P. Roche

发表

Multiscaled exploration of coupled folding and binding of an intrinsically disordered molecular recognition element in measles virus nucleoprotein

Y. Wang, S. Longhi, S. Longhi, 2013, Proceedings of the National Academy of Sciences of the United States of America.

Computational model for the IGF‐II/IGF2r complex that is predictive of mutational and surface plasmon resonance data

Adam Denley, James Brown, Robert M Esnouf, 2006, Proteins.

Metabolome Profiling by HRMAS NMR Spectroscopy of Pheochromocytomas and Paragangliomas Detects SDH Deficiency: Clinical and Pathophysiological Implications12

C. Stratakis, P. Bachellier, I. Namer, 2015, Neoplasia.

Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins.

S. Knapp, P. Roche, T. Roux, 2016, Journal of medicinal chemistry.

Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach.

D. Horvath, A. Varnek, P. Roche, 2018, Journal of medicinal chemistry.

2P2Ichem: focused chemical libraries dedicated to orthosteric modulation of protein–protein interactions

Xavier Morelli, Marie Jeanne Basse, Véronique Hamon, 2013 .

Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery.

S. Knapp, S. Müller, P. Roche, 2016, ACS chemical biology.

Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors.

B. Coutard, E. Decroly, P. Roche, 2019, European journal of medicinal chemistry.

Chemistry‐driven Hit‐to‐lead Optimization Guided by Structure‐based Approaches

P. Roche, X. Morelli, L. Hoffer, 2018, Molecular informatics.

A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays

D. Byrne, J. Herrou, P. Roche, 2019, PLoS genetics.

A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays

D. Byrne, J. Herrou, P. Roche, 2017, bioRxiv.

Anaerobic oxidation of long-chain n-alkanes by the hyperthermophilic sulfate-reducing archaeon, Archaeoglobus fulgidus

P. Roche, C. Brochier-Armanet, B. Ollivier, 2014, The ISME Journal.

Reply to Jensen and Blackledge: Dual quantifications of intrinsically disordered proteins by NMR ensembles and molecular dynamics simulations

S. Longhi, P. Roche, Yong Wang, 2014, Proceedings of the National Academy of Sciences.

TM0486 from the hyperthermophilic anaerobe Thermotoga maritima is a thiamin-binding protein involved in response of the cell to oxidative conditions.

Mitchell D. Miller, A. Deacon, I. Wilson, 2010, Journal of molecular biology.

CRCM5484: A BET-BDII Selective Compound with Differential Anti-leukemic Drug Modulation.

E. Pasquier, P. Roche, S. Betzi, 2022, Journal of medicinal chemistry.

CRCM5484: A BET- BDII Selective Compound With Differential Anti-Leukemic Drug Modulation

E. Pasquier, P. Roche, S. Betzi, 2021, bioRxiv.

Associated with Long-Term Nonprogression Identification of Related HLAs Potentially HLA-B * 5703-Peptide Complexes and Structures of Three HIV-1

R. Kaul, S. Rowland-Jones, P. Roche, 2005 .

Implications of SDHB genetic testing in patients with sporadic pheochromocytoma

P. Roche, K. Pacak, A. Barlier, 2017, Langenbeck's Archives of Surgery.

Crystal structure of the transcriptional repressor DdrO: insight into the metalloprotease/repressor-controlled radiation response in Deinococcus

F. Parcy, L. Blanchard, D. Pignol, 2019, Nucleic acids research.

18F-FDOPA PET/CT Imaging of MAX-Related Pheochromocytoma

P. Roche, K. Pacak, Clara C. Chen, 2018, The Journal of clinical endocrinology and metabolism.

Pathological and Genetic Characterization of Bilateral Adrenomedullary Hyperplasia in a Patient with Germline MAX Mutation

A. Tischler, P. Roche, K. Pacak, 2017, Endocrine Pathology.

Atomic Analysis of Protein-Protein Interfaces with Known Inhibitors: The 2P2I Database

Philippe Roche, Xavier Morelli, Raphaël Bourgeas, 2010, PloS one.

Stereoselective synthesis of original spirolactams displaying promising folded structures.

Jean Martínez, I. Parrot, P. Roche, 2013, Organic & biomolecular chemistry.

Non-nucleoside inhibitors of mitochondrial thymidine kinase (TK-2) differentially inhibit the closely related herpes simplex virus type 1 TK and Drosophila melanogaster multifunctional deoxynucleoside kinase.

R. Esnouf, P. Roche, J. Balzarini, 2003, Molecular pharmacology.

Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis

A. Sergé, B. Durand, J. Borg, 2017, PLoS genetics.

Discovery of small molecule inhibitors of the PTK7/β-catenin inter-action targeting the Wnt signaling pathway in colorectal cancer

J. Borg, P. Roche, S. Betzi, 2021, bioRxiv.

Initiation of pre-B cell receptor signaling: common and distinctive features in human and mouse.

C. Schiff, P. Roche, M. Espéli, 2006, Seminars in immunology.

Structural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) Activation*

C. Schiff, F. Guerlesquin, P. Roche, 2012, The Journal of Biological Chemistry.

Structures of Three HIV-1 HLA-B*5703-Peptide Complexes and Identification of Related HLAs Potentially Associated with Long-Term Nonprogression12

Sarah Rowland-Jones, Andrew J. McMichael, Ian M. Overton, 2005, The Journal of Immunology.

Modulation of Re-initiation of Measles Virus Transcription at Intergenic Regions by PXD to NTAIL Binding Strength

Marion Dosnon, J. Erales, S. Longhi, 2016, PLoS pathogens.

A gain-of-function RAC2 mutation is associated with bone marrow hypoplasia and an autosomal dominant form of severe combined immunodeficiency

A. Fischer, J. Casanova, C. Picard, 2020, Haematologica.

Missense mutations in the homeodomain of HOXD13 are associated with brachydactyly types D and E.

Richard C Trembath, Henk Giele, Robert M Esnouf, 2003, American journal of human genetics.

Chemical and structural lessons from recent successes in protein-protein interaction inhibition (2P2I).

Philippe Roche, Xavier Morelli, Raphaël Bourgeas, 2011, Current opinion in chemical biology.

Modeling study of human renal chloride channel (hCLC-5) mutations suggests a structural-functional relationship.

R. Esnouf, P. Roche, N. Loh, 2003, Kidney international.

MEMO associated with an ErbB2 receptor phosphopeptide reveals a new phosphotyrosine motif

F. Guerlesquin, P. Roche, D. Salaun, 2011, FEBS letters.

Paraganglioma of the organ of Zuckerkandl associated with a somatic HIF2α mutation: A case report

P. Roche, K. Pacak, A. Barlier, 2017, Oncology letters.

Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space.

Philippe Roche, Xu Zhang, Xavier Morelli, 2014, Future medicinal chemistry.

Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loading with syndecan and EpCAM cargo

D. Kovalskyy, P. Roche, S. Betzi, 2020, Journal of extracellular vesicles.

2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein–protein interactions

Philippe Roche, Xavier Morelli, Marie Jeanne Basse, 2016, Database J. Biol. Databases Curation.

NMR and MD investigations of human galectin-1/oligosaccharide complexes.

Christophe Meynier, Françoise Guerlesquin, Philippe Roche, 2009, Biophysical journal.

From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia

P. Roche, S. Betzi, P. Dubreuil, 2023, Nature communications.

Rational Design of PDZ Domain Inhibitors: Discovery of Small Organic Compounds Targeting PDZ Domains.

P. Roche, X. Morelli, L. Hoffer, 2021, Methods in molecular biology.

CovaDOTS: In Silico Chemistry-Driven Tool to Design Covalent Inhibitors Using a Linking Strategy

Dragos Horvath, Alexandre Varnek, Philippe Roche, 2019, J. Chem. Inf. Model..

Fr-PPIChem: An academic compound library dedicated to protein-protein interactions.

Olivier Sperandio, Maria A Miteva, Bruno O Villoutreix, 2020, ACS chemical biology.

2P2Idb: a structural database dedicated to orthosteric modulation of protein–protein interactions

Philippe Roche, Xavier Morelli, Raphaël Bourgeas, 2012, Nucleic Acids Res..

Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.

P. Roche, S. Betzi, Avais M. Daulat, 2023, Journal of medicinal chemistry.

Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer.

J. Borg, P. Roche, S. Betzi, 2022, ACS chemical biology.

2P2IHUNTER: a tool for filtering orthosteric protein–protein interaction modulators via a dedicated support vector machine

Philippe Roche, Xavier Morelli, Marie Jeanne Basse, 2014, Journal of The Royal Society Interface.

machine interaction modulators via a dedicated support vector protein - : a tool for filtering orthosteric protein HUNTER 2P2I

Philippe Roche, Xavier Morelli, Véronique Hamon, 2013 .

2 P 2 IHUNTER : a tool for filtering orthosteric protein – protein interaction modulators via a dedicated support vector machine

Xavier Morelli, Marie Jeanne Basse, Pierre Ducrot, 2013 .

Structures of Three HIV-1 HLA-B*5703-Peptide Complexes and Identification of Related HLAs Potentially Associated with Long-Term Nonprogression12

R. Kaul, P. Roche, G. Gillespie, 2005, The Journal of Immunology.