H. Towle

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Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain

B. Spiegelman, H. Shih, T. Ellenberger, 1995, Molecular and cellular biology.

Upstream stimulatory factor regulates Pdx-1 gene expression in differentiated pancreatic beta-cells.

L. Olson, H. Towle, J. Qian, 1999, The Biochemical journal.

Messenger Rna-S14 as a Model of Thyroid Hormone Action at the Hepatocellular Level

H. Towle, J. Oppenheimer, 1987 .

Characterization of a thyroid hormone-responsive gene from rat.

H. Towle, C. Liaw, 1984, The Journal of biological chemistry.

Metabolic Regulation of Gene Transcription in Mammals (*)

H. Towle, 1995, The Journal of Biological Chemistry.

Two CACGTG Motifs with Proper Spacing Dictate the Carbohydrate Regulation of Hepatic Gene Transcription (*)

H. Shih, H. Towle, Z. Liu, 1995, The Journal of Biological Chemistry.

Regulation of the expression of lipogenic enzyme genes by carbohydrate.

H. Shih, H. Towle, E. Kaytor, 1997, Annual review of nutrition.

Mlx Is the Functional Heteromeric Partner of the Carbohydrate Response Element-binding Protein in Glucose Regulation of Lipogenic Enzyme Genes*

H. Towle, Lin Ma, A. Stoeckman, 2004, Journal of Biological Chemistry.

Glucose Induces Protein Targeting to Glycogen in Hepatocytes by Fructose 2,6-Bisphosphate-Mediated Recruitment of MondoA to the Promoter

Z. Al-Oanzi, J. Kieswich, M. Yaqoob, 2012, Molecular and Cellular Biology.

Growth hormone induces two mRNA species of the serine protease inhibitor gene family in rat liver.

J. Yoon, H. Towle, S. Seelig, 1987, The Journal of biological chemistry.

Regulation of Na-K-ATPase gene expression by hyperoxia in MDCK cells.

H. Towle, K. Kawakami, D. Ingbar, 1998, American journal of physiology. Cell physiology.

Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.

L. Olson, H. Towle, R. Robertson, 1993, The Journal of clinical investigation.

Dietary polyunsaturated fatty acids interfere with the insulin/glucose activation of L-type pyruvate kinase gene transcription.

H. Towle, S. Clarke, D. Jump, 1994, Molecular endocrinology.

Induction of a rapidly responsive hepatic gene product by thyroid hormone requires ongoing protein synthesis

H. Towle, D. Jacoby, J. Engle, 1987, Molecular and cellular biology.

Repression of rat kidney L-arginine:glycine amidinotransferase synthesis by creatine at a pretranslational level.

H. Towle, M. Gross, J. V. van Pilsum, 1984, The Journal of biological chemistry.

On the mechanism of the alterations of rat kidney transamidinase activities by diet and hormones.

H. Towle, J. V. van Pilsum, D. McGuire, 1982, Advances in experimental medicine and biology.

Carbohydrate regulation of the rat L-type pyruvate kinase gene requires two nuclear factors: LF-A1 and a member of the c-myc family.

H. Towle, Z. Liu, K. Thompson, 1993, The Journal of biological chemistry.

Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes.

Z. Al-Oanzi, H. Towle, A. Lange, 2012, The Biochemical journal.

Glucose Toxicity and the Insulin Gene

L. Olson, H. Towle, R. Robertson, 1994 .

Regulation of gene expression in eucaryotes.

R. Schwartz, B. O’Malley, H. Towle, 1977, Annual review of genetics.

Quantitation of rat liver messenger ribonucleic acid for malic enzyme during induction by thyroid hormone.

H. Towle, C. Mariash, J. Oppenheimer, 1981, Biochemistry.

Changes in the hepatic levels of messenger ribonucleic acid for malic enzyme during induction by thyroid hormone or diet.

H. Towle, C. Mariash, J. Oppenheimer, 1980, Biochemistry.

Synergism of thyroid hormone and high carbohydrate diet in the induction of lipogenic enzymes in the rat. Mechanisms and implications.

H. Towle, C. Mariash, F. Kaiser, 1980, The Journal of clinical investigation.

Purification and characterization of bacteriophage gh-I-induced deoxyribonucleic acid-dependent ribonucleic acid polymerase from Pseudomonas putida.

H. Towle, J. Boezi, J. Jolly, 1975, The Journal of biological chemistry.

Oxidant effects on epithelial Na,K-ATPase gene expression and promoter function.

H. Towle, D. Ingbar, C. Wendt, 1998, Environmental health perspectives.

A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression.

J. Herrera, H. Towle, Chaodong Wu, 2004, Endocrinology.

Opposing effects of glucagon and triiodothyronine on the hepatic levels of messenger ribonucleic acid S14 and the dependence of such effects on circadian factors.

H. Towle, W. Kinlaw, J. Oppenheimer, 1986, The Journal of clinical investigation.

Yin-yang 1 and Glucocorticoid Receptor Participate in the Stat5-mediated Growth Hormone Response of the Serine Protease Inhibitor 2.1 Gene*

H. Towle, P. L. Bergad, S. Berry, 2000, The Journal of Biological Chemistry.

Regulation of Human Insulin Gene Transcription by Glucose, Epinephrine, and Somatostatin

H. Towle, R. Robertson, J. Redmon, 1994, Diabetes.

Sequences within the 5'-flanking region of the S14 gene confer responsiveness to glucose in primary hepatocytes.

H. Towle, D. Jacoby, N. Zilz, 1989, The Journal of biological chemistry.

Definition of the carbohydrate response element of the rat S14 gene. Evidence for a common factor required for carbohydrate regulation of hepatic genes.

H. Shih, H. Towle, 1992, The Journal of biological chemistry.

Chapter 10 Nutritional regulation of hepatic gene expression

H. Towle, 2001 .

Glucose as a regulator of eukaryotic gene transcription

H. Towle, 2005, Trends in Endocrinology & Metabolism.

Polyunsaturated fatty acids stimulate hepatic UCP-2 expression via a PPARα-mediated pathway

H. Towle, M. Armstrong, 2001 .

Identification and function of phosphorylation in the glucose-regulated transcription factor ChREBP.

H. Towle, Michael N. Davies, N. G. Tsatsos, 2008, The Biochemical journal.

An indirect role for upstream stimulatory factor in glucose-mediated induction of pyruvate kinase and S14 gene expression

L. Olson, H. Towle, J. Qian, 2000, Molecular and Cellular Biochemistry.

The Role of SREBP-1c in Nutritional Regulation of Lipogenic Enzyme Gene Expression*

H. Towle, A. Stoeckman, Angela K Stoeckman, 2002, The Journal of Biological Chemistry.

Glucose and Insulin Function through Two Distinct Transcription Factors to Stimulate Expression of Lipogenic Enzyme Genes in Liver*

S. Koo, H. Towle, A. Dutcher, 2001, The Journal of Biological Chemistry.

Glucose Regulation of the Acetyl-CoA Carboxylase Promoter PI in Rat Hepatocytes*

S. Koo, H. Freake, H. Towle, 2001, The Journal of Biological Chemistry.

Different Sterol Regulatory Element-binding Protein-1 Isoforms Utilize Distinct Co-regulatory Factors to Activate the Promoter for Fatty Acid Synthase*

T. Osborne, S. Koo, H. Towle, 2000, The Journal of Biological Chemistry.

Direct Role of ChREBP·Mlx in Regulating Hepatic Glucose-responsive Genes*

H. Towle, Lin Ma, N. G. Tsatsos, 2005, Journal of Biological Chemistry.

Hepatic expression of the SPOT 14 (S14) paralog S14-related (Mid1 interacting protein) is regulated by dietary carbohydrate.

H. Towle, C. Mariash, G. Anderson, 2008, Endocrinology.

A critical role for the loop region of the basic helix–loop–helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription

Y. Sham, H. Towle, K. Walters, 2006, Nucleic acids research.

6 – Effects of Thyroid Hormones on Cellular RNA Metabolism

H. Towle, 1983 .

The metabolic sensor GCN2 branches out.

H. Towle, 2007, Cell metabolism.

Inhibition of growth hormone action in models of inflammation.

H. Towle, S. Schwarzenberg, P. L. Bergad, 2000, American journal of physiology. Cell physiology.

Glucose regulates leucine-induced insulin release and the expression of the branched chain ketoacid dehydrogenase E1 alpha subunit gene in pancreatic islets.

H. Towle, S. Moran, J. Kaysen, 1991, The Journal of biological chemistry.

Functional synergism in the carbohydrate-induced activation of liver-type pyruvate kinase gene expression.

H. Towle, Z. Liu, 1995, The Biochemical journal.

Isolation and characterization of rat cDNA clones for two distinct thyroid hormone receptors.

H. Towle, M. J. Macdonald, M. Murray, 1988, The Journal of biological chemistry.

Carbohydrate Regulation of Hepatic Gene Expression

H. Shih, H. Towle, E. Kaytor, 1997, The Journal of Biological Chemistry.

Erratum: Reduction of insulin gene transcription in HIT-T15 β cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression (Cell (September 26, 1995) 92:20 (9127-9131))

L. Olson, Arun J Sharma, R. Stein, 1995 .

Thyroid hormone-carbohydrate interaction in the rat: correlation between age-related reductions in the inducibility of hepatic malic enzyme by triiodo-L-thyronine and a high carbohydrate, fat-free diet.

H. Towle, C. Mariash, M. Forciea, 1981, The Journal of clinical investigation.

Dissociation of hepatic messenger ribonucleic acidS14 levels and nuclear transcriptional rates in suckling rats.

H. Towle, D. Jump, J. Oppenheimer, 1986, Endocrinology.

Interaction of T3 and carbohydrate in the induction of lipogenic enzymes.

H. Towle, C. Mariash, F. Kaiser, 1981, Life sciences.

Activation and repression of glucose-stimulated ChREBP requires the concerted action of multiple domains within the MondoA conserved region.

H. Towle, Michael N. Davies, B. O’Callaghan, 2010, American journal of physiology. Endocrinology and metabolism.

Localization of the carbohydrate response element of the rat L-type pyruvate kinase gene.

H. Towle, K. Thompson, 1991, The Journal of biological chemistry.

Overlapping roles of the glucose-responsive genes, S14 and S14R, in hepatic lipogenesis.

H. Towle, D. Mashek, C. Mariash, 2010, Endocrinology.

Identification of multiple thyroid hormone response elements located far upstream from the rat S14 promoter.

H. Towle, M. Murray, N. Zilz, 1990, The Journal of biological chemistry.

Interactions of thyroid hormone, growth hormone, and high carbohydrate, fat-free diet in regulating several rat liver messenger ribonucleic acid species.

H. Towle, C. Mariash, J. Oppenheimer, 1983, Biochemistry.

Difference between thyroidectomized and hypophysectomized animals in their hepatic ribonucleic acid response to thyroid hormone.

H. Towle, J. Oppenheimer, H. Schwartz, 1980, Endocrinology.

Glucose and triiodothyronine both induce malic enzyme in the rat hepatocyte culture: evidence that triiodothyronine multiplies a primary glucose-generated signal.

H. Towle, C. Mariash, J. Oppenheimer, 1981, The Journal of clinical investigation.

Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression.

L. Olson, Arun J Sharma, R. Stein, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Glucose Regulation of Mouse S14 Gene Expression in Hepatocytes

S. Koo, H. Towle, 2000, The Journal of Biological Chemistry.

Marek's Disease Herpesvirus-Induced DNA Polymerase

R. Blakesley, M. Koenig, H. Towle, 1974, Journal of virology.

Thyroid hormone attenuates and augments hepatic gene expression at a pretranslational level.

H. Towle, J. Oppenheimer, C. Liaw, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Thyroidectomy increases rat hepatic ferritin iron.

H. Towle, C. Mariash, J. Oppenheimer, 1981, Science.

Definition of a high affinity growth hormone DNA response element

H. Towle, P. L. Bergad, S. Berry, 1999, Molecular and Cellular Endocrinology.

Regulation of Spi 2.1 and 2.2 gene expression after turpentine inflammation: discordant responses to IL-6.

H. Towle, S. Schwarzenberg, P. L. Bergad, 1999, American journal of physiology. Cell physiology.

Definition of the carbohydrate response element of the rat S14 gene. Context of the CACGTG motif determines the specificity of carbohydrate regulation.

H. Shih, H. Towle, 1994, The Journal of biological chemistry.

Changes in the rates of synthesis and messenger RNA levels of hepatic glucose-6-phosphate and 6-phosphogluconate dehydrogenases following induction by diet or thyroid hormone.

H. Towle, R. Miksicek, 1982, The Journal of biological chemistry.

Regulator of G Protein Signaling (RGS16) Inhibits Hepatic Fatty Acid Oxidation in a Carbohydrate Response Element-binding Protein (ChREBP)-dependent Manner*

H. Towle, Jie Huang, R. Gerard, 2011, The Journal of Biological Chemistry.

Effect of estrogen on gene expression in the chick oviduct.

M. Tsai, S. Tsai, H. Towle, 1976, The Journal of biological chemistry.

10 – Regulation of Gene Expression in the Eukaryotic Cell

B. O’Malley, M. Tsai, H. Towle, 1977 .

Elevated Glucose Represses Liver Glucokinase and Induces Its Regulatory Protein to Safeguard Hepatic Phosphate Homeostasis

Z. Al-Oanzi, R. Beynon, H. Towle, 2011, Diabetes.

Regulation of gene expression in chick oviduct.

B. O’Malley, M. Tsai, S. Tsai, 1978, Cold Spring Harbor symposia on quantitative biology.

Regulation of Spi 2.1 and 2.2 gene expression after turpentine inflammation: discordant responses to IL-6.

H. Towle, S. Schwarzenberg, P. L. Bergad, 1999, The American journal of physiology.

ChREBP•Mlx Is the Principal Mediator of Glucose-induced Gene Expression in the Liver*

H. Towle, Lin Ma, Luke N Robinson, 2006, Journal of Biological Chemistry.

PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner.

H. Towle, B. Finck, Ling Lai, 2013, Molecular metabolism.

An inducible nuclear factor binds to a growth hormone-regulated gene.

J. Yoon, H. Towle, S. Seelig, 1990, The Journal of biological chemistry.

Glucose regulation of mouse S(14) gene expression in hepatocytes. Involvement of a novel transcription factor complex.

S. Koo, H. Towle, Seung-Hoi Koo, 2000, Journal of Biological Chemistry.

Functional synergism between multiple thyroid hormone response elements regulates hepatic expression of the rat S14 gene.

H. Towle, H. Liu, 1994, Molecular endocrinology.

Regulation of hepatic gene expression by lipogenic diet and thyroid hormone.

H. Towle, C. Mariash, 1986, Federation proceedings.

Nuclear receptors and thyroid hormone action: a progress report.

H. Towle, J. Oppenheimer, W. Dillmann, 1979, Federation proceedings.

Role of sterol carrier protein in cholesterol metabolism.

H. Towle, S. Clarke, A. Mcmahon, 1985, Chemistry and physics of lipids.

Use of a cloned cDNA sequence to measure changes in 6-phosphogluconate dehydrogenase mRNA levels caused by thyroid hormone and dietary carbohydrate.

H. Towle, R. Miksicek, 1983, The Journal of biological chemistry.

Coordinate Regulation of Rat Liver Genes by Thyroid Hormone and Dietary Carbohydrate a

H. Towle, T. Tao, 1986, Annals of the New York Academy of Sciences.

Identification of nuclear factors that enhance binding of the thyroid hormone receptor to a thyroid hormone response element.

H. Towle, M. Murray, 1989, Molecular endocrinology.

The sensitivity of RNA polymerases I and II from Novikoff hepatoma (N1S1) cells to 3'-deoxyadenosine 5'-triphosphate.

R. Desrosiers, H. Towle, F. Rottman, 1976, Nucleic acids research.

Binding of a growth hormone-inducible nuclear factor is mediated by tyrosine phosphorylation.

H. Towle, P. L. Bergad, S. Berry, 1994, Molecular endocrinology.

Involvement of a Unique Carbohydrate-responsive Factor in the Glucose Regulation of Rat Liver Fatty-acid Synthase Gene Transcription*

Manabu T. Nakamura, S. Koo, H. Towle, 2001, The Journal of Biological Chemistry.

Paradoxical effects of cycloheximide on the ultra-rapid induction of two hepatic mRNA sequences by triiodothyronine (T3).

H. Towle, C. Mariash, D. Jump, 1982, Endocrinology.

Glucose Activates ChREBP by Increasing Its Rate of Nuclear Entry and Relieving Repression of Its Transcriptional Activity*

H. Towle, Michael N. Davies, B. O'Callaghan, 2008, Journal of Biological Chemistry.

Growth Hormone Induction of Hepatic Serine Protease Inhibitor 2.1 Transcription Is Mediated by a Stat5-related Factor Binding Synergistically to Two γ-Activated Sites (*)

H. Shih, H. Towle, S. Schwarzenberg, 1995, The Journal of Biological Chemistry.

Messenger RNA content and complexity of euthyroid and hypothyroid rat liver.

H. Towle, J. Oppenheimer, W. Dillmann, 1979, The Journal of biological chemistry.

Hyperoxia upregulated Na,K-adenosine triphosphatase beta1 gene transcription.

H. Towle, D. Ingbar, C. Wendt, 1999, Chest.

Identification and Characterization of the AF-1 Transactivation Domain of Thyroid Hormone Receptor β1*

H. Towle, J. R. Wilkinson, 1997, The Journal of Biological Chemistry.

Glucose activation of ChREBP in hepatocytes occurs via a two-step mechanism.

H. Towle, N. G. Tsatsos, 2006, Biochemical and biophysical research communications.

Metabolic regulation of hepatic gene expression.

H. Shih, H. Towle, E. Kaytor, 1996, Biochemical Society transactions.

Glucose and cAMP: Adversaries in the regulation of hepatic gene expression

H. Towle, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Cyclin D1 inhibits hepatic lipogenesis via repression of carbohydrate response element binding protein and hepatocyte nuclear factor 4α

E. Hanse, H. Towle, D. Mashek, 2012, Cell cycle.

REGULATOR OF G PROTEIN SIGNALING (RGS16) INHIBITS HEPATIC FATTY ACID OXIDATION IN A CHREBP-DEPENDENT MANNER

H. Towle, R. Gerard, D. Kurrasch, 2011 .

Multiple Agents, Including Interleukin‐6, Regulate the Synthesis of a Murine 23‐Kilodalton Acute Phase Protein

F. Cerra, H. Towle, J. Mazuski, 1989 .

Direct effects of endotoxin on hepatocytes. Synthesis of a specific secretory protein.

F. Cerra, J. Platt, H. Towle, 1988, Archives of surgery.

Translational control of the circadian rhythm of liver sterol carrier protein. Analysis of mRNA sequences with a specific cDNA probe.

H. Towle, L. Chan, M. Dempsey, 1985, The Journal of biological chemistry.

Translational control of the circadian rhythm of liver sterol carrier protein.

H. Towle, M. Dempsey, C. D. Olson, 1984, The Journal of biological chemistry.

Genetic dissection of thyroid hormone receptor beta: identification of mutations that separate hormone binding and transcriptional activation

R. Uppaluri, H. Towle, R. Uppaluri, 1995, Molecular and cellular biology.

Activation and repression of glucose-stimulated ChREBP requires the concerted action of multiple domains within the MondoA conserved region.

H. Towle, Michael N. Davies, B. O'Callaghan, 2010, American journal of physiology. Endocrinology and metabolism.