C. Pudney

发表

Monoclonal antibody stability can be usefully monitored using the excitation-energy-dependent fluorescence edge-shift

S. Wells, A. Kwok, S. Parsons, 2020, The Biochemical journal.

On the Temperature Dependence of Enzyme-Catalyzed Rates.

Adrian J Mulholland, Vickery L Arcus, Emily J Parker, 2016, Biochemistry.

Gating mechanisms for biological electron transfer: Integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper‐dependent nitrite reductase

N. Scrutton, C. Pudney, S. Rigby, 2012, FEBS letters.

Specificity of bispecific T cell receptors and antibodies targeting peptide-HLA.

T. Blicher, B. Jakobsen, M. W. van der Kamp, 2020, The Journal of clinical investigation.

Exposing the Interplay Between Enzyme Turnover, Protein Dynamics, and the Membrane Environment in Monoamine Oxidase B.

S. Wells, M. W. van der Kamp, Hannah B. L. Jones, 2019, Biochemistry.

Change in heat capacity accurately predicts vibrational coupling in enzyme catalyzed reactions

V. Arcus, C. Pudney, 2015, FEBS letters.

Fast protein motions are coupled to enzyme H-transfer reactions.

N. Scrutton, L. Johannissen, N. J. Baxter, 2013, Journal of the American Chemical Society.

Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction.

M. Sutcliffe, N. Scrutton, C. Pudney, 2009, Journal of the American Chemical Society.

Steady-State Kinetics of α-Synuclein Ferrireductase Activity Identifies the Catalytically Competent Species.

P. Whitley, C. Pudney, David R. Brown, 2017, Biochemistry.

Biocatalysis with Thermostable Enzymes: Structure and Properties of a Thermophilic ‘ene’‐Reductase related to Old Yellow Enzyme

N. Scrutton, H. Toogood, T. Jowitt, 2010, Chembiochem : a European journal of chemical biology.

N-linked glycosylation increases horse radish peroxidase rigidity leading to enhanced activity and stability

C. Pudney, D. D. Jones, H. Worthy, 2022, bioRxiv.

Peptide cargo tunes a network of correlated motions in human leucocyte antigens

V. Arcus, A. Sewell, M. W. van der Kamp, 2020, The FEBS journal.

Alpha-secondary isotope effects as probes of "tunneling-ready" configurations in enzymatic H-tunneling: insight from environmentally coupled tunneling models.

M. Sutcliffe, N. Scrutton, C. Pudney, 2006, Journal of the American Chemical Society.

et al. (2021). Sensing Enzyme Activation Heat Capacity at the Single-Molecule Level Using Gold-Nanorod-Based Optical Whispering Gallery Modes. ACS Applied Nano Materials.

V. Arcus, C. Pudney, F. Vollmer, 2021 .

A complete thermodynamic analysis of enzyme turnover links the free energy landscape to enzyme catalysis

E. Prentice, V. Arcus, S. Wells, 2017, The FEBS journal.

Conformation control of the histidine kinase BceS of Bacillus subtilis by its cognate ABC‐transporter facilitates need‐based activation of antibiotic resistance

M. W. van der Kamp, C. Pudney, S. Gebhard, 2020, Molecular microbiology.

How to make a dial not a switch: Control of histidine kinase conformation by an ABC-transporter facilitates need-based activation of antibiotic resistance

C. Pudney, S. Gebhard, M. J. Gibbon, 2020 .

Switching protein metalloporphyrin binding specificity by design from iron to fluorogenic zinc.

C. Pudney, D. D. Jones, J. Szeto, 2020, Chemical communications.

Switching metalloporphyrin binding specificity of a b-type cytochrome to fluorogenic zinc by design

C. Pudney, D. D. Jones, J. Szeto, 2019, bioRxiv.

Enzyme evolution and the temperature dependence of enzyme catalysis.

V. Arcus, M. W. van der Kamp, A. Mulholland, 2020, Current opinion in structural biology.

Excitation-Energy-Dependent Molecular Beacon Detects Early Stage Neurotoxic Aβ Aggregates in the Presence of Cortical Neurons.

C. Soeller, C. E. Gulácsy, C. Pudney, 2018, ACS chemical neuroscience.

Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms.

M. Sutcliffe, N. Scrutton, C. Pudney, 2007, Journal of the American Chemical Society.

Uncovering the Relationship between the Change in Heat Capacity for Enzyme Catalysis and Vibrational Frequency through Isotope Effect Studies

V. Arcus, C. Pudney, M. Danson, 2018 .

Molecular Rules Underpinning Enhanced Affinity Binding of Human T Cell Receptors Engineered for Immunotherapy

A. Sewell, M. W. van der Kamp, C. Pudney, 2020, Molecular therapy oncolytics.

Trends in hospital presentations following analytically confirmed synthetic cannabinoid receptor agonist exposure before and after implementation of the 2016 UK Psychoactive Substances Act

Graeme Henderson, P. Dargan, C. Pudney, 2022, Addiction.

Kinetic and spectroscopic probes of motions and catalysis in the cytochrome P450 reductase family of enzymes

N. Scrutton, C. Pudney, S. Rigby, 2012, The FEBS journal.

Coupled Motions Direct Electrons along Human Microsomal P450 Chains

N. Scrutton, L. Johannissen, C. Pudney, 2011, PLoS biology.

Direct analysis of donor-acceptor distance and relationship to isotope effects and the force constant for barrier compression in enzymatic H-tunneling reactions.

Nigel S Scrutton, Michael J Sutcliffe, M. Sutcliffe, 2010, Journal of the American Chemical Society.

Parallel Pathways and Free‐Energy Landscapes for Enzymatic Hydride Transfer Probed by Hydrostatic Pressure

M. Sutcliffe, N. Scrutton, C. Pudney, 2009, Chembiochem : a European journal of chemical biology.

Barrier compression enhances an enzymatic hydrogen-transfer reaction.

M. Sutcliffe, N. Scrutton, C. Pudney, 2009, Angewandte Chemie.

Solvent as a probe of active site motion and chemistry during the hydrogen tunnelling reaction in morphinone reductase.

M. Sutcliffe, N. Scrutton, C. Pudney, 2008, Chemphyschem : a European journal of chemical physics and physical chemistry.

Are environmentally coupled enzymatic hydrogen tunneling reactions influenced by changes in solution viscosity?

M. Sutcliffe, N. Scrutton, C. Pudney, 2008, Angewandte Chemie.

Practical aspects on the use of kinetic isotope effects as probes of flavoprotein enzyme mechanisms.

N. Scrutton, C. Pudney, S. Hay, 2014, Methods in molecular biology.

Excited state dynamics can be used to probe donor-acceptor distances for H-tunneling reactions catalyzed by flavoproteins.

N. Scrutton, C. Pudney, S. Hardman, 2013, Biophysical journal.

Probing active site geometry using high pressure and secondary isotope effects in an enzyme-catalysed 'deep' H-tunnelling reaction.

M. Sutcliffe, N. Scrutton, C. Pudney, 2010, Journal of physical organic chemistry.

Structural and mechanistic aspects of flavoproteins: probes of hydrogen tunnelling

N. Scrutton, C. Pudney, S. Hay, 2009, The FEBS journal.

Enzymatic single-molecule kinetic isotope effects.

N. Scrutton, C. Pudney, S. W. Magennis, 2013, Journal of the American Chemical Society.

Structure and in silico simulations of a cold-active esterase reveals its prime cold-adaptation mechanism

S. Wells, C. Pudney, P. Rizkallah, 2021, Open Biology.

Structure and dynamics of a cold-active esterase reveals water entropy and active site accessibility as the likely drivers for cold-adaptation

S. Wells, C. Pudney, P. Rizkallah, 2021, bioRxiv.

Modelling flavoenzymatic charge transfer events: development of catalytic indole deuteration strategies.

C. E. Gulácsy, C. Pudney, P. Raithby, 2016, Organic & biomolecular chemistry.

Reliable In Silico Ranking of Engineered Therapeutic TCR Binding Affinities with MMPB/GBSA

M. W. van der Kamp, C. Pudney, D. Cole, 2021, bioRxiv.

Synthetic Cannabinoid Receptor Agonists Detection Using Fluorescence Spectral Fingerprinting

Benedict C. May, Husain A. Naqi, C. Pudney, 2019, Analytical chemistry.

Glycosylation increases active site rigidity leading to improved enzyme stability and turnover

C. Pudney, D. D. Jones, H. Worthy, 2023, The FEBS journal.

The Effect of Isotropic Pressure on the Electronic Structure and Superatomic Orbitals of Molecular [Ag44(SPhCOOH)30]4-, [Ag44(SPhF2)30]4- & [Ag25(SPhMe2)18]- Nanoclusters

H. Gersen, C. Pudney, S. Hall, 2018, 1801.03586.

Correction of pre-steady-state KIEs for isotopic impurities and the consequences of kinetic isotope fractionation.

N. Scrutton, C. Pudney, S. Hay, 2008, The journal of physical chemistry. A.

Atomistic insight into the origin of the temperature-dependence of kinetic isotope effects and H-tunnelling in enzyme systems is revealed through combined experimental studies and biomolecular simulation.

M. Sutcliffe, N. Scrutton, L. Johannissen, 2008, Biochemical Society transactions.

Sensing Enzyme Activation Heat Capacity at the Single-Molecule Level Using Gold-Nanorod-Based Optical Whispering Gallery Modes

V. Arcus, M. W. van der Kamp, C. Pudney, 2021, ACS applied nano materials.

The red edge excitation shift phenomenon can be used to unmask protein structural ensembles: implications for NEMO–ubiquitin interactions

C. Pudney, Yi Yang, J. M. Elsen, 2016, The FEBS journal.

Bipartite recognition and conformational sampling mechanisms for hydride transfer from nicotinamide coenzyme to FMN in pentaerythritol tetranitrate reductase

N. Scrutton, C. Pudney, S. Hay, 2009, The FEBS journal.

Constant domain polymorphisms influence monoclonal antibody stability and dynamics

V. Arcus, William J Kelton, C. Pudney, 2023, Protein science : a publication of the Protein Society.

Conformation control of the histidine kinase BceS of Bacillus subtilis by its cognate ABC-transporter facilitates need-based activation of antibiotic resistance

M. W. van der Kamp, C. Pudney, S. Gebhard, 2020, bioRxiv.

Polyubiquitin Drives the Molecular Interactions of the NF-κB Essential Modulator (NEMO) by Allosteric Regulation

C. Pudney, J. Horne, G. Cooper, 2015, The Journal of Biological Chemistry.

Flavin mimetics: Synthesis and photophysical properties

C. Pudney, K. Sada, G. Pantoș, 2021 .

Photochemical Fingerprinting Is a Sensitive Probe for the Detection of Synthetic Cannabinoid Receptor Agonists; toward Robust Point-of-Care Detection

Benedict C. May, Matthew N. Grayson, R. Crespo‐Otero, 2023, Analytical chemistry.

On the Temperature Dependence of Enzyme-Catalyzed Rates.

L. Schipper, E. Prentice, V. Arcus, 2016, Biochemistry.

Barrier compression enhances an enzymatic hydrogen-transfer reaction.

M. Sutcliffe, N. Scrutton, C. Pudney, 2009, Angewandte Chemie.

Steady-state kinetics of alpha-synuclein ferrireductase activity identifies the catalytically competent species.

P. Whitley, C. Pudney, David R. Brown, 2017 .

Fast protein motions are coupled to enzyme H-transfer reactions.

N. Scrutton, L. Johannissen, N. J. Baxter, 2013, Journal of the American Chemical Society.