B. Hemmings

发表

The lipid phosphatase activity of PTEN is critical for its tumor supressor function.

M. Wigler, M. Myers, N. Tonks, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Ten years of protein kinase B signalling: a hard Akt to follow.

B. Hemmings, D. Brazil, B A Hemmings, 2001, Trends in biochemical sciences.

PKB/Akt-dependent regulation of inflammation in cancer.

C. Rüegg, B. Hemmings, Fengyuan Tang, 2017, Seminars in cancer biology.

Thymocyte Selection and Activation Lck and Erk Activities and Influences Constitutively Active Protein Kinase B Enhances

D. Kioussis, M. Tolaini, B. Hemmings, 2016 .

Structure, regulation and function of PKB/AKT--a major therapeutic target.

B. Hemmings, M. Hanada, Jianhua Feng, 2004, Biochimica et biophysica acta.

Granzyme B, a New Player in Activation-Induced Cell Death, Is Down-Regulated by Vasoactive Intestinal Peptide in Th2 but Not Th1 Effectors1

D. Kioussis, M. Wurfel, M. Tolaini, 2005, The Journal of Immunology.

Apoptosis Suppression by Raf-1 and MEK1 Requires MEK- and Phosphatidylinositol 3-Kinase-Dependent Signals

Ulf R. Rapp, C. Wellbrock, B. Hemmings, 2001, Molecular and Cellular Biology.

Protein Kinase SGK Mediates Survival Signals by Phosphorylating the Forkhead Transcription Factor FKHRL1 (FOXO3a)

Brian A. Hemmings, Michael E. Greenberg, M. Greenberg, 2001, Molecular and Cellular Biology.

PROTEIN KINASE B ( PKB / AKT ) – A COMMON ELEMENT IN MULTIPLE SIGNALING PATHWAYS INVOLVED IN INSULIN SIGNALING , CELL SURVIVALAND CANCER

B. Hemmings, 2001 .

Phosphatidylinositol 3-Kinase Confers Resistance to Encephalomyocarditis and Herpes Simplex Virus-Induced Cell Death Through the Activation of Distinct Downstream Effectors1

L. Cantley, D. Fruman, B. Hemmings, 2001, The Journal of Immunology.

Downstream Effectors Through the Activation of Distinct Herpes Simplex Virus-Induced Cell Death Resistance to Encephalomyocarditis and Phosphatidylinositol 3-Kinase Confers

L. Cantley, D. Fruman, B. Hemmings, 2001 .

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

P. Cohen, D. Alessi, B. Hemmings, 1995, Nature.

MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma.

Stephan Frank, A. Merlo, S. Frank, 2011, Cancer research.

Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction.

D. Charnock-Jones, G. Burton, B. Hemmings, 2008, The American journal of pathology.

Protein Kinase B Localization and Activation Differentially Affect S6 Kinase 1 Activity and Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 Phosphorylation

Brian A. Hemmings, George Thomas, M. Andjelkovic, 1999, Molecular and Cellular Biology.

Osmotic Shock Inhibits Insulin Signaling by Maintaining Akt/Protein Kinase B in an Inactive Dephosphorylated State

R. Fucini, B. Hemmings, J. Pessin, 1999, Molecular and Cellular Biology.

Regulation of protein kinase cascades by protein phosphatase 2A.

B. Hemmings, T. Millward, S. Zołnierowicz, 1999, Trends in biochemical sciences.

The human tumour suppressor LATS1 is activated by human MOB1 at the membrane.

B. Hemmings, A. Hergovich, D. Schmitz, 2006, Biochemical and biophysical research communications.

The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase

Brian A. Hemmings, David M. Glover, Hiroyuki Ohkura, 1993, Cell.

Important role for phylogenetically invariant PP2Acalpha active site and C-terminal residues revealed by mutational analysis in Saccharomyces cerevisiae.

B. Hemmings, D. Evans, D. R. Evans, 2000, Genetics.

NDR family of AGC kinases – essential regulators of the cell cycle and morphogenesis

B. Hemmings, R. Tamaskovic, S. Bichsel, 2003, FEBS letters.

GSK3β Regulates Differentiation and Growth Arrest in Glioblastoma

A. Merlo, B. Hemmings, P. Morin, 2009, PloS one.

The Structure of the Protein Phosphatase 2A PR65/A Subunit Reveals the Conformation of Its 15 Tandemly Repeated HEAT Motifs

Brian A. Hemmings, Matthew R. Groves, D. Barford, 1999, Cell.

NDR Kinase Is Activated by RASSF1A/MST1 in Response to Fas Receptor Stimulation and Promotes Apoptosis

Brian A. Hemmings, B. Hemmings, A. Hergovich, 2008, Current Biology.

Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways.

J. C. Clemens, C. Worby, M. Muda, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Calcium regulation of Ndr protein kinase mediated by S100 calcium‐binding proteins

C. Heizmann, B. Schäfer, B. Hemmings, 1998, The EMBO journal.

Promiscuous affairs of PKB/AKT isoforms in metabolism

B. Hemmings, Jørgen Jensen, M. Niessen, 2011, Archives of physiology and biochemistry.

Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3).

D. Vertommen, F. Dequiedt, B. Hemmings, 2010, The Biochemical journal.

Purification of glycogen synthase kinase 3 from rabbit skeletal muscle. Copurification with the activating factor (FA) of the (Mg-ATP) dependent protein phosphatase.

P. Cohen, B. Hemmings, D. Yellowlees, 1981, European journal of biochemistry.

RET/PTC (rearranged in transformation/papillary thyroid carcinomas) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): an alternative phosphatidylinositol 3-kinase-independent pathway to activate PDK1.

Jung Hun Song, B. Hemmings, Jongsun Park, 2003, Molecular endocrinology.

an Inhibitor of Protein Kinase C Target for the Anticancer and Radiosensitizing Agent PKC 412 ,-Kinase / Akt Survival Pathway Is a ′ The Phosphatidylinositide 3 Updated

D. Fabbro, S. Rocha, B. Hemmings, 2001 .

The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C.

D. Fabbro, S. Rocha, B. Hemmings, 2001, Cancer research.

Sphingosine Is a Novel Activator of 3-Phosphoinositide-dependent Kinase 1*

C. C. King, F T Zenke, A. Newton, 2000, The Journal of Biological Chemistry.

A Human Protein Kinase Bγ with Regulatory Phosphorylation Sites in the Activation Loop and in the C-terminal Hydrophobic Domain*

B. Hemmings, D. Brodbeck, P. Cron, 1999, The Journal of Biological Chemistry.

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells.

D. Alessi, B. Hemmings, É. Hajduch, 1998, Diabetes.

A recombinant calcitonin receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+/inositol phosphate signaling pathways.

H. Lodish, B. Conklin, H. Bourne, 1992, Molecular endocrinology.

Characterization of fragmented 3-phosphoinsitide-dependent protein kinase-1 (PDK1) by phosphosite-specific antibodies.

Jisoo Park, B. Hemmings, Jongsun Park, 2013, Life sciences.

Regulation of 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) by Src Involves Tyrosine Phosphorylation of PDK1 and Src Homology 2 Domain Binding*

B. Hemmings, D. Brazil, Jongsun Park, 2008, Journal of Biological Chemistry.

Interaction of nucleoredoxin with protein phosphatase 2A

I. de Baere, J. Goris, B. Hemmings, 2006, FEBS letters.

Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2.

T. Uemura, P. Ferrigno, D. Glover, 1994, Journal of cell science.

Pleckstrin Homology (PH) Domains In Signal Transduction

B. Hemmings, E. Ingley, B. A. Hemmings, 1999 .

Ultrastructural localization of the regulatory (RII) subunit of cyclic AMP-dependent protein kinase to subcellular compartments active in endocytosis and recycling of membrane receptors.

E. Nigg, B. Hemmings, G. Griffiths, 1990, Journal of cell science.

Serine/threonine protein phosphatases.

B. Hemmings, S. Wera, Brian A. HEMMINGSt, 1995, The Biochemical journal.

Chronic Akt1 Deficiency Attenuates Adverse Remodeling and Enhances Angiogenesis After Myocardial Infarction

M. Neeman, I. Biton, L. Gepstein, 2013, Circulation. Cardiovascular imaging.

Results Reduced Cardiac Function and Altered Morphology in Adult Akt 1-Deficient Mice

M. Neeman, I. Biton, L. Gepstein, 2022 .

Dosage-Dependent Effects of Akt1/Protein Kinase Bα (PKBα) and Akt3/PKBγ on Thymus, Skin, and Cardiovascular and Nervous System Development in Mice

W. Wahli, B. Hemmings, Zhong-Zhou Yang, 2005, Molecular and Cellular Biology.

Direct Identification of Tyrosine 474 as a Regulatory Phosphorylation Site for the Akt Protein Kinase* 210

R. Pearson, B. Hemmings, Briony E. Cristiano, 2002, The Journal of Biological Chemistry.

PKB/Akt phosphorylation of ERRγ contributes to insulin-mediated inhibition of hepatic gluconeogenesis

S. Koo, B. Hemmings, In-kyu Lee, 2014, Diabetologia.

Residues 36‐42 of liver RNase PL3 contribute to its uridine‐preferring substrate specificity. Cloning of the cDNA and site‐directed mutagenesis studies

J. Hofsteenge, B. Hemmings, A. Vicentini, 1994, Protein science : a publication of the Protein Society.

AGC kinases in cancer metastasis, immune checkpoint regulation and drug resistance.

B. Hemmings, G. Xue, 2018, Seminars in cancer biology.

The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility

Dawang Zhou, B. Hemmings, Fengyuan Tang, 2015, Science Signaling.

Reconstitution of a Mg‐ATP‐dependent protein phosphatase and its activation through a phosphorylation mechanism

P. Cohen, B. Hemmings, T. Resink, 1982, FEBS letters.

Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development.

K. Alitalo, B. Hemmings, Zhongzhou Yang, 2010, The American journal of pathology.

Molecular cloning of a second form of rac protein kinase.

B. Hemmings, T. Jakubowicz, P. Jones, 1991, Cell regulation.

The Hemodynamic Basis for Positional- and Inter-Fetal Dependent Effects in Dual Arterial Supply of Mouse Pregnancies

M. Neeman, B. Hemmings, A. Jaffa, 2012, PloS one.

NDR Kinases Are Essential for Somitogenesis and Cardiac Looping during Mouse Embryonic Development

Michael B. Stadler, R. Zeller, A. Zuniga, 2015, PloS one.

The 10q25.3-26.1 G protein-coupled receptor gene GPR26 is epigenetically silenced in human gliomas.

A. Merlo, B. Hemmings, D. Maier, 2009, International journal of oncology.

Modulation of the enzymatic properties of protein phosphatase 2A catalytic subunit by the recombinant 65-kDa regulatory subunit PR65alpha.

B. Hemmings, K. Campbell, P. Turowski, 1997, European journal of biochemistry.

DEV119016 732..742

B. Hemmings, Zhongzhou Yang, Jingai Zhu, 2015 .

Nerve growth factor promotes activation of the alpha, beta and gamma isoforms of protein kinase B in PC12 pheochromocytoma cells.

M. Andjelkovic, D. Alessi, M. Frech, 1998, European journal of biochemistry.

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.

B. Hemmings, F. Pitossi, T. Jakubowicz, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Involvement of the Pleckstrin Homology Domain in the Insulin-stimulated Activation of Protein Kinase B*

E. Van Obberghen, B. Hemmings, N. Filippa, 1998, The Journal of Biological Chemistry.

SYK inhibition blocks proliferation and migration of glioma cells and modifies the tumor microenvironment

H. Hotz, T. Smirnova, A. Merlo, 2018, Neuro-oncology.

DNA-dependent Protein Kinase-mediated Phosphorylation of Protein Kinase B Requires a Specific Recognition Sequence in the C-terminal Hydrophobic Motif*

O. Hammarsten, B. Hemmings, Jongsun Park, 2009, Journal of Biological Chemistry.

In Vivo Analysis of Protein Kinase B (PKB)/Akt Regulation in DNA-PKcs-null Mice Reveals a Role for PKB/Akt in DNA Damage Response and Tumorigenesis*

B. Hemmings, D. Hynx, A. Parcellier, 2008, Journal of Biological Chemistry.

Blocking Akt-ivity

B. Hemmings, D. Restuccia, 2009, Science.

Centrosome-associated NDR kinase regulates centrosome duplication.

E. Nigg, B. Hemmings, A. Hergovich, 2007, Molecular cell.

Multisite phosphorylation of glycogen synthase from rabbit skeletal muscle

P. Cohen, J. Woodgett, B. Hemmings, 1982, FEBS letters.

Staurosporine stimulates expression of the urokinase‐type (u‐PA) plasminogen activator in LLC‐PK1 cells

D. Fabbro, Y. Nagamine, B. Hemmings, 1989, International journal of cancer.

Loss of PKBβ/Akt2 predisposes mice to ovarian cyst formation and increases the severity of polycystic ovary formation in vivo

B. Hemmings, D. Hynx, D. Restuccia, 2012, Disease Models & Mechanisms.

Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing.

J. Hofsteenge, W. Merlevede, J. Goris, 1993, The Journal of biological chemistry.

In search of signaling pathways critical for ovarian graft reception: Akt1 is essential for long-term survival of ovarian grafts.

M. Neeman, I. Biton, B. Hemmings, 2014, Fertility and sterility.

Bone vascularization and trabecular bone formation are mediated by PKBalpha/Akt1 in a gene‐dosage‐dependent manner: In vivo and ex vivo MRI

M. Neeman, F. Wehrli, V. Plaks, 2010, Magnetic resonance in medicine.

Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations

R. Pearson, J. Sandow, P. Ekert, 2013, Cell Death and Differentiation.

Analysis of subunit isoforms in protein phosphatase 2A holoenzymes from rabbit and Xenopus.

J. Hofsteenge, W. Merlevede, J. Goris, 1993, The Journal of biological chemistry.

Tissue‐specific expression of mRNAs encoding α‐ and β‐catalytic subunits of protein phosphatase 2A

Y. Khew-Goodall, B. Hemmings, 1988 .

Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation

B. Hemmings, J. Götz, L. Ittner, 2006, International Journal of Developmental Neuroscience.

Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform.

J. Hofsteenge, W. Merlevede, J. Goris, 1991, Biochemistry.

The Akt1 isoform is an essential mediator of ischaemic preconditioning

B. Hemmings, M. Mocanu, D. Yellon, 2012, Journal of cellular and molecular medicine.

Phosphatidylinositol 3-Kinase Signaling in Thymocytes: The Need for Stringent Control

B. Hemmings, G. Holländer, G. Moncayo, 2010, Science Signaling.

In Vitro and In Vivo Studies of a Naturally Occurring Variant of the Human p85α Regulatory Subunit of the Phosphoinositide 3-Kinase Inhibition of Protein Kinase B and Relationships With Type 2 Diabetes, Insulin Secretion, Glucose Disappearance Constant, and Insulin Sensitivity

T. Hansen, O. Pedersen, C. Berne, 2001 .

PI 3 K rescues the detrimental effects of chronic Akt activation in the heart during ischemia / reperfusion injury

D. Kass, P. Anversa, A. Leri, 2018 .

PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury.

D. Kass, P. Anversa, A. Leri, 2005, The Journal of clinical investigation.

Control of Glycogen Synthesis in Cultured Human Muscle Cells*

B. Hemmings, J. Mccormack, J. Vandenheede, 1999, The Journal of Biological Chemistry.

Deletion of PKBα/Akt1 Affects Thymic Development

B. Hemmings, G. Holländer, J. Gill, 2007, PloS one.

PKBα is required for adipose differentiation of mouse embryonic fibroblasts

B. Hemmings, Zhong-Zhou Yang, A. Baudry, 2006, Journal of Cell Science.

Life with a Single Isoform of Akt: Mice Lacking Akt2 and Akt3 Are Viable but Display Impaired Glucose Homeostasis and Growth Deficiencies

B. Hemmings, S. Dirnhofer, D. Hynx, 2006, Molecular and Cellular Biology.

Epithelium-Mesenchyme Interactions Control the Activity of Peroxisome Proliferator-Activated Receptor β/δ during Hair Follicle Development

W. Wahli, N. Tan, B. Hemmings, 2005, Molecular and Cellular Biology.

S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt.

B. Hemmings, Zhongzhou Yang, Xiang-Qi Wu, 2012, The Biochemical journal.

K inhibition renders cardiac protection against myocardial infarction through PDK 1 phosphorylation of Akt

B. Hemmings, Zhongzhou Yang, Z. Chang, 2011 .

Serum and Glucocorticoid-Responsive Kinase-1 Regulates Cardiomyocyte Survival and Hypertrophic Response

B. Hemmings, T. Aoyama, Jongsun Park, 2005, Circulation.

Physiological functions of protein kinase B/Akt.

B. Hemmings, D. Hynx, Zhong-Zhou Yang, 2004, Biochemical Society transactions.

Phosphorylation of the Twist1-Family Basic Helix-Loop-Helix Transcription Factors Is Involved in Pathological Cardiac Remodeling

B. Hemmings, Zhongzhou Yang, Z. Chang, 2011, PloS one.

Update: PtdIns(3,4,5)P3 Gets Its Message Across

B. Hemmings, 1997, Science.

Large-scale expression and purification of a soluble form of the pleckstrin homology domain of the human protooncogenic serine/threonine protein kinase PKB (c-akt) in Escherichia coli.

B. Hemmings, E. Ingley, 1999, Protein expression and purification.

Differential Effects of Protein Kinase B/Akt Isoforms on Glucose Homeostasis and Islet Mass

B. Hemmings, Zhongzhou Yang, D. Hynx, 2009, Molecular and Cellular Biology.

RFLPs at the porcine locus encoding the type I-alpha regulatory subunit of the cAMP-dependent protein kinase (PRKAR1A).

A. Archibald, B. Hemmings, S. Couperwhite, 2009, Animal genetics.

A BamHI RFLP at the locus encoding the 65-kDa regulatory subunit of porcine protein phosphatase 2A (PPP2ARB).

A. Archibald, B. Hemmings, S. Couperwhite, 2009, Animal genetics.

Isolation of a cDNA and characterization of the 5' flanking region of the gene encoding the type I regulatory subunit of the cAMP-dependent protein kinase.

B. Hemmings, D. Jans, K. Seipel, 1987, European journal of biochemistry.

Pyk2- and Src-Dependent Tyrosine Phosphorylation of PDK1 Regulates Focal Adhesions

R. Alexander, B. Hemmings, M. Akers, 2003, Molecular and Cellular Biology.

Activation of Protein Kinase B Induced by H2O2 and Heat Shock through Distinct Mechanisms Dependent and Independent of Phosphatidylinositol 3-Kinase.

M. Andjelkovic, B. Hemmings, H. Matsuzaki, 1999 .

Glycogen synthase kinase-3 from rabbit skeletal muscle.

P. Cohen, B. Hemmings, D. Rylatt, 1981, Methods in enzymology.

Role of protein phosphatase 2A in the regulation of mitogen-activated protein kinase activity in ventricular cardiomyocytes.

B. Hemmings, M. Rebsamen, U. Lang, 1996, Biochemical and biophysical research communications.

Protein kinase B alpha/Akt1 regulates placental development and fetal growth.

B. Hemmings, Jianhua Feng, Zhong-Zhou Yang, 2003, The Journal of biological chemistry.

cDNA cloning of porcine brain prolyl endopeptidase and identification of the active-site seryl residue.

J. Hofsteenge, B. Hemmings, S. Stone, 1991, Biochemistry.

All Akt Isoforms (Akt1, Akt2, Akt3) Are Involved in Normal Hearing, but Only Akt2 and Akt3 Are Involved in Auditory Hair Cell Survival in the Mammalian Inner Ear

A. Ryan, B. Hemmings, V. Radojevic, 2015, PloS one.

Structure, Regulation and Targeting of Protein Phosphatase 2A

B. Hemmings, S. Zołnierowicz, R. E. Mayer-Jaekel, 1997 .

Molecular Complexity of Protein Phosphatase 2A Holoenzymes and Delineation of their Function

B. Hemmings, R. E. Mayer-Jaekel, 1993 .

by Cyclic AMP-Dependent Protein Kinase Mechanism of Protein Kinase B Activation

B. Hemmings, N. Filippa, C. Filloux, 1999 .

Ligation of the T cell co‐stimulatory receptor CD28 activates the serine‐threonine protein kinase protein kinase B

B. Hemmings, R. Parry, S. Ward, 1997, European journal of immunology.

Mutant defective in processing of an enzyme located in the lysosome-like vacuole of Saccharomyces cerevisiae.

B. Hemmings, A. Hasilik, E. W. Jones, 1981, Proceedings of the National Academy of Sciences of the United States of America.

AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer

Ricky W Johnstone, Katarzyna Jastrzebski, R. Pearson, 2011, Science Signaling.

The interconversion of protein phosphatase 2A between PP2A1 and PP2A0 during retinoic acid-induced granulocytic differentiation and a modification on the catalytic subunit in S phase of HL-60 cells.

M. Mumby, S. Matsuzawa, B. Hemmings, 1997, Archives of biochemistry and biophysics.

RAC: RAC PK (vertebrates and D. melanogaster) (akt, PKB)

B. Hemmings, E. Ingley, 1995 .

The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A beta catalytic subunit.

J. Hofsteenge, W. Wernet, B. Hemmings, 1988, Nucleic acids research.

Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A

R. Nitsch, B. Hemmings, J. Götz, 2002, The European journal of neuroscience.

Phosphorylation of K-casein by glycogen synthase kinase-3 from rabbit skeletal muscle.

P. Cohen, B. Hemmings, L. Pinna, 1983, Biochimica et biophysica acta.

The Protein Kinase B Family — Structure, Regulation and Function

M. Andjelkovic, M. Frech, B. Hemmings, 1997 .

Phosphorylation of NAD-dependent glutamate dehydrogenase from yeast.

B. Hemmings, 1978, The Journal of biological chemistry.

Overexpression of the alpha-type protein kinase (PK) C in LLC-PK1 cells does not lead to a proportional increase in the induction of two 12-O-tetradecanoylphorbol-13-acetate-inducible genes.

D. Fabbro, Y. Nagamine, P. Parker, 1991, Cell regulation.

Identification of the residues on cyclic GMP-dependent protein kinase that are autophosphorylated in the presence of cyclic AMP and cyclic GMP.

F. Hofmann, A. Aitken, B. Hemmings, 1984, Biochimica et biophysica acta.

cAMP-dependent protein kinase regulates renal epithelial cell properties.

B. Hemmings, K. Amsler, S. Ghatani, 1991, The American journal of physiology.

Role of Translocation in the Activation and Function of Protein Kinase B*

P. Cohen, M. Andjelkovic, D. Alessi, 1997, The Journal of Biological Chemistry.

Human cytomegalovirus carries serine/threonine protein phosphatases PP1 and a host-cell derived PP2A

L. Picard, J. Goris, B. Hemmings, 1996, Journal of virology.

Expression of the catalytic and regulatory subunits of protein phosphatase type 2A may be differentially modulated during retinoic acid-induced granulocytic differentiation of HL-60 cells.

M. Mumby, M. Nagao, B. Hemmings, 1994, Cancer research.

Expression cloning of a cDNA encoding the type II regulatory subunit of the cAMP‐dependent protein kinase

B. Hemmings, D. Jans, M. Schwarz, 1986, FEBS letters.

cAMP mediated proteolysis of the catalytic subunit of cAMP‐dependent protein kinase

B. Hemmings, 1986, FEBS letters.

Phosphorylation of the type-II regulatory subunit of cyclic-AMP-dependent protein kinase by glycogen synthase kinase 3 and glycogen synthase kinase 5.

Philip R. Cohen, P. Cohen, F. Hofmann, 2005, European journal of biochemistry.

In vitro and in vivo studies of a naturally occurring variant of the human p85alpha regulatory subunit of the phosphoinositide 3-kinase: inhibition of protein kinase B and relationships with type 2 diabetes, insulin secretion, glucose disappearance constant, and insulin sensitivity.

T. Hansen, O. Pedersen, C. Berne, 2001, Diabetes.

Protein kinase B/Akt is activated by polyomavirus middle-T antigen via a phosphatidylinositol 3-kinase-dependent mechanism

B. Hemmings, R. Meili, K. Ballmer-Hofer, 1998, Oncogene.

Mechanism of activation of protein kinase B by insulin and IGF‐1.

P. Cohen, M. Andjelkovic, D. Alessi, 1996, The EMBO journal.

UPDATE: PH Domains--A Universal Membrane Adapter

B. Hemmings, 1997, Science.

Protein Kinase Bα/Akt1 Regulates Placental Development and Fetal Growth*

Brian A. Hemmings, B. Hemmings, Jianhua Feng, 2003, Journal of Biological Chemistry.

Novel individual metabolic profile characterizes the protein kinase B-alpha (pkbα−/−) in vivo model

C. Ament, B. Hemmings, M. Niessen, 2014, Archives of physiology and biochemistry.

Biochemical characterization of recombinant subunits of type 2A protein phosphatase overexpressed in Pichia pastoris.

L. Lankiewicz, B. Hemmings, S. Zołnierowicz, 2000, European journal of biochemistry.

Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activation.

D. Kioussis, M. Tolaini, B. Hemmings, 2006, The Journal of Immunology.

Regulation of Saccharomyces cerevisiae nicotinamide adenine dinucleotide phosphate-dependent glutamate dehydrogenase by proteolysis during carbon starvation

B. Hemmings, M. J. Mazón, 1979, Journal of bacteriology.

Tethering, targeting and triggering of protein phosphatases.

B. Hemmings, S. Zołnierowicz, 1994, Trends in cell biology.

Recombinant type I regulatory subunit of the cAMP‐dependent protein kinase is biologically active

J. Parsons, B. Hemmings, D. Jans, 1987, FEBS letters.

Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex

P. Parker, M. Frech, R. Whelan, 1999, Current Biology.

Transcriptional regulation of a plasminogen activator gene by cyclic AMP in a homologous cell-free system. Involvement of cyclic AMP-dependent protein kinase in transcriptional control.

D. von der Ahe, Y. Nagamine, B. Hemmings, 1988, The Journal of biological chemistry.

Only Akt1 Is Required for Proliferation, while Akt2 Promotes Cell Cycle Exit through p21 Binding

Brian A. Hemmings, Anne Fernandez, B. Hemmings, 2006, Molecular and Cellular Biology.

Deltex-1 Activates Mitotic Signaling and Proliferation and Increases the Clonogenic and Invasive Potential of U373 and LN18 Glioblastoma Cells and Correlates with Patient Survival

A. Merlo, B. Hemmings, G. Moncayo, 2013, PloS one.

Proteolytic inactivation of the NADP-dependent glutamate dehydrogenase in proteinase-deficient mutants of Saccharomyces cerevisiae.

B. Hemmings, E. W. Jones, G. Zubenko, 1980, Archives of biochemistry and biophysics.

PH domains--a universal membrane adapter.

B. Hemmings, 1997, Science.

The PI3K-PKB/Akt pathway.

B. Hemmings, D. Restuccia, 2015, Cold Spring Harbor perspectives in biology.

Gonadotropin-Releasing Hormone and Pituitary Adenylate Cyclase-Activating Polypeptide Affect Levels of Cyclic Adenosine 3',5'-Monophosphate-Dependent Protein Kinase A (PKA) Subunits in the Clonal Gonadotrope αT3-1 Cells: Evidence for Cross-Talk between PKA and Protein Kinase C Pathways.

C. McArdle, B. Hemmings, G. Garrel, 1997, Endocrinology.

Traitement du cancer par modulation d’un mnk

A. Merlo, B. Hemmings, M. Grzmil, 2009 .

Cell polarity: Scaffold proteins par excellence

B. Hemmings, D. Brazil, 2000, Current Biology.

Pathway of urokinase-type plasminogen activator induction in the T47D and LLC-PK1 cell lines.

B. Hemmings, D. Jans, C. Dierks-Ventling, 1987, Experimental cell research.

LLC‐PK1 cell mutants in cAMP metabolism respond normally to phorbol esters

B. Hemmings, D. Jans, 1986, FEBS letters.

The 55 kDa regulatory subunit of protein phosphatase 2A plays a role in the activation of the HPV16 long control region in human cells with a deletion in the short arm of chromosome 11.

B. Hemmings, R. E. Mayer-Jaekel, R. Minnaar, 1992, The EMBO journal.

PKBalpha is required for adipose differentiation of mouse embryonic fibroblasts.

B. Hemmings, Zhong-Zhou Yang, A. Baudry, 2006, Journal of cell science.

Separation and characterisation of glycogen synthase kinase 3, glycogen synthase kinase 4 and glycogen synthase kinase 5 from rabbit skeletal muscle.

A Aitken, P. Cohen, A. Aitken, 1982, European journal of biochemistry.

Protein kinases in high grade glioma: Towards therapeutic concoctions

A. Merlo, B. Hemmings, R. M. Huber, 2012 .

Classification of Protein Phosphatases Involved in Cellular Regulation

P. Cohen, J. Goris, B. Hemmings, 1981 .

Pleckstrin domain homology

B. Hemmings, R. Haslam, H. Koide, 1993, Nature.

Glycogen synthase kinase-3 from rabbit skeletal muscle.

P. Cohen, B. Hemmings, B A Hemmings, 2005, Methods in enzymology.

The MgATP-dependent protein phosphatase and protein phosphatase 1 have identical substrate specificities.

P. Cohen, W. Merlevede, J. Goris, 2005, European journal of biochemistry.

Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors

B. Hemmings, S. Stone, D. Monard, 1992, Neuron.

Evidence for the Degradation of Nicotinamide Adenine Dinucleotide Phosphate-Dependent Glutamate Dehydrogenase of Candida utilis During Rapid Enzyme Inactivation

B. Hemmings, 1978, Journal of bacteriology.

Mutant defective in processing of a lysosome-like vacuole of Saccharom (proenzyme/posttranslational modification/proteinases/multiple hyd

B. Hemmings, 2016 .

Mutantdefective inprocessing ofanenzymelocated inthe lysosome-like vacuole ofSaccharomyces cerevisiae

B. Hemmings, 1981 .

Translation regulation as a therapeutic target in cancer.

B. Hemmings, M. Grzmil, Brian A Hemmings, 2012, Cancer research.

PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis

B. Hemmings, M. Niessen, S. Schultze, 2012, Expert Reviews in Molecular Medicine.

PI3K-PKB/Akt pathway.

B. Hemmings, Brian A Hemmings, David F Restuccia, 2012, Cold Spring Harbor perspectives in biology.

PKB and the mitochondria: AKTing on apoptosis.

B. Hemmings, L. Tintignac, A. Parcellier, 2008, Cellular signalling.

Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation*

W. Kolch, H. Mischak, M. Pacher, 2000, The Journal of Biological Chemistry.

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation.

D. Barford, B. Hemmings, V. Good, 2002, Molecular cell.

Characterisation of a reconstituted Mg-ATP-dependent protein phosphatase.

H. Tung, P. Cohen, B. Hemmings, 1983, European journal of biochemistry.

The catalytic subunit of protein phosphatase 2A associates with the translation termination factor eRF1.

C. van Hoof, J. Goris, B. Hemmings, 1996, The EMBO journal.

Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A

T. Roberts, D. Pallas, B. Hemmings, 1995, Journal of virology.

Abnormal expression of the RI subunit of cyclic AMP-dependent protein kinase in Y-79 retinoblastoma cells.

G. Chader, B. Hemmings, S. Gentleman, 1989, Experimental eye research.

Regulation of cAMP-dependent protein kinase in cultured cells.

B. Hemmings, 1985, Current topics in cellular regulation.

Integrated Akt/PKB signaling in immunomodulation and its potential role in cancer immunotherapy.

Daniela Massi, Andreas Wicki, M. Mandalà, 2015, Journal of the National Cancer Institute.

Effect of hypothyroidism and thyroid hormone replacement on the level of protein kinase C and protein kinase A in rat liver

D. Fabbro, B. Hemmings, C. Meier, 1991, FEBS letters.

Codominant expression of a mutation affecting the cAMP-dependent protein kinase catalytic subunit in somatic cell hybrids of LLC-PK1 cells.

B. Hemmings, D. Jans, S. Botterell, 1988, Experimental cell research.

PKB/Akt interacts with inosine‐5′ monophosphate dehydrogenase through its pleckstrin homology domain

B. Hemmings, E. Ingley, 2000, FEBS letters.

cAMP synthesis and degradation by phagosomes regulate actin assembly and fusion events: consequences for mycobacteria

V. Rybin, M. Houslay, B. Hemmings, 2006, Journal of Cell Science.

Acquired Resistance to Clinical Cancer Therapy: A Twist in Physiological Signaling.

D. Taverna, M. Mandalà, D. Massi, 2016, Physiological reviews.

Akt and 14-3-3η regulate Miz1 to control cell-cycle arrest after DNA damage

K. Berns, M. Eilers, B. Hemmings, 2005, Nature Cell Biology.

Identification of a PKB/Akt Hydrophobic Motif Ser-473 Kinase as DNA-dependent Protein Kinase*♦

B. Hemmings, Jongsun Park, Jianhua Feng, 2004, Journal of Biological Chemistry.

Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme

A. Merlo, S. Frank, B. Hemmings, 2013, Oncogene.

Advances in protein kinase B signalling: AKTion on multiple fronts.

B. Hemmings, D. Brazil, Zhong-Zhou Yang, 2004, Trends in biochemical sciences.

The Crystal Structure of Human Eukaryotic Release Factor eRF1—Mechanism of Stop Codon Recognition and Peptidyl-tRNA Hydrolysis

D. Barford, M. Tuite, B. Hemmings, 2000, Cell.

PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival.

B. Hemmings, D. Hynx, Banu Surucu, 2008, Molecular cell.

Crystal structure of an activated Akt/Protein Kinase B ternary complex with GSK3-peptide and AMP-PNP

Brian A. Hemmings, D. Barford, B. Hemmings, 2002, Nature Structural Biology.

Inhibition of protein kinase B/Akt. implications for cancer therapy.

B. Hemmings, M. Hill, 2002, Pharmacology & therapeutics.

Insulin-stimulated Protein Kinase B Phosphorylation on Ser-473 Is Independent of Its Activity and Occurs through a Staurosporine-insensitive Kinase*

M. Andjelkovic, D. Fabbro, B. Hemmings, 2001, The Journal of Biological Chemistry.

Mechanism of protein kinase B activation by insulin/insulin-like growth factor-1 revealed by specific inhibitors of phosphoinositide 3-kinase--significance for diabetes and cancer.

M. Andjelkovic, B. Hemmings, J. Park, 1999, Pharmacology & therapeutics.

Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes.

Y. Khew-Goodall, B. Hemmings, S. Stone, 1991, Biochemistry.

From man to mouse and back again: advances in defining tumor AKTivities in vivo

B. Hemmings, D. Restuccia, 2010, Disease Models & Mechanisms.

Vimentin dephosphorylation by protein phosphatase 2A is modulated by the targeting subunit B55.

B. Hemmings, N. Lamb, A. Fernandez, 1999, Molecular biology of the cell.

Expression profiling of insulin action in human myotubes: induction of inflammatory and pro-angiogenic pathways in relationship with glycogen synthesis and type 2 diabetes.

O. Pedersen, E. Oakeley, B. Hemmings, 2004, Biochemical and biophysical research communications.

Serum and glucocorticoid‐inducible kinase (SGK) is a target of the PI 3‐kinase‐stimulated signaling pathway

A. C. Maiyar, G. Firestone, B. Hemmings, 1999, The EMBO journal.

PKB/Akt-dependent regulation of cell motility.

B. Hemmings, G. Xue, 2013, Journal of the National Cancer Institute.

Mechanism of Protein Kinase B Activation by Cyclic AMP-Dependent Protein Kinase

E. Van Obberghen, B. Hemmings, N. Filippa, 1999, Molecular and Cellular Biology.

Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ*

D R Alessi, M. Andjelkovic, D. Alessi, 1997, The Journal of Biological Chemistry.

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha.

B. Hemmings, E. Ehler, A. Probst, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways.

B. Hemmings, A. Hergovich, 2012, Seminars in cell & developmental biology.

Intramolecular and Intermolecular Interactions of Protein Kinase B Define Its Activation In Vivo

B. Vojnovic, J. Downward, M. Laguerre, 2007, PLoS biology.

Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway.

B. Hemmings, G. Xue, A. Parcellier, 2010, Current topics in microbiology and immunology.

Downstream of human NDR kinases: Impacting on c-myc and p21 protein stability to control cell cycle progression

B. Hemmings, A. Hergovich, H. Cornils, 2011, Cell cycle.

hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.

S. Frank, B. Hemmings, Fengyuan Tang, 2014, Cancer research.

Molecular and Cellular Pathobiology hMOB 3 Modulates MST 1 Apoptotic Signaling and Supports Tumor Growth in Glioblastoma Multiforme

S. Frank, B. Hemmings, Fengyuan Tang, 2014 .

Ablation of the Kinase NDR1 Predisposes Mice to the Development of T Cell Lymphoma

B. Hemmings, S. Dirnhofer, D. Hynx, 2010, Science Signaling.

The Carboxy-Terminal Modulator Protein (CTMP) Regulates Mitochondrial Dynamics

V. Olivieri, B. Hemmings, D. Brazil, 2009, PloS one.

Regulation of OPA1-mediated mitochondrial fusion by leucine zipper/EF-hand-containing transmembrane protein-1 plays a role in apoptosis.

B. Hemmings, D. Brazil, Jongsun Park, 2009, Cellular signalling.

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity*

M. Andjelkovic, M. Frech, B. Hemmings, 1997, The Journal of Biological Chemistry.

Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis.

B. Hemmings, L. Tintignac, S. Schenk, 2009, Cellular signalling.

Association of LETM1 and MRPL36 contributes to the regulation of mitochondrial ATP production and necrotic cell death.

B. Hemmings, D. Brazil, Jongsun Park, 2009, Cancer research.

Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein

B. Hemmings, D. Brazil, Jongsun Park, 2009, BMC Cell Biology.

The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death

B. Hemmings, R. Zukin, K. Noh, 2009, Nature Neuroscience.

Mammalian NDR protein kinases: from regulation to a role in centrosome duplication.

B. Hemmings, A. Hergovich, H. Cornils, 2008, Biochimica et biophysica acta.

Regulation of NDR Protein Kinase by Hydrophobic Motif Phosphorylation Mediated by the Mammalian Ste20-Like Kinase MST3

B. Hemmings, R. Tamaskovic, A. Hergovich, 2005, Molecular and Cellular Biology.

Human NDR Kinases Are Rapidly Activated by MOB Proteins through Recruitment to the Plasma Membrane and Phosphorylation

B. Hemmings, A. Hergovich, S. Bichsel, 2005, Molecular and Cellular Biology.

Mechanism of Activation of NDR (Nuclear Dbf2-related) Protein Kinase by the hMOB1 Protein*

B. Hemmings, R. Tamaskovic, S. Bichsel, 2004, Journal of Biological Chemistry.

Deregulated signalling networks in human brain tumours.

B. Hemmings, M. Grzmil, Brian A Hemmings, 2010, Biochimica et biophysica acta.

Active-site mutations impairing the catalytic function of the catalytic subunit of human protein phosphatase 2A permit baculovirus-mediated overexpression in insect cells.

B. Hemmings, D. Evans, T. Myles, 2001, The Biochemical journal.

Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression

B. Hemmings, N. Lamb, A. Fernandez, 1995, The Journal of cell biology.

alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure.

J. Hofsteenge, W. Merlevede, J. Goris, 1990, Biochemistry.

Molecular cloning of cDNAs encoding two isoforms of the catalytic subunit of protein phosphatase 2A.

J. Hofsteenge, B. Hemmings, S. Stone, 1987, Biochemistry.

PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage

B. Hemmings, M. Schmitz, D. Hess, 2009, Oncogene.

Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling

B. Hemmings, A. Hergovich, 2009, BioFactors.

Complementation between LLC-PK1 mutants affected in polypeptide hormone-receptor function.

B. Hemmings, D. Jans, T. J. Resink, 1987, European journal of biochemistry.

Isolation of a mutant LLC-PK1 cell line defective in hormonal responsiveness. A pleiotropic lesion in receptor function.

B. Hemmings, D. Jans, E. Reich, 1986, European journal of biochemistry.

Okadaic acid-dependent induction of the urokinase-type plasminogen activator gene associated with stabilization and autoregulation of c-Jun.

Y. Nagamine, B. Hemmings, B. Favre, 1994, The Journal of biological chemistry.

Protein kinase B/Akt at a glance

Brian A. Hemmings, B. Hemmings, L. Tintignac, 2005, Journal of Cell Science.

Carboxyl-Terminal Modulator Protein (CTMP), a Negative Regulator of PKB/Akt and v-Akt at the Plasma Membrane

Brian A. Hemmings, S. Kaech, B. Hemmings, 2001, Science.

Nerve growth factor-induced PKB/Akt activity is sustained by phosphoinositide 3-kinase dependent and independent signals in sympathetic neurons

R. Heumann, B. Hemmings, A. Tolkovsky, 1999, Brain Research.

Akt Signaling--Linking Membrane Events to Life and Death Decisions

B. Hemmings, 1997, Science.

AKT-ions with a TWIST between EMT and MET

M. Mandalà, D. Massi, B. Hemmings, 2016, Oncotarget.

Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes.

C. Rüegg, B. Hemmings, G. Xue, 2012, Cancer discovery.

Stabilization of Mdm2 via Decreased Ubiquitination Is Mediated by Protein Kinase B/Akt-dependent Phosphorylation*

A. Merlo, B. Hemmings, D. Brazil, 2004, Journal of Biological Chemistry.

NDR kinases regulate essential cell processes from yeast to humans

B. Hemmings, A. Hergovich, D. Schmitz, 2006, Nature Reviews Molecular Cell Biology.

The Akt/PKB pathway is constitutively activated in Theileria‐transformed leucocytes, but does not directly control constitutive NF‐κB activation

B. Hemmings, V. Heussler, D. Dobbelaere, 2001, Cellular microbiology.

Phosphorylation and activation of p70s6k by PDK1.

M. Andjelkovic, B. Hemmings, G. Thomas, 1998, Science.

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors.

M. Andjelkovic, B. Hemmings, X. Ming, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Role of PKB/Akt in Liver Diseases

B. Hemmings, O. Tschopp, E. Zhuravleva, 2010 .

Regulation of NDR2 Protein Kinase by Multi-site Phosphorylation and the S100B Calcium-binding Protein*

B. Hemmings, R. Tamaskovic, A. Hergovich, 2004, Journal of Biological Chemistry.

Mechanism of Ca2+-mediated Regulation of NDR Protein Kinase through Autophosphorylation and Phosphorylation by an Upstream Kinase*

H. Rogniaux, B. Hemmings, R. Tamaskovic, 2003, The Journal of Biological Chemistry.

Molecular cloning and characterization of a conserved nuclear serine(threonine) protein kinase.

B. Hemmings, T. Millward, P. Cron, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Identification of a Plasma Membrane Raft-Associated PKB Ser473 Kinase Activity that Is Distinct from ILK and PDK1

B. Hemmings, Jianhua Feng, M. Hill, 2002, Current Biology.

Physiological roles of PKB/Akt isoforms in development and disease.

B. Hemmings, B A Hemmings, B Dummler, 2007, Biochemical Society transactions.

Living with Lethal PIP3 Levels: Viability of Flies Lacking PTEN Restored by a PH Domain Mutation in Akt/PKB

E. Hafen, M. Andjelkovic, S. Oldham, 2002, Science.

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase.

S. Taylor, B. Hemmings, Xiaodong Cheng, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Developmental expression of the RI subunit of cyclic AMP-dependent protein kinase in retina.

G. Chader, B. Hemmings, S. Gentleman, 1989, Experimental eye research.

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase

P. Cohen, M. Andjelkovic, D. Alessi, 1996, FEBS letters.

Gonadotropin-releasing hormone and pituitary adenylate cyclase-activating polypeptide affect levels of cyclic adenosine 3',5'-monophosphate-dependent protein kinase A (PKA) subunits in the clonal gonadotrope alphaT3-1 cells: evidence for cross-talk between PKA and protein kinase C pathways.

C. McArdle, B. Hemmings, G. Garrel, 1997, Endocrinology.

NDR Functions as a Physiological YAP1 Kinase in the Intestinal Epithelium

L. Terracciano, B. Hemmings, Fengyuan Tang, 2015, Current Biology.

The MST1 and hMOB1 Tumor Suppressors Control Human Centrosome Duplication by Regulating NDR Kinase Phosphorylation

B. Hemmings, A. Hergovich, D. Schmitz, 2009, Current Biology.

Constitutive Notch2 signaling in neural stem cells promotes tumorigenic features and astroglial lineage entry

F. Kirchhoff, A. Merlo, J. Tchorz, 2012, Cell Death and Disease.

Long-term stimulation of cAMP production in LLC-PK1 pig kidney epithelial cells by salmon calcitonin or a photoactivatable analogue of vasopressin.

F. Fahrenholz, B. Hemmings, D. Jans, 1987, Biochimica et biophysica acta.

Transcriptional profiling of myotubes from patients with type 2 diabetes: no evidence for a primary defect in oxidative phosphorylation genes

E. Oakeley, B. Hemmings, K. Højlund, 2008, Diabetologia.

Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice.

R. Nitsch, B. Hemmings, S. Kins, 2001, The Journal of biological chemistry.

PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage

B. Hemmings, D. Hess, A. Vichalkovski, 2010, Oncogene.

Meeting Report: Targeting the Kinome—20 Years of Tyrosine Kinase Inhibitor Research in Basel

T. Hunter, B. Hemmings, P. Morin, 2007, Science's STKE.

mTORC1/autophagy-regulated MerTK in mutant BRAFV600 melanoma with acquired resistance to BRAF inhibition

C. Genoud, F. Orso, D. Taverna, 2017, Oncotarget.

Functional Characterization of Human RSK4, a New 90-kDa Ribosomal S6 Kinase, Reveals Constitutive Activation in Most Cell Types*

J. Silber, D. Alessi, B. Hemmings, 2005, Journal of Biological Chemistry.

Pleckstrin homology (PH) domains in signal transducton

B. Hemmings, E. Ingley, 1994 .

Correspondence analysis of microarray time-course data in case-control design

Qihua Tan, Klaus Brusgaard, Torben Arvid Kruse, 2004, J. Biomed. Informatics.

Essential role of protein kinase Bγ (PKBγ/Akt3) in postnatal brain development but not in glucose homeostasis

J. Frahm, B. Hemmings, Takashi Watanabe, 2005, Development.

Differential Regulation by Calcium Reveals Distinct Signaling Requirements for the Activation of Akt and p70S6k *

R. Pearson, B. Hemmings, N. Conus, 1998, The Journal of Biological Chemistry.

PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage.

Jisoo Park, B. Hemmings, D. Brazil, 2013, Cellular signalling.

The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits.

C. van Hoof, W. Merlevede, J. Goris, 1996, The Biochemical journal.

Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation.

Qing Luan, Xiang Gao, B. Hemmings, 2010, Developmental biology.

Differential Inhibition and Posttranslational Modification of Protein Phosphatase 1 and 2A in MCF7 Cells Treated with Calyculin-A, Okadaic Acid, and Tautomycin*

B. Hemmings, P. Turowski, B. Favre, 1997, Journal of Biological Chemistry.

Neurofilament-associated protein phosphatase 2A: its possible role in preserving neurofilaments in filamentous states.

M. Nagao, B. Hemmings, H. Shima, 1995, Biochemistry.

Expression and purification of the human thrombin receptor.

S. Bottomley, B. Hemmings, S. Stone, 1998, Protein expression and purification.

Protein chemical and kinetic characterization of recombinant porcine ribonuclease inhibitor expressed in Saccharomyces cerevisiae.

J. Hofsteenge, B. Hemmings, B. Kieffer, 1990, Biochemistry.

Amino acid sequence of the ribonuclease inhibitor from porcine liver reveals the presence of leucine-rich repeats.

J. Hofsteenge, B. Hemmings, B. Kieffer, 1988, Biochemistry.

Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice.

W. Wahli, B. Hemmings, Zhong-Zhou Yang, 2005, Molecular and cellular biology.

Identification of Tyrosine Phosphorylation Sites on 3-Phosphoinositide-dependent Protein Kinase-1 and Their Role in Regulating Kinase Activity*

J. Hofsteenge, B. Hemmings, D. Hess, 2001, The Journal of Biological Chemistry.

Effect of Phosphoinositide-Dependent Kinase 1 on Protein Kinase B Translocation and Its Subsequent Activation

E. Van Obberghen, B. Hemmings, N. Filippa, 2000, Molecular and Cellular Biology.

Phosphorylation and proteolysis regulate the NAD‐dependent glutamate dehydrogenase from Saccharomyces cerevisiae

B. Hemmings, 1980, FEBS letters.

PKB Binding Proteins Getting in on the Akt

B. Hemmings, D. Brazil, Jongsun Park, 2002, Cell.

Human NDR Kinases Control G1/S Cell Cycle Transition by Directly Regulating p21 Stability

B. Hemmings, A. Hergovich, H. Cornils, 2011, Molecular and Cellular Biology.

The regulation of glutamate metabolism in Candida utilis. Evidence for two interconvertible forms of NAD-dependent glutamate dehydrogenase.

B. Hemmings, A. P. Sims, 1977, European journal of biochemistry.

p21-activated Kinase (PAK1) Is Phosphorylated and Activated by 3-Phosphoinositide-dependent Kinase-1 (PDK1)*

F T Zenke, A. Newton, G. Bokoch, 2000, The Journal of Biological Chemistry.

MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.

A. Merlo, S. Frank, B. Hemmings, 2014, The Journal of clinical investigation.

Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle.

H. Tung, P. Cohen, B. Hemmings, 1988, Methods in enzymology.

Isolation, characterization, and chromosomal localization of the porcine calcitonin receptor gene. Identification of two variants of the receptor generated by alternative splicing.

B. Hemmings, R. Fries, S. Zołnierowicz, 1994, The Journal of biological chemistry.

PH domains and phospholipases--a meaningful relationship?

P. Parker, B. Hemmings, P. Gierschik, 1994, Trends in biochemical sciences.

PromoterPlot: a graphical display of promoter similarities by pattern recognition

Karsten Schmidt, Alessandro Di Cara, Edward J. Oakeley, 2005, Nucleic Acids Res..

PIKKing on PKB: regulation of PKB activity by phosphorylation.

B. Hemmings, L. Bozulic, 2009, Current opinion in cell biology.

Akt1 signaling coordinates BMP signaling and β-catenin activity to regulate second heart field progenitor development

B. Hemmings, Zhongzhou Yang, Jingai Zhu, 2015, Development.

12-O-Tetradecanoylphorbol-13-acetate-induced Dephosphorylation of Protein Kinase Cα Correlates with the Presence of a Membrane-associated Protein Phosphatase 2A Heterotrimer*

P. Parker, B. Hemmings, F. Bornancin, 1996, The Journal of Biological Chemistry.

Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET

F. Hofmann, E. Nigg, B. Hemmings, 2012, Journal of Cell Science.

Two Splice Variants of Protein Kinase Bγ Have Different Regulatory Capacity Depending on the Presence or Absence of the Regulatory Phosphorylation Site Serine 472 in the Carboxyl-terminal Hydrophobic Domain*

B. Hemmings, M. Hill, D. Brodbeck, 2001, The Journal of Biological Chemistry.

Multiple mRNA species code for the catalytic subunit of the cAMP-dependent protein kinase from LLC-PK1 cells. Evidence for two forms of the catalytic subunit.

B. Hemmings, R. Maurer, M. Showers, 1987, European journal of biochemistry.

Protein kinases, from B to C.

M. Laguerre, A. Faisal, P. Parker, 2007, Biochemical Society transactions.

Molecular cloning and developmental expression of the catalytic and 65-kDa regulatory subunits of protein phosphatase 2A in Drosophila.

D. Glover, B. Hemmings, G. Bilbe, 1992, Molecular biology of the cell.

PROTEIN PHOSPHORYLATION AND THE NEURAL AND HORMONAL CONTROL OF ENZYME ACTIVITY1

P. Cohen, J. Woodgett, A. Aitken, 1983 .

Overcoming resistance to rapalogs in gliomas by combinatory therapies.

B. Hemmings, M. Grzmil, 2013, Biochimica et biophysica acta.

90-kDa Ribosomal S6 Kinase Is Phosphorylated and Activated by 3-Phosphoinositide-dependent Protein Kinase-1*

S. Gammeltoft, B. Hemmings, C. J. Jensen, 1999, The Journal of Biological Chemistry.

Hyperosmotic Stress Stimulates Promoter Activity and Regulates Cellular Utilization of the Serum- and Glucocorticoid-inducible Protein Kinase (Sgk) by a p38 MAPK-dependent Pathway*

G. Firestone, B. Hemmings, M. Leong, 2000, The Journal of Biological Chemistry.

Developmental Regulation of Expression and Activity of Multiple Forms of the Drosophila RAC Protein Kinase (*)

A. Schier, M. Andjelkovic, U. Grossniklaus, 1995, The Journal of Biological Chemistry.

Domain Swapping Used To Investigate the Mechanism of Protein Kinase B Regulation by 3-Phosphoinositide-Dependent Protein Kinase 1 and Ser473 Kinase

Brian A. Hemmings, Peter J. Parker, M. Andjelkovic, 1999, Molecular and Cellular Biology.

cAMP stimulates protein kinase B in a Wortmannin‐insensitive manner

E. Van Obberghen, B. Hemmings, N. Filippa, 1997, FEBS letters.

Activation of protein kinase B induced by H(2)O(2) and heat shock through distinct mechanisms dependent and independent of phosphatidylinositol 3-kinase.

M. Andjelkovic, T. Yamamoto, B. Hemmings, 1999, Journal of biochemistry.

The ARE‐dependent mRNA‐destabilizing activity of BRF1 is regulated by protein kinase B

B. Hemmings, D. Hess, G. Stoecklin, 2004, The EMBO journal.

S. Pikkarainen, E. Tham, A. Clerk, 2008, Cellular signalling.

Differential NDR/LATS Interactions with the Human MOB Family Reveal a Negative Role for Human MOB2 in the Regulation of Human NDR Kinases

B. Hemmings, A. Hergovich, D. Schmitz, 2010, Molecular and Cellular Biology.

Ndr Protein Kinase Is Regulated by Phosphorylation on Two Conserved Sequence Motifs*

B. Hemmings, D. Hess, T. Millward, 1999, The Journal of Biological Chemistry.

The PR55 and PR65 subunits of protein phosphatase 2A from Xenopus laevis. molecular cloning and developmental regulation of expression.

C. van Hoof, W. Merlevede, J. Goris, 1995, European journal of biochemistry.

The PR55 and PR65 Subunits of Protein Phosphatase 2A from Xenopus laevis

W. Merlevede, J. Goris, B. Hemmings, 1995 .

Constitutive activation of protein kinase B and phosphorylation of p47 phox by a membrane-targeted phosphoinositide 3-kinase

B. Hemmings, B. Tilton, M. Thelen, 1996, Current Biology.

Inactivation and dephosphorylation of protein kinase Bα (PKBα) promoted by hyperosmotic stress

B. Hemmings, M. Thelen, R. Meier, 1998, The EMBO journal.

Cobalamins and cobalamin-dependent enzymes in Candida utilis

B. Hemmings, J. Poston, 1979, Journal of bacteriology.

Reactivation of the phospho form of the NAD-dependent glutamate dehydrogenase by a yeast protein phosphatase.

B. Hemmings, 1981, European journal of biochemistry.

Alternative Splicing Controls Myotonic Dystrophy Protein Kinase Structure, Enzymatic Activity, and Subcellular Localization

B. Wieringa, B. Hemmings, D. G. Wansink, 2003, Molecular and Cellular Biology.

Structure of the Ca2+/S100B/NDR kinase peptide complex: insights into S100 target specificity and activation of the kinase.

C. Heizmann, W. Chazin, B. Hemmings, 2003, Biochemistry.

Purification and properties of the phospho and dephospho forms of yeast NAD-dependent glutamate dehydrogenase.

B. Hemmings, 1980, The Journal of biological chemistry.

Primary structure of protein phosphatase 2A as determined by molecular cloning: implications for a protein phosphatase gene family.

J. Hofsteenge, B. Hemmings, S. Stone, 1988, Advances in experimental medicine and biology.

Reduced hepatic lipid content in Pten‐haplodeficient mice because of enhanced AKT2/PKBβ activation in skeletal muscle

B. Hemmings, D. Hynx, G. Spinas, 2015, Liver international : official journal of the International Association for the Study of the Liver.

Survival and Size Are Differentially Regulated by Placental and Fetal PKBalpha/AKT1 in Mice1

M. Neeman, V. Plaks, R. Haffner, 2011, Biology of reproduction.

Negative Regulation of ERK and Elk by Protein Kinase B Modulates c-fos Transcription*

M. Andjelkovic, B. Hemmings, S. Maira, 2003, The Journal of Biological Chemistry.

Tissue-specific expression of mRNAs encoding alpha- and beta-catalytic subunits of protein phosphatase 2A.

Y. Khew-Goodall, B. Hemmings, 1988, FEBS letters.

Protein phosphatases on the piste

Brian A. Hemmings, B. Hemmings, S. Zołnierowicz, 1996 .

Acyl Coenzyme A Thioesterase Them5/Acot15 Is Involved in Cardiolipin Remodeling and Fatty Liver Development

Christel Genoud, Brian A. Hemmings, Elena Zhuravleva, 2012, Molecular and Cellular Biology.

Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy.

J. Seebacher, S. Frank, B. Hemmings, 2016, Cellular signalling.

The catalytic subunits of protein phosphatase-1 and protein phosphatase 2A are distinct gene products.

H. Tung, P. Cohen, S. Shenolikar, 1984, European journal of biochemistry.

TAZ-mediated crosstalk between Wnt and Hippo signaling.

B. Hemmings, A. Hergovich, 2010, Developmental cell.

The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo.

B. Hemmings, S. Zołnierowicz, P. Turowski, 1994, The Journal of biological chemistry.

Phosphorylation of basic helix-loop-helix transcription factor Twist in development and disease.

B. Hemmings, G. Xue, 2012, Biochemical Society transactions.

cAMP‐dependent protein kinase activation affects vasopressin V2‐receptor number and internalization in LLC‐PK1 renal epithelial cells

B. Hemmings, D. Jans, 1991, FEBS letters.

Activation of cAMP-dependent protein kinase alters the chromatin structure of the urokinase-type plasminogen activator gene promoter.

Y. Nagamine, B. Hemmings, Janet S. Lee, 1994, Nucleic acids research.

G-Protein-coupled Receptors and Fcγ-receptors Mediate Activation of Akt/Protein Kinase B in Human Phagocytes*

Brian A. Hemmings, M. Andjelkovic, B. Hemmings, 1997, The Journal of Biological Chemistry.

Protein Kinase B β/Akt2 Plays a Specific Role in Muscle Differentiation*

B. Hemmings, D. Besser, N. Lamb, 2001, The Journal of Biological Chemistry.

Regulation of protein kinase B.

B. Hemmings, R. Meier, 1999, Journal of receptor and signal transduction research.

Mutation of the C-terminal leucine residue of PP2Ac inhibits PR55/B subunit binding and confers supersensitivity to microtubule destabilization in Saccharomyces cerevisiae

B. Hemmings, D. Evans, D. R. Evans, 2000, Molecular Genetics and Genomics.

Signal transduction: What goes up must come down

B. Hemmings, David R. H. Evans, 1998, Nature.

Characterization of two mutants of the LLC-PK1 porcine kidney cell line affected in the catalytic subunit of the cAMP-dependent protein kinase.

B. Hemmings, D. Jans, S. Botterell, 1987, European journal of biochemistry.

The phospho-opsin phosphatase from bovine rod outer segments. An insight into the mechanism of stimulation of type-2A protein phosphatase activity by protamine.

B. Hemmings, M. Akhtar, N. Andjelkovic, 1994, European journal of biochemistry.

Modulation of regulatory and catalytic subunit levels of cAMP-dependent protein kinase A in anterior pituitary cells in response to direct activation of protein kinases A and C or after GnRH stimulation.

B. Hemmings, G. Garrel, R. Counis, 1995, Neuroendocrinology.

Functional Expression of Human PP2Ac in Yeast Permits the Identification of Novel C-terminal and Dominant-negative Mutant Forms*

J. Hofsteenge, B. Hemmings, T. Myles, 1999, The Journal of Biological Chemistry.

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation.

D. Barford, B. Hemmings, V. Good, 2002, Molecular cell.

Analysis of protein kinase B/Akt.

B. Hemmings, M. Hill, 2002, Methods in enzymology.

PH domain of serine-threonine protein kinase B (RAC-PKB). Expression and binding assay for phosphoinositides and inositol phosphates.

M. Frech, B. Hemmings, 1998, Methods in molecular biology.

PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis

B. Hemmings, M. Niessen, S. Schultze, 2012, Expert Reviews in Molecular Medicine.

Promiscuous affairs of PKB/AKT isoforms in metabolism

B. Hemmings, Jørgen Jensen, M. Niessen, 2011, Archives of physiology and biochemistry.

Deregulation of Translational Control of the 65-kDa Regulatory Subunit (PR65α) of Protein Phosphatase 2A Leads to Multinucleated Cells (*)

B. Hemmings, N. Lamb, Anne Fernandez, 1995, The Journal of Biological Chemistry.

Reduced PP 2 A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice

B. Hemmings, J. Götz, S. Kins, 2001 .

Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development.

W. Wahli, N. Tan, B. Hemmings, 2005, Molecular and cellular biology.

Multimodal imaging reveals a role for Akt1 in fetal cardiac development

M. Neeman, A. Harmelin, B. Hemmings, 2013, Physiological reports.

The ARE‐dependent mRNA‐destabilizing activity of BRF1 is regulated by protein kinase B

B. Hemmings, D. Hess, G. Stoecklin, 2004, The EMBO journal.

PKB/Akt-dependent regulation of cell motility.

B. Hemmings, G. Xue, 2013, Journal of the National Cancer Institute.

Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes.

C. Rüegg, B. Hemmings, G. Xue, 2012, Cancer discovery.

Dependence of urokinase-type-plasminogen-activator induction on cyclic AMP-dependent protein kinase activation in LLC-PK1 cells.

B. Hemmings, D. Jans, T. J. Resink, 1987, Biochemical Journal.

A novel LLC-PK1 renal epithelial cell mutant impaired in in vivo down-regulation of cAMP-mediated hormonal response.

B. Hemmings, D. Jans, T. J. Resink, 1991, Archives of biochemistry and biophysics.

Constitutively Active Protein Kinase B Enhances Lck and Erk Activities and Influences Thymocyte Selection and Activation1

D. Kioussis, M. Tolaini, B. Hemmings, 2003, The Journal of Immunology.

PIKKing on PKB: regulation of PKB activity by phosphorylation.

B. Hemmings, L. Bozulic, 2009, Current opinion in cell biology.

In Vivo Analysis of Protein Kinase B (PKB)/Akt Regulation in DNA-PKcs-null Mice Reveals a Role for PKB/Akt in DNA Damage Response and Tumorigenesis*

B. Hemmings, A. Parcellier, Banu Surucu, 2008, Journal of Biological Chemistry.

Human NDR Kinases Control G1/S Cell Cycle Transition by Directly Regulating p21 Stability

B. Hemmings, A. Hergovich, H. Cornils, 2011, Molecular and Cellular Biology.

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.

B. Hemmings, F. Pitossi, T. Jakubowicz, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Tumor and Stem Cell Biology MAP Kinase-Interacting Kinase 1 Regulates SMAD 2-Dependent TGF-b Signaling Pathway in HumanGlioblastoma

A. Merlo, S. Frank, B. Hemmings, 2011 .

Phosphorylation of basic helix-loop-helix transcription factor Twist in development and disease.

B. Hemmings, G. Xue, 2012, Biochemical Society transactions.

Peroxisomes, Refsum's disease and the α- and ω-oxidation of phytanic acid

J. Trimmer, M. Bootman, M. Taussig, 2007 .

S. Pikkarainen, E. Tham, A. Clerk, 2008, Cellular signalling.

Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes [Erratum to document cited in CA114(3):18572v]

Y. Khew-Goodall, B. Hemmings, S. Stone, 1991 .

Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling

B. Hemmings, A. Hergovich, 2009, BioFactors.

Mechanisms of cAMP-mediated gene induction: examination of renal epithelial cell mutants affected in the catalytic subunit of the cAMP-dependent protein kinase.

Y. Nagamine, E. Nigg, B. Hemmings, 1991, Experimental cell research.