M. Gunaratnam

发表

Optimization of anti-proliferative activity using a screening approach with a series of bis-heterocyclic G-quadruplex ligands.

Stephan A. Ohnmacht, G. Vignaroli, S. Neidle, 2013, Bioorganic & medicinal chemistry letters.

Sequences in the HSP90 promoter form G-quadruplex structures with selectivity for disubstituted phenyl bis-oxazole derivatives.

Stephan A. Ohnmacht, M. Micco, M. Zloh, 2012, Bioorganic & medicinal chemistry letters.

A new plant-derived antibacterial is an inhibitor of efflux pumps in Staphylococcus aureus.

D. Livermore, S. Neidle, M. Gunaratnam, 2013, International journal of antimicrobial agents.

Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes.

G. Parkinson, N. Campbell, S. Neidle, 2012, Journal of medicinal chemistry.

Crystal structure of a promoter sequence in the B-raf gene reveals an intertwined dimer quadruplex.

G. Parkinson, M. Zloh, S. Neidle, 2013, Journal of the American Chemical Society.

TRAP-LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules.

Julie E Reed, S. Neidle, M. Gunaratnam, 2008, Analytical biochemistry.

The prenylated dioxopiperazine alkaloid Cristatin A has selective telomeric DNA G-quadruplex stabilising properties.

T. Bui, A. Drake, S. Neidle, 2012, Chemical communications.

Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells.

S. Neidle, M. Gunaratnam, J. Riou, 2010, Bioorganic & medicinal chemistry letters.

Biaryl polyamides as a new class of DNA quadruplex-binding ligands.

S. Neidle, M. Gunaratnam, A. Reszka, 2009, Chemical communications.

Targeting pancreatic cancer with a G-quadruplex ligand.

A. Schätzlein, S. Neidle, M. Gunaratnam, 2011, Bioorganic & medicinal chemistry.

A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer

Stephan A. Ohnmacht, J. Šponer, J. Šponer, 2015, Scientific Reports.

Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule

Stephan A. Ohnmacht, S. Balasubramanian, S. Neidle, 2018, Journal of medicinal chemistry.

Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors.

S. Neidle, M. Gunaratnam, Pallavi Sharma, 2015, Organic & biomolecular chemistry.

The role of glutathione reductase in the cytotoxicity of chromium (VI) in isolated rat hepatocytes.

M. Gunaratnam, M. Grant, 2001, Chemico-biological interactions.

Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry.

S. Neidle, M. Gunaratnam, Michael J B Moore, 2006, Journal of the American Chemical Society.

The interaction of the orthopaedic metals, chromium VI and nickel, with hepatocytes

M. Gunaratnam, M. Grant, 2001, Journal of materials science. Materials in medicine.

Damage to F-actin and cell death induced by chromium VI and nickel in primary monolayer cultures of rat hepatocytes.

M. Gunaratnam, M. Grant, 2004, Toxicology in vitro : an international journal published in association with BIBRA.

Cr (VI) inhibits DNA, RNA and protein syntheses in hepatocytes: involvement of glutathione reductase, reduced glutathione and DT-diaphorase.

M. Gunaratnam, M. Grant, 2008, Toxicology in vitro : an international journal published in association with BIBRA.

Macrocyclic naphthalene diimides as G-quadruplex binders.

Stephan A. Ohnmacht, V. Tumiatti, A. Milelli, 2015, Bioorganic & medicinal chemistry.

Bioactive pyridine-N-oxide disulfides from Allium stipitatum.

Stephen Neidle, Simon Gibbons, Mekala Gunaratnam, 2009, Journal of natural products.

New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity.

S. Neidle, M. Gunaratnam, J. Mann, 2006, Organic & biomolecular chemistry.

Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation.

Stephen Neidle, Javier Cuesta, Mekala Gunaratnam, 2006, Journal of medicinal chemistry.

Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives.

G. Prencipe, S. Ley, S. Neidle, 2007, Angewandte Chemie.

Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells.

Stephen Neidle, Mekala Gunaratnam, Stephan A. Ohnmacht, 2013, Journal of medicinal chemistry.

Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands.

S. Neidle, Rupesh K. Nanjunda, W. Wilson, 2008, Bioorganic & medicinal chemistry letters.

Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule.

J. Fletcher, S. Neidle, M. Gunaratnam, 2009, Journal of medicinal chemistry.

Indolo[3,2‐c]quinoline G‐Quadruplex Stabilizers: a Structural Analysis of Binding to the Human Telomeric G‐Quadruplex

Stephan A. Ohnmacht, S. Neidle, J. Lavrado, 2015, ChemMedChem.

G-quadruplex compounds and cis-platin act synergistically to inhibit cancer cell growth in vitro and in vivo.

S. Neidle, L. Kèlland, M. Gunaratnam, 2009, Biochemical pharmacology.

Bioactive Compounds from Carissa spinarum

S. Neidle, M. Gunaratnam, V. Lipipun, 2012, Phytotherapy research : PTR.

Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents.

S. Neidle, L. Kèlland, M. Gunaratnam, 2007, Bioorganic & medicinal chemistry letters.

A naphthalene diimide G-quadruplex ligand inhibits cell growth and down-regulates BCL-2 expression in an imatinib-resistant gastrointestinal cancer cell line.

G. Parkinson, S. Neidle, M. Gunaratnam, 2018, Bioorganic & medicinal chemistry.

KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines

Stephan A. Ohnmacht, S. Neidle, J. Lavrado, 2015, Scientific Reports.

Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs.

Stephen Neidle, Mekala Gunaratnam, Gary N Parkinson, 2008, Journal of medicinal chemistry.

The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity of tetra-substituted naphthalene diimide compounds.

Stephan A. Ohnmacht, S. Neidle, M. Gunaratnam, 2013, Bioorganic & medicinal chemistry.

Pretreatment of rats with the inducing agents phenobarbitone and 3-methylcholanthrene ameliorates the toxicity of chromium (VI) in hepatocytes.

M. Gunaratnam, M. Grant, M. Pohlscheidt, 2002, Toxicology in vitro : an international journal published in association with BIBRA.

Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands.

Stephen Neidle, Shozeb Haider, Mekala Gunaratnam, 2008, Molecular bioSystems.

Mechanism of acridine-based telomerase inhibition and telomere shortening.

Stephen Neidle, Hamid Morjani, Mekala Gunaratnam, 2007, Biochemical pharmacology.

An evaluation cascade for G-quadruplex telomere targeting agents in human cancer cells.

Stephen Neidle, Mekala Gunaratnam, S. Neidle, 2010, Methods in molecular biology.

Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif.

S. Neidle, M. Gunaratnam, S. Haider, 2010, Chemical communications.

Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes.

Stephen Neidle, Mekala Gunaratnam, Silvia Sparapani, 2010, Journal of the American Chemical Society.

Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets.

Andrew J. P. White, L. Buluwela, S. Neidle, 2012, Journal of medicinal chemistry.

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors

S. Neidle, M. Gunaratnam, V. Petrucci, 2013, Beilstein journal of organic chemistry.

Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines.

S. Balasubramanian, J. Fletcher, S. Neidle, 2010, ACS medicinal chemistry letters.

Discovery of new G-quadruplex binding chemotypes.

Stephan A. Ohnmacht, S. Neidle, Rupesh K. Nanjunda, 2014, Chemical communications.

Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines.

S. Balasubramanian, J. Fletcher, S. Neidle, 2010, ACS medicinal chemistry letters.