD22 Antibody-MXD3 Antisense Oligonucleotide Conjugate

L. Beckett, Shuling Guo, N. Satake, 2014, Molecular medicine.

In Vitro and In Vivo Effects of SerpinA1 on the Modulation of Transthyretin Proteolysis

Shuling Guo, B. Monia, M. Saraiva, 2021, International journal of molecular sciences.

Chop/Ddit3 depletion in β-cells alleviates ER stress and corrects hepatic steatosis

R. Kaufman, L. Satin, Shuling Guo, 2020, bioRxiv.

SERPINA1 modulates expression of amyloidogenic transthyretin.

Shuling Guo, B. Monia, M. Saraiva, 2020, Experimental cell research.

Role of Chymotrypsin-like Elastase 1 in Lung Physiology and in α1-Antitrypsin Deficiency

Shuling Guo, B. Monia, A. Weiss, 2017, bioRxiv.

Antisense Oligonucleotide-Mediated Silencing of Mitochondrial Fusion and Fission Factors Modulates Mitochondrial Dynamics and Rescues Mitochondrial Dysfunction

Shuling Guo, M. Aghajan, Andrew F. Powers, 2021, Nucleic acid therapeutics.

Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice

Shuling Guo, B. Monia, B. Kahn, 2014, Diabetes.

2'-O-methoxyethyl splice-switching oligos correct splicing from IVS2-745 β-thalassemia patient cells restoring hemoglobin A production and chain rebalance

S. Rivella, S. Freier, Shuling Guo, 2020, Haematologica.

Using antisense technology to develop a novel therapy for α-1 antitrypsin deficient (AATD) liver disease and to model AATD lung disease

Shuling Guo, B. Monia, S. Booten, 2014, Rare diseases.

SAC1-like Domains of Yeast SAC1,INP52, and INP53 and of Human Synaptojanin Encode Polyphosphoinositide Phosphatases*

J. York, Shuling Guo, S. M. Lemrow, 1999, The Journal of Biological Chemistry.

A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-gamma activation.

O. Witte, Shuling Guo, M. Riedinger, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Antisense oligonucleotide treatment ameliorates alpha-1 antitrypsin-related liver disease in mice.

Shuling Guo, B. Monia, S. Booten, 2014, The Journal of clinical investigation.

Sex-specific differences in emphysema using a murine antisense oligonucleotide model of α-1 antitrypsin deficiency.

Shuling Guo, B. Monia, R. Joshi, 2019, American journal of physiology. Lung cellular and molecular physiology.

Knockdown of Z Mutant Alpha-1 Antitrypsin In Vivo Using Modified DNA Antisense Oligonucleotides.

Shuling Guo, B. Monia, M. Aghajan, 2017, Methods in molecular biology.

CFTR mRNAs with nonsense codons are degraded by the SMG6-mediated endonucleolytic pathway

Shuling Guo, A. Revenko, Lulu Huang, 2021 .

Tmprss6-ASO as a tool for the treatment of Polycythemia Vera mice

S. Rivella, Shuling Guo, Y. Ginzburg, 2021, PloS one.

Nonsense Mediated RNA Decay Pathway Inhibition Restores Expression and Function of W1282X CFTR.

Shuling Guo, B. Monia, H. Bihler, 2019, American journal of respiratory cell and molecular biology.

Induction of In Vivo Antipolysaccharide Immunoglobulin Responses to Intact Streptococcus pneumoniae Is More Heavily Dependent on Btk-Mediated B-Cell Receptor Signaling than Antiprotein Responses

C. Snapper, O. Witte, Shuling Guo, 2006, Infection and Immunity.

Targeting Translation Termination Machinery with Antisense Oligonucleotides for Diseases Caused by Nonsense Mutations

Shuling Guo, B. Monia, S. Murray, 2019, Nucleic acid therapeutics.

A novel and translational role for autophagy in antisense oligonucleotide trafficking and activity

Shuling Guo, J. Matson, A. Macleod, 2019, Nucleic acids research.

Clinical development of an antisense therapy for the treatment of transthyretin-associated polyneuropathy

M. Benson, Shuling Guo, B. Monia, 2012, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Erg mediates downregulation of claudin‐5 in the brain endothelium of a murine experimental model of cerebral malaria

Shuling Guo, Qiang Liu, Suhua Yan, 2019, FEBS letters.

Reducing glycosphingolipid biosynthesis in airway cells partially ameliorates disease manifestations in a mouse model of asthma.

Shuling Guo, Seng H. Cheng, Canwen Jiang, 2010, International immunology.

Mutational analysis of the SH2-kinase linker region of Bruton's tyrosine kinase defines alternative modes of regulation for cytoplasmic tyrosine kinase families.

O. Witte, Shuling Guo, M. Wahl, 2006, International immunology.

Inhaled ENaC antisense oligonucleotide ameliorates cystic fibrosis-like lung disease in mice.

Shuling Guo, B. Monia, D. Rotin, 2017, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Reversing Antisense Oligonucleotide Activity with a Sense Oligonucleotide Antidote: Proof of Concept Targeting Prothrombin.

Shuling Guo, B. Monia, A. Macleod, 2015, Nucleic acid therapeutics.

Antisense oligonucleotide targeting of mRNAs encoding ENaC subunits α, β, and γ improves cystic fibrosis-like disease in mice.

Shuling Guo, B. Monia, D. Bai, 2019, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Correcting β-thalassemia by combined therapies that restrict iron and modulate erythropoietin activity.

S. Rivella, M. Lidonnici, Shuling Guo, 2020, Blood.

Reducing dynamin 2 (DNM2) rescues DNM2-related dominant centronuclear myopathy

Shuling Guo, B. Monia, J. Matson, 2018, Proceedings of the National Academy of Sciences.

Combination of Tmprss6- ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia

S. Rivella, Shuling Guo, B. Monia, 2016, Haematologica.

MED1 Ablation Promotes Oral Mucosal Wound Healing via JNK Signaling Pathway

Shuling Guo, Danfeng Wu, Ran Wei, 2022, International journal of molecular sciences.

Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA

Huynh-Hoa Bui, Arul M. Chinnaiyan, Felix Y. Feng, 2017, Cell.

Phosphatidylinositol 4,5-Bisphosphate Functions as a Second Messenger that Regulates Cytoskeleton–Plasma Membrane Adhesion

Tobias Meyer, Michael P. Sheetz, Shuling Guo, 2000, Cell.

TMPRSS6 as a Therapeutic Target for Disorders of Erythropoiesis and Iron Homeostasis

S. Rivella, Paul W Goldberg, T. Ganz, 2023, Advances in Therapy.

Potential Therapeutic Applications of Jak2 Inhibitors and Hif2a-ASO for the Treatment of β-Thalassemia Intermedia and Major

S. Rivella, Shuling Guo, P. Ramos, 2016 .

Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice.

S. Rivella, Shuling Guo, B. Monia, 2013, The Journal of clinical investigation.

Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2′-(2-Methoxyethyl)-D-ribose Antisense Oligonucleotide–Triantenarry N-Acetyl-galactosamine Conjugate that Targets the Human Transmembrane Protease Serine 6

Shuling Guo, S. Henry, S. Burel, 2021, The Journal of Pharmacology and Experimental Therapeutics.

MXD3 antisense oligonucleotide with superparamagnetic iron oxide nanoparticles: A new targeted approach for neuroblastoma.

L. Beckett, Shuling Guo, N. Satake, 2019, Nanomedicine : nanotechnology, biology, and medicine.

The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element

I. Ulitsky, Maite Huarte, Ivan Raimondi, 2017, Genome Biology.

Partial Hepatectomy Induced Long Noncoding RNA Inhibits Hepatocyte Proliferation during Liver Regeneration

Christopher E. Hart, S. Freier, M. Sabripour, 2015, PloS one.

A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions

J. Martín-Subero, Maite Huarte, Ivan Raimondi, 2020, Nature Communications.

The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element

I. Ulitsky, Maite Huarte, Ivan Raimondi, 2017, Genome Biology.

Genome-wide analysis of the human p53 transcriptional network unveils a lncRNA tumour suppressor signature

Maite Huarte, Yolanda Sánchez, Francesco P. Marchese, 2014, Nature Communications.

Knockdown of nuclear-retained long noncoding RNAs using modified DNA antisense oligonucleotides.

Shuling Guo, Xinying Zong, S. Freier, 2015, Methods in molecular biology.

Steric Inhibition of 5′ UTR Regulatory Elements Results in Upregulation of Human CFTR

H. Bui, Shuling Guo, B. Monia, 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

An integrated microfluidic culture device for quantitative analysis of human embryonic stem cells.

Hsian-Rong Tseng, Ki-Bum Lee, Shuling Guo, 2009, Lab on a chip.

Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells.

J. York, H. Sontheimer, Shuling Guo, 2002, Molecular biology of the cell.

Chop/Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice

R. Kaufman, L. Satin, A. Saltiel, 2021, Science Translational Medicine.

Identification and Validation of PCAT14 as Prognostic Biomarker in Prostate Cancer1

S. Dhanasekaran, A. Chinnaiyan, S. Freier, 2016, Neoplasia.

Identification and Validation of PCAT 14 as Prognostic Biomarker in Prostate Cancer 1

S. Dhanasekaran, A. Chinnaiyan, S. Freier, 2016 .

Allele-Specific Inhibition of Rhodopsin With an Antisense Oligonucleotide Slows Photoreceptor Cell Degeneration.

M. Lavail, P. Adamson, Shuling Guo, 2015, Investigative ophthalmology & visual science.

Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations

Shuling Guo, B. Monia, S. Murray, 2018, Genome Biology.

New approaches to genetic therapies for cystic fibrosis.

B. Kerem, Shuling Guo, S. Hart, 2020, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Combination of Tmprss6-ASO and the Iron Chelator Deferiprone Improves Erythropoiesis and Reduces Iron Overload in a Mouse Model of Beta-Thalassemia

S. Rivella, Shuling Guo, B. Monia, 2014 .

Specificity Determinants in Phosphoinositide Dephosphorylation Crystal Structure of an Archetypal Inositol Polyphosphate 5-Phosphatase

James H. Hurley, Shuling Guo, John D. York, 2001, Cell.

HOTAIR lncRNA promotes epithelial–mesenchymal transition by redistributing LSD1 at regulatory chromatin regions

Shuling Guo, A. Morillon, M. Pinskaya, 2021, EMBO reports.

Target TMPRSS6 for the Treatment of Hereditary Hemochromatosis

Shuling Guo, B. Monia, S. Booten, 2011 .

The Distinct and Cooperative Roles of Toll-Like Receptor 9 and Receptor for Advanced Glycation End Products in Modulating In Vivo Inflammatory Responses to Select CpG and Non-CpG Oligonucleotides.

Shuling Guo, S. Henry, C. Bennett, 2017, Nucleic acid therapeutics.

Visualization of a primary anti-tumor immune response by positron emission tomography.

Sanjiv S Gambhir, Shuling Guo, S. Gambhir, 2005, Proceedings of the National Academy of Sciences of the United States of America.

CFTR mRNAs with nonsense codons are degraded by the SMG6-mediated endonucleolytic decay pathway

Shuling Guo, B. Monia, A. Revenko, 2022, Nature Communications.

Transmembrane Protease, Serine 6 (TMPRSS6) Antisense Oligonucleotide (IONIS-TMPRSS6-LRX) Reduces Plasma Iron Levels of Healthy Volunteers in a Phase 1 Clinical Study

Shuling Guo, B. Monia, R. Geary, 2018, Blood.

Developing a Galnac-Conjugated TMPRSS6 Antisense Therapy for the Treatment of β-Thalassemia

S. Rivella, Shuling Guo, B. Monia, 2016 .

Hydrophobic surfaces for enhanced differentiation of embryonic stem cell-derived embryoid bodies

Steven J. Jonas, Hong Wu, Korey Kam, 2008, Proceedings of the National Academy of Sciences.

A single approach to targeting transferrin receptor 2 corrects iron and erythropoietic defects in murine models of anemia of inflammation and chronic kidney disease.

M. Lidonnici, Shuling Guo, G. Ferrari, 2023, Kidney international.

Analysis of the androgen receptor–regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression

John T. Wei, S. Dhanasekaran, A. Chinnaiyan, 2018, Nature Genetics.

The PD-1 with PD-L1 Axis Is Pertinent with the Immune Modulation of Atrial Fibrillation by Regulating T Cell Excitation and Promoting the Secretion of Inflammatory Factors

Shuling Guo, Ying-Wei Chen, Guodong Chang, 2022, Journal of immunology research.

Protein Adsorption Alters Hydrophobic Surfaces Used for Suspension Culture of Pluripotent Stem Cells.

David N. Powers, A. Stieg, J. Wohlschlegel, 2015, The journal of physical chemistry letters.

Oligomeric β-Amyloid Suppresses Hippocampal γ-Oscillations through Activation of the mTOR/S6K1 Pathway

M. Vreugdenhil, Shuling Guo, Enjie Liu, 2023, Aging and disease.

Antisense oligonucleotides to therapeutically target SARS-CoV-2 infection

A. Chinnaiyan, Y. Qiao, Xia Jiang, 2023, PloS one.

Nucleic Acid Therapies for Cystic Fibrosis.

Shuling Guo, S. Sasaki, 2017, Nucleic acid therapeutics.

Inhibition of hepatic sulfatase‐2 In Vivo: A novel strategy to correct diabetic dyslipidemia

M. Nieuwdorp, Keyang Chen, Shuling Guo, 2012, Hepatology.

Hypoxia-inducible factor 2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency

Shuling Guo, M. Aghajan, T. Bartnikas, 2023, bioRxiv.

Mediator1 involved in functional integration of Smad3 and Notch1 promoting enamel mineralization.

Shuling Guo, Ran Wei, Lizhi Hu, 2023, Biochemical and biophysical research communications.