C. Abbott

发表

Structural Models of Human eEF1A1 and eEF1A2 Reveal Two Distinct Surface Clusters of Sequence Variation and Potential Differences in Phosphorylation

D. Porteous, D. Soares, P. Barlow, 2009, PloS one.

The Unexpected Roles of Eukaryotic Translation Elongation Factors in RNA Virus Replication and Pathogenesis

D. Harrich, C. Abbott, Ting Wei, 2013, Microbiology and Molecular Reviews.

Expression of eEF1A2 is associated with clear cell histology in ovarian carcinomas: overexpression of the gene is not dependent on modifications at the EEF1A2 locus

N. Wray, H. Gabra, H. Newbery, 2007, British Journal of Cancer.

The translation elongation factor eEF1A1 couples transcription to translation during heat shock response

R. Singer, E. Nudler, C. Abbott, 2014, eLife.

Mapping of the structural gene for S-adenosyl homocysteine hydrolase to mouse Chromosome 2, and related sequences to Chromosomes 8 and X

C. Abbott, J. Peters, P. Tissier, 2004, Mammalian Genome.

Translation factors: in sickness and in health.

C. Proud, C. Abbott, 2004, Trends in biochemical sciences.

Of mice, men and motor neurons.

H. Newbery, C. Abbott, 2002, Trends in molecular medicine.

Of mice, men and motor neurons.

H. Newbery, C. Abbott, 2001, Trends in genetics : TIG.

Functional Predictors of Causative Cis-Regulatory Mutations in Mendelian Disease

D. Grozeva, P. Kind, H. R. Crollius, 2020, bioRxiv.

The mouse homologue of the human tuberous sclerosis 2 (TSC2) gene maps to chromosome 17, but does not fall within the tw18 or th20 deletions.

M. Lyon, S. Povey, P. Glenister, 1995, Genomics.

eEF1A demonstrates paralog specific effects on HIV-1 reverse transcription efficiency.

D. Harrich, C. Abbott, Dongsheng Li, 2019, Virology.

Eukaryotic elongation factor 1 complex subunits are critical HIV-1 reverse transcription cofactors

D. Harrich, C. Abbott, Ann Apolloni, 2012, Proceedings of the National Academy of Sciences.

Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks.

D. Porteous, K. Evans, T. Spires-Jones, 2021, Cellular and molecular neurobiology.

Translation elongation factor 1A2 is encoded by one of four closely related eef1a genes and is dispensable for survival in zebrafish

D. Soares, C. Abbott, N. Idigo, 2020, Bioscience reports.

Highly homologous eEF1A1 and eEF1A2 exhibit differential post-translational modification with significant enrichment around localised sites of sequence variation

C. Abbott, D. C. Soares, 2013, Biology Direct.

Mouse Chromosome 4

J. Eppig, I. Jackson, C. Abbott, 2004, Mammalian Genome.

Translation Elongation Factor eEF1A2 Is Essential for Post-weaning Survival in Mice*

H. Newbery, C. Abbott, J. Bergmann, 2007, Journal of Biological Chemistry.

Explorer In vivo characterization of the role of tissue-specific translation elongation factor 1 A 2 in protein synthesis reveals insights into muscle atrophy

H. Newbery, C. Abbott, J. Doig, 2013 .

In vivo characterization of the role of tissue‐specific translation elongation factor 1A2 in protein synthesis reveals insights into muscle atrophy

H. Newbery, C. Abbott, J. Doig, 2013, The FEBS journal.

Mouse chromosome 2

D. Pomp, C. Abbott, L. Siracusa, 1996, Mammalian Genome.

Mouse Chromosome 2

C. Abbott, L. Siracusa, 2004, Mammalian Genome.

Haploinsufficiency for Translation Elongation Factor eEF1A2 in Aged Mouse Muscle and Neurons Is Compatible with Normal Function

H. Newbery, C. Abbott, J. Doig, 2012, PloS one.

eEF1A2 and neuronal degeneration.

D. Soares, H. Newbery, C. Abbott, 2009, Biochemical Society transactions.

Deficiency of adenosine deaminase in the wasted mouse.

C. Abbott, J. Peters, C. Skidmore, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Genetic and physical mapping of the mouse Ulnaless locus.

T. Vogt, C. Peichel, C. Abbott, 1996, Genetics.

Characterization of mouse-hamster somatic cell hybrids by PCR: A panel of mouse-specific primers for each chromosome

C. Abbott, 2004, Mammalian Genome.

The isolation and mapping of PCR markers specific to mouse Chromosome 2

C. Abbott, D. Stephenson, A. Pilz, 1996, Mammalian Genome.

The genes for endothelin 3, vitamin D 24-hydroxylase, and melanocortin 3 receptor map to distal mouse Chromosome 2, in the region of conserved synteny with human Chromosome 20

C. Abbott, J. Peters, S. Malas, 1994, Mammalian Genome.

Comparative mapping of 50 human chromosome 9 loci in the laboratory mouse.

S. Povey, K. Woodward, C. Abbott, 1995, Genomics.

Translation elongation factor 1A2 is encoded by one of four closely related eef1a genes and is dispensable for survival in zebrafish

D. Soares, C. Abbott, N. Idigo, 2019, bioRxiv.

Novel de novo EEF1A2 missense mutations causing epilepsy and intellectual disability

F. Elmslie, D. Soares, C. Abbott, 2016, Molecular genetics & genomic medicine.

Characterisation of Translation Elongation Factor eEF1B Subunit Expression in Mammalian Cells and Tissues and Co-Localisation with eEF1A2

Yuan Cao, C. Abbott, J. Janikiewicz, 2014, PloS one.

Report and abstracts of the First International Workshop on Chromosome 9. Held at Girton College Cambridge, UK, 22-24 March, 1992.

S. Povey, D. Kwiatkowski, I. Jackson, 1992, Annals of human genetics.

Novel de novo EEF 1 A 2 missense mutations causing epilepsy and intellectual disability

F. Elmslie, D. Soares, C. Abbott, 2016 .

α1-ANTTTRYPSIN-RELATED GENE (ATR) FOR PRENATAL DIAGNOSIS

S. Povey, G. Kelsey, C. Abbott, 1987, The Lancet.

REPORT on the First International Workshop on Chromosome 9 held at Girton College Cambridge, UK, 22–24 March, 1992

S. Povey, D. Kwiatkowski, I. Jackson, 1992 .

Comparative mapping of mouse Chromosome 4 and human Chromosome 9: Lv, Orm, and Hxb are closely linked on mouse Chromosome 4

C. Abbott, J. Peters, A. Pilz, 2004, Mammalian Genome.

Expression and mapping of the mouse S7/Pmsc2 gene, homolog of an essential mitotic gene in yeast

D. Davidson, C. Abbott, L. Colleaux, 1997, Mammalian Genome.

Prenatal diagnosis of alpha‐1‐antitrypsin deficiency by PCR of linked polymorphisms: A study of 17 cases

S. Povey, C. Abbott, D. Whitehouse, 1992, Prenatal diagnosis.

Genomic structure and chromosomal mapping of the murine and human Mbd 1 , Mbd 2 , Mbd 3 , and Mbd 4 genes

S. Cross, A. Bird, C. Abbott, 2022 .

Evolutionary importance of translation elongation factor eEF1A variant switching: eEF1A1 down-regulation in muscle is conserved in Xenopus but is controlled at a post-transcriptional level.

H. Newbery, C. Abbott, L. Zimmerman, 2011, Biochemical and biophysical research communications.

Genetic studies on a new deficiency gene (PI*Ztun) at the PI locus.

C. Abbott, A. Mowat, D. Whitehouse, 1989, Journal of medical genetics.

The human homolog of the mouse brown gene maps to the short arm of chromosome 9 and extends the known region of homology with mouse chromosome 4.

I. Jackson, S. Povey, C. Abbott, 1991, Genomics.

The genes coding for phosphoenolpyruvate carboxykinase‐1 (PCK1) and neuronal nicotinic acetylcholine receptor α4 subunit (CHRNA4) map to human chromosome 20, extending the known region of homology with mouse chromosome 2

S. Povey, C. Abbott, A. Pilz, 1992, Annals of human genetics.

Comparative mapping of mouse chromosome 2 and human chromosome 9q: the genes for gelsolin and dopamine beta-hydroxylase map to mouse chromosome 2.

C. Abbott, J. Peters, A. Pilz, 1992, Genomics.

Mouse chromosome 2

C. Abbott, L. Siracusa, 2004, Mammalian Genome.

The gene for human complement component C9 mapped to chromosome 5 by polymerase chain reaction.

S Povey, S. Povey, C. Abbott, 1989, Genomics.

Modelling epilepsy in the mouse: challenges and solutions

A. Gonzalez-Sulser, C. Abbott, Grant F. Marshall, 2021, Disease Models & Mechanisms.

Development of human chromosome-specific PCR primers for characterization of somatic cell hybrids.

S. Povey, C. Abbott, 1991, Genomics.

Biallelic mutations in the gene encoding eEF1A2 cause seizures and sudden death in F0 mice

Colin Smith, C. Abbott, J. Doig, 2017, Scientific Reports.

Genetic influences on ovulation of primary oocytes in LT/Sv strain mice.

M. Kaufman, C. Abbott, J. West, 2004, Reproduction.

The reticulocalbin gene maps to the WAGR region in human and to the Small eye Harwell deletion in mouse.

W. Bickmore, S. Boyle, A. Schedl, 1997, Genomics.

Explorer The translation elongation factor eEF 1 A 1 couples transcription to translation during heat shock response

R. Singer, E. Nudler, C. Abbott, 2016 .

Towards high resolution maps of the mouse and human genomes--a facility for ordering markers to 0.1 cM resolution. European Backcross Collaborative Group.

D. Simon, A. Ashworth, S. Rastan, 1994, Human molecular genetics.

Eef1a2 Promotes Cell Growth, Inhibits Apoptosis and Activates JAK/STAT and AKT Signaling in Mouse Plasmacytomas

Chen-feng Qi, A. Kovalchuk, H. Newbery, 2010, PloS one.

Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours

Naomi R Wray, N. Wray, H. Newbery, 2005, BMC Cancer.

Comparative genomic analysis of genes encoding translation elongation factor 1B(alpha) in human and mouse shows EEF1B1 to be a recent retrotransposition event.

G. Rouleau, C. Abbott, D. Chambers, 2001, Genomics.

The lethal mutation of the mouse wasted (wst) is a deletion that abolishes expression of a tissue-specific isoform of translation elongation factor 1alpha, encoded by the Eef1a2 gene.

C. Abbott, J. Peters, J. Peters, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Isolation of a microsatellite that reveals paralogy between the subtelomeric regions of mouse chromosomes 17 and 19: further evidence for telomere-telomere exchange in the mouse.

C. Abbott, D. Kipling, D. Chambers, 1998, Genomics.

Linkage mapping around the ragged (Ra) and wasted (wst) loci on distal mouse chromosome 2.

C. Abbott, J. Peters, A. Pilz, 1994, Genomics.

Genetic linkage analysis of the Ak1, Col5a1, Epb7.2, Fpgs, Grp78, Pbx3, and Notch1 genes in the region of mouse chromosome 2 homologous to human chromosome 9q.

C. Abbott, J. Peters, R. Prohaska, 1994, Genomics.

Identification and functional modelling of plausibly causative cis-regulatory variants in a highly-selected cohort with X-linked intellectual disability

D. Grozeva, P. Kind, J. Prendergast, 2021, PloS one.

PRENATAL DIAGNOSIS OF ALPHA-1-ANTITRYPSIN DEFICIENCY USING POLYMERASE CHAIN REACTION

S. Povey, C. Abbott, D. Whitehouse, 1988, The Lancet.

Thirteen genes (Cebpb, E2f1, Tcf4, Cyp24, Pck1, Acra4, Edn3, Kcnb1, Mc3r, Ntsr, Cd40, Plcg1 and Rcad) that probably lie in the distal imprinting region of mouse chromosome 2 are not monoallelically expressed.

C. Abbott, J. Peters, C. Williamson, 1995, Genetical research.

BRK/Sik expression in the gastrointestinal tract and in colon tumors.

V. Vasioukhin, A. Tyner, J. Derry, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Sik Expression in the Gastrointestinal Tract and in Colon Tumors 1

V. Vasioukhin, A. Tyner, J. Derry, 1999 .

Two opposing effects of mismatch repair on CTG repeat instability in Escherichia coli

C. Abbott, D. Leach, K. Schmidt, 2000, Molecular microbiology.

Analysis of CAG trinucleotide repeats from mouse cDNA sequences

C. Abbott, D. Chambers, 1994, Annals of human genetics.

Recapitulation of the EEF1A2 D252H neurodevelopmental disorder-causing missense mutation in mice reveals a toxic gain of function.

E. Wood, Colin Smith, C. Abbott, 2020, Human molecular genetics.

Structure and chromosomal localization of the human 2‘,3’‐cyclic nucleotide 3‘‐phosphodiesterase gene

M. Fox, S. Povey, C. Abbott, 1992, Annals of human genetics.

The role of translation elongation factor eEF1 subunits in neurodevelopmental disorders

C. Abbott, Fiona McLachlan, Anna Sirés, 2018, Human mutation.

The assignment of the genes coding for human complement components C6 and C7 to chromosome 5

S. Povey, C. Abbott, S. Jeremiah, 1990, Annals of human genetics.

Adenosine deaminase,Ada, is in mouse chromosome 2H3, and is not allelic with wasted,wst

C. Abbott, J. Peters, C. Skidmore, 1991, Biochemical Genetics.

Adenosine deaminase,Ada, is in mouse chromosome 2H3, and is not allelic with wasted,wst

C. Abbott, J. Peters, C. Skidmore, 1991, Biochemical Genetics.

The Use of the Polymerase Chain Reaction in the Mapping of Human Genes Using Somatic Cell Hybrids

S. Povey, C. Abbott, 1991 .

A linkage map for the hybridising toads Bombina bombina and B. variegata (Anura: Discoglossidae)

N. Barton, C. Abbott, J. Szymura, 2003, Heredity.

Genetic studies onanewdeficiency gene(PI*ZtUn) atthePIlocus

C. Abbott, D. Whitehouse, J. Lovegrove, 1989 .

Efficient and versatile CRISPR engineering of human neurons in culture to model neurological disorders

A. Bird, E. Heard, C. Abbott, 2016, Wellcome open research.

Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes

S. Cross, A. Bird, C. Abbott, 1999, Mammalian Genome.

Mouse models of human single gene disorders I: Non‐transgenic mice

C. Abbott, S. Darling, 1992, BioEssays : news and reviews in molecular, cellular and developmental biology.

Specific Interaction between eEF1A and HIV RT Is Critical for HIV-1 Reverse Transcription and a Potential Anti-HIV Target

D. Harrich, D. Soares, C. Abbott, 2015, PLoS pathogens.

Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks

D. Porteous, K. Evans, T. Spires-Jones, 2021, bioRxiv.

Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice

C. Abbott, G. Muscat, P. Koopman, 2000, Nature Genetics.

Endogenous epitope tagging of eEF1A2 in mice reveals early embryonic expression of eEF1A2 and subcellular compartmentalisation of neuronal eEF1A1 and eEF1A2

C. Abbott, Faith Davies, Grant F. Marshall, 2023, Molecular and Cellular Neuroscience.

Progressive loss of motor neuron function in wasted mice: effects of a spontaneous null mutation in the gene for the eEF1 A2 translation factor.

R. Ribchester, H. Newbery, C. Abbott, 2005, Journal of neuropathology and experimental neurology.

Multiple molecular dynamics simulation of the isoforms of human translation elongation factor 1A reveals reversible fluctuations between "open" and "closed" conformations and suggests specific for eEF1A1 affinity for Ca2+-calmodulin

A. El'skaya, C. Abbott, B. Negrutskii, 2008, BMC Structural Biology.

Mapping in the region of Danforth's short tail and the localization of tail length modifiers.

I. Jackson, B. Taylor, C. Abbott, 1997, Genome research.

Mapping of the human homologs of the murine paired-box-containing genes

S. Povey, P. Gruss, C. Abbott, 2004, Mammalian Genome.

Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours

N. Wray, H. Newbery, C. Abbott, 2005, BMC Cancer.

Efficient and versatile CRISPR engineering of human neurons in culture to model neurological disorders [version 1; peer review: 2 approved]

A. Bird, E. Heard, T. Bürckstümmer, 2022 .

Linkage mapping of the Aldo-2, Pax-5, Ambp, and D4h9S3E loci on mouse chromosome 4 in the region of homology with human chromosome 9.

C. Abbott, J. Peters, J. Fountain, 1993, Genomics.

Mouse chromosome 2

C. Abbott, L. Siracusa, 1996, Mammalian Genome.

Dinucleotide repeats in the mouse Hox-4.4 and Hox-4.5 genes on Chromosome 2, and their analysis in the BXD and BXH recombinant inbred strains

C. Abbott, A. Pilz, 2004, Mammalian Genome.

Mouse genetics and transgenics : a practical approach

I. Jackson, C. Abbott, 2000 .

The translation elongation factor eEF1A1 couples transcription to translation during heat shock response

R. Singer, E. Nudler, C. Abbott, 2014, eLife.

Evolutionary importance of translation elongation factor eEF1A variant switching

H. Newbery, C. Abbott, I. Stancheva, 2013 .

Efficient and versatile CRISPR engineering of human neurons in culture to model neurological disorders

A. Bird, E. Heard, C. Abbott, 2016, Wellcome open research.