Toshiyuki Shimizu

发表

Structural basis for the diversity of DNA recognition by bZIP transcription factors

Toshio Hakoshima, Mitsuhiro Yanagida, Toshiyuki Shimizu, 2000, Nature Structural Biology.

Epigenetic Control of rDNA Loci in Response to Intracellular Energy Status

Toshiyuki Shimizu, A. Fukamizu, K. Nagata, 2008, Cell.

Insights into Multistep Phosphorelay from the Crystal Structure of the C-Terminal HPt Domain of ArcB

Takeshi Mizuno, Toshio Hakoshima, Toshiyuki Shimizu, 1997, Cell.

DNase II-dependent DNA digestion is required for DNA sensing by TLR9

Toshiyuki Shimizu, G. Barber, K. Miyake, 2015, Nature Communications.

Crystal Structure of Human β-Galactosidase

Y. Satow, Toshiyuki Shimizu, K. Usui, 2011, The Journal of Biological Chemistry.

Emerging roles of the processing of nucleic acids and Toll‐like receptors in innate immune responses to nucleic acids

Toshiyuki Shimizu, K. Miyake, Takuma Shibata, 2017, Journal of leukocyte biology.

Guanosine and its modified derivatives are endogenous ligands for TLR7.

Toshiyuki Shimizu, K. Miyake, Tomoki Ito, 2016, International immunology.

Synthesis and evaluation of [2-(4-quinolyloxy)phenyl]methanone derivatives: novel selective inhibitors of transforming growth factor-beta kinase.

Toshiyuki Shimizu, T. Miyazaki, K. Kimura, 2008, Journal of medicinal chemistry.

The Crystal Structure of the Novel Calcium-binding Protein AtCBL2 from Arabidopsis thaliana*

Mamoru Sato, Akira Nozawa, Hiroshi Sano, 2003, Journal of Biological Chemistry.

Synthesis and structure-activity relationship for new series of 4-phenoxyquinoline derivatives as specific inhibitors of platelet-derived growth factor receptor tyrosine kinase.

H. Iijima, Toshiyuki Shimizu, Yoshiko Kobayashi, 2003, Bioorganic & Medicinal Chemistry.

Use of a fusion protein to obtain crystals suitable for X‐ray analysis: Crystallization of a GST‐fused protein containing the DNA‐binding domain of DNA replication‐related element‐binding factor, DREF

T. Hakoshima, A. Matsukage, Y. Fujii, 1997, Protein science : a publication of the Protein Society.

Crystal structure of basic 7S globulin, a xyloglucan‐specific endo‐β‐1,4‐glucanase inhibitor protein‐like protein from soybean lacking inhibitory activity against endo‐β‐glucanase

H. Hirano, Toshiyuki Shimizu, H. Hashimoto, 2011, The FEBS journal.

Coagulation Factor X Activates Innate Immunity to Human Species C Adenovirus

James W. MacDonald, P. Stewart, N. D. Di Paolo, 2012, Science.

Mechanisms controlling nucleic acid-sensing Toll-like receptors

Toshiyuki Shimizu, K. Miyake, Y. Murakami, 2018, International immunology.

Mechanistic insights into the activation of Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 complex.

M. Ikeguchi, Toshiyuki Shimizu, Y. Tsutsui, 2012, Structure.

Structure and Functional Characterization of Vibrio parahaemolyticus Thermostable Direct Hemolysin*

T. Ikegami, T. Yamane, M. Ikeguchi, 2010, The Journal of Biological Chemistry.

Structural basis of adhesion‐molecule recognition by ERM proteins revealed by the crystal structure of the radixin—ICAM‐2 complex

T. Hakoshima, Toshiyuki Shimizu, S. Tsukita, 2003, The EMBO journal.

Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding

T. Katada, Toshiyuki Shimizu, N. Shimizu, 2017, The Journal of Biological Chemistry.

Crystal structure of GCN5 PCAF N-terminal domain reveals atypical ubiquitin ligase structure

Toshiyuki Shimizu, N. Shimizu, M. Matsumoto, 2020, The Journal of Biological Chemistry.

Orally active anti-proliferation agents: novel diphenylamine derivatives as FGF-R2 autophosphorylation inhibitors.

Toshiyuki Shimizu, K. Kimura, T. Sakai, 2004, Bioorganic & medicinal chemistry letters.

Structural Characterization of Calcineurin B Homologous Protein 1*

Y. Naoe, Toshiyuki Shimizu, H. Hashimoto, 2005, Journal of Biological Chemistry.

Crystallization and preliminary X-ray crystallographic studies of transportin 1 in complex with nucleocytoplasmic shuttling and nuclear localization fragments.

Toshiyuki Shimizu, H. Hashimoto, M. Yamada, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Homeostatic and pathogenic roles of GM3 ganglioside molecular species in TLR4 signaling in obesity

Kenichi Sato, Toshiyuki Shimizu, A. Cattaneo, 2020, The EMBO journal.

Structural basis for species‐specific activation of mouse Toll‐like receptor 9

Toshiyuki Shimizu, K. Miyake, Takuma Shibata, 2018, FEBS letters.

Structural aspects of nucleic acid-sensing Toll-like receptors

Toshiyuki Shimizu, U. Ohto, 2016, Biophysical Reviews.

Structural basis of the Rho effector recognition

K. Kaibuchi, T. Hakoshima, Toshiyuki Shimizu, 2002 .

Structure of SARS-CoV-2 membrane protein essential for virus assembly

M. Ikeguchi, S. Iwata, Takeshi Noda, 2022, Nature Communications.

Crystallization and X-ray diffraction analysis of the ternary complex of the C-terminal domain of human REV1 in complex with REV7 bound to a REV3 fragment involved in translesion DNA synthesis.

Toshiyuki Shimizu, H. Hashimoto, Mamoru Sato, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Purification, crystallization and initial X-ray diffraction study of human REV7 in complex with a REV3 fragment

Hashimoto, S. Akashi, Toshiyuki Shimizu, 2009 .

Crystallization and preliminary X-ray crystallographic analysis of human peptidylarginine deiminase V.

Toshiyuki Shimizu, H. Hashimoto, M. Yamada, 2003, Acta Crystallographica Section D: Biological Crystallography.

Structural analysis reveals TLR7 dynamics underlying antagonism

M. Ikeguchi, H. Shigematsu, Masaki Yamamoto, 2020, Nature Communications.

Nucleosides drive histiocytosis in SLC29A3 disorders by activating TLR7

T. Ichinohe, Toshiyuki Shimizu, N. Yoshida, 2019, bioRxiv.

Expression, purification, crystallization and preliminary X-ray crystallographic analysis of human β-galactosidase.

Y. Satow, Toshiyuki Shimizu, K. Usui, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Purification, crystallization and X-ray diffraction study of extracellular dermal glycoprotein from carrot and the inhibition complex that it forms with an endo-β-glucanase from Aspergillus aculeatus.

H. Hirano, Toshiyuki Shimizu, H. Hashimoto, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystal structure of GCN5 PCAF N-terminal domain reveals atypical ubiquitin ligase structure

Toshiyuki Shimizu, N. Shimizu, M. Matsumoto, 2020, The Journal of Biological Chemistry.

Suppression of Matrix Metalloproteinase Production in Nasal Fibroblasts by Tranilast, an Antiallergic Agent, In Vitro

Toshiyuki Shimizu, K. Asano, H. Suzaki, 2005, Mediators of inflammation.

AUTOINDUCTION OF MKC-963 [(R)-1-(1-CYCLOHEXYLETHYLAMINO)-4-PHENYLPHTHALAZINE] METABOLISM IN HEALTHY VOLUNTEERS AND ITS RETROSPECTIVE EVALUATION USING PRIMARY HUMAN HEPATOCYTES AND CDNA-EXPRESSED ENZYMES

Toshiyuki Shimizu, Kaoru Kobayashi, K. Chiba, 2006, Drug Metabolism and Disposition.

Crystal Structure of Human RhoA in a Dominantly Active Form Complexed with a GTP Analogue*

M. Shirakawa, S. Kuroda, K. Kaibuchi, 1998, The Journal of Biological Chemistry.

The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane.

Toshiyuki Shimizu, K. Fukase, K. Miyake, 2014, International immunology.

Crystallographic characterization of the N-terminal domain of a plant NADPH oxidase.

K. Shimamoto, Toshiyuki Shimizu, C. Kojima, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystallographic study of G178S mutant of human proliferating cell nuclear antigen.

Toshiyuki Shimizu, H. Hashimoto, H. Ohmori, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystallization and preliminary X-ray crystallographic analysis of rat calcineurin B homologous protein 1.

Y. Naoe, Toshiyuki Shimizu, H. Hashimoto, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystallographic characterization of the N-terminal domain of PEX1.

Y. Akiyama, M. Shirakawa, K. Tomii, 2004, Acta crystallographica. Section D, Biological crystallography.

Crystallization and preliminary X-ray characterization of a novel calcium-binding protein AtCBL2 from Arabidopsis thaliana.

Toshiyuki Shimizu, H. Hashimoto, H. Sano, 2003, Acta crystallographica. Section D, Biological crystallography.

Immunostimulatory activities of monoglycosylated α-d-pyranosylceramides

Toshiyuki Shimizu, T. Natori, M. Morita, 1997 .

Discovery of a lectin domain that regulates enzyme activity in mouse N-acetylglucosaminyltransferase-IVa (MGAT4A)

R. J. Doerksen, N. Manabe, Toshiyuki Shimizu, 2022, Communications Biology.

Initial crystallographic study of human PCNA in complex with a peptide containing the noncanonical PIP-box sequence of human DNA polymerase iota.

Toshiyuki Shimizu, H. Hashimoto, H. Ohmori, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structural basis of membrane targeting function of ERM proteins revealed by the crystal structures of the radixin FERM domain

T. Hakoshima, Toshiyuki Shimizu, T. Matsui, 2000 .

Structural aspects of nucleic acid-sensing Toll-like receptors

Toshiyuki Shimizu, U. Ohto, 2016, Biophysical Reviews.

Identification of potent and selective inhibitors of PDGF receptor autophosphorylation.

T. Furuta, Toshiyuki Shimizu, R. Suzuki, 2006, Journal of medicinal chemistry.

Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-like Receptor 7 and 8.

Toshiyuki Shimizu, H. Yin, Rosaura Padilla-Salinas, 2019, Journal of medicinal chemistry.

Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA.

Toshiyuki Shimizu, M. Taoka, Y. Yamauchi, 2016, Immunity.

Toll-like receptor 8 senses degradation products of single-stranded RNA

Toshiyuki Shimizu, M. Taoka, Y. Yamauchi, 2015, Nature Structural &Molecular Biology.

Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure–Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds

Xiaoqiang Guo, Toshiyuki Shimizu, Toshiyuki Shimizu, 2014, Journal of medicinal chemistry.

Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex

T. Hirokawa, Toshiyuki Shimizu, K. Takatsu, 2017, The Journal of Biological Chemistry.

Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity

Toshiyuki Shimizu, Giuseppe Caruso, Diptesh Sil, 2015, Journal of medicinal chemistry.

Crystal structure of PHO4 bHLH domain–DNA complex: flanking base recognition

Y. Kyōgoku, N. Ogawa, T. Hakoshima, 1997, The EMBO journal.

Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation

Toshiyuki Shimizu, C. Hirama, U. Ohto, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Structural Basis of Pharmacological Chaperoning for Human β-Galactosidase*

Toshiyuki Shimizu, Toshiyuki Shimizu, 2014, The Journal of Biological Chemistry.

Purification, crystallization and initial X-ray diffraction study of the zinc-finger domain of zebrafish Nanos.

Toshiyuki Shimizu, H. Hashimoto, Keishi Nakamura, 2009, Acta crystallographica. Section F, Structural biology and crystallization communications.

Small-molecule inhibition of TLR8 through stabilization of its resting state

Toshiyuki Shimizu, H. Yin, Shuangshuang Jiang, 2017, Nature chemical biology.

Immunostimulatory activities of mono- or diglycosylated α-galactosylceramides

Toshiyuki Shimizu, T. Natori, Y. Koezuka, 1997 .

Identification of a Human Toll-Like Receptor (TLR) 8-Specific Agonist and a Functional Pan-TLR Inhibitor in 2-Aminoimidazoles.

Toshiyuki Shimizu, Giuseppe Caruso, U. Ohto, 2016, Journal of medicinal chemistry.

Fission Yeast Swi5-Sfr1 Protein Complex, an Activator of Rad51 Recombinase, Forms an Extremely Elongated Dogleg-shaped Structure

M. Ikeguchi, S. Akashi, Toshiyuki Shimizu, 2011, The Journal of Biological Chemistry.

The β-prism: a new folding motif

K. Morikawa, Toshiyuki Shimizu, 1996 .

Intrinsic dynamics of restriction endonuclease EcoO109I studied by molecular dynamics simulations and X-ray scattering data analysis.

Mamoru Sato, Mitsunori Ikeguchi, Tomotaka Oroguchi, 2009, Biophysical journal.

Structural and functional understanding of the toll‐like receptors

Toshiyuki Shimizu, Jinta Asami, 2021, Protein science : a publication of the Protein Society.

Targeting the innate immune receptor TLR8 using small-molecule agents

Toshiyuki Shimizu, K. Sakaniwa, 2020, Acta crystallographica. Section D, Structural biology.

Structural insights into ligand recognition and regulation of nucleic acid-sensing Toll-like receptors.

Toshiyuki Shimizu, 2017, Current opinion in structural biology.

Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9

Toshiyuki Shimizu, S. Uchiyama, Elena Krayukhina, 2015, Nature.

Structure and function of toll-like receptor 8.

Toshiyuki Shimizu, U. Ohto, H. Tanji, 2014, Microbes and infection.

Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands

Takuma Shibata, Toshiyuki Shimizu, Toshiyuki Shimizu, 2013, Science.

Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A.

Toshiyuki Shimizu, K. Miyake, T. Suganami, 2013, International immunology.

Structural Analyses of Human Toll-like Receptor 4 Polymorphisms D299G and T399I*

Toshiyuki Shimizu, K. Miyake, S. Akashi-Takamura, 2012, The Journal of Biological Chemistry.

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

Koichi Fukase, Toshiyuki Shimizu, Toshiyuki Shimizu, 2012, Proceedings of the National Academy of Sciences.

Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family.

Toshiyuki Shimizu, K. Miyake, U. Ohto, 2011, Journal of molecular biology.

Structural Insights into the Regulation Mechanism of Small GTPases by GEFs

Toshiyuki Shimizu, S. Toma-Fukai, 2019, Molecules.

Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.

Toshiyuki Shimizu, N. Takahashi, Yoshiko Kobayashi, 2005, Journal of medicinal chemistry.

Crystal structure of an IRF‐DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences

T. Taniguchi, Y. Kyōgoku, T. Hakoshima, 1999, The EMBO journal.

The common phospholipid‐binding activity of the N‐terminal domains of PEX1 and VCP/p97

K. Mizuguchi, M. Shirakawa, Toshiyuki Shimizu, 2006, The FEBS journal.

Structure of the N-terminal Domain of PEX1 AAA-ATPase

Yutaka Akiyama, Hidekazu Hiroaki, Kentaro Tomii, 2004, Journal of Biological Chemistry.

Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling.

Toshiyuki Shimizu, T. Kanai, Takahiko Shimizu, 2020, Free radical biology & medicine.

Structure of IZUMO1–JUNO reveals sperm–oocyte recognition during mammalian fertilization

Toshiyuki Shimizu, S. Uchiyama, Elena Krayukhina, 2016, Nature.

A Pentatricopeptide Repeat Protein Is a Site Recognition Factor in Chloroplast RNA Editing*♦

Toshiyuki Shimizu, T. Shikanai, K. Okuda, 2006, Journal of Biological Chemistry.

Effect of tranilast on matrix metalloproteinase production from neutrophils in‐vitro

Toshiyuki Shimizu, K. Asano, H. Suzaki, 2006, The Journal of pharmacy and pharmacology.

Structural Basis for Neurofibromatosis Type 2

T. Hakoshima, Toshiyuki Shimizu, S. Tsukita, 2002, The Journal of Biological Chemistry.

Structure of the bile acid transporter and HBV receptor NTCP

S. Iwata, H. Shigematsu, Takeshi Noda, 2022, Nature.

A nonclassical vitamin D receptor pathway suppresses renal fibrosis.

Toshiyuki Shimizu, J. Yanagisawa, A. Murayama, 2013, The Journal of clinical investigation.

Structural basis of the membrane‐targeting and unmasking mechanisms of the radixin FERM domain

Toshio Hakoshima, Takeshi Matsui, Shoichiro Tsukita, 2000, The EMBO journal.

Structure of the N-terminal Regulatory Domain of a Plant NADPH Oxidase and Its Functional Implications*

K. Shimamoto, S. Akashi, Toshiyuki Shimizu, 2009, The Journal of Biological Chemistry.

Parallel Coiled-coil Association of the RhoA-binding Domain in Rho-kinase*

Toshio Hakoshima, Kozo Kaibuchi, Toshiyuki Shimizu, 2003, Journal of Biological Chemistry.

NML-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a p53-dependent manner

Toshiyuki Shimizu, A. Fukamizu, Toshiyuki Shimizu, 2016, Journal of Cell Science.

Structure of a Novel DNA-binding Domain of Helicase-like Transcription Factor (HLTF) and Its Functional Implication in DNA Damage Tolerance*

Toshiyuki Shimizu, H. Hashimoto, H. Yokoyama, 2015, The Journal of Biological Chemistry.

Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.

Toshiyuki Shimizu, M. Taoka, Y. Yamauchi, 2018, Cell reports.

The crystal structure of human DEAH-box RNA helicase 15 reveals a domain organization of the mammalian DEAH/RHA family.

K. Nakano, Toshiyuki Shimizu, U. Ohto, 2017, Acta crystallographica. Section F, Structural biology communications.

Toll‐like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation

Toshiyuki Shimizu, K. Miyake, Takuma Shibata, 2018, Immunity.

The crystal structure of the AhRR–ARNT heterodimer reveals the structural basis of the repression of AhR-mediated transcription

Toshiyuki Shimizu, S. Sakurai, U. Ohto, 2017, The Journal of Biological Chemistry.

Structural basis of recruitment of DNA polymerase ζ by interaction between REV1 and REV7 proteins.

Toshiyuki Shimizu, H. Hashimoto, Mamoru Sato, 2012, The Journal of biological chemistry.

Small-Molecule TLR8 Antagonists via Structure-Based Rational Design.

Toshiyuki Shimizu, H. Yin, Shuangshuang Jiang, 2018, Cell chemical biology.

Structural basis for inhibition of xyloglucan-specific endo-β-1,4-glucanase (XEG) by XEG-protein inhibitor.

H. Hirano, Toshiyuki Shimizu, H. Hashimoto, 2012, The Journal of biological chemistry.

The structure of NLRP9 reveals a unique C‐terminal region with putative regulatory function

K. Nakano, K. Hirata, Masaki Yamamoto, 2022, FEBS letters.

Structural basis for Ca2+-induced activation of human PAD4

Toshiyuki Shimizu, H. Hashimoto, M. Yamada, 2004, Nature Structural &Molecular Biology.

Novel helical assembly in arginine methyltransferase 8.

A. Fukamizu, Toshiyuki Shimizu, N. Shimizu, 2016, Journal of molecular biology.

TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction

M. Ikeguchi, H. Shigematsu, Toshiyuki Shimizu, 2023, Nature Communications.

Rationally designed small-molecule inhibitors targeting an unconventional pocket on the TLR8 protein-protein interface.

Toshiyuki Shimizu, H. Yin, Shuangshuang Jiang, 2020, Journal of medicinal chemistry.

Toward a structural understanding of nucleic acid‐sensing Toll‐like receptors in the innate immune system

Toshiyuki Shimizu, U. Ohto, Zhikuan Zhang, 2017, FEBS letters.

Crystal structure of NOD2 and its implications in human disease

Toshiyuki Shimizu, K. Miyake, Takuma Shibata, 2016, Nature Communications.

Crystal Structure of Human REV7 in Complex with a Human REV3 Fragment and Structural Implication of the Interaction between DNA Polymerase ζ and REV1*

Y. Murakumo, S. Akashi, Toshiyuki Shimizu, 2010, The Journal of Biological Chemistry.

Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases

Toshiyuki Shimizu, Kazuhide Yamamoto, K. Miyake, 2015, Nature Communications.

The crystal structure of plant-specific calcium-binding protein AtCBL2 in complex with the regulatory domain of AtCIPK14.

Toshiyuki Shimizu, H. Hashimoto, N. Koizumi, 2008, Journal of molecular biology.

Characterisation of an intrinsically disordered protein complex of Swi5-Sfr1 by ion mobility mass spectrometry and small-angle X-ray scattering.

Mamoru Sato, Mitsunori Ikeguchi, Naoyuki Kuwabara, 2013, The Analyst.

Crystal structure of the FYCO1 RUN domain suggests possible interfaces with small GTPases.

Toshiyuki Shimizu, S. Sakurai, U. Ohto, 2020, Acta crystallographica. Section F, Structural biology communications.

Protein arginine methyltransferase 7 has a novel homodimer‐like structure formed by tandem repeats

A. Fukamizu, Toshiyuki Shimizu, Jun-Dal Kim, 2014, FEBS letters.

Structure of human Roquin-2 and its complex with constitutive-decay element RNA.

Toshiyuki Shimizu, S. Sakurai, U. Ohto, 2015, Acta crystallographica. Section F, Structural biology communications.

Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4.

Toshiyuki Shimizu, H. Hashimoto, M. Yamada, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Structural basis for substrate recognition and dissociation by human transportin 1.

N. Imamoto, Toshiyuki Shimizu, H. Hashimoto, 2007, Molecular cell.

An Open Conformation of Switch I Revealed by the Crystal Structure of a Mg2+-free Form of RHOA Complexed with GDP

S. Kuroda, K. Kaibuchi, T. Hakoshima, 2000, The Journal of Biological Chemistry.

Reduced Expression of the Survivin Gene in PBMC from Silicosis Patients

Toshiyuki Shimizu, H. Sakaguchi, A. Ueki, 2001 .

GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism

T. Katada, Toshiyuki Shimizu, K. Kontani, 2018, Proceedings of the National Academy of Sciences.

Structural Diversity of Ubiquitin E3 Ligase

Toshiyuki Shimizu, S. Toma-Fukai, 2021, Molecules.

Structural basis of the Rho GTPase signaling.

T. Hakoshima, Toshiyuki Shimizu, R. Maesaki, 2003, Journal of biochemistry.

Expression, purification and crystallization of Swi5 and the Swi5-Sfr1 complex from fission yeast.

M. Ikeguchi, Toshiyuki Shimizu, H. Hashimoto, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes

O. Levy, Toshiyuki Shimizu, Nikunj M. Shukla, 2015, PloS one.

Crystal structure of human beta-galactosidase: structural basis of Gm1 gangliosidosis and morquio B diseases

Y. Satow, Toshiyuki Shimizu, K. Usui, 2011 .

Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide

Y. Urano, Yasuo Watanabe, K. Hanaoka, 2017, Scientific Reports.

Structural analysis of HTL and D14 proteins reveals the basis for ligand selectivity in Striga

M. Tanokura, Toshiyuki Shimizu, T. Asami, 2018, Nature Communications.

Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen*

Toshiyuki Shimizu, H. Hashimoto, H. Ohmori, 2009, Journal of Biological Chemistry.

Crystal structure of the protein histidine phosphatase SixA in the multistep His‐Asp phosphorelay

T. Mizuno, Masato Kato, T. Hakoshima, 2004, Genes to cells : devoted to molecular & cellular mechanisms.

Swi5-Sfr1 protein stimulates Rad51-mediated DNA strand exchange reaction through organization of DNA bases in the presynaptic filament

B. Nordén, Toshiyuki Shimizu, Y. Tsutsui, 2013, Nucleic acids research.

Crystal structure of zinc‐finger domain of Nanos and its functional implications

Toshiyuki Shimizu, H. Hashimoto, S. Unzai, 2010, EMBO reports.

Crystallization and preliminary X-ray crystallographic analyses of EcoO109I and its complex with DNA.

Toshiyuki Shimizu, H. Hashimoto, Mamoru Sato, 2004, Acta crystallographica. Section D, Biological crystallography.

Structure of the bile acid transporter and HBV receptor NTCP

S. Iwata, H. Shigematsu, Takeshi Noda, 2022, Nature.

The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif.

Toshiyuki Shimizu, S. Sakurai, T. Tomita, 2017, Acta crystallographica. Section F, Structural biology communications.

A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation

Toshiyuki Shimizu, Yoshiko Kobayashi, M. Yagi, 1997 .

Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists

Toshiyuki Shimizu, H. Yin, Shuangshuang Jiang, 2021, Nature Communications.

Crystal Structure of Neuropsin, a Hippocampal Protease Involved in Kindling Epileptogenesis*

K. Matsumoto, T. Kishi, Masato Kato, 1999, The Journal of Biological Chemistry.

Structural insight into the activation of an Arabidopsis organellar C-to-U RNA editing enzyme by active site complementation.

Toshiyuki Shimizu, T. Shikanai, M. Takenaka, 2022, The Plant cell.

Improving particle quality in cryo-EM analysis using a PEGylation method.

H. Shigematsu, Toshiyuki Shimizu, U. Ohto, 2021, Structure.

Cryo-EM structures of Toll-like receptors in complex with UNC93B1

H. Shigematsu, T. Nishizawa, Toshiyuki Shimizu, 2021, Nature Structural & Molecular Biology.

Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1

K. Wakabayashi, Toshiyuki Shimizu, H. Hashimoto, 2017, The Journal of Biological Chemistry.

Regulation of the vitamin D receptor by vitamin D lactam derivatives

Toshiyuki Shimizu, J. Yanagisawa, Tsuyoshi Waku, 2016, FEBS letters.

Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype.

Naoyuki Kuwabara, Toshiyuki Shimizu, Masao Ohashi, 2012, Journal of medicinal chemistry.

Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8

Takuma Shibata, Toshiyuki Shimizu, Toshiyuki Shimizu, 2016, Proceedings of the National Academy of Sciences.

Crystal structure of TEX101, a glycoprotein essential for male fertility, reveals the presence of tandemly arranged Ly6/uPAR domains

Toshiyuki Shimizu, M. Masutani, S. Sakurai, 2020, FEBS letters.

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

Y. Furukawa, T. Ichinohe, E. Latz, 2022, bioRxiv.

Crystal structure of human REV 7 in complex with a human REV 3 fragment and structural implication of the interaction between DNA polymerase ζ and REV 1

Y. Murakumo, S. Akashi, Toshiyuki Shimizu, 2010 .

Structural Basis for Novel Interactions Between Human Translesion Synthesis Polymerases and PCNA

Toshiyuki Shimizu, H. Hashimoto, H. Ohmori, 2008 .

Structural basis for vitamin D receptor agonism by novel non‐secosteroidal ligands

Toshiyuki Shimizu, J. Yanagisawa, Tsuyoshi Waku, 2013, FEBS letters.

Structural analysis of HTL and D14 proteins reveals the basis for ligand selectivity in Striga

M. Tanokura, Toshiyuki Shimizu, T. Asami, 2018, Nature Communications.

Intrinsic dynamics of restriction endonuclease EcoO109I studied by molecular dynamics simulations and X-ray scattering data analysis.

M. Ikeguchi, Toshiyuki Shimizu, H. Hashimoto, 2009, Biophysical journal.

Structure of the N-terminal domain of PEX1 AAA-ATPase. Characterization of a putative adaptor-binding domain.

Yutaka Akiyama, Hidekazu Hiroaki, Kentaro Tomii, 2005, The Journal of biological chemistry.

The crystal structure of human DEAH-box RNA helicase 15 reveals a domain organization of the mammalian DEAH/RHA family.

K. Nakano, Toshiyuki Shimizu, U. Ohto, 2017, Acta crystallographica. Section F, Structural biology communications.

Analysis of the Fine-Tuning of Cyanobacterial Circadian Phase by Monochromatic Light and Long-Day Conditions.

Toshiyuki Shimizu, Yohko Kitayama, R. Kanaly, 2016, Plant & cell physiology.