I. Pass

发表

The lipid phosphatase activity of PTEN is critical for its tumor supressor function.

M. Wigler, M. Myers, N. Tonks, 1998, Proceedings of the National Academy of Sciences of the United States of America.

The Adaptor Protein Fish Associates with Members of the ADAMs Family and Localizes to Podosomes of Src-transformed Cells*

I. Pass, D. Seals, S. Courtneidge, 2003, The Journal of Biological Chemistry.

The serine-threonine kinase TAO3 promotes cancer invasion and tumor growth by facilitating trafficking of endosomes containing the invadopodia scaffold TKS5α

S. McWeeney, E. Sergienko, I. Pass, 2020, bioRxiv.

Table 3, CID 56639556 [ML307] MLS-0471611

Santhi Ganji, Ian Pass, Robert Ardecky, 2014 .

A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo.

I. Pass, D. Seals, S. Courtneidge, 2008, European journal of cell biology.

Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes.

T. Chung, Brock T Brown, M. Hedrick, 2014, Bioorganic & medicinal chemistry letters.

Advances in Brief NeurofÃ-bromatosis Type 2 ( NF 2 ) Gene Is Somatically Mutated in Mesothelioma but not in Lung Cancer 1

Yoshitaka, J. Minna, A. Gazdar, 2006 .

Table 4, Probe and Analog Submissions to MLSMR (BioFocus DPI) for Gli-Sufu Antagonist ML340

Santhi Ganji, Ian Pass, Robert Ardecky, 2014 .

Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase.

I. Pass, C. Downes, N. Leslie, 2000, The Biochemical journal.

Scheme 1, Synthesis of ML261, conditions

Jiwen Zou, Santhi Ganji, Ian Pass, 2013 .

Small-molecule antagonists of Gli function

Tram A. Ngo, Jennifer K. T. Casabar, T. Chung, 2014 .

The novel adaptor protein Tks4 (SH3PXD2B) is required for functional podosome formation.

I. Pass, P. Cejudo-Martı́n, S. Courtneidge, 2009, Molecular biology of the cell.

Necessary for Invadopodia Formation Tks5-Dependent, Nox-Mediated Generation of Reactive Oxygen Species Is

Diana Anderson, I. Pass, M. Quintavalle, 2009 .

Figure 10, SAR strategy for Scaffold I

Jiwen Zou, Santhi Ganji, Ian Pass, 2014 .

The SRC substrate Tks5, podosomes (invadopodia), and cancer cell invasion.

I. Pass, D. Seals, S. Courtneidge, 2005, Cold Spring Harbor symposia on quantitative biology.

Cell-Based High-Throughput Luciferase Reporter Gene Assays for Identifying and Profiling Chemical Modulators of Endoplasmic Reticulum Signaling Protein, IRE1

Tram A. Ngo, John Calvin Reed, N. Cosford, 2015, Journal of biomolecular screening.

Development of a Robust High-Throughput Screening Platform for Inhibitors of the Striatal-Enriched Tyrosine Phosphatase (STEP)

T. Chung, N. Cosford, A. Bobkov, 2021, International journal of molecular sciences.

Improving drug discovery using image-based multiparametric analysis of the epigenetic landscape

Ian Pass, Fu-Yue Zeng, David W Andrews, 2019, eLife.

Improving drug discovery using image-based multiparametric analysis of epigenetic landscape

D. Andrews, I. Pass, A. Terskikh, 2019, bioRxiv.

Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation

S. Stylli, I. Pass, A. Verhagen, 2009, Journal of Cell Science.

Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11.

Seth M. Cohen, T. Chung, R. Deshaies, 2017, Nature chemical biology.

The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells.

J. Resau, I. Pass, D. Seals, 2005, Cancer cell.

Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN

I. Pass, C. Downes, Stephen A. Smith, 2001, Current Biology.

The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors

E. Ruppin, J. Lee, I. Jeremias, 2021, Nature Communications.

RNF5 Regulation of RBBP4 Defines Acute Myeloid Leukemia Growth and Susceptibility to Histone Deacetylase Inhibitors

E. Ruppin, K. Brown, J. Lee, 2020 .

Tks5-Dependent, Nox-Mediated Generation of Reactive Oxygen Species Is Necessary for Invadopodia Formation

Diana Anderson, I. Pass, S. Courtneidge, 2009, Science Signaling.

Antagonism of PI 3-kinase-dependent signalling pathways by the tumour suppressor protein, PTEN.

I. Pass, C. Downes, N. Leslie, 2001, Biochemical Society transactions.

Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids.

Ian Pass, Steven M Walker, I. Pass, 2003, The Biochemical journal.

Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions.

K. Hoang-Xuan, I. Pass, C. Downes, 2001, The Biochemical journal.

TR-FRET-Based High-Throughput Screening Assay for Identification of UBC13 Inhibitors

Tram A. Ngo, John Calvin Reed, K. Welsh, 2012, Journal of biomolecular screening.

Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth

M. Abelman, S. McWeeney, E. Sergienko, 2021, Cancer Research.

Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells.

R. Liddington, M. Jackson, M. Gleave, 2019, Cancer letters.

Selective UBC 13 Inhibitors

Tram A. Ngo, J. Reed, T. Chung, 2014 .

High-throughput screening of compounds targeting RNA editing in Trypanosoma brucei: Novel molecular scaffolds with broad trypanocidal effects.

I. Pass, F. Zeng, R. Salavati, 2023, Biochemical pharmacology.