Dongshu Chen

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Muc1 oncoprotein suppresses activation of the ARF-MDM2-p53 pathway

D. Kufe, S. Kharbanda, D. Raina, 2008, Cancer biology & therapy.

Nuclear Import of the MUC1-C Oncoprotein Is Mediated by Nucleoporin Nup62*

D. Kufe, Dongshu Chen, Masaki Ito, 2007, Journal of Biological Chemistry.

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

C. Roberts, V. Myer, C. Mickanin, 2014, Proceedings of the National Academy of Sciences.

Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells

D. Kufe, Dongshu Chen, M. Kashiwaba, 1997, Nature Medicine.

Immunotherapy of spontaneous mammary carcinoma with fusions of dendritic cells and mucin 1‐positive carcinoma cells

D. Kufe, Dongshu Chen, J. Xia, 2003, Immunology.

Human DF3/MUC1 carcinoma-associated protein functions as an oncogene

D. Kufe, S. Kharbanda, Dongshu Chen, 2003, Oncogene.

Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight.

Y. Mishina, E. Martin, W. Shao, 2016, Journal of Medicinal Chemistry.

The Kinetics of In Vivo Priming of CD4 and CD8 T Cells by Dendritic/Tumor Fusion Cells in MUC1-Transgenic Mice1

D. Kufe, Dongshu Chen, J. Gong, 2002, The Journal of Immunology.

Induction of anti-leukemic cytotoxic T lymphocytes by fusion of patient-derived dendritic cells with autologous myeloblasts.

D. Kufe, D. DeAngelo, I. Galinsky, 2004, Leukemia research.

MUC 1-Transgenic Mice CellsCD 8 T Cells by Dendritic / Tumor Fusion The Kinetics of In Vivo Priming of CD 4 and Kufe and Jianlin

D. Kufe, Dongshu Chen, J. Gong, 2002 .

Immunization against murine multiple myeloma with fusions of dendritic and plasmacytoma cells is potentiated by interleukin 12.

D. Kufe, Dongshu Chen, T. Ohno, 2002, Blood.

Inhibition of Casein Kinase 1 Alpha Prevents Acquired Drug Resistance to Erlotinib in EGFR-Mutant Non-Small Cell Lung Cancer.

J. Korn, Sreenath V. Sharma, D. Ruddy, 2015, Cancer research.

Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents.

D. Kufe, S. Kharbanda, D. Raina, 2004, Cancer cell.

SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms

G. Dranoff, S. Silver, J. Engelman, 2021, Scientific Reports.

MUC1 Cytoplasmic Domain Coactivates Wnt Target Gene Transcription and Confers Transformation

D. Kufe, S. Kharbanda, Dongshu Chen, 2003, Cancer biology & therapy.

An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin.

W. Sellers, J. Gu, C. Arteaga, 2013, Cancer research.

MUC1 Oncoprotein Blocks Glycogen Synthase Kinase 3β–Mediated Phosphorylation and Degradation of β-Catenin

L. Yin, D. Kufe, S. Kharbanda, 2005 .

Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway

Pablo Tamayo, Justin Klekota, Jill P Mesirov, 2010, Nature Medicine.

MUC1 oncoprotein blocks glycogen synthase kinase 3beta-mediated phosphorylation and degradation of beta-catenin.

L. Yin, D. Kufe, S. Kharbanda, 2005, Cancer research.

Interaction of Glycogen Synthase Kinase 3β with the DF3/MUC1 Carcinoma-Associated Antigen and β-Catenin

D. Kufe, Dongshu Chen, J. Gong, 1998, Molecular and Cellular Biology.

T cell suppression as a mechanism for tolerance to MUC1 antigen in MUC1 transgenic mice

Dongshu Chen, S. Gendler, J. Gong, 2000, Breast Cancer Research and Treatment.

Induction of Antitumor Immunity by Vaccination of Dendritic Cells Transfected with MUC1 RNA1

D. Kufe, Dongshu Chen, S. Gendler, 2000, The Journal of Immunology.

Fusions of Human Ovarian Carcinoma Cells with Autologous or Allogeneic Dendritic Cells Induce Antitumor Immunity1

S. Cannistra, D. Kufe, Dongshu Chen, 2000, The Journal of Immunology.

Development of Anti-CD32b Antibodies with Enhanced Fc Function for the Treatment of B and Plasma Cell Malignancies

E. Lees, J. Williams, M. Scharenberg, 2020, Molecular Cancer Therapeutics.

Reversal of tolerance to human MUC1 antigen in MUC1 transgenic mice immunized with fusions of dendritic and carcinoma cells.

D. Kufe, Dongshu Chen, S. Gendler, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Induction of antigen-specific antitumor immunity with adenovirus-transduced dendritic cells

D. Kufe, T. Tanaka, Dongshu Chen, 1997, Gene Therapy.

Bone marrow and peripheral blood dendritic cells from patients with multiple myeloma are phenotypically and functionally normal despite the detection of Kaposi's sarcoma herpesvirus gene sequences.

Dongshu Chen, G. Teoh, D. Chauhan, 1999, Blood.

Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene.

D. Waxman, D. Kufe, Dongshu Chen, 1996, Cancer research.

Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the DF3/MUC1 promoter.

Dongshu Chen, Y. Manome, Ling Chen, 1995, The Journal of clinical investigation.

Inhibition of Casein Kinase 1 Alpha Prevents Acquired Drug Resistance to Erlotinib in EGFR-Mutant Non-Small Cell Lung Cancer.

Joshua M. Korn, Sreenath V. Sharma, D. Ruddy, 2015, Cancer research.

Abstract 1680:In vitroandin vivoactivity of a highly potent and novel FGFR2/FGFR4 dual targeting antibody-drug conjugate

T. Hu, E. Lees, Dongshu Chen, 2015 .

Abstract 2733: LJM716: an anti-HER3 antibody that inhibits both HER2 and NRG driven tumor growth by trapping HER3 in the inactive conformation.

Dongshu Chen, Q. Sheng, S. Ettenberg, 2012 .

Vaccination with allogeneic dendritic cells fused to carcinoma cells induces antitumor immunity in MUC1 transgenic mice.

D. Kufe, Dongshu Chen, Y. Tanaka, 2001, Clinical immunology.