R. Sabaté

发表

Native structure protects SUMO proteins from aggregation into amyloid fibrils.

Raimon Sabate, Salvador Ventura, David Reverter, 2012, Biomacromolecules.

Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids.

F. J. Luque, R. Lamuela-Raventós, V. Andrisano, 2017, Future medicinal chemistry.

Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies.

F. J. Luque, J. Juárez-Jiménez, R. Sabaté, 2014, European journal of medicinal chemistry.

Temperature dependence of the nucleation constant rate in beta amyloid fibrillogenesis.

R. Sabaté, J. Estelrich, M. Gallardo, 2005, International journal of biological macromolecules.

Evidence of Protein Adsorption in Pegylated Liposomes: Influence of Liposomal Decoration

R. Sabaté, A. Espargaró, M. Busquets, 2017, Nanomaterials.

Determination of the dimerization constant of pinacyanol: role of the thermochromic effect.

R. Sabaté, J. Estelrich, 2008, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

Key Points Concerning Amyloid Infectivity and Prion-Like Neuronal Invasion

R. Sabaté, A. Espargaró, M. Busquets, 2016, Front. Mol. Neurosci..

1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease.

B. Malawska, R. Sabaté, S. Gobec, 2019, European journal of medicinal chemistry.

Magnetic Nanoparticles Cross the Blood-Brain Barrier: When Physics Rises to a Challenge

R. Sabaté, A. Espargaró, M. Busquets, 2015, Nanomaterials.

Potential applications of magnetic particles to detect and treat Alzheimer's disease

R. Sabaté, M. Busquets, J. Estelrich, 2014, Nanoscale Research Letters.

Histidine-Rich Oligopeptides To Lessen Copper-Mediated Amyloid-β Toxicity.

R. Sabaté, A. Espargaró, E. Nicolás, 2016, Chemistry.

Solid state NMR reveals a parallel in register architecture for an infectious recombinant prion

M. Martín-Pastor, J. Castilla, R. Sabaté, 2021, bioRxiv.

The effect of amyloidogenic peptides on bacterial aging correlates with their intrinsic aggregation propensity.

A. Muga, R. Sabaté, S. Ventura, 2012, Journal of molecular biology.

Predicting the aggregation propensity of prion sequences.

R. Sabaté, A. Espargaró, M. Busquets, 2015, Virus research.

Design, Synthesis, and In Vitro, In Silico and In Cellulo Evaluation of New Pyrimidine and Pyridine Amide and Carbamate Derivatives as Multi-Functional Cholinesterase Inhibitors

A. Stringaro, R. Sabaté, A. Espargaró, 2022, Pharmaceuticals.

Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies.

F. J. Luque, I. Ferrer, R. Sabaté, 2015, Journal of medicinal chemistry.

Identification of a novel cell death-inducing domain reveals that fungal amyloid-controlled programmed cell death is related to necroptosis

B. Habenstein, K. Hofmann, R. Sabaté, 2016, Proceedings of the National Academy of Sciences.

Regioselective synthesis of 7-O-esters of the flavonolignan silibinin and SARs lead to compounds with overadditive neuroprotective effects.

M. Decker, R. Sabaté, P. Maher, 2018, European journal of medicinal chemistry.

On the Binding of Congo Red to Amyloid Fibrils.

F. J. Luque, R. Sabaté, A. Espargaró, 2020, Angewandte Chemie.

In vivo amyloid aggregation kinetics tracked by time‐lapse confocal microscopy in real‐time

R. Sabaté, A. Espargaró, S. Ventura, 2016, Biotechnology journal.

Amyloids or prions? That is the question

J. Schymkowitz, F. Rousseau, R. Sabaté, 2015, Prion.

Thioflavin-T excimer formation upon interaction with amyloid fibers.

L. Rodríguez-Santiago, M. Sodupe, R. Sabaté, 2013, Chemical communications.

Cross-β-sheet supersecondary structure in amyloid folds: techniques for detection and characterization.

R. Sabaté, S. Ventura, 2013, Methods in molecular biology.

Thioflavin-S staining coupled to flow cytometry. A screening tool to detect in vivo protein aggregation.

R. Sabaté, A. Espargaró, S. Ventura, 2012, Molecular bioSystems.

Temperature dependence of the aggregation kinetics of Sup35 and Ure2p yeast prions.

R. Sabaté, A. Espargaró, S. Ventura, 2012, Biomacromolecules.

Characterization of the amyloid bacterial inclusion bodies of the HET-s fungal prion.

R. Sabaté, A. Espargaró, S. Ventura, 2009 .

Thioflavin T fluorescence anisotropy: an alternative technique for the study of amyloid aggregation.

R. Sabaté, S. Saupe, 2007, Biochemical and biophysical research communications.

Prion and non-prion amyloids of the HET-s prion forming domain.

U. Baxa, A. Steven, M. Maddelein, 2007, Journal of molecular biology.

Role of Hsp104 in the propagation and inheritance of the [Het-s] prion.

R. Sabaté, S. Saupe, Suzana Dos Reis, 2007, Molecular biology of the cell.

Pinacyanol as effective probe of fibrillar beta-amyloid peptide: comparative study with Congo Red.

R. Sabaté, J. Estelrich, 2003, Biopolymers.

Dual Inhibitors of Amyloid-β and Tau Aggregation with Amyloid-β Disaggregating Properties: Extended In Cellulo, In Silico, and Kinetic Studies of Multifunctional Anti-Alzheimer’s Agents

M. Bajda, B. Malawska, R. Sabaté, 2021, ACS chemical neuroscience.

Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer’s disease

M. Bajda, B. Malawska, R. Sabaté, 2020, Journal of enzyme inhibition and medicinal chemistry.

Peptidic Scaffolds To Reduce the Interaction of Cu(II) Ions with β-Amyloid Protein.

R. Sabaté, O. Iranzo, P. Gamez, 2019, Inorganic chemistry.

Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer’s Disease

R. Sabaté, A. Espargaró, M. de Candia, 2020, Molecules.

An autocatalytic reaction as a model for the kinetics of the aggregation of β‐amyloid

R. Sabaté, J. Estelrich, M. Gallardo, 2003, Biopolymers.

Spontaneous incorporation of β-amyloid peptide into neutral liposomes

R. Sabaté, J. Estelrich, M. Gallardo, 2005 .

Three to Tango: Inhibitory Effect of Quercetin and Apigenin on Acetylcholinesterase, Amyloid-β Aggregation and Acetylcholinesterase-Amyloid Interaction

F. J. Luque, R. Sabaté, A. Espargaró, 2022, Pharmaceutics.

Thiosemicarbazone Derivatives as Inhibitors of Amyloid-β Aggregation: Effect of Metal Coordination.

R. Sabaté, A. Espargaró, P. Gamez, 2020, Inorganic chemistry.

Aggregation characteristics of ovalbumin in beta-sheet conformation determined by spectroscopy.

R. Sabaté, J. Estelrich, 2002, Biopolymers.

Mass Analysis by Scanning Transmission Electron Microscopy and Electron Diffraction Validate Predictions of Stacked β-Solenoid Model of HET-s Prion Fibrils*

U. Baxa, A. Steven, J. Wall, 2007, Journal of Biological Chemistry.

From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects.

V. Andrisano, M. Bartolini, M. Bolognesi, 2021, European journal of medicinal chemistry.

Electrophoretic properties of dodecyltrimethylammonium bromide micelles in KBr solution

R. Sabaté, J. Estelrich, M. Gallardo, 2000, Electrophoresis.

Two structurally similar fungal prions efficiently cross‐seed in vivo but form distinct polymers when coexpressed

R. Sabaté, S. Saupe, F. Ness, 2011, Molecular microbiology.

Methods for the in vivo and in vitro analysis of [Het-s] prion infectivity.

M. Maddelein, R. Sabaté, S. Saupe, 2006, Methods.

New Pyrimidine and Pyridine Derivatives as Multitarget Cholinesterase Inhibitors: Design, Synthesis, and In Vitro and In Cellulo Evaluation

A. Stringaro, R. Sabaté, A. Espargaró, 2021, ACS chemical neuroscience.

Investigation into the stability and reactivity of the pentacyclic alkaloid dehydroevodiamine and the benz-analog thereof

M. Decker, R. Sabaté, A. Espargaró, 2016 .

Influence of Dielectric Constant on the Spectral Behavior of Pinacyanol. A Spectrophotometric Experiment for Physical Chemistry

R. Sabaté, J. Estelrich, Llúcia Freire, 2001 .

Infectious and noninfectious amyloids of the HET-s(218-289) prion have different NMR spectra.

R. Riek, B. Meier, R. Sabaté, 2008, Angewandte Chemie.

Raimon Sabaté, Christiane Ritter, Alice Soragni, 2010, Journal of molecular biology.

A Spectroscopy Study of the Interaction of Pinacyanol with n-dodecyltrimethylammonium Bromide Micelles

R. Sabaté, J. Estelrich, M. Gallardo, 2001 .

Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.

F. J. Luque, F Javier Luque, Vincenza Andrisano, 2014, Journal of medicinal chemistry.

Dual inhibitors of β-amyloid aggregation and acetylcholinesterase as multi-target anti-Alzheimer drug candidates.

R. Sabaté, D. Muñoz-Torrero, E. Viayna, 2013, Current topics in medicinal chemistry.

A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.

V. Andrisano, M. Bartolini, R. Sabaté, 2019, European journal of medicinal chemistry.

Air Curtains Equipped With Hydroalcoholic Aerosol Sprayers for Massive COVID-19 Disinfection

R. Sabaté, Judit Raventós, 2021, Frontiers in Public Health.

Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs.

F. J. Luque, R. Sabaté, A. Espargaró, 2017, Journal of natural products.

Copper, dityrosine cross-links and amyloid-β aggregation

R. Sabaté, P. Gamez, Ana B. Caballero, 2019, JBIC Journal of Biological Inorganic Chemistry.

Natural Xanthones from Garcinia mangostana with Multifunctional Activities for the Therapy of Alzheimer’s Disease

Raimon Sabaté, R. Sabaté, R. Pi, 2016, Neurochemical Research.

The role of protein sequence and amino acid composition in amyloid formation: scrambling and backward reading of IAPP amyloid fibrils.

Salvador Ventura, Raimon Sabaté, R. Sabaté, 2010, Journal of molecular biology.

Energy barriers for HET‐s prion forming domain amyloid formation

R. Sabaté, A. Espargaró, S. Ventura, 2009, The FEBS journal.

Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties.

F. J. Luque, Ornella Di Pietro, R. Lamuela-Raventós, 2014, Bioorganic & medicinal chemistry.

Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents.

J. Kos, M. Bajda, B. Malawska, 2018, ACS chemical neuroscience.

Bacterial Inclusion Bodies for Anti-Amyloid Drug Discovery: Current and Future Screening Methods.

R. Sabaté, A. Espargaró, M. Busquets, 2019, Current protein & peptide science.

Amyloid Pan-inhibitors: One Family of Compounds To Cope with All Conformational Diseases.

R. Sabaté, A. Espargaró, D. Muñoz-Torrero, 2018, ACS chemical neuroscience.

When amyloids become prions

R. Sabaté, 2014, Prion.

PrionW: a server to identify proteins containing glutamine/asparagine rich prion-like domains and their amyloid cores

Joost Schymkowitz, Frederic Rousseau, Rafael Zambrano, 2015, Nucleic Acids Res..

Signal Transduction by a Fungal NOD-Like Receptor Based on Propagation of a Prion Amyloid Fold

B. Habenstein, R. Sabaté, A. Debets, 2015, PLoS biology.

Amyloids in solid-state nuclear magnetic resonance: potential causes of the usually low resolution

R. Sabaté, A. Espargaró, M. Busquets, 2015, International journal of nanomedicine.

Bacterial Inclusion Bodies of Alzheimer's Disease β‐Amyloid Peptides Can Be Employed To Study Native‐Like Aggregation Intermediate States

U. Fink, B. Reif, R. Sabaté, 2011, Chembiochem : a European journal of chemical biology.

Protein folding and aggregation in bacteria

R. Sabaté, S. Ventura, N. Groot, 2010, Cellular and Molecular Life Sciences.

Kinetic and thermodynamic stability of bacterial intracellular aggregates

R. Sabaté, A. Espargaró, S. Ventura, 2008, FEBS letters.

Protein aggregation: mechanisms and functional consequences.

Elena Papaleo, Raimon Sabate, Salvador Ventura, 2012, The international journal of biochemistry & cell biology.

New cyclopentaquinoline and 3,5-dichlorobenzoic acid hybrids with neuroprotection against oxidative stress for the treatment of Alzheimer’s disease

M. Bajda, R. Sabaté, A. Espargaró, 2023, Journal of enzyme inhibition and medicinal chemistry.

Biological role of bacterial inclusion bodies: a model for amyloid aggregation

Antonio Villaverde, Raimon Sabate, Salvador Ventura, 2011, The FEBS journal.

Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies

M. D. Di Bari, R. Nonno, J. Castilla, 2019, PLoS pathogens.

Protein Folding Activity of Ribosomal RNA Is a Selective Target of Two Unrelated Antiprion Drugs

C. Voisset, S. Supattapone, S. Sanyal, 2008, PloS one.

Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease.

J. D. del Río, E. Laurini, S. Pricl, 2023, European journal of medicinal chemistry.

Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6.

F. J. Luque, F. Ciruela, I. Ferrer, 2020, Journal of medicinal chemistry.

Amyloid-Like Protein Inclusions in Tobacco Transgenic Plants

R. Sabaté, S. Ventura, J. Torné, 2010, PloS one.

Prediction of the aggregation propensity of proteins from the primary sequence: Aggregation properties of proteomes

Raimon Sabate, Salvador Ventura, Virginia Castillo, 2011, Biotechnology journal.

Yeast prions form infectious amyloid inclusion bodies in bacteria

R. Sabaté, A. Espargaró, S. Ventura, 2012, Microbial Cell Factories.

Amyloids in bacterial inclusion bodies.

R. Sabaté, S. Ventura, N. S. de Groot, 2009, Trends in biochemical sciences.

Evidence of the existence of micelles in the fibrillogenesis of beta-amyloid peptide.

Raimon Sabaté, R. Sabaté, J. Estelrich, 2005, The journal of physical chemistry. B.

Aggregation of the neuroblastoma-associated mutant (S120G) of the human nucleoside diphosphate kinase-A/NM23-H1 into amyloid fibrils

I. Lascu, R. Sabaté, A. Espargaró, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Preparation and characterization of extruded magnetoliposomes.

Raimon Sabaté, José Callejas-Fernández, R. Sabaté, 2008, International journal of pharmaceutics.

Ultra rapid in vivo screening for anti-Alzheimer anti-amyloid drugs

R. Sabaté, A. Espargaró, D. Muñoz-Torrero, 2016, Scientific Reports.

Could α-Synuclein Amyloid-Like Aggregates Trigger a Prionic Neuronal Invasion?

R. Sabaté, A. Espargaró, M. Busquets, 2015, BioMed research international.

Screening for amyloid aggregation: in-silico, in-vitro and in-vivo detection.

R. Sabaté, A. Espargaró, S. Ventura, 2014, Current protein & peptide science.

Self-assembly of human amylin-derived peptides studied by atomic force microscopy and single molecule force spectroscopy

J. Samitier, R. Sabaté, S. Ventura, 2012 .

What Makes a Protein Sequence a Prion?

Joost Schymkowitz, Frederic Rousseau, Raimon Sabate, 2015, PLoS Comput. Biol..

Probing the jellium model with colloidal dispersions of charged liposomes

R. Sabaté, R. Hidalgo-Álvarez, M. Quesada-Pérez, 2005 .

Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and β-amyloid inhibitors for the treatment of Alzheimer's disease.

B. Malawska, R. Sabaté, A. Espargaró, 2023, Bioorganic & medicinal chemistry.

Disaggregating effects of ethanol at low concentration on β-poly-l-lysines

R. Sabaté, J. Estelrich, 2003 .

Effect of the surface charge of artificial model membranes on the aggregation of amyloid β-peptide.

R. Sabaté, A. Espargaró, S. Ventura, 2012, Biochimie.

Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer’s Disease

M. Bartolini, M. Bolognesi, R. Sabaté, 2022, ACS chemical neuroscience.

Thioflavin-S staining of bacterial inclusion bodies for the fast, simple, and inexpensive screening of amyloid aggregation inhibitors.

R. Sabaté, A. Espargaró, S. Ventura, 2014, Current medicinal chemistry.

Using bacterial inclusion bodies to screen for amyloid aggregation inhibitors

R. Sabaté, A. Espargaró, S. Ventura, 2012, Microbial Cell Factories.

Stimulatory and inhibitory effects of alkyl bromide surfactants on beta-amyloid fibrillogenesis.

R. Sabaté, J. Estelrich, 2005, Langmuir : the ACS journal of surfaces and colloids.

Translational diffusion in charged phospholipid bilayer membranes

R. Sabaté, J. Estelrich, J. D. Solier, 2005 .

On the binding of Thioflavin-T to HET-s amyloid fibrils assembled at pH 2.

I. Lascu, R. Sabaté, S. Saupe, 2008, Journal of structural biology.

Solid-state NMR spectroscopy reveals that E. coli inclusion bodies of HET-s(218-289) are amyloids.

R. Riek, B. Meier, M. Steinmetz, 2009, Angewandte Chemie.

Protein aggregation: mechanisms and functional consequences.

R. Sabaté, S. Ventura, G. Invernizzi, 2012, The international journal of biochemistry & cell biology.

Natural Xanthones from Garcinia mangostana with Multifunctional Activities for the Therapy of Alzheimer’s Disease

R. Sabaté, R. Pi, Qian Li, 2016, Neurochemical Research.

Two structurally similar fungal prions efficiently cross‐seed in vivo but form distinct polymers when coexpressed

R. Sabaté, S. Saupe, F. Ness, 2011, Molecular microbiology.

Phosphorylation-driven aggregative proteins in neurodegenerative diseases: implications and therapeutics

R. Sabaté, A. Espargaró, 2023, Neural Regeneration Research.

Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs.

R. Sabaté, A. Espargaró, Tiziana Ginex, 2017, Journal of natural products.

Temperature dependence of the aggregation kinetics of Sup35 and Ure2p yeast prions.

R. Sabaté, A. Espargaró, S. Ventura, 2012, Biomacromolecules.

Microbial Cell Factories Characterization of the Amyloid Bacterial Inclusion Bodies of the Het-s Fungal Prion

R. Sabaté, A. Espargaró, S. Ventura, 2022 .

Predicting the aggregation propensity of prion sequences.

R. Sabaté, A. Espargaró, M. Busquets, 2015, Virus research.

Proximity-Induced Pharmacology for Amyloid-Related Diseases

R. Sabaté, A. Espargaró, Irene Álvarez-Berbel, 2024, Cells.