A. Porras

发表

Apoptosis by cisplatin requires p53 mediated p38α MAPK activation through ROS generation

Augusto Silva, P. Bragado, A. Armesilla, 2007, Apoptosis.

P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli.

M. Benito, C. Ambrosino, A. Porras, 2003, Molecular biology of the cell.

p42/p44 mitogen-activated protein kinases activation is required for the insulin-like growth factor-I/insulin induced proliferation, but inhibits differentiation, in rat fetal brown adipocytes.

M. Benito, A. Porras, A. Valladares, 1998, Molecular endocrinology.

p 38 Mediates Cell Survival in Response to Oxidative Stress via Induction of Antioxidant Genes EFFECT ON THE p 70 S 6 K PATHWAY

P. Bragado, A. Porras, J. Aguirre-Ghiso, 2012 .

MAPK14 (mitogen-activated protein kinase 14)

A. Porras, C. Guerrero, 2012 .

Role of p38α in apoptosis: implication in cancer development and therapy

A. Porras, C. Guerrero, 2011 .

p38α Mediates Cell Survival in Response to Oxidative Stress via Induction of Antioxidant Genes

P. Bragado, A. Porras, J. Aguirre-Ghiso, 2011, The Journal of Biological Chemistry.

C3G silencing enhances STI-571-induced apoptosis in CML cells through p38 MAPK activation, but it antagonizes STI-571 inhibitory effect on survival.

A. Porras, M. Sanz, C. Guerrero, 2009, Cellular signalling.

Notch-1 Controls the Expression of Fatty Acid-activated Transcription Factors and Is Required for Adipogenesis*

A. Porras, J. Laborda, C. Park, 1997, The Journal of Biological Chemistry.

TNF-alpha inhibits UCP-1 expression in brown adipocytes via ERKs. Opposite effect of p38MAPK.

M. Benito, A. Porras, A. Valladares, 2001, FEBS letters.

Mitogen-activated protein kinase activation is not necessary for, but antagonizes, 3T3-L1 adipocytic differentiation

N. Ahn, A. Porras, E. Santos, 1997, Molecular and cellular biology.

p38α MAPK can positively or negatively regulate Rac‐1 activity depending on the presence of serum

M. Benito, P. Bragado, A. Porras, 2007, FEBS letters.

HGK promotes metastatic dissemination in prostate cancer

B. Győrffy, P. Bragado, A. Porras, 2021, Scientific Reports.

TWEAK prevents TNF-α-induced insulin resistance through PP2A activation in human adipocytes.

A. Porras, J. Vendrell, M. Lorenzo, 2013, American journal of physiology. Endocrinology and metabolism.

Differentiation of 3T3-L1 fibroblasts to adipocytes induced by transfection of ras oncogenes.

M. Benito, A. Porras, A. Nebreda, 1991, Science.

How Rap and its GEFs control liver physiology and cancer development. C3G alterations in human hepatocarcinoma

A. Porras, C. Guerrero, S. Manzano, 2018, Hepatic oncology.

C3G Is Upregulated in Hepatocarcinoma, Contributing to Tumor Growth and Progression and to HGF/MET Pathway Activation

P. Bragado, A. Porras, F. Maina, 2020, Cancers.

p 38 Mitogen-Activated Protein Kinase Mediates Tumor Necrosis Factor-a-Induced Apoptosis in Rat Fetal

M. Benito, A. Porras, A. Valladares, 2000 .

TNF-alpha induces apoptosis in rat fetal brown adipocytes in primary culture.

M. Benito, A. Porras, A. Valladares, 1997, FEBS letters.

C3G, through its GEF activity, induces megakaryocytic differentiation and proplatelet formation

A. Porras, J. M. de Pereda, E. Anguita, 2018, Cell Communication and Signaling.

p38 Mitogen-Activated Protein Kinase Mediates Tumor Necrosis Factor-α-Induced Apoptosis in Rat Fetal Brown Adipocytes.

M. Benito, A. Porras, A. Valladares, 2000, Endocrinology.

Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1.

M. Benito, A. Porras, S. Zuluaga, 2007, Cellular signalling.

The ras signaling pathway mimics insulin action on glucose transporter translocation.

A. Porras, M. Czech, J. Klarlund, 1993, Proceedings of the National Academy of Sciences of the United States of America.

TNF‐α inhibits UCP‐1 expression in brown adipocytes via ERKs

M. Benito, A. Porras, A. Valladares, 2001 .

TWEAK promotes migration and invasion in MEFs through a mechanism dependent on ERKs activation and Fibulin 3 down‐regulation

A. Porras, S. Fernández-Veledo, M. Arechederra, 2018, Journal of cellular physiology.

Triiodothyronine Induces the Transcription of the Uncoupling Protein Gene and Stabilizes Its mRNA in Fetal Rat Brown Adipocyte Primary Cultures (*)

M. Benito, A. Porras, C. Roncero, 1996, The Journal of Biological Chemistry.

Differential role of PPARγ in the regulation of UCP‐1 and adipogenesis by TNF‐α in brown adipocytes

M. Benito, A. Porras, A. Valladares, 2002 .

Lymphocyte antigen 6G6D-mediated modulation through p38α MAPK and DNA methylation in colorectal cancer

L. Cerulo, A. Porras, L. Coppola, 2022, Cancer cell international.

Noradrenaline induces brown adipocytes cell growth via β‐receptors by a mechanism dependent on ERKs but independent of cAMP and PKA

M. Benito, A. Porras, A. Valladares, 2000, Journal of cellular physiology.

Dissociation between activation of Raf-1 kinase and the 42-kDa mitogen-activated protein kinase/90-kDa S6 kinase (MAPK/RSK) cascade in the insulin/Ras pathway of adipocytic differentiation of 3T3 L1 cells.

A. Porras, U. Rapp, K. Muszynski, 1994, The Journal of biological chemistry.

Characterization of a System to Study the Uncoupling Protein Expression in Brown Adipocyte Primary Cultures

M. Benito, A. Porras, Margarita Fernández, 1990 .

Chapter 19 – Regulation of Proliferation, Differentiation and Apoptosis of Brown Adipocytes: Signal Transduction Pathways Involved

M. Benito, A. Porras, 2002 .

In vivo production of fluorine-18 in a chicken egg tumor model of breast cancer for proton therapy range verification

S. España, P. Bragado, A. Porras, 2022, Scientific reports.

Could 18O-enriched water increase signal for PET proton range verification? A study using a chicken embryo model

S. España, P. Bragado, A. Porras, 2021, 2104.13090.

New functions of C3G in platelet biology: Contribution to ischemia-induced angiogenesis, tumor metastasis and TPO clearance

M. Sánchez-Martín, A. Porras, C. Guerrero, 2022, Frontiers in Cell and Developmental Biology.

p21ras-induced meiotic maturation of Xenopus oocytes in the absence of protein synthesis: MPF activation is preceded by activation of MAP and S6 kinases.

A. Porras, A. Nebreda, E. Santos, 1993, Oncogene.

C3G contributes to platelet activation and aggregation by regulating major signaling pathways

J. Balsinde, A. Porras, J. González-Porras, 2020, Signal Transduction and Targeted Therapy.

C3G transgenic mouse models with specific expression in platelets reveal a new role for C3G in platelet clotting through its GEF activity.

A. Porras, J. González-Porras, M. Sanz, 2012, Biochimica et biophysica acta.

A role for p38α mitogen‐activated protein kinase in embryonic cardiac differentiation

A. Porras, S. Zuluaga, A. Nebreda, 2008, FEBS letters.

C3G down-regulation enhances pro-migratory and stemness properties of oval cells by promoting an epithelial-mesenchymal-like process

P. Bragado, A. Porras, A. Cuesta, 2022, International journal of biological sciences.

C3G Protein, a New Player in Glioblastoma

P. Bragado, A. Porras, A. Cuesta, 2021, International journal of molecular sciences.

p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation

A. Porras, T. Decker, A. Nebreda, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Contribution of C3G and other GEFs to liver cancer development and progression

P. Bragado, A. Porras, Álvaro Gutierrez-Uzquiza, 2021, Hepatoma Research.

Germline gain‐of‐function MMP11 variant results in an aggressive form of colorectal cancer

P. Bragado, A. Porras, T. Caldés, 2022, International journal of cancer.

C3G forms complexes with Bcr-Abl and p38α MAPK at the focal adhesions in chronic myeloid leukemia cells: implication in the regulation of leukemic cell adhesion

A. Porras, J. M. de Pereda, M. Sanz, 2013, Cell Communication and Signaling.

Met acts on Mdm2 via mTOR to signal cell survival during development

A. Porras, F. Maina, R. Dono, 2007, Development.

Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development.

R. Klein, M. Jones, A. Porras, 2000, Molecular cell.

LY6G6D is Epigenetically Activated in Classical Colorectal Adenocarcinoma and Hyper-Methylated in Mucinous Subtypes Determining Resistance to FOLFOX Therapeutic Regimens.

L. Cerulo, A. Porras, L. Coppola, 2021 .

Immune Resistance and EGFR Antagonists in Colorectal Cancer

A. Porras, A. Remo, M. Pancione, 2019, Cancers.

JAK/Stat5-mediated subtype-specific lymphocyte antigen 6 complex, locus G6D (LY6G6D) expression drives mismatch repair proficient colorectal cancer

L. Cerulo, A. Scarpa, A. Porras, 2019, Journal of Experimental & Clinical Cancer Research.

C3G downregulation induces the acquisition of a mesenchymal phenotype that enhances aggressiveness of glioblastoma cells

P. Bragado, A. Porras, I. Rubio, 2021, Cell Death & Disease.

C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38α activation, while it impairs tumor growth through p38α-independent mechanisms

P. Bragado, A. Porras, M. Kazanietz, 2016, Oncotarget.

C3G down-regulates p38 MAPK activity in response to stress by Rap-1 independent mechanisms: involvement in cell death.

Carmen Guerrero, Manuel Benito, M. Benito, 2010, Cellular signalling.

C3G promotes a selective release of angiogenic factors from activated mouse platelets to regulate angiogenesis and tumor metastasis

A. Porras, J. González-Porras, L. San-Segundo, 2017, Oncotarget.

C3G contributes to platelet activation and aggregation by regulating major signaling pathways

J. Balsinde, A. Porras, J. González-Porras, 2020, Signal transduction and targeted therapy.

Differential role of PPAR gamma in the regulation of UCP-1 and adipogenesis by TNF-alpha in brown adipocytes.

M. Benito, A. Porras, A. Valladares, 2002, FEBS Letters.

Activation of p38MAPK by TGF‐β in fetal rat hepatocytes requires radical oxygen production, but is dispensable for cell death

M. Benito, A. Porras, I. Fabregat, 2001, FEBS letters.

p38 MAPK Down-regulates Fibulin 3 Expression through Methylation of Gene Regulatory Sequences

A. Porras, A. Cuenda, C. Roncero, 2014, The Journal of Biological Chemistry.

Long-term treatment with insulin induces apoptosis in brown adipocytes: role of oxidative stress.

Manuel Benito, M. Benito, A. Porras, 2003, Endocrinology.

p38 MAP kinases: beyond the stress response.

A. Porras, A. Nebreda, 2000, Trends in biochemical sciences.

Critical role of hydrogen peroxide signaling in the sequential activation of p38 MAPK and eNOS in laminar shear stress.

J. Laranjinha, A. Porras, R. Radi, 2012, Free radical biology & medicine.

HGF/c-Met signaling promotes liver progenitor cell migration and invasion by an epithelial-mesenchymal transition-independent, phosphatidyl inositol-3 kinase-dependent pathway in an in vitro model.

A. Porras, I. Fabregat, C. Roncero, 2015, Biochimica et biophysica acta.

Development of the uncoupling protein in the rat brown-adipose tissue during the perinatal period. Its relationship with the mitochondrial GDP-binding and GDP-sensitive ion permeabilities and respiration.

M. Benito, A. Porras, Margarita Fernández, 1990, European journal of biochemistry.

The role of temperature in the growth of the germ tubes of ascospores of Mycosphaerella spp., responsible for leaf spot diseases of banana.

A. Porras, L. Perez, 1997 .

Centrosome Dynamics and Its Role in Inflammatory Response and Metastatic Process

L. Cerulo, P. Bragado, A. Porras, 2021, Biomolecules.

Activation of Ras by insulin in 3T3 L1 cells does not involve GTPase-activating protein phosphorylation.

M. Benito, A. Porras, A. Nebreda, 1992, The Journal of biological chemistry.

TNF‐α induces apoptosis in rat fetal brown adipocytes in primary culture

M. Benito, A. Porras, A. Valladares, 1997 .

Ras proteins mediate induction of uncoupling protein, IGF-I, and IGF-I receptor in rat fetal brown adipocyte cell lines.

M. Benito, A. Porras, E. Hernández, 1996, DNA and cell biology.

Met signaling in cardiomyocytes is required for normal cardiac function in adult mice.

P. Bragado, A. Porras, J. López-Novoa, 2013, Biochimica et biophysica acta.

Adrenergic regulation of the uncoupling protein expression in foetal rat brown adipocytes in primary culture.

M. Benito, A. Porras, M. Fernández, 1989, Biochemical and biophysical research communications.

Emerging Insight into MAPK Inhibitors and Immunotherapy in Colorectal Cancer.

L. Cerulo, A. Porras, M. Milella, 2017, Current Medicinal Chemistry.

JAK/Stat5-mediated subtype-specific lymphocyte antigen 6 complex, locus G6D (LY6G6D) expression drives mismatch repair proficient colorectal cancer

L. Cerulo, A. Scarpa, A. Porras, 2019, Journal of experimental & clinical cancer research : CR.

Triiodothyronine induces the expression of the uncoupling protein in long term fetal rat brown adipocyte primary cultures: role of nuclear thyroid hormone receptor expression.

M. Benito, A. Porras, C. Roncero, 1994, Endocrinology.

C3G, through its GEF activity, induces megakaryocytic differentiation and proplatelet formation

A. Porras, J. M. de Pereda, E. Anguita, 2018, Cell Communication and Signaling.

Establishment of permanent brown adipocyte cell lines achieved by transfection with SV40 large T antigen and ras genes.

M. Benito, A. Porras, E. Santos, 1993, Experimental cell research.

CRISPR/Cas9 screenings unearth protein arginine methyltransferase 7 as a novel driver of metastasis in prostate cancer

H. Hakonarson, H. Qu, M. Mendiburu-Eliçabe, 2023, bioRxiv.

JAK/Stat5-mediated subtype-specific lymphocyte antigen 6 complex, locus G6D (LY6G6D) expression drives mismatch repair proficient colorectal cancer

L. Cerulo, A. Scarpa, A. Porras, 2019, Journal of Experimental & Clinical Cancer Research.

Met signaling in cardiomyocytes is required for normal cardiac function in adult mice.

P. Bragado, A. Porras, J. López-Novoa, 2013, Biochimica et Biophysica Acta.

P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli.

M. Benito, C. Ambrosino, A. Porras, 2004, Molecular biology of the cell.

The insulin/Ras pathway of adipocytic differentiation of 3T3 L1 cells: dissociation between Raf-1 kinase and the MAPK/RSK cascade.

A. Porras, E. Santos, 1996, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.